GABPB1-IT1

Summary

GABPB1-IT1 (GABPB1 intronic transcript, HGNC:25469) is a long non-coding RNA gene on chromosome 15q21.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25469
Approved symbol	GABPB1-IT1
Name	GABPB1 intronic transcript
Location	15q21.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ10038
Ensembl gene	ENSG00000285410
Ensembl biotype	lncRNA
Entrez	55056
RNAcentral	URS000075E02F — lncRNA, 5944 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000615671

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000615671 — 1 exons

Exon	Start	End
ENSE00003746235	50348936	50354861

Expression profiles

Bgee: expression breadth ubiquitous, 263 present calls, max score 87.34.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 9.3515 / max 117.2877, expressed in 1738 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
149861	7.7874	1716
149860	1.5641	582

Top tissues by expression

287 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endothelial cell	CL:0000115	87.34	silver quality
Brodmann (1909) area 23	UBERON:0013554	84.47	gold quality
middle temporal gyrus	UBERON:0002771	84.24	gold quality
cortical plate	UBERON:0005343	83.96	gold quality
buccal mucosa cell	CL:0002336	82.76	gold quality
cervix squamous epithelium	UBERON:0006922	81.78	silver quality
choroid plexus epithelium	UBERON:0003911	81.51	gold quality
tendon of biceps brachii	UBERON:0008188	81.44	silver quality
tibia	UBERON:0000979	80.72	gold quality
epithelium of mammary gland	UBERON:0003244	80.38	gold quality
monocyte	CL:0000576	79.99	gold quality
mononuclear cell	CL:0000842	79.71	gold quality
mucosa of stomach	UBERON:0001199	79.60	gold quality
leukocyte	CL:0000738	79.46	gold quality
entorhinal cortex	UBERON:0002728	79.40	gold quality
Brodmann (1909) area 46	UBERON:0006483	79.16	silver quality
mammary duct	UBERON:0001765	79.10	gold quality
primary visual cortex	UBERON:0002436	78.96	gold quality
gastrocnemius	UBERON:0001388	78.92	gold quality
bone marrow cell	CL:0002092	78.89	gold quality
ganglionic eminence	UBERON:0004023	78.87	gold quality
postcentral gyrus	UBERON:0002581	78.59	gold quality
tibial artery	UBERON:0007610	78.59	gold quality
popliteal artery	UBERON:0002250	78.58	gold quality
muscle of leg	UBERON:0001383	78.37	gold quality
nephron tubule	UBERON:0001231	78.32	silver quality
right lung	UBERON:0002167	78.22	gold quality
hair follicle	UBERON:0002073	78.09	silver quality
synovial joint	UBERON:0002217	78.04	gold quality
cerebellar hemisphere	UBERON:0002245	77.91	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.22

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• LncRNA GABPB1-IT1 inhibits the tumorigenesis of renal cancer via the miR-21/PTEN axis. (PMID:36756790)
• LncRNA GABPB1-IT1 Is Upregulated in Ischemia-Induced Acute Kidney Injury and Downregulates miR-204-5p to Promote Hypoxia-Induced Human Renal Proximal Tubular Epithelial Cell Apoptosis. (PMID:38824919)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.