GABRQ

Summary

GABRQ (gamma-aminobutyric acid type A receptor subunit theta, HGNC:14454) is a protein-coding gene on chromosome Xq28, encoding Gamma-aminobutyric acid receptor subunit theta (Q9UN88). Theta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain.

The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes the theta subunit of the GABA A receptor. The gene is mapped to chromosome Xq28 in a cluster of genes including those that encode the alpha 3 and epsilon subunits of the GABA A receptor.

Source: NCBI Gene 55879 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 96 total
• GTEx eGene: eQTL in 8 tissues, sQTL in 0 (q < 0.05)
• ChEMBL bioactivity: 15 clinical-phase molecules tested; no curated mechanism-of-action drug
• MANE Select transcript: NM_018558
• Notable: 96 clinical variants but no curated precision-oncology (CIViC) evidence yet

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14454
Approved symbol	GABRQ
Name	gamma-aminobutyric acid type A receptor subunit theta
Location	Xq28
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000268089
Ensembl biotype	protein_coding
OMIM	300349
Entrez	55879

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 1 protein_coding, 1 nonsense_mediated_decay

MANE Select: ENST00000598523

Transcript support level (Ensembl TSL; 1 = fully mRNA-supported): TSL 1: 1

ENST00000598523, ENST00001065232

RefSeq mRNA: 1 — MANE Select: NM_018558 NM_018558

CCDS: CCDS14707

Canonical transcript exons

ENST00000598523 — 9 exons

Exon	Start	End
ENSE00002977626	152640378	152640466
ENSE00003003037	152650428	152650580
ENSE00003019998	152651526	152651782
ENSE00003070943	152637895	152638351
ENSE00003114752	152646948	152647168
ENSE00003129640	152645527	152645594
ENSE00003165516	152649742	152649879
ENSE00003186348	152652541	152657542
ENSE00003218910	152649251	152649333

Expression profiles

Bgee: expression breadth broad, 82 present calls, max score 76.41.

FANTOM5 (CAGE): breadth broad, TPM avg 2.7121 / max 134.1467, expressed in 535 samples.

Highest expression (Bgee): hypothalamus, primordial germ cell in gonad, tibialis anterior, anterior cingulate cortex, amygdala.

Genetic regulation across tissues (GTEx eQTL / sQTL)

GABRQ is an eGene in GTEx v10 — its expression is genetically regulated (eQTL) in 8 tissues and its splicing (sQTL) in 0 (q < 0.05). Strongest associations first; slope = normalized effect of the lead variant’s alternative allele.

8 significant tissue × QTL associations:

Tissue	QTL	q-value	Slope	Lead variant
Esophagus Mucosa	eqtl	5.1e-06	-0.15	X:151724341:G:A
Thyroid	eqtl	1.2e-04	-0.19	X:152734231:G:C
Colon Sigmoid	eqtl	3.0e-03	+0.45	X:151737648:G:A
Skin Not Sun Exposed Suprapubic	eqtl	6.4e-03	-0.13	X:151725721:G:A
Brain Hippocampus	eqtl	1.1e-02	-1.24	X:152258967:A:G
Nerve Tibial	eqtl	1.5e-02	-0.10	X:151700327:C:G
Brain Cortex	eqtl	1.9e-02	-0.54	X:151677815:C:T
Brain Caudate basal ganglia	eqtl	2.3e-02	+0.27	X:152546178:A:G

FANTOM5 promoters

1 alternative TSS:

