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GCNT4

gene
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Also known as C2GNT3

Summary

GCNT4 (glucosaminyl (N-acetyl) transferase 4, HGNC:17973) is a protein-coding gene on chromosome 5q13.3, encoding Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 (Q9P109). Glycosyltransferase that mediates core 2 O-glycan branching, an important step in mucin-type biosynthesis.

Predicted to enable acetylglucosaminyltransferase activity. Predicted to be involved in O-glycan processing and carbohydrate metabolic process. Predicted to act upstream of or within several processes, including inter-male aggressive behavior; neutrophil homeostasis; and thyroid hormone metabolic process. Predicted to be located in Golgi membrane.

Source: NCBI Gene 51301 — RefSeq curated summary.

At a glance

  • GWAS associations: 6
  • Clinical variants (ClinVar): 58 total
  • MANE Select transcript: NM_001366737

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:17973
Approved symbolGCNT4
Nameglucosaminyl (N-acetyl) transferase 4
Location5q13.3
Locus typegene with protein product
StatusApproved
AliasesC2GNT3
Ensembl geneENSG00000176928
Ensembl biotypeprotein_coding
OMIM616782
Entrez51301

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 9 protein_coding

ENST00000322348, ENST00000652361, ENST00000856429, ENST00000856430, ENST00000856431, ENST00000856432, ENST00000856433, ENST00000856434, ENST00000913096

RefSeq mRNA: 1 — MANE Select: NM_001366737 NM_001366737

CCDS: CCDS4026

Canonical transcript exons

ENST00000652361 — 4 exons

ExonStartEnd
ENSE000020300347505216975052227
ENSE000020685387505242975052558
ENSE000020734227504789775048037
ENSE000038446767502534675030038

Expression profiles

Bgee: expression breadth ubiquitous, 156 present calls, max score 83.52.

FANTOM5 (CAGE): breadth broad, TPM avg 0.7370 / max 39.9712, expressed in 289 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter IDTPM avgSamples expressed
621080.6229248
621070.114056

Top tissues by expression

255 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
islet of LangerhansUBERON:000000683.52gold quality
male germ line stem cell (sensu Vertebrata) in testisCL:0000089 ∩ UBERON:000047382.32gold quality
body of stomachUBERON:000116176.69gold quality
stromal cell of endometriumCL:000225576.22gold quality
gall bladderUBERON:000211076.17gold quality
stomachUBERON:000094574.97gold quality
pancreasUBERON:000126473.70gold quality
duodenumUBERON:000211472.91gold quality
small intestine Peyer’s patchUBERON:000345472.43gold quality
small intestineUBERON:000210871.79gold quality
prefrontal cortexUBERON:000045171.15gold quality
lymph nodeUBERON:000002970.53gold quality
body of pancreasUBERON:000115070.42gold quality
smooth muscle tissueUBERON:000113570.26gold quality
Brodmann (1909) area 9UBERON:001354070.16gold quality
popliteal arteryUBERON:000225069.48gold quality
tibial arteryUBERON:000761069.48gold quality
lower esophagusUBERON:001347369.45gold quality
lower esophagus muscularis layerUBERON:003583369.44gold quality
aortaUBERON:000094768.27gold quality
mucosa of stomachUBERON:000119968.12gold quality
fundus of stomachUBERON:000116068.02gold quality
esophagogastric junction muscularis propriaUBERON:003584167.87gold quality
descending thoracic aortaUBERON:000234567.53gold quality
thoracic aortaUBERON:000151567.05gold quality
ascending aortaUBERON:000149666.93gold quality
right frontal lobeUBERON:000281066.78gold quality
right coronary arteryUBERON:000162566.75gold quality
left coronary arteryUBERON:000162666.59gold quality
vermiform appendixUBERON:000115466.51gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

ExperimentMarker?Max mean expression
E-ANND-3yes9.26
E-MTAB-6911no96.68

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): GATA3

miRNA regulators (miRDB)

