GAB3

Summary

GAB3 (GRB2 associated binding protein 3, HGNC:17515) is a protein-coding gene on chromosome Xq28, encoding GRB2-associated-binding protein 3 (Q8WWW8).

This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 139716 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 163 total — 1 pathogenic
• MANE Select transcript: NM_001081573

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17515
Approved symbol	GAB3
Name	GRB2 associated binding protein 3
Location	Xq28
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000160219
Ensembl biotype	protein_coding
OMIM	300482
Entrez	139716

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 9 protein_coding, 2 protein_coding_CDS_not_defined

ENST00000369568, ENST00000369575, ENST00000424127, ENST00000454973, ENST00000475685, ENST00000496390, ENST00000872120, ENST00000872121, ENST00000872122, ENST00000872123, ENST00000943825

RefSeq mRNA: 3 — MANE Select: NM_001081573 NM_001081573, NM_001282283, NM_080612

CCDS: CCDS14760, CCDS48198, CCDS65357

Canonical transcript exons

ENST00000424127 — 10 exons

Exon	Start	End
ENSE00001096286	154712229	154712701
ENSE00001450374	154675249	154678294
ENSE00002097975	154750954	154751077
ENSE00003491409	154699294	154699513
ENSE00003493606	154695917	154696019
ENSE00003528967	154700004	154700059
ENSE00003533915	154697132	154697213
ENSE00003559769	154680132	154680248
ENSE00003560057	154716026	154716329
ENSE00003659487	154713207	154713426

Expression profiles

Bgee: expression breadth ubiquitous, 187 present calls, max score 93.39.

FANTOM5 (CAGE): breadth broad, TPM avg 3.3954 / max 95.4385, expressed in 826 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
201056	3.1187	800
201057	0.1828	94
201058	0.0939	43

Top tissues by expression

243 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left ventricle myocardium	UBERON:0006566	93.39	gold quality
cardiac muscle of right atrium	UBERON:0003379	91.63	gold quality
granulocyte	CL:0000094	90.88	gold quality
apex of heart	UBERON:0002098	90.04	gold quality
blood	UBERON:0000178	88.37	gold quality
spleen	UBERON:0002106	86.75	gold quality
leukocyte	CL:0000738	86.40	gold quality
monocyte	CL:0000576	86.33	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.67	gold quality
trabecular bone tissue	UBERON:0002483	84.81	gold quality
heart left ventricle	UBERON:0002084	84.75	gold quality
cardiac ventricle	UBERON:0002082	84.36	gold quality
myocardium	UBERON:0002349	84.20	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.50	gold quality
heart	UBERON:0000948	81.95	gold quality
cardiac atrium	UBERON:0002081	81.94	gold quality
bone marrow	UBERON:0002371	81.86	gold quality
right atrium auricular region	UBERON:0006631	81.73	gold quality
bone marrow cell	CL:0002092	79.18	gold quality
right lung	UBERON:0002167	79.14	gold quality
upper lobe of left lung	UBERON:0008952	78.09	gold quality
vermiform appendix	UBERON:0001154	77.86	gold quality
upper lobe of lung	UBERON:0008948	77.12	gold quality
lymph node	UBERON:0000029	77.00	gold quality
small intestine Peyer’s patch	UBERON:0003454	76.99	gold quality
subcutaneous adipose tissue	UBERON:0002190	76.96	gold quality
omental fat pad	UBERON:0010414	76.95	gold quality
peritoneum	UBERON:0002358	76.89	gold quality
adipose tissue of abdominal region	UBERON:0007808	76.74	gold quality
right coronary artery	UBERON:0001625	76.06	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.40
E-GEOD-100618	no	498.13
E-MTAB-6075	no	315.06

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

84 targeting GAB3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-6748-5P	100.00	65.81	1057
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-188-3P	100.00	68.76	1240
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-6759-5P	99.99	66.54	785
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-568	99.98	69.86	2084
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-98-5P	99.98	72.33	1787
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-8087	99.90	69.55	1351
HSA-MIR-4302	99.89	67.94	1187
HSA-MIR-345-3P	99.89	70.23	1421
HSA-MIR-3151-5P	99.86	63.83	1069