Promoter ID	TPM avg	Samples expressed
198003	2.7121	535

Top tissues by expression

showing 100 of 251 tissues by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
hypothalamus	UBERON:0001898	76.41	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	75.59	gold quality
tibialis anterior	UBERON:0001385	69.58	silver quality
anterior cingulate cortex	UBERON:0009835	68.14	gold quality
amygdala	UBERON:0001876	68.09	gold quality
cingulate cortex	UBERON:0003027	68.08	gold quality
Ammon’s horn	UBERON:0001954	68.01	gold quality
superior vestibular nucleus	UBERON:0007227	66.10	silver quality
pancreatic ductal cell	CL:0002079	65.45	silver quality
ectocervix	UBERON:0012249	64.23	gold quality
endocervix	UBERON:0000458	64.08	gold quality
prefrontal cortex	UBERON:0000451	63.53	gold quality
nucleus accumbens	UBERON:0001882	63.11	gold quality
buccal mucosa cell	CL:0002336	62.93	gold quality
temporal lobe	UBERON:0001871	61.45	gold quality
ileal mucosa	UBERON:0000331	60.35	silver quality
ventricular zone	UBERON:0003053	59.92	gold quality
lateral nuclear group of thalamus	UBERON:0002736	59.71	gold quality
cerebral cortex	UBERON:0000956	59.10	gold quality
neocortex	UBERON:0001950	58.77	gold quality
cortical plate	UBERON:0005343	58.77	silver quality
uterine cervix	UBERON:0000002	58.62	gold quality
gingival epithelium	UBERON:0001949	58.51	silver quality
deltoid	UBERON:0001476	58.30	silver quality
tibial nerve	UBERON:0001323	58.29	gold quality
telencephalon	UBERON:0001893	57.69	gold quality
ganglionic eminence	UBERON:0004023	57.46	silver quality
dorsolateral prefrontal cortex	UBERON:0009834	57.02	gold quality
frontal cortex	UBERON:0001870	56.86	gold quality
forebrain	UBERON:0001890	56.85	gold quality
gingiva	UBERON:0001828	56.27	gold quality
Brodmann (1909) area 9	UBERON:0013540	55.59	gold quality
lower esophagus mucosa	UBERON:0035834	55.24	gold quality
middle temporal gyrus	UBERON:0002771	54.38	gold quality
brain	UBERON:0000955	54.29	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	54.14	gold quality
endometrium	UBERON:0001295	54.12	gold quality
medulla oblongata	UBERON:0001896	53.98	silver quality
esophagus mucosa	UBERON:0002469	53.64	gold quality
seminal vesicle	UBERON:0000998	53.61	silver quality
embryo	UBERON:0000922	53.46	silver quality
smooth muscle tissue	UBERON:0001135	53.45	gold quality
spinal cord	UBERON:0002240	53.04	gold quality
cerebellar vermis	UBERON:0004720	53.02	gold quality
right frontal lobe	UBERON:0002810	52.84	gold quality
caudate nucleus	UBERON:0001873	52.60	gold quality
tibia	UBERON:0000979	52.30	gold quality
epithelial cell of pancreas	CL:0000083	52.14	gold quality
substantia nigra	UBERON:0002038	51.88	gold quality
upper leg skin	UBERON:0004262	51.76	silver quality
midbrain	UBERON:0001891	51.08	gold quality
vagina	UBERON:0000996	51.02	gold quality
sural nerve	UBERON:0015488	50.25	gold quality
quadriceps femoris	UBERON:0001377	50.16	gold quality
putamen	UBERON:0001874	50.16	gold quality
uterus	UBERON:0000995	49.72	gold quality
cervix squamous epithelium	UBERON:0006922	49.20	gold quality
hair follicle	UBERON:0002073	49.18	gold quality
oviduct epithelium	UBERON:0004804	49.07	gold quality
squamous epithelium	UBERON:0006914	49.07	gold quality
olfactory bulb	UBERON:0002264	48.92	gold quality
myocardium	UBERON:0002349	48.87	gold quality
type B pancreatic cell	CL:0000169	48.83	gold quality
cardiac muscle of right atrium	UBERON:0003379	48.55	gold quality
CA1 field of hippocampus	UBERON:0003881	48.50	gold quality
vastus lateralis	UBERON:0001379	48.34	gold quality
left ventricle myocardium	UBERON:0006566	48.24	gold quality
orbitofrontal cortex	UBERON:0004167	48.20	gold quality
thymus	UBERON:0002370	48.12	gold quality
muscle tissue	UBERON:0002385	48.10	gold quality
upper arm skin	UBERON:0004263	48.06	gold quality
cervix epithelium	UBERON:0004801	48.04	gold quality
tongue squamous epithelium	UBERON:0006919	47.92	gold quality
mucosa of urinary bladder	UBERON:0001259	47.80	gold quality
metanephric glomerulus	UBERON:0004736	47.45	gold quality
kidney epithelium	UBERON:0004819	47.39	gold quality
nephron tubule	UBERON:0001231	47.30	gold quality
diaphragm	UBERON:0001103	47.05	gold quality
gluteal muscle	UBERON:0002000	47.03	gold quality
triceps brachii	UBERON:0001509	47.01	gold quality
superior frontal gyrus	UBERON:0002661	46.63	gold quality
trigeminal ganglion	UBERON:0001675	46.36	gold quality
tendon of biceps brachii	UBERON:0008188	46.33	gold quality
dorsal plus ventral thalamus	UBERON:0001897	46.26	gold quality
placenta	UBERON:0001987	46.10	silver quality
prostate gland	UBERON:0002367	45.99	gold quality
layer of synovial tissue	UBERON:0007616	45.76	gold quality
nasal cavity epithelium	UBERON:0005384	45.61	gold quality
epithelium of esophagus	UBERON:0001976	45.59	gold quality
ventral tegmental area	UBERON:0002691	45.53	gold quality
female reproductive system	UBERON:0000474	45.14	gold quality
colonic epithelium	UBERON:0000397	44.72	gold quality
cauda epididymis	UBERON:0004360	44.66	gold quality
lymph node	UBERON:0000029	44.40	gold quality
tonsil	UBERON:0002372	44.34	silver quality
corpus callosum	UBERON:0002336	44.11	silver quality
subthalamic nucleus	UBERON:0001906	43.93	gold quality
right adrenal gland	UBERON:0001233	43.82	gold quality
esophagus squamous epithelium	UBERON:0006920	43.62	gold quality
adult organism	UBERON:0007023	43.49	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.10

HPA expression

RNA tissue specificity: Group enriched

41 HPA tissues / cells by nTPM:

Tissue / cell	Axis	nTPM
Locus coeruleus	tissue	48.0
Substantia nigra	tissue	33.1
Hippocampus	tissue	21.0
Hypothalamus	tissue	12.4
Pons	tissue	10.2
Cervix	tissue	7.2
Septum	tissue	4.4
Periaqueductal gray	tissue	4.3
Midbrain	tissue	3.2
Nucleus accumbens	tissue	3.1
Adrenal gland	tissue	2.1
Postcentral gyrus	tissue	1.6
Medulla oblongata	tissue	1.4
Testis	tissue	1.1
Endometrium 1	tissue	1.1
Amygdala	tissue	1.0
Caudate putamen	tissue	0.9
Smooth muscle	tissue	0.7
Vagina	tissue	0.6
Seminal vesicle	tissue	0.5
Superior colliculi	tissue	0.5
Hippocampal formation	tissue	0.5
Frontal cortex	tissue	0.4
Esophagus	tissue	0.3
Choroid plexus	tissue	0.3
Prostate	tissue	0.3
Ventral forebrain	tissue	0.3
Skin 1	tissue	0.2
Retina	tissue	0.2
Basal ganglia	tissue	0.2
Small intestine	tissue	0.2
Pituitary gland	tissue	0.1
Prefrontal cortex	tissue	0.1
Cerebral cortex	tissue	0.1
Epididymis	tissue	0.1
Thalamus	tissue	0.1
Placenta	tissue	0.1
Spinal cord	tissue	0.1
Tonsil	tissue	0.1
Olfactory bulb	tissue	0.1
Temporal cortex	tissue	0.1

Brain sub-regions (HPA Brain Atlas): detected in 185; highest nTPM — Arcuate nucleus (154.3), Ventromedial nucleus (81.8), Posterior cingulate cortex (61.3), Median raphe nucleus (58.7), Nucleus of the diagonal band (52.0).

