GCFC2

Summary

GCFC2 (GC-rich sequence DNA-binding factor 2, HGNC:1317) is a protein-coding gene on chromosome 2p12, encoding Intron Large complex component GCFC2 (P16383). Involved in pre-mRNA splicing through regulating spliceosome C complex formation.

The first mRNA transcript isolated for this gene was part of an artificial chimera derived from two distinct gene transcripts and a primer used in the cloning process (see Genbank accession M29204). A positively charged amino terminus present only in the chimera was determined to bind GC-rich DNA, thus mistakenly thought to identify a transcription factor gene.

Source: NCBI Gene 6936 — RefSeq curated summary.

At a glance

• GWAS associations: 7
• Clinical variants (ClinVar): 123 total
• MANE Select transcript: NM_003203

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:1317
Approved symbol	GCFC2
Name	GC-rich sequence DNA-binding factor 2
Location	2p12
Locus type	gene with protein product
Status	Approved
Aliases	DNABF, GCF
Ensembl gene	ENSG00000005436
Ensembl biotype	protein_coding
OMIM	189901
Entrez	6936

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 15 protein_coding, 2 retained_intron, 2 nonsense_mediated_decay

ENST00000321027, ENST00000409857, ENST00000427862, ENST00000442309, ENST00000470197, ENST00000470285, ENST00000470503, ENST00000472230, ENST00000486016, ENST00000492826, ENST00000541687, ENST00000884726, ENST00000884727, ENST00000884728, ENST00000884729, ENST00000884730, ENST00000884731, ENST00000970645, ENST00000970646

RefSeq mRNA: 4 — MANE Select: NM_003203 NM_001201334, NM_001201335, NM_001410845, NM_003203

CCDS: CCDS1961, CCDS62943, CCDS92788

Canonical transcript exons

ENST00000321027 — 17 exons

Exon	Start	End
ENSE00001261900	75710591	75710915
ENSE00003465078	75662705	75664783
ENSE00003474620	75673444	75673520
ENSE00003475605	75671950	75672016
ENSE00003492242	75696200	75696315
ENSE00003522865	75680193	75680314
ENSE00003535454	75691977	75692100
ENSE00003556420	75690638	75690719
ENSE00003563051	75670138	75670284
ENSE00003566359	75687827	75687977
ENSE00003582023	75665929	75666053
ENSE00003593081	75689969	75690081
ENSE00003608878	75702199	75702423
ENSE00003615519	75689026	75689225
ENSE00003651464	75706523	75706651
ENSE00003663933	75694241	75694427
ENSE00003668748	75701190	75701287

Expression profiles

Bgee: expression breadth ubiquitous, 268 present calls, max score 92.34.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 11.7927 / max 74.4960, expressed in 1782 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
29285	11.4934	1780
29286	0.2993	147

Top tissues by expression

289 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ventricular zone	UBERON:0003053	92.34	gold quality
gastrocnemius	UBERON:0001388	92.02	gold quality
muscle of leg	UBERON:0001383	91.65	gold quality
right lobe of liver	UBERON:0001114	91.32	gold quality
calcaneal tendon	UBERON:0003701	90.75	gold quality
adrenal tissue	UBERON:0018303	90.21	gold quality
endocervix	UBERON:0000458	90.00	gold quality
hindlimb stylopod muscle	UBERON:0004252	90.00	gold quality
right uterine tube	UBERON:0001302	89.77	gold quality
body of pancreas	UBERON:0001150	89.71	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	89.58	gold quality
muscle organ	UBERON:0001630	89.38	gold quality
ectocervix	UBERON:0012249	89.34	gold quality
left ovary	UBERON:0002119	89.06	gold quality
ganglionic eminence	UBERON:0004023	88.96	gold quality
metanephros cortex	UBERON:0010533	88.86	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	88.85	gold quality
right ovary	UBERON:0002118	88.76	gold quality
right lobe of thyroid gland	UBERON:0001119	88.61	gold quality
tibial nerve	UBERON:0001323	88.46	gold quality
left lobe of thyroid gland	UBERON:0001120	88.28	gold quality
body of uterus	UBERON:0009853	88.21	gold quality
left uterine tube	UBERON:0001303	88.18	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.01	gold quality
thyroid gland	UBERON:0002046	87.39	gold quality
mucosa of stomach	UBERON:0001199	87.35	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	87.03	gold quality
adenohypophysis	UBERON:0002196	87.00	gold quality
right coronary artery	UBERON:0001625	86.82	gold quality
skin of abdomen	UBERON:0001416	86.80	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.44
E-MTAB-4850	no	1178.85

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

7 targets.

