GDNF-AS1

Summary

GDNF-AS1 (GDNF antisense RNA 1, HGNC:43592) is a long non-coding RNA gene on chromosome 5p13.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43592
Approved symbol	GDNF-AS1
Name	GDNF antisense RNA 1
Location	5p13.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	GDNFOS
Ensembl gene	ENSG00000248587
Ensembl biotype	lncRNA
Entrez	100861519
RNAcentral	URS0000ABD86A — lncRNA, 1531 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 30 — 30 lncRNA

ENST00000503382, ENST00000503870, ENST00000506429, ENST00000508853, ENST00000510986, ENST00000513039, ENST00000514532, ENST00000637595, ENST00000637926, ENST00000652286, ENST00000655756, ENST00000662564, ENST00000666505, ENST00000669275, ENST00000669619, ENST00000671526, ENST00000715998, ENST00000716015, ENST00000716016, ENST00000716017, ENST00000716018, ENST00000716019, ENST00000750372, ENST00000750373, ENST00000811473, ENST00000811474, ENST00000811475, ENST00000811476, ENST00000811477, ENST00000811478

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000503382 — 4 exons

Exon	Start	End
ENSE00002024037	37874107	37874266
ENSE00002037394	37872352	37872465
ENSE00002070276	37874701	37874894
ENSE00002078005	37840438	37840573

Expression profiles

Bgee: expression breadth ubiquitous, 126 present calls, max score 79.87.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2832 / max 44.1967, expressed in 110 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
56182	0.1459	55
56181	0.0796	26
56183	0.0577	18

Top tissues by expression

129 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cerebellar hemisphere	UBERON:0002245	79.87	gold quality
cerebellar cortex	UBERON:0002129	79.80	gold quality
cerebellum	UBERON:0002037	79.59	gold quality
hindlimb stylopod muscle	UBERON:0004252	79.55	gold quality
right hemisphere of cerebellum	UBERON:0014890	79.43	gold quality
cerebellar vermis	UBERON:0004720	76.40	gold quality
muscle layer of sigmoid colon	UBERON:0035805	75.51	gold quality
left ovary	UBERON:0002119	74.66	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	74.50	gold quality
skeletal muscle tissue	UBERON:0001134	73.37	gold quality
ovary	UBERON:0000992	73.03	gold quality
muscle of leg	UBERON:0001383	72.94	gold quality
gastrocnemius	UBERON:0001388	72.86	gold quality
lower esophagus muscularis layer	UBERON:0035833	72.14	gold quality
lower esophagus	UBERON:0013473	72.02	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	71.23	gold quality
right ovary	UBERON:0002118	71.17	gold quality
sural nerve	UBERON:0015488	69.23	gold quality
stromal cell of endometrium	CL:0002255	68.08	gold quality
colon	UBERON:0001155	67.99	gold quality
nucleus accumbens	UBERON:0001882	67.49	gold quality
putamen	UBERON:0001874	67.32	gold quality
mucosa of stomach	UBERON:0001199	66.95	gold quality
right uterine tube	UBERON:0001302	66.70	gold quality
prostate gland	UBERON:0002367	65.52	gold quality
intestine	UBERON:0000160	65.23	gold quality
caudate nucleus	UBERON:0001873	64.95	gold quality
Ammon’s horn	UBERON:0001954	64.70	gold quality
smooth muscle tissue	UBERON:0001135	64.68	gold quality
gall bladder	UBERON:0002110	64.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.36

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.