Literature-anchored findings (GeneRIF, showing 6)

• The carboxy-terminal SH3 domain of the adapter protein Mona interacts with the atypical proline-rich domain of Gab3 to mediate late signaling of the macrophage colony-stimulating factor receptor. (PMID:11997510)
• Hematopoiesis in mice lacking Gab3 is not impaired, macrophages develop in normal numbers and exhibit normal function, and there is no major immune deficiency in T- and B-lymphocyte responses to protein antigens or during viral infection. (PMID:12640125)
• Together, our results suggest that Gab3 expression in CRC cells is important for Akt-Erk activation and cell proliferation. (PMID:28115166)
• we conclude that Gab3 overexpression in human glioma mediates Akt activation and cancer cell proliferation (PMID:28291820)
• Identification of Grb2-associated binding protein 3 expression to predict clinical outcomes and immunotherapeutic responses in lung adenocarcinoma. (PMID:35822560)
• High expression of GRB2 associated binding protein 3 mRNA predicts positive prognosis in melanoma. (PMID:36545920)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio		ENSDARG00000076998
danio_rerio	si:ch73-149c21.1	ENSDARG00000093081
mus_musculus	Gab3	ENSMUSG00000032750
drosophila_melanogaster	dos	FBGN0016794
caenorhabditis_elegans		WBGENE00004928

Paralogs (7): PHLDB1 (ENSG00000019144), GAB2 (ENSG00000033327), GAB1 (ENSG00000109458), PHLDB2 (ENSG00000144824), PLEKHS1 (ENSG00000148735), PHLDB3 (ENSG00000176531), GAB4 (ENSG00000215568)

Protein

Protein identifiers

GRB2-associated-binding protein 3 — Q8WWW8 (reviewed: Q8WWW8)

Alternative names: GRB2-associated binder 3, Growth factor receptor bound protein 2-associated protein 3

All UniProt accessions (2): Q8WWW8, H7C3J9

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Interacts with PIK3R/p85, SHP2 and GRAP2/MONA. May interact with Grb2.

Post-translational modifications. Phosphorylated on tyrosine residue(s) after macrophage colony-stimulating factor (M-CSF) receptor stimulation.

Similarity. Belongs to the GAB family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q8WWW8-1	1	yes
Q8WWW8-2	2
Q8WWW8-3	3

RefSeq proteins (3): NP_001075042, NP_001269212, NP_542179 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001849	PH_domain	Domain
IPR011993	PH-like_dom_sf	Homologous_superfamily
IPR046355	Gab1-4-like	Family

Pfam: PF00169

UniProt features (12 total): region of interest 3, splice variant 2, compositionally biased region 2, modified residue 2, chain 1, domain 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8WWW8-F1	55.14	0.10

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 344, 482

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9680350	Signaling by CSF1 (M-CSF) in myeloid cells

MSigDB gene sets: 157 (showing top): GOBP_MYELOID_CELL_DIFFERENTIATION, BENPORATH_ES_WITH_H3K27ME3, REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM, GOBP_MYELOID_LEUKOCYTE_DIFFERENTIATION, GOBP_MACROPHAGE_DIFFERENTIATION, GOMF_SIGNALING_ADAPTOR_ACTIVITY, MIKKELSEN_ES_ICP_WITH_H3K4ME3, MIKKELSEN_NPC_ICP_WITH_H3K4ME3, chrXq28, GOBP_MONONUCLEAR_CELL_DIFFERENTIATION, RAO_BOUND_BY_SALL4_ISOFORM_A, RB_DN.V1_UP, CAHOY_OLIGODENDROCUTIC, GSE5503_MLN_DC_VS_SPLEEN_DC_ACTIVATED_ALLOGENIC_TCELL_UP, GSE14415_INDUCED_TREG_VS_TCONV_DN

GO Biological Process (2): signal transduction (GO:0007165), macrophage differentiation (GO:0030225)

GO Molecular Function (1): signaling adaptor activity (GO:0035591)

