GBP3

Summary

GBP3 (guanylate binding protein 3, HGNC:4184) is a protein-coding gene on chromosome 1p22.2, encoding Guanylate-binding protein 3 (Q9H0R5). Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens.

This gene encodes a member of the guanylate-binding protein (GBP) family. GBPs specifically bind guanine nucleotides (GMP, GDP, and GTP) and contain two of the three consensus motifs found in typical GTP-binding proteins. The encoded protein interacts with a member of the germinal center kinase family. Multiple transcript variants encoding different isoforms have been found for this gene.

Source: NCBI Gene 2635 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 102 total
• MANE Select transcript: NM_018284

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:4184
Approved symbol	GBP3
Name	guanylate binding protein 3
Location	1p22.2
Locus type	gene with protein product
Status	Approved
Aliases	FLJ10961
Ensembl gene	ENSG00000117226
Ensembl biotype	protein_coding
OMIM	600413
Entrez	2635

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 9 protein_coding, 4 nonsense_mediated_decay, 2 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000235878, ENST00000370481, ENST00000370482, ENST00000445969, ENST00000461384, ENST00000475853, ENST00000489444, ENST00000493594, ENST00000564037, ENST00000564665, ENST00000568006, ENST00000850557, ENST00000879050, ENST00000879051, ENST00000955700, ENST00000955701

RefSeq mRNA: 4 — MANE Select: NM_018284 NM_001319179, NM_001319180, NM_001319181, NM_018284

CCDS: CCDS717

Canonical transcript exons

ENST00000370481 — 11 exons

Exon	Start	End
ENSE00001452833	89022684	89022866
ENSE00002583738	89006680	89007852
ENSE00003458347	89013185	89013427
ENSE00003458558	89015287	89015414
ENSE00003484376	89011747	89012027
ENSE00003607022	89008947	89009140
ENSE00003624427	89020532	89020743
ENSE00003626849	89014547	89014656
ENSE00003630886	89009392	89009494
ENSE00003677074	89014083	89014279
ENSE00003677590	89010904	89011116

Expression profiles

Bgee: expression breadth ubiquitous, 254 present calls, max score 99.25.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 9.1526 / max 811.5466, expressed in 1317 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
13136	5.2922	1224
13135	1.9515	664
13133	1.8011	200
13134	0.1078	51

Top tissues by expression

262 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ileal mucosa	UBERON:0000331	99.25	gold quality
ileum	UBERON:0002116	99.17	silver quality
epithelial cell of pancreas	CL:0000083	99.12	gold quality
jejunal mucosa	UBERON:0000399	98.90	gold quality
pancreatic ductal cell	CL:0002079	98.52	gold quality
palpebral conjunctiva	UBERON:0001812	97.98	gold quality
colonic mucosa	UBERON:0000317	97.21	gold quality
mucosa of sigmoid colon	UBERON:0004993	97.04	gold quality
bronchial epithelial cell	CL:0002328	96.91	gold quality
bronchus	UBERON:0002185	96.64	gold quality
epithelium of nasopharynx	UBERON:0001951	96.61	gold quality
nasopharynx	UBERON:0001728	96.60	gold quality
germinal epithelium of ovary	UBERON:0001304	95.88	gold quality
pericardium	UBERON:0002407	95.67	gold quality
mucosa of paranasal sinus	UBERON:0005030	94.85	gold quality
visceral pleura	UBERON:0002401	94.63	gold quality
seminal vesicle	UBERON:0000998	94.62	gold quality
rectum	UBERON:0001052	94.00	gold quality
urethra	UBERON:0000057	93.98	gold quality
caput epididymis	UBERON:0004358	93.90	gold quality
duodenum	UBERON:0002114	93.03	gold quality
corpus epididymis	UBERON:0004359	92.02	gold quality
superficial temporal artery	UBERON:0001614	91.78	gold quality
pylorus	UBERON:0001166	91.64	gold quality
calcaneal tendon	UBERON:0003701	91.33	gold quality
nasal cavity epithelium	UBERON:0005384	91.25	gold quality
parietal pleura	UBERON:0002400	90.96	gold quality
oviduct epithelium	UBERON:0004804	90.51	gold quality
endometrium	UBERON:0001295	90.11	gold quality
small intestine	UBERON:0002108	89.95	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-ENAD-27	yes	6.10
E-ANND-3	yes	6.07