99 targeting GCNT4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-4682100.0068.891258
HSA-MIR-6833-3P100.0070.633197
HSA-MIR-450099.9972.722367
HSA-MIR-10401-5P99.9965.79948
HSA-MIR-186-5P99.9970.833707
HSA-LET-7A-5P99.9872.291790
HSA-LET-7B-5P99.9872.311790
HSA-LET-7C-5P99.9872.291790
HSA-LET-7E-5P99.9872.291790
HSA-LET-7F-5P99.9872.561784
HSA-LET-7G-5P99.9872.371784
HSA-LET-7I-5P99.9872.371788
HSA-MIR-98-5P99.9872.331787
HSA-MIR-485-3P99.9870.681585
HSA-MIR-539-3P99.9870.741616
HSA-MIR-548P99.9872.253784
HSA-MIR-433-3P99.9869.371203
HSA-MIR-6793-5P99.9765.95758
HSA-LET-7D-5P99.9671.761632
HSA-MIR-445899.9671.641650
HSA-MIR-590-3P99.9674.346478
HSA-MIR-7-1-3P99.9171.534384
HSA-MIR-7-2-3P99.9171.404394
HSA-MIR-7162-3P99.8968.161682
HSA-MIR-6780A-5P99.8866.692776
HSA-MIR-182-5P99.8774.032589
HSA-MIR-1211999.8768.351653
HSA-MIR-6817-3P99.7968.352126
HSA-MIR-1273H-5P99.7766.322471
HSA-MIR-320A-3P99.7769.732107

Literature-anchored findings (GeneRIF, showing 3)

  • MicroRNA MiR-130a-3p promotes gastric cancer by targeting Glucosaminyl N-acetyl transferase 4 (GCNT4) to regulate the TGF-beta1/SMAD3 pathway. (PMID:34696660)
  • Circ_0005758 impedes gastric cancer progression through miR-1229-3p/GCNT4 feedback loop. (PMID:35970245)
  • CircPRDM5 inhibits the proliferation, migration, invasion, and glucose metabolism of gastric cancer cells by reducing GCNT4 expression in a miR-485-3p-dependent manner. (PMID:38180297)

Cross-species orthologs

24 orthologs

OrganismSymbolGene ID
danio_reriogcnt4aENSDARG00000035198
danio_reriogcnt4b.2ENSDARG00000044755
danio_reriogcnt4b.1ENSDARG00000077550
mus_musculusGcnt4ENSMUSG00000091387
rattus_norvegicusGcnt4ENSRNOG00000064612
drosophila_melanogasteroxtFBGN0015360
drosophila_melanogasterCG9164FBGN0030634
caenorhabditis_elegansgly-15WBGENE00001640
caenorhabditis_elegansgly-16WBGENE00001641
caenorhabditis_elegansgly-17WBGENE00001642
caenorhabditis_elegansgly-18WBGENE00001643
caenorhabditis_elegansgly-19WBGENE00001644
caenorhabditis_elegansWBGENE00005024
caenorhabditis_elegansWBGENE00009148
caenorhabditis_elegansF30A10.4WBGENE00009263
caenorhabditis_elegansWBGENE00011090
caenorhabditis_elegansT09E11.6WBGENE00011655
caenorhabditis_elegansT09E11.9WBGENE00011658
caenorhabditis_elegansT27F6.1WBGENE00012102
caenorhabditis_elegansWBGENE00012135
caenorhabditis_elegansWBGENE00013119
caenorhabditis_elegansZK1225.2WBGENE00014236
caenorhabditis_elegansWBGENE00019270
caenorhabditis_elegansWBGENE00019919

Paralogs (8): XYLT2 (ENSG00000015532), WSCD2 (ENSG00000075035), XYLT1 (ENSG00000103489), GCNT2 (ENSG00000111846), GCNT7 (ENSG00000124091), GCNT3 (ENSG00000140297), WSCD1 (ENSG00000179314), GCNT1 (ENSG00000187210)

Protein

Protein identifiers

Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 — Q9P109 (reviewed: Q9P109)

Alternative names: Core 2-branching enzyme 3, Core2-GlcNAc-transferase 3

All UniProt accessions (1): Q9P109

UniProt curated annotations — full annotation on UniProt →

Function. Glycosyltransferase that mediates core 2 O-glycan branching, an important step in mucin-type biosynthesis. Does not have core 4 O-glycan or I-branching enzyme activity.

Subcellular location. Golgi apparatus membrane.

Tissue specificity. Predominantly expressed in thymus. Weakly expressed in pancreas, peripheral blood leukocytes, placenta, small intestine and stomach. Barely detectable in liver, spleen, lung and lymph node.

Pathway. Protein modification; protein glycosylation.

Similarity. Belongs to the glycosyltransferase 14 family.

RefSeq proteins (1): NP_001353666* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR003406Glyco_trans_14Family

Pfam: PF02485

Enzyme classification (BRENDA):

  • EC 2.4.1.102 — beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (BRENDA: 13 organisms, 110 substrates, 35 inhibitors, 50 Km, 0 kcat entries)

Substrate kinetics (BRENDA)

19 substrates with measured Km, best-characterized 15. Km ranges are aggregated across organisms/conditions.

