GAGE8

Summary

GAGE8 (G antigen 8, HGNC:4106) is a protein-coding gene on chromosome Xp11 not on reference assembly, encoding G antigen 2D (Q9UEU5).

This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions. The antigenic peptide YRPRPRRY, which is also encoded by several other family members, is recognized by autologous cytolytic T lymphocytes.

Source: NCBI Gene 100101629 — RefSeq curated summary.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:4106
Approved symbol	GAGE8
Name	G antigen 8
Location	Xp11 not on reference assembly
Locus type	gene with protein product
Status	Approved
Aliases	CT4.8
OMIM	300638
Entrez	100101629

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

G antigen 2D — Q9UEU5 (reviewed: Q9UEU5)

Alternative names: Cancer/testis antigen 4.8, G antigen 8

All UniProt accessions (0):

UniProt curated annotations — full annotation on UniProt →

Tissue specificity. Not expressed in normal tissues, except in testis, but expressed by a large proportion of tumors of various histological origins.

Miscellaneous. This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Similarity. Belongs to the GAGE family.

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR008625	GAGE_fam	Family
IPR031320	GAGE	Domain

Pfam: PF05831

UniProt features (5 total): compositionally biased region 3, chain 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9UEU5-F1	65.44	0.00

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

12 interactions, top by confidence:

A	B	Type	Score
GAGE8	GMCL2	psi-mi:“MI:0915”(physical association)	0.700
GMCL2	GAGE8	psi-mi:“MI:0915”(physical association)	0.700
FLJ13057	GAGE8	psi-mi:“MI:0915”(physical association)	0.560
GAGE8	FLJ13057	psi-mi:“MI:0915”(physical association)	0.560
GAGE8	WIZ	psi-mi:“MI:0914”(association)	0.350

BioGRID (10): GAGE2D (Affinity Capture-MS), GAGE2D (Positive Genetic), GMCL1 (Affinity Capture-MS), GAGE1 (Affinity Capture-MS), WIZ (Affinity Capture-MS), KCTD6 (Affinity Capture-MS), ZNF644 (Affinity Capture-MS), DPP9 (Affinity Capture-MS), EHMT2 (Affinity Capture-MS), EHMT1 (Affinity Capture-MS)

ESM2 similar proteins: A0A0U1RQG5, A1L429, A6NDE8, A6NER3, A6NGK3, E1AZ71, O08664, O60829, O75459, O76087, P0C2W7, P0CL80, P0CL81, P0CL82, P0DSO3, P0DTW1, P52651, P62521, P86478, P86479, P86480, P86481, P86496, Q13066, Q13069, Q13070, Q17QW4, Q28181, Q2T9P9, Q32PA2, Q4V321, Q4V326, Q5JQC4, Q5U2Y8, Q62100, Q63803, Q64256, Q6NT46, Q6X7S9, Q7Z2X7

Diamond homologs: A1L429, A6NDE8, A6NER3, A6NGK3, O75459, O76087, P0CL80, P0CL81, P0CL82, P0DSO3, P0DTW1, Q13066, Q13069, Q13070, Q4V321, Q4V326, Q6NT46, Q8WTP9, Q96GT9, Q9UEU5, Q8WWM1, Q5JUK9, Q5JRK9, Q7Z2X7, Q9HD64

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

Disease associations

OMIM: gene MIM:300638 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.