GATA2-AS1

Summary

GATA2-AS1 (GATA2 antisense RNA 1, HGNC:51108) is a long non-coding RNA gene on chromosome 3q21.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51108
Approved symbol	GATA2-AS1
Name	GATA2 antisense RNA 1
Location	3q21.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	GATA2AS
Ensembl gene	ENSG00000244300
Ensembl biotype	lncRNA
OMIM	621229
Entrez	101927167
RNAcentral	URS00007E3383 — lncRNA, 2358 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 15 lncRNA

ENST00000464242, ENST00000468377, ENST00000473958, ENST00000669945, ENST00000740166, ENST00000740167, ENST00000740168, ENST00000740169, ENST00000740170, ENST00000740171, ENST00000740172, ENST00000740173, ENST00000740174, ENST00000740175, ENST00000740176

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000464242 — 3 exons

Exon	Start	End
ENSE00001895201	128489779	128490069
ENSE00004076094	128489203	128489415
ENSE00004076105	128496699	128497366

Expression profiles

Bgee: expression breadth ubiquitous, 157 present calls, max score 86.55.

FANTOM5 (CAGE): breadth broad, TPM avg 3.2995 / max 83.6374, expressed in 750 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
38447	2.8232	721
38448	0.2978	90
38449	0.1396	48
38450	0.0389	10

Top tissues by expression

240 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lung	UBERON:0002167	86.55	gold quality
body of pancreas	UBERON:0001150	83.30	gold quality
body of uterus	UBERON:0009853	82.58	gold quality
left uterine tube	UBERON:0001303	81.15	gold quality
prostate gland	UBERON:0002367	80.50	gold quality
endocervix	UBERON:0000458	80.41	gold quality
upper lobe of left lung	UBERON:0008952	79.51	gold quality
upper lobe of lung	UBERON:0008948	78.15	gold quality
metanephros cortex	UBERON:0010533	77.26	gold quality
pancreas	UBERON:0001264	77.05	gold quality
omental fat pad	UBERON:0010414	76.77	gold quality
peritoneum	UBERON:0002358	76.67	gold quality
apex of heart	UBERON:0002098	76.63	gold quality
right atrium auricular region	UBERON:0006631	76.60	gold quality
endometrium	UBERON:0001295	76.17	gold quality
spleen	UBERON:0002106	76.08	gold quality
uterus	UBERON:0000995	75.83	gold quality
stromal cell of endometrium	CL:0002255	75.77	gold quality
cardiac atrium	UBERON:0002081	75.68	gold quality
adipose tissue of abdominal region	UBERON:0007808	75.61	gold quality
heart left ventricle	UBERON:0002084	74.64	gold quality
ectocervix	UBERON:0012249	74.54	gold quality
cardiac ventricle	UBERON:0002082	73.75	gold quality
smooth muscle tissue	UBERON:0001135	72.98	gold quality
uterine cervix	UBERON:0000002	72.73	gold quality
heart	UBERON:0000948	72.61	gold quality
right lobe of thyroid gland	UBERON:0001119	72.45	gold quality
myometrium	UBERON:0001296	72.04	gold quality
lung	UBERON:0002048	71.11	gold quality
urinary bladder	UBERON:0001255	70.82	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.82

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• GATA2-AS1 is transcriptionally repressed by MYC in non-small cell lung cancer cells (PMID:31607132)
• GATA2 deficiency phenotype associated with tandem duplication of GATA2 and overexpression of GATA2-AS1. (PMID:34638133)
• LncRNA GATA2-AS1 suppresses esophageal squamous cell carcinoma progression via the mir-940/PTPN12 axis. (PMID:35364057)
• A feedback loop between GATA2-AS1 and GATA2 promotes colorectal cancer cell proliferation, invasion, epithelial-mesenchymal transition and stemness via recruiting DDX3X. (PMID:35752837)
• Long noncoding RNA GATA2-AS1 augments endothelial hypoxia inducible factor 1-alpha induction and regulates hypoxic signaling. (PMID:36806681)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.