GAS1RR

Summary

GAS1RR (GAS1 adjacent regulatory RNA, HGNC:52261) is a long non-coding RNA gene on chromosome 9q21.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52261
Approved symbol	GAS1RR
Name	GAS1 adjacent regulatory RNA
Location	9q21.33
Locus type	RNA, long non-coding
Status	Approved
Aliases	LncRNA-Hh, RP11-276H19.1
Ensembl gene	ENSG00000226237
Ensembl biotype	lncRNA
Entrez	100506834
RNAcentral	URS000075D128 — lncRNA, 4388 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 16 lncRNA

ENST00000415801, ENST00000654660, ENST00000701854, ENST00000846239, ENST00000846240, ENST00000846241, ENST00000846242, ENST00000846243, ENST00000846244, ENST00000846245, ENST00000846246, ENST00000846247, ENST00000846248, ENST00000846249, ENST00000846250, ENST00000846251

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000415801 — 7 exons

Exon	Start	End
ENSE00001628413	86950867	86950999
ENSE00001691213	86987448	86987615
ENSE00001696665	86998594	87002033
ENSE00001714338	86997314	86997403
ENSE00001727915	86988802	86988906
ENSE00001759943	86981770	86981925
ENSE00001779195	86948699	86948993

Expression profiles

Bgee: expression breadth ubiquitous, 160 present calls, max score 78.10.

FANTOM5 (CAGE): breadth broad, TPM avg 1.0621 / max 45.1388, expressed in 447 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
97193	0.6403	344
97194	0.4218	223

Top tissues by expression

237 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left ovary	UBERON:0002119	78.10	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	77.62	gold quality
body of uterus	UBERON:0009853	76.67	gold quality
right ovary	UBERON:0002118	76.06	gold quality
germinal epithelium of ovary	UBERON:0001304	75.64	gold quality
smooth muscle tissue	UBERON:0001135	75.59	gold quality
body of pancreas	UBERON:0001150	75.39	gold quality
ovary	UBERON:0000992	74.97	gold quality
muscle layer of sigmoid colon	UBERON:0035805	73.67	gold quality
left uterine tube	UBERON:0001303	73.65	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	72.98	gold quality
calcaneal tendon	UBERON:0003701	72.89	gold quality
omental fat pad	UBERON:0010414	72.28	gold quality
peritoneum	UBERON:0002358	72.19	gold quality
lower esophagus	UBERON:0013473	71.58	gold quality
lower esophagus muscularis layer	UBERON:0035833	71.54	gold quality
adipose tissue of abdominal region	UBERON:0007808	70.61	gold quality
prostate gland	UBERON:0002367	70.60	gold quality
skin of abdomen	UBERON:0001416	69.82	gold quality
endocervix	UBERON:0000458	69.68	gold quality
gall bladder	UBERON:0002110	69.11	gold quality
stromal cell of endometrium	CL:0002255	68.80	gold quality
ascending aorta	UBERON:0001496	68.56	gold quality
thoracic aorta	UBERON:0001515	68.54	gold quality
pancreas	UBERON:0001264	68.52	gold quality
descending thoracic aorta	UBERON:0002345	68.28	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	67.93	gold quality
fallopian tube	UBERON:0003889	67.60	gold quality
ventricular zone	UBERON:0003053	67.50	gold quality
colonic epithelium	UBERON:0000397	67.25	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.57

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• the Shh-GLI1 pathway associated lncRNA-Hh, transcriptionally regulated by Twist, directly targets GAS1 to stimulate the activation of hedgehog signaling (Hh). (PMID:26418365)
• GAS1RR, an immune-related enhancer RNA, is related to biochemical recurrence-free survival in prostate cancer. (PMID:36408742)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.