GACAT1

Summary

GACAT1 (gastric cancer associated transcript 1, HGNC:48336) is a long non-coding RNA gene on chromosome 2q12.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48336
Approved symbol	GACAT1
Name	gastric cancer associated transcript 1
Location	2q12.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	LINC00876, AC096655.1-002
Ensembl gene	ENSG00000232991
Ensembl biotype	lncRNA
Entrez	104326057
RNAcentral	URS00007E3549 — lncRNA, 610 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000419650, ENST00000441383

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000419650 — 4 exons

Exon	Start	End
ENSE00001643594	107810680	107810740
ENSE00001673380	107754145	107754270
ENSE00001784738	107812078	107812348
ENSE00001794862	107755482	107755600

Expression profiles

Bgee: expression breadth broad, 35 present calls, max score 80.35.

Top tissues by expression

35 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.35	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	66.99	gold quality
skeletal muscle tissue	UBERON:0001134	62.66	silver quality
monocyte	CL:0000576	57.41	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	54.30	gold quality
blood	UBERON:0000178	52.93	silver quality
gastrocnemius	UBERON:0001388	46.74	silver quality
skin of leg	UBERON:0001511	46.11	gold quality
ascending aorta	UBERON:0001496	45.97	gold quality
subcutaneous adipose tissue	UBERON:0002190	45.41	gold quality
myometrium	UBERON:0001296	44.94	silver quality
thoracic aorta	UBERON:0001515	44.54	silver quality
right frontal lobe	UBERON:0002810	44.35	silver quality
Ammon’s horn	UBERON:0001954	43.13	silver quality
right testis	UBERON:0004534	41.40	gold quality
thoracic mammary gland	UBERON:0005200	41.30	silver quality
body of uterus	UBERON:0009853	41.28	silver quality
left ovary	UBERON:0002119	41.04	silver quality
right atrium auricular region	UBERON:0006631	41.00	gold quality
multicellular organism	UBERON:0000468	40.88	gold quality
spleen	UBERON:0002106	40.58	silver quality
amygdala	UBERON:0001876	40.30	silver quality
hypothalamus	UBERON:0001898	40.23	silver quality
testis	UBERON:0000473	40.19	gold quality
esophagus mucosa	UBERON:0002469	39.78	silver quality
fundus of stomach	UBERON:0001160	39.48	silver quality
body of pancreas	UBERON:0001150	39.43	silver quality
left testis	UBERON:0004533	39.09	gold quality
putamen	UBERON:0001874	38.80	silver quality
body of stomach	UBERON:0001161	37.90	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.44

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• GACAT1 long noncoding RNA (AC096655.1-002) expression correlates with clinicopathological features of patients with gastric cancer. (PMID:23645148)
• LncRNA GACAT1 induces tongue squamous cell carcinoma migration and proliferation via miR-149. (PMID:34378327)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.