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

74 targeting GBP3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-3667-3P	99.99	67.17	1636
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-2110	99.96	66.68	1930
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-23A-3P	99.95	74.24	3163
HSA-MIR-23B-3P	99.95	74.24	3163
HSA-MIR-23C	99.95	73.92	3192
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-6744-5P	99.93	66.82	748
HSA-MIR-106A-5P	99.90	73.94	2683
HSA-MIR-3671	99.90	73.04	3897
HSA-MIR-3686	99.90	70.53	2432
HSA-MIR-17-5P	99.89	73.83	2665
HSA-MIR-9902	99.89	69.15	2250
HSA-MIR-106B-5P	99.88	74.72	2795
HSA-MIR-20A-5P	99.88	74.76	2769
HSA-MIR-20B-5P	99.88	74.01	2621
HSA-MIR-519D-3P	99.88	73.97	2607
HSA-MIR-526B-3P	99.88	74.06	2587
HSA-MIR-93-5P	99.88	73.98	2606
HSA-MIR-137-3P	99.87	74.74	2401
HSA-MIR-6124	99.87	69.78	3551
HSA-MIR-944	99.82	70.85	3042
HSA-MIR-323A-3P	99.79	70.30	1739
HSA-MIR-204-5P	99.79	71.62	2439
HSA-MIR-211-5P	99.79	71.65	2440
HSA-MIR-4668-5P	99.79	70.58	3782

Literature-anchored findings (GeneRIF, showing 5)

• Data show that the novel splice variant of guanylate binding protein 3 hGBP-3, named hGBP-3DeltaC, showed the most prominent antiviral activity in epithelial cells. (PMID:22106366)
• GBP3 over-expression promotes glioma growth in mice and is inversely correlated with patients survival rate. (PMID:29128363)
• GBP3 promotes glioblastoma resistance to temozolomide by enhancing DNA damage repair. (PMID:35780181)
• The function of guanylate binding protein 3 (GBP3) in human cancers by pan-cancer bioinformatics. (PMID:37161254)
• Helical domain of hGBP3 cannot stimulate the second phosphate cleavage of GTP. (PMID:38301888)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
drosophila_melanogaster	atl	FBGN0039213

Paralogs (10): GBP1 (ENSG00000117228), ATL2 (ENSG00000119787), RNF112 (ENSG00000128482), GBP5 (ENSG00000154451), GBP2 (ENSG00000162645), GBP4 (ENSG00000162654), GBP6 (ENSG00000183347), ATL3 (ENSG00000184743), ATL1 (ENSG00000198513), GBP7 (ENSG00000213512)

Protein

Protein identifiers

Guanylate-binding protein 3 — Q9H0R5 (reviewed: Q9H0R5)

Alternative names: GTP-binding protein 3, Guanine nucleotide-binding protein 3

All UniProt accessions (8): Q9H0R5, F6SPX6, F6X827, H3BNS1, H3BP53, H3BPH2, H3BRX6, Q5T8M0

UniProt curated annotations — full annotation on UniProt →

Function. Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria. Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol. Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome. Exhibits antiviral activity against influenza virus. Shows the most prominent antiviral activity in epithelial cells.

Subunit / interactions. Heterodimer with other family members, including GBP1, GBP2 and GBP5. Dimerization regulates subcellular location.

Subcellular location. Cytoplasm. Perinuclear region. Golgi apparatus membrane.

Similarity. Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9H0R5-1	1	yes
Q9H0R5-4	2, GBP-3DeltaC

RefSeq proteins (4): NP_001306108, NP_001306109, NP_001306110, NP_060754* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003191	Guanylate-bd/ATL_C	Domain
IPR015894	Guanylate-bd_N	Domain
IPR027417	P-loop_NTPase	Homologous_superfamily
IPR030386	G_GB1_RHD3_dom	Domain
IPR036543	Guanylate-bd_C_sf	Homologous_superfamily
IPR037684	GBP_C	Domain

Pfam: PF02263, PF02841

Catalyzed reactions (Rhea), 1 shown:

• GTP + H2O = GDP + phosphate + H(+) (RHEA:19669)

UniProt features (19 total): sequence variant 6, sequence conflict 3, binding site 3, splice variant 2, chain 1, domain 1, mutagenesis site 1, region of interest 1, coiled-coil region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H0R5-F1	88.43	0.57

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (3): 45–52; 67–69; 97–101

Mutagenesis-validated functional residues (1):

Position	Phenotype
105	promotes ubiquitination and degradation by s. flexneri ipah9.8.