SubstrateKm (mM)Measurements
UDP-N-ACETYL-D-GLUCOSAMINE0.0063–5.69
BETA-D-GALACTOSYL-1,3-N-ACETYL-ALPHA-D-GALACTOSA0.77–27
3-DEOXY-BETA-D-GALACTOSYL-1,3-N-ACETYL-D-GALACTO2–5.55
4-DEOXY-BETA-D-GALACTOSYL-1,3-N-ACETYL-D-GALACTO3.1–105
BETA-D-GALACTOSYL-1,3-(6-DEOXY)-N-ACETYL-D-GALAC12–374
GALBETA(1-3)GALNACALPHA-P-NITROPHENOL0.11–1.64
BETA-D-GALACTOSYL-1,3-N-ACETYL-ALPHA-D-GALACTOSA0.52–0.922
BETA-D-GALACTOSYL-1,3-N-ACETYL-D-GALACTOSAMINYL-0.36–0.432
ANTIFREEZE GLYCOPROTEIN POLYPEPTIDE231
ASIALO-BLOOD GROUP A NEGATIVE PSM5.21
BETA-D-GALACTOSYL-1,3-N-ACETYL-ALPHA-D-GALACTOSA1.21
BETA-D-GALACTOSYL-1,3-N-ACETYL-ALPHA-D-GALACTOSA0.861
BETA-D-GALACTOSYL-1,3-N-ACETYL-ALPHA-D-GALACTOSA4.21
BETA-D-GALACTOSYL-1,3-N-ACETYL-BETA-D-GALACTOSAM0.921

Catalyzed reactions (Rhea), 2 shown:

  • a 3-O-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP + H(+) (RHEA:56212)
  • a 3-O-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = a 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP + H(+) (RHEA:56216)

UniProt features (13 total): disulfide bond 4, sequence variant 3, topological domain 2, glycosylation site 2, chain 1, transmembrane region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q9P109-F191.410.80

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (4): 73–227, 161–382, 182–209, 391–423

Glycosylation sites (2): 72, 286

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

IDPathway
R-HSA-913709O-linked glycosylation of mucins

MSigDB gene sets: 89 (showing top): GOBP_PHENOL_CONTAINING_COMPOUND_METABOLIC_PROCESS, ACTACCT_MIR196A_MIR196B, GOBP_BEHAVIOR, SHEPARD_CRASH_AND_BURN_MUTANT_UP, GOBP_REGULATION_OF_HORMONE_LEVELS, GOBP_THYROID_HORMONE_METABOLIC_PROCESS, GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS, GOBP_ANIMAL_ORGAN_MORPHOGENESIS, GOBP_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS, GOBP_CARBOHYDRATE_METABOLIC_PROCESS, GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_HOMEOSTASIS, GOBP_KIDNEY_MORPHOGENESIS, GOBP_PROTEIN_O_LINKED_GLYCOSYLATION_VIA_N_ACETYL_GALACTOSAMINE, GOBP_TISSUE_MORPHOGENESIS, GOBP_MODIFIED_AMINO_ACID_METABOLIC_PROCESS

GO Biological Process (10): neutrophil homeostasis (GO:0001780), inter-male aggressive behavior (GO:0002121), carbohydrate metabolic process (GO:0005975), protein O-linked glycosylation (GO:0006493), protein O-linked glycosylation via N-acetylgalactosamine (GO:0016266), thyroid hormone metabolic process (GO:0042403), tissue morphogenesis (GO:0048729), kidney morphogenesis (GO:0060993), obsolete protein glycosylation (GO:0006486), glycoprotein biosynthetic process (GO:0009101)

GO Molecular Function (6): beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity (GO:0003829), N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity (GO:0008109), acetylglucosaminyltransferase activity (GO:0008375), UDP-glycosyltransferase activity (GO:0008194), transferase activity (GO:0016740), glycosyltransferase activity (GO:0016757)

GO Cellular Component (3): Golgi membrane (GO:0000139), Golgi apparatus (GO:0005794), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

CategoryPathways
O-linked glycosylation1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
acetylglucosaminyltransferase activity2
leukocyte homeostasis1
myeloid cell homeostasis1
aggressive behavior1
primary metabolic process1
glycoprotein biosynthetic process1
protein O-linked glycosylation1
modified amino acid metabolic process1
phenol-containing compound metabolic process1
hormone metabolic process1
anatomical structure morphogenesis1
tissue development1
kidney development1
animal organ morphogenesis1
macromolecule biosynthetic process1
glycoprotein metabolic process1
carbohydrate derivative biosynthetic process1
catalytic activity, acting on a glycoprotein1
UDP-glycosyltransferase activity1
hexosyltransferase activity1
glycosyltransferase activity1
catalytic activity1
transferase activity1
Golgi apparatus1
bounding membrane of organelle1
cytoplasm1
endomembrane system1
intracellular membrane-bounded organelle1
cellular anatomical structure1

