GAGE10

Summary

GAGE10 (G antigen 10, HGNC:30968) is a protein-coding gene on chromosome Xp11.23, encoding G antigen 10 (A6NGK3).

At a glance

• Clinical variants (ClinVar): 49 total
• MANE Select transcript: NM_001098413

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30968
Approved symbol	GAGE10
Name	G antigen 10
Location	Xp11.23
Locus type	gene with protein product
Status	Approved
Aliases	OTTHUMG00000024136
Ensembl gene	ENSG00000215274
Ensembl biotype	protein_coding
OMIM	300737
Entrez	102724473

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000407599

RefSeq mRNA: 1 — MANE Select: NM_001098413 NM_001098413

CCDS: CCDS78483

Canonical transcript exons

ENST00000407599 — 5 exons

Exon	Start	End
ENSE00001629864	49319728	49319841
ENSE00001639904	49317163	49317288
ENSE00001692657	49304852	49304940
ENSE00001729670	49305404	49305524
ENSE00001783509	49303646	49303753

Expression profiles

Bgee: expression breadth ubiquitous, 117 present calls, max score 82.73.

Top tissues by expression

128 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.73	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.72	silver quality
pituitary gland	UBERON:0000007	66.50	gold quality
adenohypophysis	UBERON:0002196	65.10	gold quality
right coronary artery	UBERON:0001625	60.66	gold quality
nucleus accumbens	UBERON:0001882	60.43	gold quality
caudate nucleus	UBERON:0001873	59.71	gold quality
right testis	UBERON:0004534	58.95	gold quality
left ovary	UBERON:0002119	57.67	gold quality
lower esophagus mucosa	UBERON:0035834	57.50	gold quality
putamen	UBERON:0001874	57.38	gold quality
right ovary	UBERON:0002118	57.21	gold quality
right uterine tube	UBERON:0001302	56.67	gold quality
testis	UBERON:0000473	56.66	gold quality
ovary	UBERON:0000992	56.54	gold quality
left testis	UBERON:0004533	56.26	gold quality
apex of heart	UBERON:0002098	55.70	gold quality
fallopian tube	UBERON:0003889	51.19	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	50.98	gold quality
lower esophagus muscularis layer	UBERON:0035833	50.07	gold quality
right hemisphere of cerebellum	UBERON:0014890	50.02	gold quality
cerebellar hemisphere	UBERON:0002245	50.00	gold quality
lower esophagus	UBERON:0013473	49.97	gold quality
cerebellar cortex	UBERON:0002129	49.79	gold quality
brain	UBERON:0000955	49.72	gold quality
cerebellum	UBERON:0002037	49.72	gold quality
amygdala	UBERON:0001876	48.91	gold quality
hypothalamus	UBERON:0001898	48.81	gold quality
temporal lobe	UBERON:0001871	48.63	gold quality
popliteal artery	UBERON:0002250	48.49	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-7249	yes	11.48
E-ANND-3	no	1.30

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (22): PAGE1 (ENSG00000068985), PAGE4 (ENSG00000101951), XAGE2 (ENSG00000155622), PAGE5 (ENSG00000158639), XAGE3 (ENSG00000171402), XAGE5 (ENSG00000171405), GAGE2A (ENSG00000189064), PAGE3 (ENSG00000204279), XAGE1A (ENSG00000204379), XAGE1B (ENSG00000204382), GAGE1 (ENSG00000205777), GAGE12G (ENSG00000215269), GAGE12E (ENSG00000216649), GAGE12J (ENSG00000224659), GAGE12H (ENSG00000224902), GAGE12D (ENSG00000227488), PAGE2 (ENSG00000234068), GAGE12F (ENSG00000236362), GAGE12C (ENSG00000237671), PAGE2B (ENSG00000238269), GAGE13 (ENSG00000274274), GAGE2E (ENSG00000275113)

Protein

Protein identifiers

G antigen 10 — A6NGK3 (reviewed: A6NGK3)

All UniProt accessions (1): A6NGK3

UniProt curated annotations — full annotation on UniProt →

Miscellaneous. This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Similarity. Belongs to the GAGE family.

RefSeq proteins (1): NP_001091883* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR008625	GAGE_fam	Family
IPR031320	GAGE	Domain

Pfam: PF05831

UniProt features (7 total): compositionally biased region 3, sequence variant 2, chain 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A6NGK3-F1	65.72	0.00

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 1 (showing top): chrXp11

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (0):

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	1

Protein interactions and networks

STRING

1127 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
GAGE10	PPP1R3F	Q6ZSY5	572
GAGE10	ZNF428	Q96B54	472
GAGE10	MAGEA3	P43357	470
GAGE10	CCDC97	Q96F63	447
GAGE10	RWDD1	Q9H446	447
GAGE10	MAGEA1	P43355	428
GAGE10	UBL7	Q96S82	427
GAGE10	CHAC2	Q8WUX2	370
GAGE10	NXF2B	Q9GZY0	351
GAGE10	AAMP	Q13685	325
GAGE10	IFT38	Q96AJ1	321
GAGE10	FIGN	Q5HY92	312
GAGE10	SMG9	Q9H0W8	310
GAGE10	MINDY3	Q9H8M7	303
GAGE10	ZNF48	Q96MX3	301