Regulation

Is transcription factor: no

Functional genomics

Regional missense constraint (gnomAD RMC): no regional variation along ENST00000598523 — one region, missense o/e 1.00.

Literature-anchored findings (GeneRIF, showing 8)

• Although GABRQ genes did not show positive association, further studies are necessary to consider the role of other GABA receptor genes in migraine susceptibility (PMID:19087248)
• single nucleotide polymorphisms studied in the GABRA4, GABRE, and GABRQ genes are not related to the risk for familial ET. (PMID:21422964)
• GABRQ plays important roles in hepatocellular carcinoma development and progression (PMID:22690081)
• We identified truncating mutations in distinct X-linked gamma-aminobutyric acid A (GABAA) receptor subunit-encoding genes, GABRQ and GABRA3.this is the first report of ASD patients with truncating mutations in GABA receptors genes. (PMID:23169495)
• data from the present study suggest a possible role of GABRQ rs3810651 single nucleotide polymorphism in the modification of the age at onset of migraine in the Caucasian Spanish people (PMID:29299688)
• The intracellular domain of GABRQ disrupts GABRB3 homomeric plasma membrane expression. (PMID:31610743)
• A pioneering study indicate role of GABRQ rs3810651 in ASD severity of Indo-Caucasoid female probands. (PMID:33772085)
• The severity of behavioural symptoms in FTD is linked to the loss of GABRQ-expressing VENs and pyramidal neurons. (PMID:35152451)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Gabrq	ENSMUSG00000031344
rattus_norvegicus	Gabrq	ENSRNOG00000053402

Paralogs (45): GABRA3 (ENSG00000011677), GABRA1 (ENSG00000022355), CHRNA3 (ENSG00000080644), GABRP (ENSG00000094755), CHRNA4 (ENSG00000101204), GLRA2 (ENSG00000101958), GABRE (ENSG00000102287), CHRNE (ENSG00000108556), GABRA4 (ENSG00000109158), GLRB (ENSG00000109738), GABRR2 (ENSG00000111886), GABRG2 (ENSG00000113327), CHRNB4 (ENSG00000117971), CHRNA2 (ENSG00000120903), CHRNA10 (ENSG00000129749), CHRND (ENSG00000135902), CHRNA1 (ENSG00000138435), GLRA3 (ENSG00000145451), GABRA6 (ENSG00000145863), GABRB2 (ENSG00000145864), GLRA1 (ENSG00000145888), GABRR1 (ENSG00000146276), CHRNB3 (ENSG00000147432), CHRNA6 (ENSG00000147434), HTR3B (ENSG00000149305), GABRA2 (ENSG00000151834), CHRNB2 (ENSG00000160716), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRB3 (ENSG00000166206), CHRFAM7A (ENSG00000166664), HTR3A (ENSG00000166736), CHRNA5 (ENSG00000169684), CHRNB1 (ENSG00000170175), CHRNA9 (ENSG00000174343), CHRNA7 (ENSG00000175344), HTR3C (ENSG00000178084), GABRG3 (ENSG00000182256), GABRR3 (ENSG00000183185), HTR3E (ENSG00000186038), HTR3D (ENSG00000186090), GABRA5 (ENSG00000186297), ZACN (ENSG00000186919), GABRD (ENSG00000187730), CHRNG (ENSG00000196811)

Mouse-model phenotypes

Observed phenotypes of the mouse ortholog (MGI:1888498) from MGI (Alliance of Genome Resources) — knockout/mutant phenotypes, ranked by annotation count. 1 distinct phenotype terms.

Mouse phenotype (MP)	Records
decreased prepulse inhibition	1

Additional cross-species homologs

Sequence homologs in species beyond Ensembl Compara’s model organisms, by Diamond local protein alignment (% sequence identity; best hit per species). Lower-identity rows are more distant homologs. The matched accessions’ gene symbols aren’t in biobtree yet, so each row shows the UniProt accession.

Organism	UniProt	Identity	Method
Macaca mulatta	D1LYT2	100.0%	Diamond
Drosophila melanogaster	P25123	99.8%	Diamond
Bos taurus	P57695	99.8%	Diamond
Macaca fascicularis	Q4R534	99.8%	Diamond
Pongo abelii	Q5RCC5	99.8%	Diamond
Drosophila simulans	Q9BLY8	99.8%	Diamond
Gallus gallus	P19150	96.9%	Diamond
Danio rerio	O93430	85.6%	Diamond
Musca domestica	Q75NA5	84.3%	Diamond
Haemonchus contortus	P91730	81.4%	Diamond
Caenorhabditis elegans	Q17328	81.4%	Diamond
Lymnaea stagnalis	P26714	58.6%	Diamond

Genomic neighbors (locus context)

Genes flanking this one on the chromosome (NCBI/Entrez gene neighborhood). Positional context only — some neighbors share regulatory elements (bidirectional promoters, antisense/overlapping transcripts), but chromosomal adjacency is not itself a functional relationship (see Interactions for that).

Symbol	Type	Entrez
CSAG2	protein-coding	102723547
MAGEA3-DT	ncRNA	105373370
MAGEA3	protein-coding	4102
GABRA3	protein-coding	2556
MIR105-2	ncRNA	406898
MIR767	ncRNA	768215
MIR105-1	ncRNA	406897
MAGEA10	protein-coding	4109

Protein

Protein identifiers

Gamma-aminobutyric acid receptor subunit theta — Q9UN88 (reviewed: Q9UN88)

Alternative names: GABA(A) receptor subunit theta

All UniProt accessions (1): Q9UN88

UniProt curated annotations — full annotation on UniProt →

Function. Theta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces. When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient.

Subunit / interactions. Heteropentamer, formed by a combination of alpha (GABRA1-6), beta (GABRB1-3), gamma (GABRG1-3), delta (GABRD), epsilon (GABRE), rho (GABRR1-3), pi (GABRP) and theta (GABRQ) chains, each subunit exhibiting distinct physiological and pharmacological properties.

Subcellular location. Postsynaptic cell membrane. Cell membrane.