Protein interactions and networks

STRING

540 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
GCNT4A4GNTQ9UNA3724
GCNT4C1GALT1Q9NS00701
GCNT4B3GNT6Q6ZMB0607
GCNT4ST3GAL2Q16842598
GCNT4ST3GAL1Q11201595
GCNT4ST3GAL4Q11206544
GCNT4MUC6Q6W4X9541
GCNT4GKN1Q9NS71508
GCNT4A4GALTQ9NPC4492
GCNT4C1GALT1C1Q96EU7481
GCNT4GAL3ST4Q96RP7457
GCNT4B3GALT1Q9Y5Z6432
GCNT4FUT1P19526422
GCNT4LRRN1Q6UXK5419
GCNT4B3GNT3Q9Y2A9418

IntAct

2 interactions, top by confidence:

ABTypeScore
GCNT4LRP10psi-mi:“MI:0914”(association)0.350

BioGRID (4): GCNT4 (Synthetic Lethality), LRP10 (Affinity Capture-MS), CNNM1 (Affinity Capture-MS), CECR1 (Affinity Capture-MS)

ESM2 similar proteins: A2AJQ3, A2AUQ7, A5GFW8, A6NG13, A7RX69, D3ZNQ3, E1BPQ3, E9PU17, E9PX95, E9Q649, G3V9Q9, O15466, P0DN25, P23336, P27473, P38566, P38567, P48794, P61646, P97402, Q02742, Q09324, Q21389, Q2NKH9, Q2YDM8, Q3L7M0, Q3SX46, Q499P3, Q4R5T7, Q4V8F8, Q53G44, Q5U258, Q5ZLK4, Q6ZNI0, Q6ZXC8, Q71SG7, Q7Z388, Q7Z4J2, Q812F3, Q8BV66

Diamond homologs: A5GFW8, E9Q649, O95395, P97402, Q02742, Q09324, Q1M0V6, Q3V3K7, Q5JCT0, Q5U258, Q6ZNI0, Q71SG7, Q7YQE1, Q805R1, Q80RC7, Q866Z4, Q866Z5, Q866Z6, Q8CH87, Q8N0V5, Q92180, Q99CW3, Q9IZK2, Q9P109, Q5QQ53, Q7KVA1, Q5QQ54, Q5QQ55, A2BGL3, D4AUF4, D4PHA7, P54867, P84675, Q0IIY2, Q5QQ49, Q5QQ50, Q5QQ51, Q5QQ52, Q5QQ56, Q5QQ57

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

58 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance54
Likely benign4
Benign0

Top pathogenic / likely-pathogenic (0)

SpliceAI

171 predictions. Top by Δscore:

VariantEffectΔscore
5:75030790:AC:Adonor_gain0.9400
5:75030791:CC:Cdonor_gain0.9400
5:75029899:CA:Cdonor_gain0.9200
5:75029900:AA:Adonor_gain0.9200
5:75026880:T:Cacceptor_gain0.8800
5:75029901:A:Cdonor_gain0.8700
5:75028838:C:CTdonor_gain0.8300
5:75026880:T:TCacceptor_gain0.7900
5:75028839:C:CTdonor_gain0.7900
5:75028947:CT:Cdonor_gain0.7800
5:75030039:C:CCacceptor_gain0.7400
5:75030881:T:TAdonor_gain0.7400
5:75030841:A:Cdonor_gain0.7300
5:75026889:G:Cacceptor_gain0.7000
5:75028837:G:Cdonor_gain0.7000
5:75030783:TGTAC:Tdonor_loss0.7000
5:75030784:GTACC:Gdonor_loss0.7000
5:75030785:TACC:Tdonor_loss0.7000
5:75030786:ACCC:Adonor_loss0.7000
5:75030787:C:Gdonor_loss0.7000
5:75030788:CCA:Cdonor_loss0.7000
5:75030789:CA:Cdonor_loss0.7000
5:75030790:ACC:Adonor_loss0.7000
5:75030791:C:CGdonor_loss0.7000
5:75029169:T:TAdonor_gain0.6900
5:75028942:T:TAdonor_gain0.6800
5:75030034:TCATT:Tacceptor_loss0.6600
5:75030036:ATTC:Aacceptor_loss0.6600
5:75030037:TTCT:Tacceptor_loss0.6600
5:75030038:TC:Tacceptor_loss0.6600