GO Cellular Component (1): cytoplasm (GO:0005737)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Cytokine Signaling in Immune system	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
myeloid leukocyte differentiation	1
mononuclear cell differentiation	1
protein-macromolecule adaptor activity	1
intracellular anatomical structure	1
cellular anatomical structure	1

Protein interactions and networks

STRING

484 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
GAB3	A1BG	P04217	821
GAB3	PTPN11	Q06124	694
GAB3	GRB2	P29354	682
GAB3	CSF1	P09603	587
GAB3	PLEK	P08567	573
GAB3	PLEK2	Q9NYT0	568
GAB3	CSF1R	P07333	519
GAB3	CRKL	P46109	459
GAB3	DUSP10	Q9Y6W6	454
GAB3	FRS2	Q8WU20	435
GAB3	AKT1	P31749	433
GAB3	LYN	P07948	423
GAB3	CRK	P46108	421
GAB3	UNK	Q9C0B0	397
GAB3	GAB2	Q9UQC2	392

IntAct

108 interactions, top by confidence:

A	B	Type	Score
PIK3R3	PIK3CD	psi-mi:“MI:0914”(association)	0.800
GRB2	SH3PXD2B	psi-mi:“MI:0914”(association)	0.530
GAB3	PDZD2	psi-mi:“MI:0407”(direct interaction)	0.440
GAB3	MAST2	psi-mi:“MI:0407”(direct interaction)	0.440
GAB3	SNX27	psi-mi:“MI:0407”(direct interaction)	0.440
GAB3	SNTB1	psi-mi:“MI:0407”(direct interaction)	0.440
GAB3	SNTA1	psi-mi:“MI:0407”(direct interaction)	0.440
GAB3	PDZK1	psi-mi:“MI:0407”(direct interaction)	0.440
GAB3	RHPN1	psi-mi:“MI:0407”(direct interaction)	0.440
GAB3	PTPN3	psi-mi:“MI:0407”(direct interaction)	0.440
GAB3	ARHGAP21	psi-mi:“MI:0407”(direct interaction)	0.440
GAB3	GRID2IP	psi-mi:“MI:0407”(direct interaction)	0.440
GAB3	DLG4	psi-mi:“MI:0407”(direct interaction)	0.440
PATJ	GAB3	psi-mi:“MI:0407”(direct interaction)	0.440
DLG1	GAB3	psi-mi:“MI:0407”(direct interaction)	0.440
GAB3	IL16	psi-mi:“MI:0407”(direct interaction)	0.440
SNTG1	GAB3	psi-mi:“MI:0407”(direct interaction)	0.440
GAB3	MAGI2	psi-mi:“MI:0407”(direct interaction)	0.440
GAB3	WHRN	psi-mi:“MI:0407”(direct interaction)	0.440
APBA3	GAB3	psi-mi:“MI:0407”(direct interaction)	0.440
GAB3	PALS2	psi-mi:“MI:0407”(direct interaction)	0.440
GAB3	HTRA4	psi-mi:“MI:0407”(direct interaction)	0.440
GAB3	MPP2	psi-mi:“MI:0407”(direct interaction)	0.440
GAB3	PICK1	psi-mi:“MI:0407”(direct interaction)	0.440
GAB3	LIN7C	psi-mi:“MI:0407”(direct interaction)	0.440
GAB3	LIN7B	psi-mi:“MI:0407”(direct interaction)	0.440
GAB3	LIN7A	psi-mi:“MI:0407”(direct interaction)	0.440

BioGRID (10): PTPN11 (Affinity Capture-Western), GAB3 (Affinity Capture-Western), GAB3 (Reconstituted Complex), GAB3 (Reconstituted Complex), GAB3 (Reconstituted Complex), GAB3 (Reconstituted Complex), GRB2 (Reconstituted Complex), MIPEP (Affinity Capture-MS), ABL1 (Affinity Capture-Western), LYN (Affinity Capture-Western)