Tissue specificity. Expressed in brain.

Activity regulation. Potentiated by etomidate, propofol, pregnanolone and pentobarbital.

Domain organisation. GABAARs subunits share a common topological structure: a peptide sequence made up of a long extracellular N-terminal, four transmembrane domains, intracellular or cytoplasmic domain located between the third and the fourth transmembrane domains.

Similarity. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRQ sub-subfamily.

RefSeq proteins (1): NP_061028* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR006028	GABAA/Glycine_rcpt	Family
IPR006029	Neurotrans-gated_channel_TM	Domain
IPR006201	Neur_channel	Family
IPR006202	Neur_chan_lig-bd	Domain
IPR008101	GABAAt_rcpt	Family
IPR018000	Neurotransmitter_ion_chnl_CS	Conserved_site
IPR036719	Neuro-gated_channel_TM_sf	Homologous_superfamily
IPR036734	Neur_chan_lig-bd_sf	Homologous_superfamily
IPR038050	Neuro_actylchol_rec	Homologous_superfamily

Pfam: PF02931, PF02932

Catalyzed reactions (Rhea)

• chloride(in) = chloride(out) (RHEA:29823)

UniProt features (20 total): compositionally biased region 4, topological domain 4, transmembrane region 4, region of interest 2, sequence variant 2, signal peptide 1, chain 1, glycosylation site 1, disulfide bond 1

Structure

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9UN88-F1	67.55	0.34

Human Protein Atlas

Protein class: Predicted membrane proteins, FDA approved drug targets, Small molecule drugs

Protein evidence: Evidence at protein level

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1)

Type	Positions
Disulfide bond	183–197

Glycosylation sites (1)

Type	Positions
N-linked (glcnac…) asparagine	127

Function

Pathways and Gene Ontology

Reactome pathways

0 curated (TAS) of 7; 0 disease pathways. Curated-first; evidence = TAS (manually curated) vs IEA (electronic inference).

7 pathways:

ID	Pathway	Evidence
R-HSA-977443	GABA receptor activation	electronic
R-HSA-112316	Neuronal System	—
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	—
R-HSA-162582	Signal Transduction	—
R-HSA-1236394	Signaling by ERBB4	electronic
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	—
R-HSA-112315	Transmission across Chemical Synapses	—

MSigDB gene sets: 92 (showing top): GOBP_NEUROTRANSMITTER_TRANSPORT, GOBP_INORGANIC_ANION_TRANSPORT, GOBP_GAMMA_AMINOBUTYRIC_ACID_SIGNALING_PATHWAY, GOBP_CELL_CELL_SIGNALING, MYOD_01, GOBP_CHLORIDE_TRANSPORT, BLALOCK_ALZHEIMERS_DISEASE_UP, KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION, OCT1_06, GOBP_SYNAPTIC_SIGNALING, REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES, GCM_CDH5, RIGGI_EWING_SARCOMA_PROGENITOR_UP, GOBP_TRANSMEMBRANE_TRANSPORT, TGGAAA_NFAT_Q4_01

GO Biological Process (8): signal transduction (GO:0007165), gamma-aminobutyric acid signaling pathway (GO:0007214), synaptic transmission, GABAergic (GO:0051932), chloride transmembrane transport (GO:1902476), monoatomic ion transport (GO:0006811), chloride transport (GO:0006821), neurotransmitter transport (GO:0006836), monoatomic ion transmembrane transport (GO:0034220)

GO Molecular Function (8): transmembrane signaling receptor activity (GO:0004888), GABA-A receptor activity (GO:0004890), neurotransmitter transmembrane transporter activity (GO:0005326), GABA-gated chloride ion channel activity (GO:0022851), monoatomic ion channel activity (GO:0005216), extracellular ligand-gated monoatomic ion channel activity (GO:0005230), chloride channel activity (GO:0005254), protein binding (GO:0005515)

GO Cellular Component (7): plasma membrane (GO:0005886), chloride channel complex (GO:0034707), signaling receptor complex (GO:0043235), postsynaptic membrane (GO:0045211), GABA-A receptor complex (GO:1902711), membrane (GO:0016020), GABA-ergic synapse (GO:0098982)

Reactome top-level categories

5 top-level categories:

Category	Pathways
Signaling by Receptor Tyrosine Kinases	1
Neurotransmitter receptors and postsynaptic signal transmission	1
Transmission across Chemical Synapses	1
Neuronal System	1
Signal Transduction	1

GO top-level categories

36 GO namespaces:

Category	Terms
GABA receptor activity	2
transport	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
cell-cell signaling	1
chemical synaptic transmission	1
chloride transport	1
monoatomic anion transmembrane transport	1
monoatomic anion transport	1
inorganic anion transport	1
monoatomic ion transport	1
transmembrane transport	1
signaling receptor activity	1
neurotransmitter transport	1
transmembrane transporter activity	1
chloride channel activity	1
transmitter-gated monoatomic ion channel activity	1
ligand-gated monoatomic anion channel activity	1
monoatomic ion transmembrane transporter activity	1
channel activity	1
ligand-gated monoatomic ion channel activity	1
monoatomic anion channel activity	1
chloride transmembrane transporter activity	1
binding	1
membrane	1
cell periphery	1
monoatomic ion channel complex	1
protein-containing complex	1
synaptic membrane	1
postsynapse	1
GABA receptor complex	1
cellular anatomical structure	1
synapse	1

Experimentally-supported GO annotations

GO terms backed by direct experimental evidence (ECO experimental codes) — 3 of 23 annotations. The rest are phylogenetic / computational / electronic (IEA).

