GABPB1-AS1

Summary

GABPB1-AS1 (GABPB1 antisense RNA 1, HGNC:44157) is a long non-coding RNA gene on chromosome 15q21.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44157
Approved symbol	GABPB1-AS1
Name	GABPB1 antisense RNA 1
Location	15q21.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000244879
Ensembl biotype	lncRNA
Entrez	100129387
RNAcentral	URS000075E186 — lncRNA, 4139 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 30 — 30 lncRNA

ENST00000499326, ENST00000499624, ENST00000558593, ENST00000560359, ENST00000561289, ENST00000619314, ENST00000648591, ENST00000659570, ENST00000667317, ENST00000668321, ENST00000670332, ENST00000738176, ENST00000738177, ENST00000738178, ENST00000738179, ENST00000738180, ENST00000738181, ENST00000738182, ENST00000738183, ENST00000738184, ENST00000738185, ENST00000738186, ENST00000738187, ENST00000738188, ENST00000738189, ENST00000738190, ENST00000738191, ENST00000738192, ENST00000738193, ENST00000738194

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000499326 — 2 exons

Exon	Start	End
ENSE00001986410	50356100	50356436
ENSE00004073177	50355464	50355932

Expression profiles

Bgee: expression breadth ubiquitous, 251 present calls, max score 96.38.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 26.5365 / max 266.7659, expressed in 1806 samples.

FANTOM5 promoters (10 alternative TSS)

Promoter ID	TPM avg	Samples expressed
146607	14.5748	1773
146610	7.4161	1610
146604	0.9214	517
146609	0.8746	549
146605	0.7113	328
146608	0.6930	382
146603	0.5737	312
146606	0.4880	230
146601	0.2045	75
146602	0.0792	31

Top tissues by expression

255 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	96.38	gold quality
oviduct epithelium	UBERON:0004804	95.60	gold quality
buccal mucosa cell	CL:0002336	95.42	gold quality
caput epididymis	UBERON:0004358	94.36	gold quality
nipple	UBERON:0002030	91.99	gold quality
tibia	UBERON:0000979	91.80	gold quality
corpus epididymis	UBERON:0004359	91.77	gold quality
bronchial epithelial cell	CL:0002328	91.26	gold quality
corpus callosum	UBERON:0002336	90.91	gold quality
bronchus	UBERON:0002185	90.80	gold quality
adenohypophysis	UBERON:0002196	90.09	gold quality
pituitary gland	UBERON:0000007	89.74	gold quality
tibialis anterior	UBERON:0001385	89.59	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	89.35	gold quality
fallopian tube	UBERON:0003889	89.34	gold quality
nucleus accumbens	UBERON:0001882	89.09	gold quality
calcaneal tendon	UBERON:0003701	89.08	gold quality
right ovary	UBERON:0002118	89.00	gold quality
spinal cord	UBERON:0002240	88.90	gold quality
cauda epididymis	UBERON:0004360	88.89	gold quality
left ovary	UBERON:0002119	88.73	gold quality
tibial nerve	UBERON:0001323	88.64	gold quality
putamen	UBERON:0001874	88.62	gold quality
endocervix	UBERON:0000458	88.42	gold quality
ganglionic eminence	UBERON:0004023	88.37	gold quality
ventricular zone	UBERON:0003053	88.11	gold quality
spleen	UBERON:0002106	88.06	gold quality
caudate nucleus	UBERON:0001873	88.03	gold quality
amygdala	UBERON:0001876	87.94	gold quality
hypothalamus	UBERON:0001898	87.64	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-10596	yes	177.84
E-ANND-3	yes	16.38

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• six novel lncRNAs (CDKN2B-AS1, MIR22HG, GABPB1-AS1, FLJ33630, LINC00152, and LINC0541471_v2) that respond to model chemical stresses (cycloheximide, hydrogen peroxide, cadmium, or arsenic) in hiPSCs. (PMID:25171338)
• LncRNA GABPB1-AS1 and GABPB1 regulate oxidative stress during erastin-induced ferroptosis in HepG2 hepatocellular carcinoma cells. (PMID:31700067)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.