Target	Regulation
EGF
EGFR	Repression
GC
GCFC2
IGF1R
INSR
TGFA

Upstream regulators (CollecTRI, top): GCFC2

miRNA regulators (miRDB)

97 targeting GCFC2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-568	99.98	69.86	2084
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-146A-5P	99.96	68.93	988
HSA-MIR-146B-5P	99.96	69.13	977
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-9-3P	99.96	70.88	2068
HSA-MIR-7153-5P	99.94	68.89	1006
HSA-MIR-3143	99.93	71.96	3104
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-205-3P	99.92	69.92	3165
HSA-MIR-338-5P	99.92	72.34	2951
HSA-MIR-1305	99.91	71.43	3443
HSA-MIR-3671	99.90	73.04	3897
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-6780A-5P	99.88	66.69	2776
HSA-MIR-4728-5P	99.85	69.39	4718

Literature-anchored findings (GeneRIF, showing 3)

• Study refined the 2p12 candidate region in two populations and report evidence supporting MRPL19 and C2ORF3 as candidate susceptibility genes for dyslexia. (PMID:17309879)
• C2ORF3 protein is required for pre-mRNA splicing through its presumable role in efficient intron turnover (PMID:24304693)
• Authors propose the GCF regulated transcriptional activity, at least in part, contributed to the upregulation of IER5 on radiation in HepG2 cells. The present findings provide insights into understanding the regulatory mechanisms of IER5. (PMID:26915404)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	gcfc2	ENSDARG00000079020
mus_musculus	Gcfc2	ENSMUSG00000035125
rattus_norvegicus	Gcfc2	ENSRNOG00000006888
drosophila_melanogaster	CG1965	FBGN0037466
caenorhabditis_elegans	mog-7	WBGENE00009672

Paralogs (1): PAXBP1 (ENSG00000159086)

Protein

Protein identifiers

Intron Large complex component GCFC2 — P16383 (reviewed: P16383)

Alternative names: GC-rich sequence DNA-binding factor, GC-rich sequence DNA-binding factor 2, Transcription factor 9

All UniProt accessions (6): P16383, C9JII4, H7C335, S4R3C1, S4R461, S4R465

UniProt curated annotations — full annotation on UniProt →

Function. Involved in pre-mRNA splicing through regulating spliceosome C complex formation. May play a role during late-stage splicing events and turnover of excised introns.

Subunit / interactions. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TFIP11 and DHX15.

Subcellular location. Nucleus. Nucleoplasm. Nucleolus.

Tissue specificity. Widely expressed in tissues and cell lines.

Similarity. Belongs to the GCF family.

Isoforms (4)

UniProt ID	Names	Canonical?
P16383-1	1	yes
P16383-2	2
P16383-3	3
P16383-4	4

RefSeq proteins (4): NP_001188263, NP_001188264, NP_001397774, NP_003194* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR012890	GCFC2-like	Family
IPR022783	GCFC_dom	Domain

Pfam: PF07842

UniProt features (33 total): modified residue 12, compositionally biased region 8, splice variant 5, sequence variant 5, chain 1, region of interest 1, coiled-coil region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P16383-F1	74.12	0.44

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (12): 16, 17, 19, 40, 96, 97, 129, 174, 180, 213, 214, 217

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-72163	mRNA Splicing - Major Pathway

MSigDB gene sets: 143 (showing top): MORF_ATRX, PUJANA_CHEK2_PCC_NETWORK, OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP, BLALOCK_ALZHEIMERS_DISEASE_UP, REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA, GOBP_PROTEIN_RNA_COMPLEX_ORGANIZATION, GOBP_RNA_SPLICING, REACTOME_MRNA_SPLICING, DODD_NASOPHARYNGEAL_CARCINOMA_UP, chr2p12, DANG_BOUND_BY_MYC, GOBP_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS, REACTOME_METABOLISM_OF_RNA, GOCC_U2_TYPE_SPLICEOSOMAL_COMPLEX, GOCC_SPLICEOSOMAL_COMPLEX