3 experimentally-supported GO terms:

GO term	NS	Evidence
signaling receptor complex	CC	direct assay
GABA-A receptor activity	MF	direct assay
GABA-gated chloride ion channel activity	MF	direct assay

Protein interactions and networks

STRING

showing 15 of 688 interactions by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
GABRQ	ADRA1A	P35348	534
GABRQ	SLC18A2	Q05940	532
GABRQ	TH	P07101	526
GABRQ	GABBR2	O75899	463
GABRQ	FEZF2	Q8TBJ5	460
GABRQ	DRD3	P35462	404
GABRQ	DRD2	P14416	385
GABRQ	SEZ6	Q53EL9	372
GABRQ	ID3	Q02535	370
GABRQ	STON2	Q8WXE9	369
GABRQ	SLC38A11	Q08AI6	365
GABRQ	ATF3	P18847	364
GABRQ	SLC6A11	P48066	360
GABRQ	SLC47A1	Q96FL8	357
GABRQ	ID1	P41134	357

IntAct

Human interaction partners of GABRQ in IntAct, one row per partner (best MIscore; records = supporting IntAct interaction records).

2 partners by confidence:

Partner	Interaction type	MIscore	Records
GNMT	physical association	0.560	3
TXNDC12	physical association	0.400	1

BioGRID (5 interactions; top human partners by supporting records): CLEC2B (Affinity Capture-MS), GNMT (Two-hybrid), HLA-G (Affinity Capture-MS), KIAA1429 (Affinity Capture-RNA), TXNDC12 (Cross-Linking-MS (XL-MS))

Protein complexes (CORUM) (1)

Experimentally-characterized complexes this protein is a subunit of (★ = the complex contains a known drug target).

1 complexes by size:

Complex	Subunits	Members
★ GABRA3-GABRB1-GABRE-GABRQ complex	4	GABRA3, GABRB1, GABRE, GABRQ

Ligand–receptor pairs (CellPhoneDB) (1)

Curated ligand–receptor partners (cell-cell communication), distinct from the protein–protein interactions above.

1 ligand–receptor pairs:

Partner	This gene’s role	Signaling class
GABRA3;GABRB3;GABRQ		Signaling by GABA

Disease & clinical

Genetic variants

Variant evidence for GABRQ: 96 ClinVar records (0 pathogenic / likely pathogenic); 1 PharmGKB clinical annotation.

ClinVar

96 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	62
Likely benign	9
Benign	0

SpliceAI

Top 10 splice-impact sites by Δscore (adjacent positions with the same effect merged into one range; 36 predictions of 695):

Position(s)	Effect	Δscore	Sites
X:152638353	donor_loss	1.0000	2
X:152645525–152645526	acceptor_loss	1.0000	6
X:152647169–152647170	donor_loss	1.0000	4
X:152649236	acceptor_gain	1.0000
X:152649246	acceptor_gain	1.0000
X:152649249–152649250	acceptor_loss	1.0000	6
X:152649334–152649335	donor_loss	1.0000	5
X:152649740–152649741	acceptor_loss	1.0000	5
X:152649880–152649881	donor_loss	1.0000	4
X:152638352	donor_loss	0.9900	2

AlphaMissense

883 missense substitutions predicted likely pathogenic (of 4,182 scored), across 241 residues. Top 20 hotspot residues, ranked by the number of likely-pathogenic substitutions (of those reachable by a single-nucleotide change), then by mean score:

Residue	Likely-pathogenic substitutions	Mean am_pathogenicity	Max am_pathogenicity
D116	8	0.983	0.995
D210	8	0.940	0.988
F287	8	0.923	0.988
D193	8	0.913	0.968
D142	8	0.910	0.957
D329	8	0.887	0.966
S203	8	0.884	0.996
N160	8	0.869	0.955
D71	8	0.867	0.923
D608	8	0.864	0.914
F615	8	0.861	0.939
F145	8	0.860	0.983
D131	8	0.857	0.943
F163	8	0.832	0.976
F338	8	0.822	0.954
W114	7	0.990	0.997
W139	7	0.986	0.997
C197	7	0.972	0.989
C183	7	0.971	0.986
W215	7	0.948	0.988

HPA cancer prognostics

RNA cancer specificity: Cancer enhanced (Testicular Germ Cell Tumor)

Human Protein Atlas survival analysis — favorable = higher expression predicts better survival.

2 prognostic cancer types:

Cancer	Prognostic	p-value
Breast Invasive Carcinoma (TCGA)	unfavorable	9.58e-05
Lung Squamous Cell Carcinoma (validation)	favorable	0.000796

Disease associations

OMIM: gene MIM:300349 | disease phenotypes:

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (2): CHEMBL2093872 (PROTEIN COMPLEX GROUP), CHEMBL3885575 (PROTEIN COMPLEX)

Molecules with ChEMBL bioactivity

Phase ≥1, by development phase (incl. off-target/promiscuous compounds). Patent mentions across the top 20 by phase: 447,242 (via chembl_molecule»patent_compound — counts attach to the compound, not the gene–compound relationship, so off-target/promiscuous molecules can dominate).

15 molecules by phase:

Molecule	Name	Phase	Patents
CHEMBL3183409	APALUTAMIDE	4	4,347
CHEMBL207538	BREXANOLONE	4	1,647
CHEMBL452	CLONAZEPAM	4	33,611
CHEMBL12	DIAZEPAM	4	92,923
CHEMBL1082407	ENZALUTAMIDE	4	10,210
CHEMBL407	FLUMAZENIL	4	7,208
CHEMBL1568698	GANAXOLONE	4	1,695
CHEMBL1544	LIOTHYRONINE	4	23,991
CHEMBL454095	ABECARNIL	2	566
CHEMBL8260	BAICALEIN	2	8,718
CHEMBL268254	DELORAZEPAM	2	1,315
CHEMBL275638	FLAVONE	2	89,655
CHEMBL287631	PROGABIDE	2	3,882
CHEMBL96	GAMMA-AMINOBUTYRIC ACID	1	161,661
CHEMBL273481	MUSCIMOL	1	5,813

PharmGKB: 1 entry (CPIC guideline: no)

PharmGKB clinical annotations

1 annotations by evidence level (1 strongest → 4):

Variant	Association	Level	Drugs	Phenotypes
rs3810651	Efficacy	3	venlafaxine	Major Depressive Disorder

PharmGKB variants

1 variants:

Variant	Genes	Level	Score	#Clin annots	Drugs
rs3810651	GABRQ	3	3.00	1	venlafaxine

PharmGKB variant annotations

Per-publication pharmacogenomic findings for this gene (significant associations).

