GCAWKR

Summary

GCAWKR (gastric cancer associated WDR5 and KAT2A binding lncRNA, HGNC:53740) is a long non-coding RNA gene on chromosome 15q26.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53740
Approved symbol	GCAWKR
Name	gastric cancer associated WDR5 and KAT2A binding lncRNA
Location	15q26.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000272808
Ensembl biotype	lncRNA
Entrez	105369201
RNAcentral	URS0000E60AC9 — lncRNA, 527 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 23 — 23 lncRNA

ENST00000431060, ENST00000557962, ENST00000558254, ENST00000558427, ENST00000558475, ENST00000558641, ENST00000559331, ENST00000559673, ENST00000561231, ENST00000647806, ENST00000826402, ENST00000826403, ENST00000826404, ENST00000826405, ENST00000826406, ENST00000826407, ENST00000826408, ENST00000826409, ENST00000826410, ENST00000826411, ENST00000826412, ENST00000826413, ENST00000826414

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000431060 — 5 exons

Exon	Start	End
ENSE00001634368	100860946	100865457
ENSE00002081595	100849831	100849910
ENSE00003702745	100855231	100855348
ENSE00003708528	100850211	100850332
ENSE00003710166	100859800	100860035

Expression profiles

Bgee: expression breadth ubiquitous, 141 present calls, max score 77.65.

FANTOM5 (CAGE): breadth broad, TPM avg 2.0426 / max 46.6923, expressed in 726 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
148921	1.4303	640
148922	0.3774	183
148925	0.1320	72
148923	0.1029	35

Top tissues by expression

228 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
C1 segment of cervical spinal cord	UBERON:0006469	77.65	gold quality
spinal cord	UBERON:0002240	74.28	gold quality
minor salivary gland	UBERON:0001830	72.10	gold quality
saliva-secreting gland	UBERON:0001044	69.22	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	68.88	gold quality
mouth mucosa	UBERON:0003729	67.93	gold quality
substantia nigra	UBERON:0002038	66.86	gold quality
endocervix	UBERON:0000458	66.77	gold quality
putamen	UBERON:0001874	66.53	gold quality
nucleus accumbens	UBERON:0001882	66.42	gold quality
cortical plate	UBERON:0005343	66.21	gold quality
midbrain	UBERON:0001891	64.62	gold quality
sural nerve	UBERON:0015488	64.55	gold quality
Brodmann (1909) area 9	UBERON:0013540	64.51	gold quality
caudate nucleus	UBERON:0001873	64.13	gold quality
amygdala	UBERON:0001876	63.81	gold quality
tibial nerve	UBERON:0001323	63.32	gold quality
corpus callosum	UBERON:0002336	63.10	gold quality
right frontal lobe	UBERON:0002810	63.10	gold quality
palpebral conjunctiva	UBERON:0001812	62.49	gold quality
hypothalamus	UBERON:0001898	62.21	gold quality
prefrontal cortex	UBERON:0000451	61.55	gold quality
buccal mucosa cell	CL:0002336	60.98	gold quality
Ammon’s horn	UBERON:0001954	60.95	gold quality
omental fat pad	UBERON:0010414	59.46	gold quality
peritoneum	UBERON:0002358	59.41	gold quality
forebrain	UBERON:0001890	59.03	gold quality
ventricular zone	UBERON:0003053	58.96	silver quality
prostate gland	UBERON:0002367	58.87	gold quality
anterior cingulate cortex	UBERON:0009835	58.58	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.35

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.