GO Biological Process (4): spliceosomal complex assembly (GO:0000245), mRNA splicing, via spliceosome (GO:0000398), mRNA processing (GO:0006397), RNA splicing (GO:0008380)

GO Molecular Function (2): DNA binding (GO:0003677), protein binding (GO:0005515)

GO Cellular Component (5): nucleus (GO:0005634), nucleoplasm (GO:0005654), nucleolus (GO:0005730), cytosol (GO:0005829), U2-type post-mRNA release spliceosomal complex (GO:0071008)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
mRNA Splicing	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA processing	2
nuclear lumen	2
cellular anatomical structure	2
mRNA splicing, via spliceosome	1
protein-RNA complex assembly	1
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	1
mRNA processing	1
mRNA metabolic process	1
nucleic acid binding	1
binding	1
intracellular membrane-bounded organelle	1
intracellular membraneless organelle	1
cytoplasm	1
U2-type spliceosomal complex	1
U6 snRNP	1
post-mRNA release spliceosomal complex	1

Protein interactions and networks

STRING

906 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
GCFC2	LRRFIP1	Q32MZ4	845
GCFC2	KIAA0319	Q5VV43	780
GCFC2	MRPL19	P49406	773
GCFC2	DNAAF4	Q8WXU2	773
GCFC2	DCDC2	Q9UHG0	766
GCFC2	FLII	Q13045	763
GCFC2	KNL1	Q8NG31	689
GCFC2	TFIP11	Q9UBB9	650
GCFC2	RBM8A	Q9Y5S9	640
GCFC2	ROBO1	Q9Y6N7	582
GCFC2	KIAA0319L	Q8IZA0	580
GCFC2	ATP2C2	O75185	577
GCFC2	CMIP	Q8IY22	573
GCFC2	SRY	Q05066	571
GCFC2	DHX15	O43143	567

IntAct

62 interactions, top by confidence:

A	B	Type	Score
PPIE	AQR	psi-mi:“MI:0914”(association)	0.810
GCFC2	TFIP11	psi-mi:“MI:0915”(physical association)	0.670
SNRPB	PRMT5	psi-mi:“MI:0914”(association)	0.670
SNRPA1	HTATSF1	psi-mi:“MI:0914”(association)	0.640
HDAC11	CLUH	psi-mi:“MI:0914”(association)	0.640
GCFC2	SNRNP200	psi-mi:“MI:0914”(association)	0.640
SNRPA1	U2SURP	psi-mi:“MI:0914”(association)	0.640
TFIP11	DHX15	psi-mi:“MI:0914”(association)	0.600
SNRPE	PRMT5	psi-mi:“MI:0914”(association)	0.530
SNRPE	SNRPGP15	psi-mi:“MI:0914”(association)	0.530
ELAVL2	IGF2BP3	psi-mi:“MI:0914”(association)	0.530
YJU2B	RCCD1	psi-mi:“MI:0914”(association)	0.530
LPAR1	TMEM223	psi-mi:“MI:0914”(association)	0.530
GCFC2	DHX15	psi-mi:“MI:0914”(association)	0.530
CRK	GCFC2	psi-mi:“MI:0915”(physical association)	0.400
GCFC2	FYN	psi-mi:“MI:0915”(physical association)	0.400
GCFC2	VIM	psi-mi:“MI:0915”(physical association)	0.400
CREB3L2	GCFC2	psi-mi:“MI:0915”(physical association)	0.370
SLF2	GCFC2	psi-mi:“MI:0914”(association)	0.350
CDK8	CCNC	psi-mi:“MI:0914”(association)	0.350
HNRNPD	ARHGAP32	psi-mi:“MI:0914”(association)	0.350
SYNCRIP	ARHGAP32	psi-mi:“MI:0914”(association)	0.350
DHX15	BBX	psi-mi:“MI:0914”(association)	0.350
BSG	METTL15	psi-mi:“MI:0914”(association)	0.350
ELAVL2	IGF2BP3	psi-mi:“MI:0914”(association)	0.350