1 published findings:

Variant	Drug(s)	Category	Finding	PMID
rs3810651	venlafaxine	Efficacy	Genotypes AA + AT are associated with increased response to venlafaxine in people with Depressive Disorder, Major as compared to genotype TT.	PMID:23394390

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: lgic — GABA_A receptors

ChEMBL bioactivities

475 potent at pChembl≥5 of 512 total, top 50 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
10.00	IC50	0.1	nM	CHEMBL454349
9.80	IC50	0.16	nM	CHEMBL309517
9.70	IC50	0.2	nM	CHEMBL4747460
9.62	IC50	0.24	nM	CHEMBL79037
9.40	IC50	0.3981	nM	CGS-8216
9.40	IC50	0.4	nM	CHEMBL1271047
9.34	IC50	0.46	nM	CHEMBL78730
9.31	IC50	0.49	nM	CHEMBL76263
9.30	IC50	0.5	nM	CHEMBL5266498
9.30	IC50	0.5	nM	CHEMBL5290464
9.30	IC50	0.5	nM	CHEMBL5280240
9.30	IC50	0.5	nM	CHEMBL49141
9.30	IC50	0.5	nM	CHEMBL1518572
9.22	IC50	0.6026	nM	CGS-9896
9.22	IC50	0.6	nM	CHEMBL419096
9.12	IC50	0.76	nM	CHEMBL540583
9.10	IC50	0.79	nM	CHEMBL77226
9.10	IC50	0.8	nM	CHEMBL5265845
9.10	IC50	0.8	nM	CHEMBL5291368
9.10	IC50	0.8	nM	CHEMBL5271392
9.07	Ki	0.85	nM	CLONAZEPAM
9.05	Ki	0.9	nM	FLUMAZENIL
9.05	IC50	0.9	nM	CHEMBL5285377
9.00	Ki	1	nM	CHEMBL3410222
9.00	IC50	1	nM	BETA-CCM
9.00	IC50	1	nM	CHEMBL454606
9.00	IC50	1	nM	CHEMBL1337028
9.00	IC50	1	nM	CHEMBL509197
9.00	IC50	1	nM	ABECARNIL
9.00	Ki	1	nM	CHEMBL54341
9.00	Ki	1	nM	CHEMBL348367
8.96	IC50	1.1	nM	CHEMBL444586
8.77	Ki	1.7	nM	CHEMBL154342
8.74	IC50	1.8	nM	CHEMBL444050
8.70	IC50	2	nM	MUSCIMOL
8.66	IC50	2.2	nM	CHEMBL80610
8.64	IC50	2.3	nM	FIPRONIL
8.55	IC50	2.8	nM	CHEMBL75642
8.55	Ki	2.8	nM	CHEMBL372281
8.55	IC50	2.8	nM	DELORAZEPAM
8.52	Ki	3	nM	CHEMBL265547
8.52	IC50	3	nM	CHEMBL510764
8.52	IC50	3	nM	CHEMBL5266558
8.52	IC50	3	nM	CHEMBL2262044
8.52	IC50	3	nM	CHEMBL499814
8.52	IC50	3	nM	CHEMBL1161036
8.48	IC50	3.3	nM	CHEMBL75642
8.40	IC50	3.981	nM	CHEMBL301605
8.40	Ki	4	nM	CHEMBL330116
8.40	Ki	4	nM	CHEMBL3407528