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-877300	Interferon gamma signaling
R-HSA-9948001	CASP4 inflammasome assembly
R-HSA-9953170	GBP-mediated host defense
R-HSA-9956593	Enterobacterial factors antagonize host defense

MSigDB gene sets: 144 (showing top): REACTOME_INNATE_IMMUNE_SYSTEM, REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM, GOBP_INFLAMMATORY_RESPONSE, GOBP_RESPONSE_TO_PEPTIDE, GOBP_CELLULAR_RESPONSE_TO_LIPID, GOBP_CELLULAR_RESPONSE_TO_BIOTIC_STIMULUS, GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND, GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS, GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM, ROZANOV_MMP14_TARGETS_UP, GOBP_REGULATION_OF_RESPONSE_TO_STRESS, GOBP_RESPONSE_TO_INTERLEUKIN_1, GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND, GOBP_RESPONSE_TO_LIPID, GOBP_DEFENSE_RESPONSE_TO_VIRUS

GO Biological Process (10): defense response to bacterium (GO:0042742), defense response to virus (GO:0051607), cytolysis in another organism (GO:0051715), cellular response to lipopolysaccharide (GO:0071222), cellular response to type II interferon (GO:0071346), cellular response to interleukin-1 (GO:0071347), cellular response to tumor necrosis factor (GO:0071356), positive regulation of pyroptotic inflammatory response (GO:0140639), immune system process (GO:0002376), innate immune response (GO:0045087)

GO Molecular Function (7): GTPase activity (GO:0003924), GTP binding (GO:0005525), identical protein binding (GO:0042802), protein homodimerization activity (GO:0042803), nucleotide binding (GO:0000166), protein binding (GO:0005515), hydrolase activity (GO:0016787)

GO Cellular Component (7): Golgi membrane (GO:0000139), cytoplasm (GO:0005737), cytosol (GO:0005829), cytoplasmic vesicle (GO:0031410), perinuclear region of cytoplasm (GO:0048471), Golgi apparatus (GO:0005794), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-4 pathways:

Category	Pathways
Interferon Signaling	1
Non-canonical inflammasome activation	1
Antimicrobial mechanism of IFN-stimulated genes	1
Infection with Enterobacteria	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
cytoplasm	4
cellular response to cytokine stimulus	3
defense response	2
response to bacterium	1
response to virus	1
cytolysis	1
killing of cells of another organism	1
response to lipopolysaccharide	1
cellular response to molecule of bacterial origin	1
cellular response to lipid	1
cellular response to oxygen-containing compound	1
response to type II interferon	1
response to interleukin-1	1
response to tumor necrosis factor	1
positive regulation of inflammatory response	1
pyroptotic inflammatory response	1
biological_process	1
immune response	1
defense response to symbiont	1
ribonucleoside triphosphate phosphatase activity	1
guanyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
protein binding	1
identical protein binding	1
protein dimerization activity	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
binding	1
catalytic activity	1
Golgi apparatus	1
bounding membrane of organelle	1
intracellular anatomical structure	1
intracellular vesicle	1
endomembrane system	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

698 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
GBP3	ISG15	P05161	611
GBP3	IFNG	P01579	586
GBP3	IRGM	A1A4Y4	586
GBP3	IRF9	Q00978	572
GBP3	IFI44	Q8TCB0	551
GBP3	IL1B	P01584	535
GBP3	RTP4	Q96DX8	513
GBP3	MAP4K4	O95819	504
GBP3	TNF	P01375	482
GBP3	CMPK2	Q5EBM0	476
GBP3	IFIT3	O14879	474
GBP3	GBP2	P32456	465
GBP3	PYHIN1	Q6K0P9	462
GBP3	IFIT1	P09914	446
GBP3	IRF1	P10914	435
GBP3	HERC6	Q8IVU3	435

IntAct

23 interactions, top by confidence:

