GAS6-DT

Summary

GAS6-DT (GAS6 divergent transcript, HGNC:43694) is a long non-coding RNA gene on chromosome 13q34.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43694
Approved symbol	GAS6-DT
Name	GAS6 divergent transcript
Location	13q34
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ44054
Ensembl gene	ENSG00000272695
Ensembl biotype	lncRNA
Entrez	100506394
RNAcentral	URS000075DB95 — lncRNA, 1942 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000608651, ENST00000655351, ENST00000669254, ENST00000757209

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000608651 — 2 exons

Exon	Start	End
ENSE00003703118	113865010	113866833
ENSE00003704653	113864168	113864295

Expression profiles

Bgee: expression breadth ubiquitous, 131 present calls, max score 82.75.

FANTOM5 (CAGE): breadth broad, TPM avg 0.8075 / max 35.7376, expressed in 454 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
136260	0.8075	454

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cerebellar vermis	UBERON:0004720	82.75	silver quality
ascending aorta	UBERON:0001496	80.28	gold quality
thoracic aorta	UBERON:0001515	80.04	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.75	gold quality
quadriceps femoris	UBERON:0001377	78.62	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.28	gold quality
lower esophagus muscularis layer	UBERON:0035833	77.91	gold quality
lower esophagus	UBERON:0013473	77.86	gold quality
descending thoracic aorta	UBERON:0002345	77.63	gold quality
popliteal artery	UBERON:0002250	74.43	gold quality
tibial artery	UBERON:0007610	74.42	gold quality
smooth muscle tissue	UBERON:0001135	73.81	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	73.54	gold quality
right coronary artery	UBERON:0001625	73.43	gold quality
urinary bladder	UBERON:0001255	73.29	gold quality
myometrium	UBERON:0001296	72.68	gold quality
right uterine tube	UBERON:0001302	72.50	gold quality
endocervix	UBERON:0000458	72.35	gold quality
fallopian tube	UBERON:0003889	72.14	gold quality
left coronary artery	UBERON:0001626	71.52	gold quality
ectocervix	UBERON:0012249	71.31	gold quality
body of uterus	UBERON:0009853	71.23	gold quality
heart left ventricle	UBERON:0002084	70.91	gold quality
stromal cell of endometrium	CL:0002255	70.81	gold quality
uterine cervix	UBERON:0000002	70.71	gold quality
heart	UBERON:0000948	70.59	gold quality
left uterine tube	UBERON:0001303	70.59	gold quality
tibial nerve	UBERON:0001323	70.38	gold quality
apex of heart	UBERON:0002098	70.08	gold quality
esophagus	UBERON:0001043	69.76	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Long non-coding RNA GAS6-AS2 promotes bladder cancer proliferation and metastasis via GAS6-AS2/miR-298/CDK9 axis. (PMID:30394665)
• Long noncoding RNA GAS6-AS2 sponges microRNA-493, thereby enhancing the malignant characteristics of breast cancer cells via upregulation of FUT4. (PMID:31839366)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.