FTX

Summary

FTX (FTX transcript, XIST regulator, HGNC:37190) is a long non-coding RNA gene on chromosome Xq13.2.

This gene is located upstream of XIST, within the X-inactivation center (XIC). It produces a spliced long non-coding RNA that is thought to positively regulate the expression of XIST, which is essential for the initiation and spread of X-inactivation.

Source: NCBI Gene 100302692 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37190
Approved symbol	FTX
Name	FTX transcript, XIST regulator
Location	Xq13.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	LINC00182, FLJ33139
Ensembl gene	ENSG00000230590
Ensembl biotype	lncRNA
OMIM	300936
Entrez	100302692
RNAcentral	URS000043C800 — lncRNA, 2356 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 79 — 79 lncRNA

ENST00000418855, ENST00000423992, ENST00000429124, ENST00000430772, ENST00000455395, ENST00000602420, ENST00000602576, ENST00000602776, ENST00000602812, ENST00000603037, ENST00000603672, ENST00000603952, ENST00000638232, ENST00000638437, ENST00000638681, ENST00000638985, ENST00000639539, ENST00000641360, ENST00000651140, ENST00000651392, ENST00000651451, ENST00000651703, ENST00000651936, ENST00000652013, ENST00000652071, ENST00000652319, ENST00000652327, ENST00000652331, ENST00000652496, ENST00000652527, ENST00000652540, ENST00000652609, ENST00000652970, ENST00000653018, ENST00000653390, ENST00000653874, ENST00000654373, ENST00000654870, ENST00000656041, ENST00000656977, ENST00000657070, ENST00000657327, ENST00000657611, ENST00000658203, ENST00000658439, ENST00000658448, ENST00000659012, ENST00000659390, ENST00000659407, ENST00000659574, ENST00000660100, ENST00000660224, ENST00000660481, ENST00000660829, ENST00000661084, ENST00000661133, ENST00000661335, ENST00000662240, ENST00000662494, ENST00000662864, ENST00000664123, ENST00000664343, ENST00000664803, ENST00000665069, ENST00000665313, ENST00000666535, ENST00000668224, ENST00000669263, ENST00000670936, ENST00000671067, ENST00000671343, ENST00000671385, ENST00000685808, ENST00000687056, ENST00000691187, ENST00000693483, ENST00000701078, ENST00000701244, ENST00000701585

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000418855 — 5 exons

Exon	Start	End
ENSE00001634411	74281702	74281848
ENSE00001651003	74280931	74281085
ENSE00001698212	74280394	74280494
ENSE00003847482	74292169	74292359
ENSE00003871216	74274260	74274410

Expression profiles

Bgee: expression breadth ubiquitous, 254 present calls, max score 99.37.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 22.7717 / max 373.1940, expressed in 1781 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
199766	9.5804	1613
199764	4.0565	1391
199762	3.7207	1341
199763	2.0959	980
199765	1.5755	670
199760	1.2791	687
199761	0.4636	224

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pancreatic ductal cell	CL:0002079	99.37	gold quality
seminal vesicle	UBERON:0000998	98.94	gold quality
kidney epithelium	UBERON:0004819	98.90	gold quality
nipple	UBERON:0002030	98.70	gold quality
trabecular bone tissue	UBERON:0002483	98.65	gold quality
cardiac muscle of right atrium	UBERON:0003379	98.32	gold quality
colonic epithelium	UBERON:0000397	98.15	gold quality
pylorus	UBERON:0001166	98.12	gold quality
renal medulla	UBERON:0000362	98.05	gold quality
adult organism	UBERON:0007023	97.87	gold quality
mammalian vulva	UBERON:0000997	97.68	gold quality
cardia of stomach	UBERON:0001162	97.66	gold quality
cerebellar vermis	UBERON:0004720	97.57	gold quality
corpus epididymis	UBERON:0004359	97.53	gold quality
caput epididymis	UBERON:0004358	97.51	gold quality
skin of hip	UBERON:0001554	97.46	gold quality
calcaneal tendon	UBERON:0003701	97.43	gold quality
sural nerve	UBERON:0015488	97.35	gold quality
corpus callosum	UBERON:0002336	97.31	gold quality
trachea	UBERON:0003126	97.29	gold quality
myocardium	UBERON:0002349	97.22	gold quality
cauda epididymis	UBERON:0004360	97.19	gold quality
tibialis anterior	UBERON:0001385	97.16	gold quality
adrenal tissue	UBERON:0018303	97.13	gold quality
urethra	UBERON:0000057	96.97	gold quality
trigeminal ganglion	UBERON:0001675	96.93	gold quality
thymus	UBERON:0002370	96.90	gold quality
penis	UBERON:0000989	96.77	gold quality
superior surface of tongue	UBERON:0007371	96.67	gold quality
dorsal root ganglion	UBERON:0000044	96.55	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	9.58
E-MTAB-9543	no	2.17