A	B	Type	Score
GBP1	GBP3	psi-mi:“MI:0915”(physical association)	0.790
GBP1	GBP2	psi-mi:“MI:0914”(association)	0.720
GBP2	GBP3	psi-mi:“MI:0915”(physical association)	0.720
GBP3	MAP4K4	psi-mi:“MI:0915”(physical association)	0.590
GBP3	MAP4K4	psi-mi:“MI:0407”(direct interaction)	0.590
MAP4K4	GBP3	psi-mi:“MI:0915”(physical association)	0.590
GBP3	GBP3	psi-mi:“MI:0915”(physical association)	0.510
GBP5	GBP3	psi-mi:“MI:0915”(physical association)	0.510
GBP3	S100A10	psi-mi:“MI:0915”(physical association)	0.400
H1-2	GBP3	psi-mi:“MI:0915”(physical association)	0.400
GBP2	HSP90AA1	psi-mi:“MI:0914”(association)	0.350
GBP3	ACTL6B	psi-mi:“MI:0914”(association)	0.350
GBP3	tktA	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (16): GBP3 (Affinity Capture-MS), GBP3 (Affinity Capture-MS), GBP3 (Affinity Capture-MS), GBP3 (Proximity Label-MS), GBP3 (Proximity Label-MS), GBP3 (Reconstituted Complex), MAP4K4 (Affinity Capture-Western), MAP4K4 (Two-hybrid), GBP3 (Affinity Capture-MS), GBP3 (Affinity Capture-MS), GBP2 (Affinity Capture-MS), ACTL6B (Affinity Capture-MS), DECR2 (Affinity Capture-MS), CASP6 (Affinity Capture-MS), GBP3 (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: A0A0G2JDV3, A0MWD1, A1E2I4, A4UUI3, A6QQL3, A7VK00, B0BNF1, B0KWP7, B1H120, B1MTN8, B2KIE9, B3GNI6, B5FW69, P20591, P20592, P32455, P32456, Q01514, Q0VCP4, Q14141, Q1MT80, Q28379, Q2KTC2, Q3SZN0, Q4R555, Q5D1D6, Q5I2P5, Q5R5G3, Q5R9T9, Q5RBE1, Q61107, Q63663, Q642H3, Q6AXA6, Q6IRQ5, Q6ZN66, Q6ZU15, Q8C1B7, Q8C650, Q8CFB4

Diamond homologs: A0A0G2JDV3, A4UUI3, P32455, P32456, Q01514, Q1MT80, Q5D1D6, Q5R9T9, Q5RBE1, Q61107, Q63663, Q6ZN66, Q8CFB4, Q8N8V2, Q91Z40, Q96PP8, Q96PP9, Q9H0R5, Q9Z0E6, A0E2L1, B6K0N7, P0CQ46, P0CQ47, A5DB26, Q4PEQ0, Q525S7, Q9UTE0, A0A386CAB9, Q9P5X6, C4JQN4, Q6BK59

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

102 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	77
Likely benign	8
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

1738 predictions. Top by Δscore:

Variant	Effect	Δscore
1:89008942:GATAC:G	donor_loss	1.0000
1:89008943:ATAC:A	donor_loss	1.0000
1:89008945:ACC:A	donor_loss	1.0000
1:89008946:C:CT	donor_loss	1.0000
1:89009136:TTCCA:T	acceptor_gain	1.0000
1:89009137:TCCA:T	acceptor_gain	1.0000
1:89009138:CCA:C	acceptor_gain	1.0000
1:89009138:CCAC:C	acceptor_gain	1.0000
1:89009139:CA:C	acceptor_gain	1.0000
1:89009139:CAC:C	acceptor_gain	1.0000
1:89009140:ACT:A	acceptor_loss	1.0000
1:89009141:C:CA	acceptor_loss	1.0000
1:89009141:C:CC	acceptor_gain	1.0000
1:89009143:G:GC	acceptor_gain	1.0000
1:89009496:T:C	acceptor_gain	1.0000
1:89009504:C:CT	acceptor_gain	1.0000
1:89009504:C:T	acceptor_gain	1.0000
1:89009505:A:T	acceptor_gain	1.0000
1:89011778:T:TA	donor_gain	1.0000
1:89013183:A:AC	donor_gain	1.0000
1:89013184:C:CC	donor_gain	1.0000
1:89013184:CGAGG:C	donor_gain	1.0000
1:89013207:T:TA	donor_gain	1.0000
1:89013262:A:AC	donor_gain	1.0000
1:89013263:C:CC	donor_gain	1.0000
1:89014118:T:C	donor_gain	1.0000
1:89014561:AG:A	donor_gain	1.0000
1:89014653:CACC:C	acceptor_gain	1.0000
1:89014655:CC:C	acceptor_gain	1.0000
1:89014656:CC:C	acceptor_gain	1.0000

