GAS6-AS1

Summary

GAS6-AS1 (GAS6 antisense RNA 1, HGNC:39826) is a long non-coding RNA gene on chromosome 13q34.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:39826
Approved symbol	GAS6-AS1
Name	GAS6 antisense RNA 1
Location	13q34
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000233695
Ensembl biotype	lncRNA
Entrez	650669
RNAcentral	URS000075CA64 — lncRNA, 902 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000458001, ENST00000611082

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000458001 — 5 exons

Exon	Start	End
ENSE00001626999	113815630	113815691
ENSE00001651020	113834578	113834764
ENSE00001670101	113833492	113833579
ENSE00001697197	113838077	113838247
ENSE00001744383	113839084	113845744

Expression profiles

Bgee: expression breadth ubiquitous, 200 present calls, max score 95.83.

FANTOM5 (CAGE): breadth broad, TPM avg 0.3914 / max 22.0243, expressed in 184 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
136254	0.3914	184

Top tissues by expression

233 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	95.83	gold quality
right uterine tube	UBERON:0001302	86.46	gold quality
spleen	UBERON:0002106	79.31	gold quality
pancreatic ductal cell	CL:0002079	78.77	silver quality
sural nerve	UBERON:0015488	77.56	gold quality
vermiform appendix	UBERON:0001154	74.41	gold quality
endothelial cell	CL:0000115	73.49	silver quality
upper arm skin	UBERON:0004263	73.26	gold quality
cardiac muscle of right atrium	UBERON:0003379	72.67	gold quality
left ventricle myocardium	UBERON:0006566	72.45	gold quality
right adrenal gland cortex	UBERON:0035827	72.36	gold quality
colonic epithelium	UBERON:0000397	71.83	silver quality
gall bladder	UBERON:0002110	71.52	gold quality
caecum	UBERON:0001153	71.46	gold quality
mucosa of paranasal sinus	UBERON:0005030	71.45	gold quality
epithelium of nasopharynx	UBERON:0001951	71.19	gold quality
oviduct epithelium	UBERON:0004804	70.58	gold quality
bone marrow cell	CL:0002092	70.15	silver quality
right adrenal gland	UBERON:0001233	70.14	gold quality
lymph node	UBERON:0000029	69.76	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	69.48	silver quality
seminal vesicle	UBERON:0000998	69.17	gold quality
small intestine Peyer’s patch	UBERON:0003454	69.16	gold quality
myocardium	UBERON:0002349	69.12	gold quality
bronchial epithelial cell	CL:0002328	68.96	gold quality
sperm	CL:0000019	68.81	silver quality
nasal cavity epithelium	UBERON:0005384	68.79	gold quality
bronchus	UBERON:0002185	68.55	gold quality
adrenal cortex	UBERON:0001235	68.22	gold quality
bone marrow	UBERON:0002371	68.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.93

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Study using gastric cancer (GC) tissue samples and mouse xenograft model showed that GAS6-AS1 can control the expression of its cognate sense gene GAS6 at the transcriptional or translational levels by forming a RNA-RNA duplex, significantly driving the aggressive GC phenotype, and consequently inducing an increase of AXL level and promoting AXL signaling pathway activation. (PMID:30735718)
• GAS6-AS1, a long noncoding RNA, functions as a key candidate gene in atrial fibrillation related stroke determined by ceRNA network analysis and WGCNA. (PMID:36894947)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.