IntAct

5 interactions, top by confidence:

A	B	Type	Score
GAGE10	GMCL1	psi-mi:“MI:0915”(physical association)	0.600
GMCL1	GAGE10	psi-mi:“MI:0915”(physical association)	0.600
GMCL1	GAGE10	psi-mi:“MI:0915”(physical association)	0.000

ESM2 similar proteins: A0A0U1RQG5, A1L429, A6NDE8, A6NER3, A6NGK3, E1AZ71, O08664, O60829, O75459, O76087, P0C2W7, P0CL80, P0CL81, P0CL82, P0DSO3, P0DTW1, P52651, P62521, P86478, P86479, P86480, P86481, P86496, Q13066, Q13069, Q13070, Q17QW4, Q28181, Q2T9P9, Q32PA2, Q4V321, Q4V326, Q5JQC4, Q5U2Y8, Q62100, Q63803, Q64256, Q6NT46, Q6X7S9, Q7Z2X7

Diamond homologs: A1L429, A6NDE8, A6NER3, A6NGK3, O75459, O76087, P0CL80, P0CL81, P0CL82, P0DSO3, P0DTW1, Q13066, Q13069, Q13070, Q4V321, Q4V326, Q6NT46, Q8WTP9, Q96GT9, Q9UEU5, Q8WWM1, Q5JUK9, Q5JRK9, Q7Z2X7, Q96GU1, Q9HD64

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

49 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	23
Likely benign	8
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

913 predictions. Top by Δscore:

Variant	Effect	Δscore
X:49305380:T:TA	acceptor_gain	1.0000
X:49305383:A:AG	acceptor_gain	1.0000
X:49305384:C:G	acceptor_gain	1.0000
X:49305385:A:AG	acceptor_gain	1.0000
X:49305386:C:G	acceptor_gain	1.0000
X:49305389:A:AG	acceptor_gain	1.0000
X:49305389:ACAC:A	acceptor_gain	1.0000
X:49305390:C:G	acceptor_gain	1.0000
X:49305391:A:AG	acceptor_gain	1.0000
X:49305391:AC:A	acceptor_gain	1.0000
X:49305392:C:CA	acceptor_gain	1.0000
X:49305392:C:G	acceptor_gain	1.0000
X:49305395:A:AG	acceptor_gain	1.0000
X:49305396:T:G	acceptor_gain	1.0000
X:49305491:G:GT	donor_gain	1.0000
X:49305506:G:GT	donor_gain	1.0000
X:49305537:G:T	donor_gain	1.0000
X:49317160:A:AG	acceptor_gain	1.0000
X:49317160:AAT:A	acceptor_gain	1.0000
X:49317162:T:A	acceptor_gain	1.0000
X:49304850:A:AG	acceptor_gain	0.9900
X:49304851:G:GG	acceptor_gain	0.9900
X:49304851:GT:G	acceptor_gain	0.9900
X:49305377:A:AG	acceptor_gain	0.9900
X:49305377:ATTT:A	acceptor_gain	0.9900
X:49305378:T:G	acceptor_gain	0.9900
X:49305399:CCCA:C	acceptor_loss	0.9900
X:49305400:CCA:C	acceptor_loss	0.9900
X:49305402:A:AG	acceptor_gain	0.9900
X:49305402:A:C	acceptor_loss	0.9900

AlphaMissense

751 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
X:49305413:T:C	F31L	0.820
X:49305415:C:A	F31L	0.820
X:49305415:C:G	F31L	0.820
X:49304868:G:C	W3C	0.678
X:49304868:G:T	W3C	0.678
X:49304877:A:C	R6S	0.657
X:49304877:A:T	R6S	0.657
X:49304866:T:A	W3R	0.615
X:49304866:T:C	W3R	0.615

dbSNP variants (sampled 300 via entrez): RS10580626 (X:49306836 TAAACAAAC>T,TAAAC,TAAACAAACAAAC), RS111602038 (X:49315479 G>A), RS111622823 (X:49315072 C>A), RS111674184 (X:49315529 G>A), RS111851556 (X:49304192 C>A,T), RS112088965 (X:49306588 A>G), RS112203838 (X:49314542 C>G,T), RS113024221 (X:49315679 C>T), RS113164859 (X:49302690 CTTTTTTTT>C,CTT,CTTTTT,CTTTTTT,CTTTTTTT,CTTTTTTTTT,CTTTTTTTTTT,CTTTTTTTTTTT,CTTTTTTTTTTTT), RS113679867 (X:49309515 T>C), RS113941332 (X:49305128 C>G), RS113974606 (X:49305218 G>A,T), RS115299246 (X:49303646 G>A), RS1156314549 (X:49309542 G>C), RS1156545242 (X:49310897 C>G)

Disease associations

OMIM: gene MIM:300737 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
clothianidin	increases expression	1
Benzo(a)pyrene	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.