GAU1

Summary

GAU1 (GALNT8 antisense upstream 1, HGNC:53880) is a long non-coding RNA gene on chromosome 12p13.32.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53880
Approved symbol	GAU1
Name	GALNT8 antisense upstream 1
Location	12p13.32
Locus type	RNA, long non-coding
Status	Approved
Aliases	GALNT8-DT
Ensembl gene	ENSG00000255474
Ensembl biotype	lncRNA
Entrez	101929549
RNAcentral	URS0000362066 — lncRNA, 1249 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000527518

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000527518 — 4 exons

Exon	Start	End
ENSE00002146834	4704178	4704297
ENSE00002150888	4703313	4703440
ENSE00002151206	4700417	4701179
ENSE00002171903	4719865	4720102

Expression profiles

Bgee: expression breadth ubiquitous, 138 present calls, max score 89.24.

Top tissues by expression

225 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of transverse colon	UBERON:0004991	89.24	gold quality
rectum	UBERON:0001052	85.80	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.77	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.59	gold quality
mucosa of sigmoid colon	UBERON:0004993	75.57	gold quality
transverse colon	UBERON:0001157	75.19	gold quality
colonic epithelium	UBERON:0000397	73.37	gold quality
colonic mucosa	UBERON:0000317	73.03	gold quality
small intestine Peyer’s patch	UBERON:0003454	72.14	gold quality
small intestine	UBERON:0002108	71.14	gold quality
cerebellar hemisphere	UBERON:0002245	70.95	gold quality
cerebellar cortex	UBERON:0002129	70.87	gold quality
right hemisphere of cerebellum	UBERON:0014890	69.94	gold quality
cerebellum	UBERON:0002037	68.75	gold quality
intestine	UBERON:0000160	67.63	gold quality
large intestine	UBERON:0000059	66.67	gold quality
colon	UBERON:0001155	66.09	gold quality
cortical plate	UBERON:0005343	65.53	gold quality
duodenum	UBERON:0002114	62.69	gold quality
sural nerve	UBERON:0015488	62.28	silver quality
apex of heart	UBERON:0002098	61.93	gold quality
vermiform appendix	UBERON:0001154	61.11	gold quality
ganglionic eminence	UBERON:0004023	60.14	gold quality
ventricular zone	UBERON:0003053	59.71	gold quality
heart left ventricle	UBERON:0002084	59.61	gold quality
Brodmann (1909) area 9	UBERON:0013540	59.17	gold quality
cardiac ventricle	UBERON:0002082	58.95	gold quality
anterior cingulate cortex	UBERON:0009835	58.53	gold quality
right frontal lobe	UBERON:0002810	58.48	gold quality
prefrontal cortex	UBERON:0000451	57.78	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.06

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Dynamic tuning of chromatin co-drives the activation of a gene cluster that includes the lncRNA GAU1 and the protein-coding gene GALNT8, thereby inducing tumorigenesis. (PMID:29741668)
• Peptidylprolyl isomerase A guides SENP5/GAU1 DNA-lncRNA triplex generation for driving tumorigenesis. (PMID:39433793)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.