BioGRID (92): PRPF6 (Affinity Capture-MS), SNRNP200 (Affinity Capture-MS), PRPF8 (Affinity Capture-MS), DDX23 (Affinity Capture-MS), CSNK2A2 (Affinity Capture-MS), UBR2 (Affinity Capture-MS), CSNK2A1 (Affinity Capture-MS), ECD (Affinity Capture-MS), GCFC2 (Affinity Capture-MS), GCFC2 (Affinity Capture-MS), GCFC2 (Affinity Capture-MS), GCFC2 (Affinity Capture-MS), GCFC2 (Affinity Capture-MS), GCFC2 (Affinity Capture-MS), GCFC2 (Affinity Capture-MS)

ESM2 similar proteins: A2BDB7, A6PVY3, F6RRD7, F7BHS0, O14990, O55036, O60566, P16383, P54274, P58501, Q08B36, Q0VFF9, Q28C41, Q28GJ0, Q28GL6, Q2T9X8, Q2TBG9, Q2WG79, Q3ZCI6, Q4R6Q9, Q5BJ78, Q5M8L3, Q5NVK0, Q5R6R3, Q5R789, Q5R939, Q5RA37, Q5RBY6, Q5TID7, Q5XIG5, Q640L3, Q68G75, Q6AYN9, Q6GNQ4, Q6NTW1, Q6NZY4, Q6PCG6, Q80VH0, Q80ZU5, Q8AVX1

Diamond homologs: P16383, P58501, Q8BKT3, Q9Y5B6

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 74 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
mRNA Splicing	10	21.5×	2e-09
mRNA Splicing - Major Pathway	17	18.2×	4e-15
Processing of Capped Intron-Containing Pre-mRNA	11	17.7×	2e-09
Dengue Virus-Host Interactions	15	13.4×	2e-11
mRNA Polyadenylation	7	12.1×	7e-05
CHD1 and CHD2 subfamily	5	10.7×	3e-03
Metabolism of RNA	12	9.8×	1e-07

GO biological processes:

GO term	Partners	Fold	FDR
mRNA splicing, via spliceosome	17	23.6×	1e-16
RNA processing	7	23.2×	4e-06
RNA splicing	8	10.7×	1e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

123 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	90
Likely benign	12
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

3954 predictions. Top by Δscore:

Variant	Effect	Δscore
2:75652213:A:G	donor_gain	1.0000
2:75652261:GTCA:G	donor_gain	1.0000
2:75652265:G:GG	donor_gain	1.0000
2:75652269:GAGCT:G	donor_gain	1.0000
2:75652271:GCT:G	donor_gain	1.0000
2:75652512:T:TA	acceptor_gain	1.0000
2:75652515:A:AG	acceptor_gain	1.0000
2:75652516:T:G	acceptor_gain	1.0000
2:75652518:T:TA	acceptor_gain	1.0000
2:75652518:TGTA:T	acceptor_loss	1.0000
2:75652520:TA:T	acceptor_loss	1.0000
2:75652521:A:G	acceptor_loss	1.0000
2:75652521:AG:A	acceptor_gain	1.0000
2:75652522:GG:G	acceptor_gain	1.0000
2:75652522:GGAA:G	acceptor_gain	1.0000
2:75652653:ACAAG:A	donor_gain	1.0000
2:75652654:CAAG:C	donor_gain	1.0000
2:75652654:CAAGG:C	donor_loss	1.0000
2:75652655:AAGG:A	donor_loss	1.0000
2:75652656:AG:A	donor_gain	1.0000
2:75652657:GG:G	donor_gain	1.0000
2:75652657:GGTA:G	donor_loss	1.0000
2:75652658:G:GG	donor_gain	1.0000
2:75652658:GTAA:G	donor_loss	1.0000
2:75664779:CATCC:C	acceptor_gain	1.0000
2:75664781:TCC:T	acceptor_gain	1.0000
2:75664781:TCCCT:T	acceptor_loss	1.0000
2:75664782:CC:C	acceptor_gain	1.0000
2:75664782:CCC:C	acceptor_gain	1.0000
2:75664782:CCCT:C	acceptor_loss	1.0000