AlphaMissense

3003 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
5:75028893:C:GC382S0.999
5:75028894:A:TC382S0.999
5:75028805:T:AK411N0.998
5:75028805:T:GK411N0.998
5:75028866:C:GC391S0.998
5:75028867:A:TC391S0.998
5:75028892:A:CC382W0.998
5:75028893:C:TC382Y0.998
5:75028925:C:AW371C0.998
5:75028925:C:GW371C0.998
5:75028806:T:AK411I0.997
5:75028807:T:CK411E0.997
5:75028865:A:CC391W0.997
5:75028866:C:TC391Y0.997
5:75028867:A:GC391R0.997
5:75028893:C:AC382F0.997
5:75028927:A:GW371R0.997
5:75028927:A:TW371R0.997
5:75028812:G:TA409D0.996
5:75028894:A:GC382R0.996
5:75028938:C:GR367P0.996
5:75028939:G:TR367S0.996
5:75029007:C:GR344P0.996
5:75029023:A:GW339R0.996
5:75029023:A:TW339R0.996
5:75029411:G:CC209W0.996
5:75028866:C:AC391F0.995
5:75029380:A:GW220R0.995
5:75029380:A:TW220R0.995
5:75029448:T:CY197C0.995

dbSNP variants (sampled 300 via entrez): RS1000009403 (5:75031402 A>G,T), RS1000036505 (5:75037008 T>C), RS1000087025 (5:75037240 AG>A), RS1000154591 (5:75046220 G>C), RS1000200750 (5:75017308 C>A,T), RS1000234492 (5:75033849 C>T), RS1000324348 (5:75023950 AGGCCC>A), RS1000333573 (5:75030956 A>G), RS1000389036 (5:75052523 C>T), RS1000400220 (5:75034153 G>A), RS1000443844 (5:75024182 CA>C,CAA), RS1000527555 (5:75027820 A>T), RS1000580471 (5:75040273 G>A,C), RS1000590853 (5:75020673 C>A,T), RS1000822946 (5:75027522 C>T)

Disease associations

OMIM: gene MIM:616782 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

6 associations (top):

StudyTraitp-value
GCST001840_4Stearic acid (18:0) levels4.000000e-06
GCST003678_15C-reactive protein levels or total cholesterol levels (pleiotropy)7.000000e-13
GCST003679_4C-reactive protein levels or LDL-cholesterol levels (pleiotropy)2.000000e-11
GCST006296_1Response to ziprazidone in schizophrenia1.000000e-06
GCST008129_44Body mass index9.000000e-32
GCST90011899_43Aspartate aminotransferase levels2.000000e-15

EFO canonical traits (5, from GWAS)

EFO IDTrait name
EFO:0004458C-reactive protein measurement
EFO:0004574total cholesterol measurement
EFO:0004611low density lipoprotein cholesterol measurement
EFO:0004340body mass index
EFO:0004736aspartate aminotransferase measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

27 total (human), top 27 by PubMed support.

ChemicalActions (top 5)PubMed papers
triphenyl phosphateaffects expression1
2-methyl-4-isothiazolin-3-oneincreases expression1
ethyl-p-hydroxybenzoateincreases expression1
trichostatin Adecreases expression1
nickel sulfateincreases expression1
S-(1,2-dichlorovinyl)cysteineaffects cotreatment, affects response to substance, increases expression1
4-nonylphenolaffects cotreatment, increases expression1
CGP 52608affects binding, increases reaction1
4-tert-octylphenolaffects cotreatment, increases expression1
Glyphosateincreases expression1
Air Pollutantsincreases abundance, increases expression1
Arsenicaffects methylation1
Atrazineincreases expression1
Benzo(a)pyreneincreases methylation1
Dichlorodiphenyl Dichloroethyleneincreases expression1
Diethylhexyl Phthalateincreases expression1
Estradiolincreases expression, affects cotreatment1
Lipopolysaccharidesincreases expression, affects response to substance, affects cotreatment1
Tobacco Smoke Pollutionincreases expression1
Urethanedecreases expression1
Valproic Aciddecreases expression1
2,4-Dichlorophenoxyacetic Acidincreases expression1
1-Methyl-4-phenylpyridiniumdecreases expression1
Propofolincreases expression1
Lactic Aciddecreases expression1
S-Nitrosoglutathionedecreases expression1
Particulate Matterincreases abundance, increases expression1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 75

This page pulls from 75 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomereactomeparentrefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot