GCSIR

Summary

GCSIR (GPR55 cis regulatory suppressor of immune response RNA, HGNC:54400) is a long non-coding RNA gene on chromosome 2q37.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:54400
Approved symbol	GCSIR
Name	GPR55 cis regulatory suppressor of immune response RNA
Location	2q37.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	Lnc-ITM2C-1
Ensembl gene	ENSG00000232520
Ensembl biotype	lncRNA
Entrez	151484
RNAcentral	URS000075BDFA — lncRNA, 1893 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 8 lncRNA

ENST00000415628, ENST00000434807, ENST00000447074, ENST00000455128, ENST00000658438, ENST00000663229, ENST00000670310, ENST00000770323

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000415628 — 3 exons

Exon	Start	End
ENSE00001632005	230895398	230895605
ENSE00001671001	230886546	230886969
ENSE00001770955	230895959	230897091

Expression profiles

Bgee: expression breadth ubiquitous, 112 present calls, max score 79.50.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0869 / max 13.7251, expressed in 29 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
25840	0.0869	29

Top tissues by expression

209 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
nucleus accumbens	UBERON:0001882	79.50	gold quality
caudate nucleus	UBERON:0001873	78.72	gold quality
putamen	UBERON:0001874	78.06	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	75.47	gold quality
sural nerve	UBERON:0015488	73.55	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	72.08	gold quality
prefrontal cortex	UBERON:0000451	69.52	gold quality
hypothalamus	UBERON:0001898	69.02	gold quality
anterior cingulate cortex	UBERON:0009835	68.39	gold quality
cortical plate	UBERON:0005343	67.69	gold quality
ganglionic eminence	UBERON:0004023	67.04	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.72	gold quality
right frontal lobe	UBERON:0002810	66.27	gold quality
amygdala	UBERON:0001876	66.09	gold quality
forebrain	UBERON:0001890	64.09	gold quality
neocortex	UBERON:0001950	63.65	gold quality
frontal cortex	UBERON:0001870	63.13	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.02	gold quality
brain	UBERON:0000955	62.55	gold quality
buccal mucosa cell	CL:0002336	60.94	gold quality
parotid gland	UBERON:0001831	60.74	gold quality
cerebral cortex	UBERON:0000956	60.72	gold quality
mucosa of transverse colon	UBERON:0004991	60.63	gold quality
substantia nigra	UBERON:0002038	59.27	gold quality
leukocyte	CL:0000738	58.06	gold quality
Ammon’s horn	UBERON:0001954	58.02	gold quality
stromal cell of endometrium	CL:0002255	57.48	gold quality
monocyte	CL:0000576	57.40	gold quality
midbrain	UBERON:0001891	57.08	gold quality
pituitary gland	UBERON:0000007	56.69	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.63

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The authors conclude that hepatitis C virus induces lncR 8 expression, while lncR 8 indirectly favors hepatitis C virus replication by stimulating expression of its neighboring gene GPR55, which in turn downregulates expression of ISGs. The latter fact is also consistent with an anti-inflammatory role of GPR55. (PMID:31200545)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.