GATA3-AS1

Summary

GATA3-AS1 (GATA3 antisense RNA 1, HGNC:33786) is a long non-coding RNA gene on chromosome 10p14.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33786
Approved symbol	GATA3-AS1
Name	GATA3 antisense RNA 1
Location	10p14
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000197308
Ensembl biotype	lncRNA
Entrez	399717
RNAcentral	URS000075AB9F — lncRNA, 915 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 23 — 23 lncRNA

ENST00000355358, ENST00000417359, ENST00000420815, ENST00000438755, ENST00000458727, ENST00000831060, ENST00000831061, ENST00000831063, ENST00000831064, ENST00000831066, ENST00000831067, ENST00000831068, ENST00000831069, ENST00000831070, ENST00000831071, ENST00000831072, ENST00000831073, ENST00000831074, ENST00000831075, ENST00000831076, ENST00000831077, ENST00000831078, ENST00000831079

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000355358 — 2 exons

Exon	Start	End
ENSE00001408888	8052400	8053484
ENSE00001414048	8050450	8051578

Expression profiles

Bgee: expression breadth ubiquitous, 101 present calls, max score 93.23.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 2.3649 / max 90.7085, expressed in 157 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
108201	2.1374	152
108200	0.2275	97

Top tissues by expression

202 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	93.23	gold quality
seminal vesicle	UBERON:0000998	78.22	gold quality
colonic epithelium	UBERON:0000397	73.73	gold quality
metanephros cortex	UBERON:0010533	73.52	gold quality
adult mammalian kidney	UBERON:0000082	70.78	gold quality
skin of abdomen	UBERON:0001416	69.24	gold quality
anterior cingulate cortex	UBERON:0009835	69.04	gold quality
cortex of kidney	UBERON:0001225	68.45	gold quality
pituitary gland	UBERON:0000007	68.16	gold quality
urinary bladder	UBERON:0001255	65.29	gold quality
adenohypophysis	UBERON:0002196	65.18	gold quality
kidney	UBERON:0002113	65.10	gold quality
metanephros	UBERON:0000081	63.74	gold quality
zone of skin	UBERON:0000014	62.57	gold quality
skin of leg	UBERON:0001511	62.47	gold quality
corpus epididymis	UBERON:0004359	61.14	gold quality
hindlimb stylopod muscle	UBERON:0004252	61.03	gold quality
vena cava	UBERON:0004087	58.08	gold quality
right adrenal gland cortex	UBERON:0035827	58.01	gold quality
caput epididymis	UBERON:0004358	57.81	silver quality
cauda epididymis	UBERON:0004360	56.58	gold quality
heart right ventricle	UBERON:0002080	56.02	gold quality
right adrenal gland	UBERON:0001233	55.94	gold quality
leukocyte	CL:0000738	55.72	gold quality
prostate gland	UBERON:0002367	55.03	gold quality
adrenal gland	UBERON:0002369	54.29	gold quality
ectocervix	UBERON:0012249	54.15	gold quality
left adrenal gland cortex	UBERON:0035825	53.76	gold quality
left adrenal gland	UBERON:0001234	53.28	gold quality
left ovary	UBERON:0002119	53.09	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.90

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• LncRNA GATA3-AS1 facilitates tumour progression and immune escape in triple-negative breast cancer through destabilization of GATA3 but stabilization of PD-L1. (PMID:32687248)
• LncRNA GATA3AS1miR30b5pTex10 axis modulates tumorigenesis in pancreatic cancer. (PMID:33760161)
• The lncRNA GATA3-AS1/miR-495-3p/CENPU axis predicts poor prognosis of breast cancer via the PLK1 signaling pathway. (PMID:33902008)
• Transcriptome Analysis Identifies GATA3-AS1 as a Long Noncoding RNA Associated with Resistance to Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer Patients. (PMID:34358678)
• LncRNA GATA3-AS1 promoted invasion and migration in human endometrial carcinoma by regulating the miR-361/ARRB2 axis. (PMID:35788718)
• [Effect of LncRNA GATA3-AS1 Targeting MiR-515-5p on Cell Proliferation and Apoptosis in Childhood Acute Lymphoblastic Leukemia Cells]. (PMID:37551473)
• Increased level of GATA3-AS1 long non-coding RNA is correlated with the upregulation of GATA3 and IL-4 genes in multiple sclerosis patients. (PMID:39080124)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.