GATA6-AS1

Summary

GATA6-AS1 (GATA6 antisense RNA 1, HGNC:48840) is a long non-coding RNA gene on chromosome 18q11.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48840
Approved symbol	GATA6-AS1
Name	GATA6 antisense RNA 1
Location	18q11.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	locus5689, BM742401
Ensembl gene	ENSG00000266010
Ensembl biotype	lncRNA
Entrez	100128893
RNAcentral	URS00002AE1E3 — lncRNA, 1788 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 27 — 27 lncRNA

ENST00000579431, ENST00000583490, ENST00000584201, ENST00000584373, ENST00000648976, ENST00000649008, ENST00000649729, ENST00000650323, ENST00000650586, ENST00000686744, ENST00000687106, ENST00000689947, ENST00000691935, ENST00000701458, ENST00000780840, ENST00000780841, ENST00000780842, ENST00000780843, ENST00000780844, ENST00000780845, ENST00000780846, ENST00000780847, ENST00000780848, ENST00000780849, ENST00000780850, ENST00000780851, ENST00000780852

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579431 — 4 exons

Exon	Start	End
ENSE00002693007	22167604	22167803
ENSE00002698218	22166891	22167308
ENSE00002714636	22168044	22168162
ENSE00003931903	22168311	22168553

Expression profiles

Bgee: expression breadth ubiquitous, 172 present calls, max score 97.72.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.6903 / max 95.0496, expressed in 182 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
171330	0.2115	79
171328	0.1932	81
171331	0.1076	38
171326	0.0947	33
171327	0.0508	27
171329	0.0324	16

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pylorus	UBERON:0001166	97.72	gold quality
left ventricle myocardium	UBERON:0006566	97.71	gold quality
cardiac muscle of right atrium	UBERON:0003379	97.59	gold quality
cardia of stomach	UBERON:0001162	96.78	gold quality
left adrenal gland cortex	UBERON:0035825	94.93	gold quality
left adrenal gland	UBERON:0001234	94.75	gold quality
adrenal cortex	UBERON:0001235	94.63	gold quality
right adrenal gland	UBERON:0001233	94.44	gold quality
ileal mucosa	UBERON:0000331	94.08	gold quality
right adrenal gland cortex	UBERON:0035827	93.55	gold quality
apex of heart	UBERON:0002098	93.51	gold quality
myocardium	UBERON:0002349	93.47	gold quality
cardiac atrium	UBERON:0002081	93.08	gold quality
adrenal gland	UBERON:0002369	92.89	gold quality
right atrium auricular region	UBERON:0006631	92.87	gold quality
spleen	UBERON:0002106	92.45	gold quality
heart left ventricle	UBERON:0002084	91.96	gold quality
cardiac ventricle	UBERON:0002082	91.91	gold quality
epithelial cell of pancreas	CL:0000083	91.78	silver quality
fundus of stomach	UBERON:0001160	91.36	gold quality
germinal epithelium of ovary	UBERON:0001304	91.25	gold quality
heart	UBERON:0000948	90.71	gold quality
stomach	UBERON:0000945	90.48	gold quality
left ovary	UBERON:0002119	90.36	gold quality
body of stomach	UBERON:0001161	90.27	gold quality
right ovary	UBERON:0002118	89.06	gold quality
heart right ventricle	UBERON:0002080	89.01	gold quality
jejunal mucosa	UBERON:0000399	88.76	gold quality
adrenal tissue	UBERON:0018303	88.67	gold quality
right uterine tube	UBERON:0001302	88.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.91

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• BM742401 is a tumor suppressor lncRNA frequently methylated in chronic lymphocytic leukemia. (PMID:27689399)
• The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2 (PMID:29339785)
• GATA6-AS overexpression promoted glioma cell proliferation and inhibited apoptosis, TUG1 overexpression inhibited cell proliferation and attenuated the effects of GATA6-AS overexpression. (PMID:31809214)
• GATA6-AS1 Regulates GATA6 Expression to Modulate Human Endoderm Differentiation. (PMID:32795420)
• A long non-coding RNA GATA6-AS1 adjacent to GATA6 is required for cardiomyocyte differentiation from human pluripotent stem cells. (PMID:32888237)
• GATA6 activated long non-coding RNA PCAT1 maintains stemness of non-small cell lung cancer by mediating FRK. (PMID:33277858)
• GATA6-AS1 Regulates Intestinal Epithelial Mitochondrial Functions, and its Reduced Expression is Linked to Intestinal Inflammation and Less Favourable Disease Course in Ulcerative Colitis. (PMID:36655602)
• GATA6-AS1 via Sponging miR-543 to Regulate PTEN/AKT Signaling Axis Suppresses Cell Proliferation and Migration in Gastric Cancer. (PMID:37273453)
• GATA6-AS1 suppresses epithelial-mesenchymal transition of pancreatic cancer under hypoxia through regulating SNAI1 mRNA stability. (PMID:38057853)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.