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 22)

• these findings suggest that lnc-FTX may act as a tumor suppressor in hepatocellular carcinoma (HCC) through physically binding miR-374a and MCM2. It may also be one of the reasons for HCC gender disparity and may potentially contribute to HCC treatment (PMID:27065331)
• Study showed that lncRNA Ftx was upregulated in human hepatocellular carcinoma (HCC) tissues and cell lines and associated with aggressive clinicopathological features. lncRNA Ftx overexpression promoted the proliferation, invasion and migration of HCC cells, whereas its knockdown resulted in the opposite effects. lncRNA Ftx seems to be a promoter of the Warburg effect and tumor progression, partly via the PPARgamma pa… (PMID:29845188)
• Data demonstrated an oncogenic role of lncRNA FTX in CRC tumorigenesis and progression via interaction with miR-215 and vimentin. (PMID:29925853)
• Quantitative Proteomics Analysis Revealed the Potential Role of lncRNA Ftx in Promoting Gastric Cancer Progression. (PMID:31709769)
• LncRNA FTX inhibition restrains osteosarcoma proliferation and migration via modulating miR-320a/TXNRD1. (PMID:31920141)
• Long non-coding RNA FTX alleviates hypoxia/reoxygenation-induced cardiomyocyte injury via miR-410-3p/Fmr1 axis. (PMID:31957854)
• LncRNA FTX activates FOXA2 expression to inhibit non-small-cell lung cancer proliferation and metastasis. (PMID:32176463)
• Long non-coding RNA FTX promotes gastric cancer progression by targeting miR-215. (PMID:32271421)
• Long noncoding RNA FTX is associated with prognosis of glioma patients. (PMID:32476208)
• Down-regulation of FTX promotes the differentiation of osteoclasts in osteoporosis through the Notch1 signaling pathway by targeting miR-137. (PMID:32660465)
• The Function of LncRNA FTX in Several Common Cancers. (PMID:33121404)
• LncRNA FTX Promotes Colorectal Cancer Cells Migration and Invasion by miRNA-590-5p/RBPJ Axis. (PMID:33389283)
• Long non-coding RNA FTX predicts a poor prognosis of human cancers: a meta-analysis. (PMID:33398336)
• Silencing of FTX suppresses pancreatic cancer cell proliferation and invasion by upregulating miR-513b-5p. (PMID:33736615)
• Long non-coding RNA (lncRNA) five prime to Xist (FTX) promotes retinoblastoma progression by regulating the microRNA-320a/with-no-lysine kinases 1 (WNK1) axis. (PMID:34720057)
• Prognostic significance of long non-coding RNA five prime to XIST in various cancers. (PMID:35027040)
• Overexpressed lncRNA FTX promotes the cell viability, proliferation, migration and invasion of renal cell carcinoma via FTX/miR4429/UBE2C axis. (PMID:35866591)
• Emerging roles of long non-coding RNA FTX in human disorders. (PMID:37095425)
• The pluripotent factor OCT4A enhances the self-renewal of human dental pulp stem cells by targeting lncRNA FTX in an LPS-induced inflammatory microenvironment. (PMID:37106382)
• Long noncoding RNA FTX promotes epithelial-mesenchymal transition of epithelial ovarian cancer through modulating miR-7515/TPD52 and activating Met/Akt/mTOR. (PMID:37140169)
• Quantitative Proteomics Analysis Reveals the Potential Role of lncRNA FTX in Endothelial Cells. (PMID:38287828)
• Mechanism of LncRNA FTX regulates nephroblastoma progression through MiR-215-5p/PI3K/AKT axis. (PMID:38365477)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.