GDF5-AS1

Summary

GDF5-AS1 (GDF5 antisense RNA 1, HGNC:33435) is a long non-coding RNA gene on chromosome 20q11.22.

Located in mitochondrion.

Source: NCBI Gene 554250 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33435
Approved symbol	GDF5-AS1
Name	GDF5 antisense RNA 1
Location	20q11.22
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000204183
Ensembl biotype	lncRNA
Entrez	554250
RNAcentral	URS0000E60AD7 — lncRNA, 935 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000374375

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000374375 — 2 exons

Exon	Start	End
ENSE00001463332	35433852	35435450
ENSE00001463333	35433029	35433163

Expression profiles

Bgee: expression breadth broad, 68 present calls, max score 68.74.

Top tissues by expression

68 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	68.74	silver quality
cortical plate	UBERON:0005343	61.35	silver quality
ventricular zone	UBERON:0003053	58.32	silver quality
ganglionic eminence	UBERON:0004023	56.59	silver quality
sural nerve	UBERON:0015488	51.24	silver quality
prefrontal cortex	UBERON:0000451	51.22	gold quality
blood	UBERON:0000178	49.54	gold quality
saliva-secreting gland	UBERON:0001044	49.28	gold quality
minor salivary gland	UBERON:0001830	48.86	gold quality
frontal cortex	UBERON:0001870	47.64	silver quality
anterior cingulate cortex	UBERON:0009835	47.22	silver quality
gall bladder	UBERON:0002110	46.72	gold quality
duodenum	UBERON:0002114	46.30	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	45.65	silver quality
popliteal artery	UBERON:0002250	45.52	silver quality
tibial artery	UBERON:0007610	45.49	silver quality
lymph node	UBERON:0000029	45.37	silver quality
adrenal gland	UBERON:0002369	45.26	silver quality
right atrium auricular region	UBERON:0006631	44.82	gold quality
gastrocnemius	UBERON:0001388	44.41	silver quality
ascending aorta	UBERON:0001496	44.34	silver quality
body of uterus	UBERON:0009853	44.20	silver quality
endometrium	UBERON:0001295	44.12	silver quality
thoracic aorta	UBERON:0001515	44.04	silver quality
heart	UBERON:0000948	43.94	gold quality
myometrium	UBERON:0001296	43.86	silver quality
superior frontal gyrus	UBERON:0002661	43.84	silver quality
adipose tissue	UBERON:0001013	43.58	gold quality
subcutaneous adipose tissue	UBERON:0002190	43.54	gold quality
lung	UBERON:0002048	43.19	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.95

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.