ESM2 similar proteins: A5PMU4, A6QLU3, O89032, P35568, P35569, P35570, P81122, P84770, Q06649, Q13094, Q13191, Q13480, Q13625, Q1LY51, Q1LYG0, Q28224, Q3TTA7, Q4KM52, Q5NBX1, Q5RJW5, Q5TCZ1, Q60787, Q62415, Q6DFR2, Q6GQL0, Q6P4Y6, Q6ZNC4, Q80UZ0, Q8BM65, Q8BSM5, Q8C180, Q8CG79, Q8IVF5, Q8TEW8, Q8WU20, Q8WV28, Q8WWW8, Q91615, Q93073, Q96KQ4

Diamond homologs: A6QLU3, Q00IB7, Q13480, Q2WGN9, Q86SQ0, Q8BUL6, Q8K1N2, Q8WWW8, Q99PF6, Q9EQH1, Q9HB21, Q9QYY0, Q9ULM0, Q9UQC2, Q9VZZ9, Q9W5D0, Q9Z1S8, E9PXF8, O95248, P54644, Q63312, Q6NSJ2, Q6NTN5, Q6PDH0, Q6ZPE2, Q86IV4, Q86UU1, Q86WG5, Q8BSM5, B1AVY7, O35889, Q80TF6, Q96L93, Q9EQW7, Q9H1H9, Q9NQT8, Q9P2P6, Q9QZQ1, A8JQ65, B4I4Y1

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 74 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Ras activation upon Ca2+ influx through NMDA receptor	5	57.1×	1e-06
Unblocking of NMDA receptors, glutamate binding and activation	5	54.4×	1e-06
Negative regulation of NMDA receptor-mediated neuronal transmission	5	54.4×	1e-06
Assembly and cell surface presentation of NMDA receptors	10	50.8×	8e-13
Dopamine Neurotransmitter Release Cycle	5	49.6×	2e-06
Long-term potentiation	5	47.6×	2e-06
Neurexins and neuroligins	10	39.4×	7e-12
Protein-protein interactions at synapses	6	31.9×	1e-06

GO biological processes:

GO term	Partners	Fold	FDR
establishment or maintenance of epithelial cell apical/basal polarity	9	73.7×	1e-12
receptor clustering	7	61.5×	4e-09
protein localization to synapse	5	53.9×	3e-06
regulation of postsynaptic membrane neurotransmitter receptor levels	6	41.9×	1e-06
cell-cell adhesion	9	12.9×	3e-06
protein-containing complex assembly	6	9.6×	1e-03
chemical synaptic transmission	7	7.6×	1e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

163 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	57
Likely benign	1
Benign	2

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
816364	GRCh37/hg19 Xq21.1-28(chrX:78444738-155233731)x1	Pathogenic

SpliceAI

1858 predictions. Top by Δscore:

Variant	Effect	Δscore
X:154696017:CTG:C	acceptor_gain	1.0000
X:154699376:T:TA	donor_gain	1.0000
X:154716170:T:TA	donor_gain	1.0000
X:154750952:A:AC	donor_gain	1.0000
X:154750953:C:CC	donor_gain	1.0000
X:154750953:CGTAG:C	donor_gain	1.0000
X:154678291:GTTT:G	acceptor_gain	0.9900
X:154678292:TTT:T	acceptor_gain	0.9900
X:154678292:TTTC:T	acceptor_loss	0.9900
X:154678294:TC:T	acceptor_loss	0.9900
X:154678295:C:A	acceptor_loss	0.9900
X:154678295:C:CC	acceptor_gain	0.9900
X:154680128:CTA:C	donor_loss	0.9900
X:154680129:TACC:T	donor_loss	0.9900
X:154680130:A:AT	donor_loss	0.9900
X:154680131:C:T	donor_loss	0.9900
X:154680131:CCTG:C	donor_gain	0.9900
X:154680132:C:A	donor_loss	0.9900
X:154696020:C:CC	acceptor_gain	0.9900
X:154697209:CCGTG:C	acceptor_gain	0.9900
X:154697210:CGTG:C	acceptor_gain	0.9900
X:154697210:CGTGC:C	acceptor_gain	0.9900
X:154697214:C:CC	acceptor_gain	0.9900
X:154699292:A:AC	donor_gain	0.9900
X:154699293:C:CC	donor_gain	0.9900
X:154699293:CATTT:C	donor_gain	0.9900
X:154699297:T:TA	donor_gain	0.9900
X:154699511:TGG:T	acceptor_gain	0.9900
X:154699514:C:CC	acceptor_gain	0.9900
X:154700060:C:CC	acceptor_gain	0.9900