PubChem BioAssay actives

409 with measured affinity, of 877 total; 50 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
2-(4-methoxyphenyl)-1H-pyrazolo[4,3-c]quinolin-3-one	40988: Inhibition on Benzodiazepine receptor	ic50	0.0001	uM
ethyl 4-(methoxymethyl)-5-phenylmethoxy-9H-pyrido[3,4-b]indole-3-carboxylate	1932290: Displacement of [3H]flunitrazepam from GABAA (unknown origin ) receptor by radioligand binding assay	ic50	0.0002	uM
ethyl 4-methyl-5-propan-2-yloxy-9H-pyrido[3,4-b]indole-3-carboxylate	1932290: Displacement of [3H]flunitrazepam from GABAA (unknown origin ) receptor by radioligand binding assay	ic50	0.0004	uM
2-phenyl-3aH-pyrazolo[4,3-c]quinolin-3-one	40988: Inhibition on Benzodiazepine receptor	ic50	0.0004	uM
ethyl 4-(methoxymethyl)-6-phenylmethoxy-9H-pyrido[3,4-b]indole-3-carboxylate	1932290: Displacement of [3H]flunitrazepam from GABAA (unknown origin ) receptor by radioligand binding assay	ic50	0.0005	uM
ethyl 4-(methoxymethyl)-9H-pyrido[3,4-b]indole-3-carboxylate	1932290: Displacement of [3H]flunitrazepam from GABAA (unknown origin ) receptor by radioligand binding assay	ic50	0.0005	uM
ethyl 6-methoxy-4-(methoxymethyl)-9H-pyrido[3,4-b]indole-3-carboxylate	1932290: Displacement of [3H]flunitrazepam from GABAA (unknown origin ) receptor by radioligand binding assay	ic50	0.0005	uM
ethyl 4-(methoxymethyl)-6-propoxy-9H-pyrido[3,4-b]indole-3-carboxylate	1932290: Displacement of [3H]flunitrazepam from GABAA (unknown origin ) receptor by radioligand binding assay	ic50	0.0005	uM
ethyl 6-hydroxy-4-(methoxymethyl)-9H-pyrido[3,4-b]indole-3-carboxylate	1932290: Displacement of [3H]flunitrazepam from GABAA (unknown origin ) receptor by radioligand binding assay	ic50	0.0005	uM
2-(4-chlorophenyl)-3aH-pyrazolo[4,3-c]quinolin-3-one	40988: Inhibition on Benzodiazepine receptor	ic50	0.0006	uM
5-[[3-(1,3-benzodioxol-5-yl)-6-iminopyridazin-1-yl]methyl]-1,2-thiazol-3-one;hydrobromide	72153: Affinity for gamma-aminobutyric-acid A receptor measured by its ability to displace [3H]gabazine antagonist from rat brain preparations.	ic50	0.0008	uM
propan-2-yl 16-(methoxymethyl)-3,6,11,14-tetrazatetracyclo[8.7.0.02,7.012,17]heptadeca-1(10),2,4,6,8,12,14,16-octaene-15-carboxylate	1932305: Inhibition of GABAA receptor (unknown origin)	ic50	0.0008	uM
propan-2-yl 4-(methoxymethyl)-6,9,14,21-tetrazapentacyclo[11.8.0.02,10.03,8.015,20]henicosa-1(21),2,4,6,8,10,12,15(20)-octaene-5-carboxylate	1932305: Inhibition of GABAA receptor (unknown origin)	ic50	0.0008	uM
propan-2-yl 15-(methoxymethyl)-4-propan-2-yl-5-oxa-10,13-diazatetracyclo[7.7.0.02,6.011,16]hexadeca-1(9),2(6),3,7,11,13,15-heptaene-14-carboxylate	1932305: Inhibition of GABAA receptor (unknown origin)	ic50	0.0008	uM
Clonazepam	239299: Displacement of [3H]flumazenil from bovine benzodiazepine receptor GABA-A channel of brain membranes	ki	0.0008	uM
15-(methoxymethyl)-14-(5-methyl-1,2-oxazol-3-yl)-4-propan-2-yl-5-oxa-3,10,13-triazatetracyclo[7.7.0.02,6.011,16]hexadeca-1(9),2(6),3,7,11,13,15-heptaene	1932305: Inhibition of GABAA receptor (unknown origin)	ic50	0.0009	uM
Flumazenil	239299: Displacement of [3H]flumazenil from bovine benzodiazepine receptor GABA-A channel of brain membranes	ki	0.0009	uM
ethyl 9H-pyrido[3,4-b]indole-3-carboxylate	1932290: Displacement of [3H]flunitrazepam from GABAA (unknown origin ) receptor by radioligand binding assay	ic50	0.0010	uM
methyl 9H-pyrido[3,4-b]indole-3-carboxylate	1932290: Displacement of [3H]flunitrazepam from GABAA (unknown origin ) receptor by radioligand binding assay	ic50	0.0010	uM
propyl 9H-pyrido[3,4-b]indole-3-carboxylate	1932290: Displacement of [3H]flunitrazepam from GABAA (unknown origin ) receptor by radioligand binding assay	ic50	0.0010	uM
tert-butyl 9H-pyrido[3,4-b]indole-3-carboxylate	1932290: Displacement of [3H]flunitrazepam from GABAA (unknown origin ) receptor by radioligand binding assay	ic50	0.0010	uM
7-chloro-5-methyl-3-(2-phenylethynyl)-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one	1196597: Displacement of [3H]flumazenil from rat cortex GABAA receptor BDZ binding site expressed in HEK293 cells by competition binding assay	ki	0.0010	uM
6-bromo-2-(3-nitrophenyl)chromen-4-one	72729: Binding affinity towards benzodiazepine site in GABAA receptor	ki	0.0010	uM
(2-methoxyphenyl)methyl 8-chloro-5-oxido-3,3a-dihydropyrazolo[5,1-c][1,2,4]benzotriazin-5-ium-3-carboxylate	41860: Binding affinity towards Benzodiazepine receptor from bovine brain membrane using [3H]Ro-151788 as radioligand	ki	0.0010	uM
propan-2-yl 4-(methoxymethyl)-6-phenylmethoxy-9H-pyrido[3,4-b]indole-3-carboxylate	1932290: Displacement of [3H]flunitrazepam from GABAA (unknown origin ) receptor by radioligand binding assay	ic50	0.0010	uM
(2-methoxyphenyl)methyl 8-chloropyrazolo[5,1-c][1,2,4]benzotriazine-3-carboxylate	41860: Binding affinity towards Benzodiazepine receptor from bovine brain membrane using [3H]Ro-151788 as radioligand	ki	0.0017	uM
5-(aminomethyl)-1,2-oxazol-3-one	72155: Binding affinity in vivo for gamma-aminobutyric-acid A receptor measured by its ability to displace [3H]-GABA agonist from rat brain preparations after iv injection.	ic50	0.0020	uM
Fipronil	242615: In vitro insecticidal activity as inhibition of [3H]EBOB binding to Gamma-aminobutyric acid GABA-A receptor of housefly neuronal membranes	ic50	0.0023	uM
9-chloro-2-phenyl-6H-triazolo[1,2-a][1,2,4]benzotriazine-1,5-dione	239299: Displacement of [3H]flumazenil from bovine benzodiazepine receptor GABA-A channel of brain membranes	ki	0.0028	uM
7-chloro-5-(2-chlorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one	40974: In vitro displacement of [3H]-diazepam from GABA-A Benzodiazepine receptor	ic50	0.0028	uM
3-isothiocyanato-9H-pyrido[3,4-b]indole	1932290: Displacement of [3H]flunitrazepam from GABAA (unknown origin ) receptor by radioligand binding assay	ic50	0.0030	uM
9H-pyrido[3,4-b]indole-3-carbonitrile	1932290: Displacement of [3H]flunitrazepam from GABAA (unknown origin ) receptor by radioligand binding assay	ic50	0.0030	uM
3-(6,7-difluoro-1,3-benzoxazol-2-yl)-1,3a,4,5,6,7,8,8a-octahydrocyclohepta[d]imidazol-2-one	40986: Binding affinity against GABA-A benzodiazepine receptor	ki	0.0030	uM
(5aR,7R,9aS,11aS)-2-amino-7-hydroxy-9a,11a-dimethyl-3,3a,3b,4,5,5a,6,7,8,9,9b,11-dodecahydronaphtho[2,1-e]indol-10-one	72153: Affinity for gamma-aminobutyric-acid A receptor measured by its ability to displace [3H]gabazine antagonist from rat brain preparations.	ic50	0.0030	uM
3-propoxy-9H-pyrido[3,4-b]indole	1932290: Displacement of [3H]flunitrazepam from GABAA (unknown origin ) receptor by radioligand binding assay	ic50	0.0030	uM
1-(9H-pyrido[3,4-b]indol-3-yl)butan-1-one	1932290: Displacement of [3H]flunitrazepam from GABAA (unknown origin ) receptor by radioligand binding assay	ic50	0.0030	uM
8-fluoro-5-methyl-3-(2-phenylethynyl)-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one	1196597: Displacement of [3H]flumazenil from rat cortex GABAA receptor BDZ binding site expressed in HEK293 cells by competition binding assay	ki	0.0040	uM
methyl 6-hydroxy-9H-pyrido[3,4-b]indole-3-carboxylate	1932290: Displacement of [3H]flunitrazepam from GABAA (unknown origin ) receptor by radioligand binding assay	ic50	0.0040	uM
2-phenyl-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-one	40986: Binding affinity against GABA-A benzodiazepine receptor	ki	0.0040	uM
17-chloro-9,12,20-triazapentacyclo[11.7.0.02,10.03,8.014,19]icosa-1(13),2(10),3,5,7,11,14,16,18-nonaene	1932305: Inhibition of GABAA receptor (unknown origin)	ic50	0.0040	uM
5-nitro-9,12,20-triazapentacyclo[11.7.0.02,10.03,8.014,19]icosa-1(13),2(10),3,5,7,11,14,16,18-nonaene	1932305: Inhibition of GABAA receptor (unknown origin)	ic50	0.0040	uM
5-bromo-9,12,20-triazapentacyclo[11.7.0.02,10.03,8.014,19]icosa-1(13),2(10),3,5,7,11,14,16,18-nonaene	1932305: Inhibition of GABAA receptor (unknown origin)	ic50	0.0040	uM
17-methoxy-9,12,20-triazapentacyclo[11.7.0.02,10.03,8.014,19]icosa-1(13),2(10),3,5,7,11,14,16,18-nonaene	1932305: Inhibition of GABAA receptor (unknown origin)	ic50	0.0040	uM
9,12,20-triazapentacyclo[11.7.0.02,10.03,8.014,19]icosa-1(13),2(10),3,5,7,11,14,16,18-nonaene	1932305: Inhibition of GABAA receptor (unknown origin)	ic50	0.0040	uM
methyl 6-(benzylamino)-9H-pyrido[3,4-b]indole-3-carboxylate	1932290: Displacement of [3H]flunitrazepam from GABAA (unknown origin ) receptor by radioligand binding assay	ic50	0.0040	uM
Diazepam	1934094: Inhibition of GABA-A receptor (unknown origin)	ic50	0.0042	uM
4-acetyl-13-(4-chlorophenyl)-5-thia-13,14-diazatricyclo[8.4.0.02,6]tetradeca-1(10),2(6),3-trien-12-one	40977: Binding affinity for GABA-A Benzodiazepine receptor	ki	0.0042	uM
1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(trifluoromethylsulfinyl)pyrazole	242615: In vitro insecticidal activity as inhibition of [3H]EBOB binding to Gamma-aminobutyric acid GABA-A receptor of housefly neuronal membranes	ic50	0.0042	uM
2-amino-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]acetamide	40974: In vitro displacement of [3H]-diazepam from GABA-A Benzodiazepine receptor	ic50	0.0048	uM
3-(7-fluoro-1,3-benzoxazol-2-yl)-1,3a,4,5,6,7,8,8a-octahydrocyclohepta[d]imidazol-2-one	40986: Binding affinity against GABA-A benzodiazepine receptor	ki	0.0050	uM

