GASAL1

Summary

GASAL1 (growth arrest associated lncRNA 1, HGNC:53461) is a long non-coding RNA gene on chromosome 8q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53461
Approved symbol	GASAL1
Name	growth arrest associated lncRNA 1
Location	8q22.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	GASL1
Ensembl gene	ENSG00000253669
Ensembl biotype	lncRNA
Entrez	401472
RNAcentral	URS0002853B76 — lncRNA, 3813 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 lncRNA

ENST00000517910, ENST00000522715, ENST00000663613, ENST00000665815, ENST00000670970, ENST00000810725

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000517910 — 2 exons

Exon	Start	End
ENSE00002112568	102806822	102808553
ENSE00002114420	102808934	102809971

Expression profiles

Bgee: expression breadth ubiquitous, 132 present calls, max score 79.04.

FANTOM5 (CAGE): breadth broad, TPM avg 0.6304 / max 24.7539, expressed in 296 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
90063	0.2436	125
90066	0.1899	71
90064	0.1131	57
90065	0.0677	22
90062	0.0162	9

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.04	silver quality
sural nerve	UBERON:0015488	77.81	gold quality
duodenum	UBERON:0002114	75.96	gold quality
colonic epithelium	UBERON:0000397	71.95	gold quality
placenta	UBERON:0001987	71.93	gold quality
islet of Langerhans	UBERON:0000006	70.41	gold quality
bone marrow cell	CL:0002092	69.61	silver quality
rectum	UBERON:0001052	67.67	gold quality
granulocyte	CL:0000094	66.88	gold quality
hindlimb stylopod muscle	UBERON:0004252	66.34	gold quality
bone marrow	UBERON:0002371	65.92	gold quality
stromal cell of endometrium	CL:0002255	65.41	gold quality
liver	UBERON:0002107	65.38	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	64.18	gold quality
right lobe of liver	UBERON:0001114	64.12	gold quality
smooth muscle tissue	UBERON:0001135	63.99	gold quality
cortical plate	UBERON:0005343	63.67	gold quality
ventricular zone	UBERON:0003053	63.55	gold quality
tonsil	UBERON:0002372	62.86	gold quality
muscle tissue	UBERON:0002385	62.57	gold quality
leukocyte	CL:0000738	62.32	gold quality
monocyte	CL:0000576	62.31	gold quality
gastrocnemius	UBERON:0001388	62.28	gold quality
ganglionic eminence	UBERON:0004023	62.08	gold quality
mucosa of transverse colon	UBERON:0004991	61.88	gold quality
muscle of leg	UBERON:0001383	61.70	gold quality
skeletal muscle tissue	UBERON:0001134	61.43	gold quality
vermiform appendix	UBERON:0001154	60.42	gold quality
right coronary artery	UBERON:0001625	60.21	gold quality
right adrenal gland cortex	UBERON:0035827	60.13	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.99

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• Data identify GASL1 as a novel lncRNA regulator of cell cycle progression and cell proliferation with a potential role in cancer. (PMID:28423601)
• lncRNA GASL1 may inhibit tumor growth of non-small cell lung cancer cells by down-regulating TGF-beta1. (PMID:30468472)
• Expression of the novel lncRNA, GASL1, was downregulated in patients with intracranial aneurysms and regulated the proliferation of VSMCs in vitro by targeting TGF-beta1. (PMID:30742604)
• GASL1 was downregulated in chronic heart failure (CHF). GASL1 overexpression may improve CHF by inhibiting cardiomyocyte apoptosis through the inactivation of TGF-beta1. (PMID:31223316)
• Long non-coding RNA GASL1 restrains gastric carcinoma cell proliferation and metastasis by sponging microRNA-106a. (PMID:32897806)
• The novel target of esophageal squamous cell carcinoma: lncRNA GASL1 regulates cell migration, invasion and cell cycle stagnation by inactivating the Wnt3a/beta-catenin signaling. (PMID:33248356)
• LncRNA GASAL1 promotes hepatocellular carcinoma progression by up-regulating USP10-stabilized PCNA. (PMID:34914965)
• Upgulation of lncRNA GASL1 inhibits atherosclerosis by regulating miR-106a/LKB1 axis. (PMID:36627571)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.