AlphaMissense

3848 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
X:154716309:A:C	F31L	1.000
X:154716309:A:T	F31L	1.000
X:154716310:A:G	F31S	1.000
X:154716311:A:G	F31L	1.000
X:154716326:A:G	W26R	1.000
X:154716326:A:T	W26R	1.000
X:154750984:C:A	K14N	1.000
X:154750984:C:G	K14N	1.000
X:154716080:A:G	W108R	0.999
X:154716080:A:T	W108R	0.999
X:154716112:A:G	L97P	0.999
X:154716139:A:T	V88D	0.999
X:154716145:A:G	F86S	0.999
X:154716263:A:G	Y47H	0.999
X:154716268:A:G	L45S	0.999
X:154716324:C:A	W26C	0.999
X:154716324:C:G	W26C	0.999
X:154750991:A:G	L12P	0.999
X:154716078:C:A	W108C	0.998
X:154716078:C:G	W108C	0.998
X:154716106:G:T	A99D	0.998
X:154716112:A:T	L97Q	0.998
X:154716117:G:C	F95L	0.998
X:154716117:G:T	F95L	0.998
X:154716119:A:G	F95L	0.998
X:154716304:A:G	L33P	0.998
X:154716310:A:C	F31C	0.998
X:154716314:A:G	W30R	0.998
X:154716314:A:T	W30R	0.998
X:154716317:G:T	R29S	0.998

dbSNP variants (sampled 300 via entrez): RS1000060258 (X:154724907 A>C), RS1000255046 (X:154747548 C>A), RS1000255455 (X:154701967 C>T), RS1000436453 (X:154691439 G>A), RS1000561373 (X:154731572 T>C), RS1000729784 (X:154740902 T>C), RS1000839568 (X:154710005 G>A,C), RS1000858353 (X:154681057 A>C), RS1000858540 (X:154680476 A>C), RS1000862070 (X:154749647 C>T), RS1000911369 (X:154730996 A>C), RS1000983675 (X:154693399 T>G), RS1001220938 (X:154715278 T>C), RS1001227841 (X:154726090 T>C), RS1001273306 (X:154715637 C>T)

Disease associations

OMIM: gene MIM:300482 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST004334_12	Mean corpuscular hemoglobin	2.000000e-29
GCST90002389_498	Lymphocyte percentage of white cells	4.000000e-09
GCST90002397_164	Mean spheric corpuscular volume	3.000000e-09

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004527	mean corpuscular hemoglobin
EFO:0007993	lymphocyte percentage of leukocytes

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

26 total (human), top 26 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Nickel	increases expression	2
propionaldehyde	increases expression	1
bisphenol A	affects cotreatment, increases methylation	1
butyraldehyde	increases expression	1
tobacco tar	decreases expression, decreases reaction	1
benzo(e)pyrene	decreases methylation	1
potassium chromate(VI)	decreases expression	1
diallyl disulfide	decreases expression, decreases reaction	1
maleic acid	increases expression	1
CGP 52608	affects binding, increases reaction	1
abrine	increases expression	1
jinfukang	increases expression	1
Sunitinib	increases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Acetaminophen	increases expression	1
Benzo(a)pyrene	affects methylation, decreases methylation	1
Cadmium	increases abundance, increases expression	1
Doxorubicin	decreases expression	1
Estradiol	affects cotreatment, increases expression	1
Methapyrilene	decreases methylation	1
Phthalic Acids	decreases expression, decreases methylation	1
Tobacco Smoke Pollution	decreases expression	1
Tretinoin	increases expression	1
Triclosan	decreases expression	1
Antirheumatic Agents	decreases expression	1
Cadmium Chloride	increases abundance, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.