AlphaMissense

3929 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:89014606:G:C	S123R	0.970
1:89014606:G:T	S123R	0.970
1:89014608:T:G	S123R	0.970
1:89015410:G:C	F65L	0.961
1:89015410:G:T	F65L	0.961
1:89015412:A:G	F65L	0.961
1:89014603:G:C	S124R	0.957
1:89014603:G:T	S124R	0.957
1:89014605:T:G	S124R	0.957
1:89014176:A:G	W178R	0.953
1:89014176:A:T	W178R	0.953
1:89013273:A:C	F260L	0.947
1:89013273:A:T	F260L	0.947
1:89013275:A:G	F260L	0.947
1:89011812:C:G	A362P	0.941
1:89013369:G:C	F228L	0.941
1:89013369:G:T	F228L	0.941
1:89013371:A:G	F228L	0.941
1:89015324:A:T	V94D	0.940
1:89013351:A:C	F234L	0.939
1:89013351:A:T	F234L	0.939
1:89013353:A:G	F234L	0.939
1:89011911:C:G	A329P	0.935
1:89020570:T:A	K51I	0.920
1:89011783:G:C	F371L	0.915
1:89011783:G:T	F371L	0.915
1:89011785:A:G	F371L	0.915
1:89013219:T:A	K278N	0.904
1:89013219:T:G	K278N	0.904
1:89011027:G:C	F413L	0.902

dbSNP variants (sampled 300 via entrez): RS1000386063 (1:89013076 G>A,T), RS1000464213 (1:89011257 T>TA), RS1000565183 (1:89018870 T>C), RS1000733588 (1:89009944 C>A,G), RS1000766409 (1:89010163 C>G), RS1000771786 (1:89012439 C>A,G), RS1000816677 (1:89024713 A>T), RS1000892266 (1:89024780 C>A), RS1000961892 (1:89018620 A>C,G), RS1001078426 (1:89018832 G>T), RS1001204536 (1:89021841 G>A), RS1001340368 (1:89022088 T>C), RS1001453925 (1:89015476 G>A), RS1001512438 (1:89008004 T>C), RS1001654993 (1:89012994 T>C)

Disease associations

OMIM: gene MIM:600413 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST003114_9	Carotid intima media thickness	2.000000e-06
GCST012490_650	Femur bone mineral density x serum urate levels interaction	6.000000e-09

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004531	urate measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

42 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	increases expression, increases methylation	4
sodium arsenite	increases abundance, increases expression, decreases expression	2
Acetaminophen	decreases expression, increases expression	2
Air Pollutants	decreases expression, increases abundance	2
Arsenic	affects methylation, decreases expression, increases abundance	2
Nickel	decreases expression, increases expression	2
Smoke	decreases expression, increases abundance	2
Tetrachlorodibenzodioxin	increases expression	2
Tretinoin	increases expression	2
fulvic acid	affects cotreatment, decreases reaction, increases expression	1
triphenyl phosphate	affects expression	1
hydroxyhydroquinone	increases expression	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
perfluorooctane sulfonic acid	decreases expression	1
CGP 52608	affects binding, increases reaction	1
2-palmitoylglycerol	increases expression	1
entinostat	increases expression	1
beta-hydroxy simvastatin acid	decreases expression	1
abrine	decreases expression	1
BIX 01294	increases expression, increases reaction	1
(+)-JQ1 compound	decreases expression	1
Calcimycin	affects cotreatment, decreases reaction, increases expression	1
Air Pollutants, Occupational	decreases expression	1
Calcitriol	increases expression, affects cotreatment	1
Citrulline	increases expression	1
Doxorubicin	decreases expression	1
Drugs, Chinese Herbal	increases expression	1
Ethyl Methanesulfonate	increases expression	1
Formaldehyde	increases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B2MW	Abcam A-549 GBP3 KO	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.