AlphaMissense

5174 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:75680297:A:G	W570R	0.994
2:75680297:A:T	W570R	0.994
2:75687947:A:G	W524R	0.990
2:75687947:A:T	W524R	0.990
2:75689136:A:G	W477R	0.989
2:75689136:A:T	W477R	0.989
2:75689132:C:G	R478P	0.988
2:75670263:A:G	W660R	0.987
2:75670263:A:T	W660R	0.987
2:75673464:A:C	F623L	0.973
2:75673464:A:T	F623L	0.973
2:75673466:A:G	F623L	0.973
2:75689040:A:G	W509R	0.971
2:75689040:A:T	W509R	0.971
2:75680295:C:A	W570C	0.970
2:75680295:C:G	W570C	0.970
2:75694251:A:G	L337P	0.969
2:75689134:C:A	W477C	0.968
2:75689134:C:G	W477C	0.968
2:75689135:C:G	W477S	0.966
2:75701229:C:A	W226C	0.965
2:75701229:C:G	W226C	0.965
2:75689057:C:G	R503P	0.963
2:75689112:A:C	Y485D	0.963
2:75666029:A:G	W710R	0.962
2:75666029:A:T	W710R	0.962
2:75680285:A:G	S574P	0.961
2:75690018:A:C	S430R	0.961
2:75690018:A:T	S430R	0.961
2:75690020:T:G	S430R	0.961

dbSNP variants (sampled 300 via entrez): RS1000042858 (2:75680714 A>C), RS1000136704 (2:75663392 G>A), RS1000278429 (2:75680399 C>G), RS1000300017 (2:75692321 T>G), RS1000325280 (2:75710264 T>C), RS1000411013 (2:75714418 T>A), RS1000577582 (2:75700087 G>A), RS1000616626 (2:75686545 T>C), RS1000688879 (2:75690949 T>A), RS1000753859 (2:75687424 A>C), RS1000893498 (2:75675174 T>C,G), RS1000954087 (2:75697211 T>C), RS1000954524 (2:75705266 T>A,C), RS1000977013 (2:75670851 T>G), RS1001077221 (2:75663922 G>A)

Disease associations

OMIM: gene MIM:189901 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

7 associations (top):

Study	Trait	p-value
GCST001530_7	Hippocampal atrophy	5.000000e-08
GCST002449_1	Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid)	4.000000e-06
GCST002701_36	Verbal declarative memory	5.000000e-06
GCST003901_12	Cognitive decline (age-related)	3.000000e-06
GCST007576_269	Chronotype	2.000000e-10
GCST009391_647	Metabolite levels	5.000000e-07
GCST011678_1	Depression in multiple sclerosis (post-diagnosis)	3.000000e-06

EFO canonical traits (6, from GWAS)

EFO ID	Trait name
EFO:0005039	hippocampal atrophy
EFO:0005680	omega-6 polyunsaturated fatty acid measurement
EFO:0004874	memory performance
EFO:0006805	word list delayed recall measurement
EFO:0008328	chronotype measurement
EFO:0010505	isocitrate measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

39 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, affects cotreatment, increases abundance, increases expression	2
manganese chloride	decreases expression, affects cotreatment, increases abundance, increases expression	2
Air Pollutants	decreases expression, increases abundance, increases expression	2
Arsenic	affects methylation, affects cotreatment, increases abundance, increases expression	2
Manganese	increases abundance, increases expression, decreases expression, affects cotreatment	2
Particulate Matter	decreases expression, increases abundance, increases expression	2
FR900359	affects phosphorylation	1
triphenyl phosphate	affects expression	1
ochratoxin A	decreases expression	1
aflatoxin B2	decreases methylation	1
tanespimycin	increases expression	1
nutlin 3	affects cotreatment, increases secretion	1
abrine	increases expression	1
5-(2,4-dihydroxy-5-isopropylphenyl)-4-(4-morpholin-4-ylmethylphenyl)isoxazole-3-carboxylic acid ethylamide	increases expression	1
STA 9090	increases expression	1
bisphenol S	affects cotreatment, decreases methylation	1
jinfukang	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	increases expression	1
Fulvestrant	affects cotreatment, decreases methylation	1
Vorinostat	increases expression	1
Benzo(a)pyrene	increases methylation	1
Cadmium	increases abundance, increases expression	1
Caffeine	increases phosphorylation	1
Dactinomycin	affects cotreatment, increases secretion	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Diazinon	increases methylation	1
Enzyme Inhibitors	increases O-linked glycosylation, decreases activity	1
Ivermectin	decreases expression	1
Methyl Methanesulfonate	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.