CTD chemical–gene interactions

15 total (human), top 15 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects expression, affects cotreatment, decreases expression, increases abundance	2
Valproic Acid	decreases methylation, increases expression	2
butyraldehyde	increases expression	1
manganese chloride	affects cotreatment, decreases expression, increases abundance	1
abrine	decreases expression	1
jinfukang	affects cotreatment, increases expression	1
Sunitinib	increases expression	1
Arsenic	affects cotreatment, decreases expression, increases abundance	1
Benzo(a)pyrene	affects methylation	1
Cadmium	decreases expression, increases abundance	1
Cisplatin	affects cotreatment, increases expression	1
Lead	affects expression	1
Manganese	increases abundance, affects cotreatment, decreases expression	1
Cyclosporine	decreases methylation	1
Cadmium Chloride	decreases expression, increases abundance	1

ChEMBL screening assays

186 unique, capped per target: 167 binding, 15 functional, 3 toxicity, 1 admet

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL3363914	Binding	Displacement of [3H]Muscimol from rat GABAA receptor at 10 uM after 90 mins by microbeta counting analysis	Griseorhodins D-F, neuroactive intermediates and end products of post-PKS tailoring modification in Griseorhodin biosynthesis. — *J Nat Prod*
CHEMBL4810229	ADMET	Inhibition of GABA A receptor (unknown origin) at 0.1 to 1 uM	Discovery of Pemigatinib: A Potent and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor. — *J Med Chem*
CHEMBL5335653	Toxicity	Antagonist activity at GABA-A (unknown origin)	Discovery of a Novel Bifunctional Steroid Analog, YXG-158, as an Androgen Receptor Degrader and CYP17A1 Inhibitor for the Treatment of Enzalutamide-Resistant Prostate Cancer. — *J Med Chem*

Clinical trials (associated diseases)

Via MONDO — disease-level, not drug-specific.

Predicted chemistry — Sugi Predict

The predicted patent-compound landscape for GABRQ across ~30M SureChEMBL compounds — explore on Sugi Predict.