GEM

Summary

GEM (GTP binding protein overexpressed in skeletal muscle, HGNC:4234) is a protein-coding gene on chromosome 8q22.1, encoding GTP-binding protein GEM (P55040). Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane.

The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.

Source: NCBI Gene 2669 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 49 total
• MANE Select transcript: NM_005261

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:4234
Approved symbol	GEM
Name	GTP binding protein overexpressed in skeletal muscle
Location	8q22.1
Locus type	gene with protein product
Status	Approved
Aliases	KIR
Ensembl gene	ENSG00000164949
Ensembl biotype	protein_coding
OMIM	600164
Entrez	2669

Gene structure

Transcript identifiers

Ensembl transcripts: 18 — 16 protein_coding, 2 retained_intron

ENST00000297596, ENST00000396194, ENST00000521817, ENST00000523433, ENST00000523660, ENST00000893822, ENST00000893823, ENST00000893824, ENST00000893825, ENST00000893826, ENST00000893827, ENST00000893828, ENST00000893829, ENST00000893830, ENST00000893831, ENST00000969492, ENST00000969493, ENST00000969494

RefSeq mRNA: 2 — MANE Select: NM_005261 NM_005261, NM_181702

CCDS: CCDS6261

Canonical transcript exons

ENST00000297596 — 5 exons

Exon	Start	End
ENSE00001088910	94253036	94253112
ENSE00001088911	94262090	94262319
ENSE00001088912	94260173	94260512
ENSE00001088914	94252019	94252223
ENSE00002114213	94249253	94250587

Expression profiles

Bgee: expression breadth ubiquitous, 278 present calls, max score 99.38.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 12.9844 / max 919.3369, expressed in 1309 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
93983	12.5517	1307
93982	0.4326	207

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pigmented layer of retina	UBERON:0001782	99.38	gold quality
retina	UBERON:0000966	99.35	gold quality
blood vessel layer	UBERON:0004797	99.27	gold quality
gall bladder	UBERON:0002110	99.23	gold quality
cauda epididymis	UBERON:0004360	98.76	gold quality
vena cava	UBERON:0004087	98.45	gold quality
mucosa of stomach	UBERON:0001199	98.11	gold quality
ascending aorta	UBERON:0001496	98.09	gold quality
right coronary artery	UBERON:0001625	98.09	gold quality
thoracic aorta	UBERON:0001515	98.03	gold quality
cartilage tissue	UBERON:0002418	97.71	gold quality
descending thoracic aorta	UBERON:0002345	97.30	gold quality
mucosa of urinary bladder	UBERON:0001259	97.02	gold quality
secondary oocyte	CL:0000655	96.85	gold quality
choroid plexus epithelium	UBERON:0003911	96.82	gold quality
muscle layer of sigmoid colon	UBERON:0035805	96.82	gold quality
aorta	UBERON:0000947	96.81	gold quality
saphenous vein	UBERON:0007318	96.42	gold quality
left uterine tube	UBERON:0001303	96.05	gold quality
popliteal artery	UBERON:0002250	95.90	gold quality
tibial artery	UBERON:0007610	95.89	gold quality
artery	UBERON:0001637	95.85	gold quality
left coronary artery	UBERON:0001626	95.84	gold quality
urethra	UBERON:0000057	95.73	gold quality
mammary duct	UBERON:0001765	95.53	gold quality
coronary artery	UBERON:0001621	95.52	gold quality
endocervix	UBERON:0000458	95.51	gold quality
epithelium of mammary gland	UBERON:0003244	94.61	gold quality
pericardium	UBERON:0002407	94.57	gold quality
omental fat pad	UBERON:0010414	94.57	gold quality

Single-cell (SCXA)

Detected in 10 experiment(s), a significant marker in 9.

Experiment	Marker?	Max mean expression
E-GEOD-135922	yes	51.49
E-MTAB-6701	yes	44.75
E-MTAB-10287	yes	44.39
E-CURD-122	yes	12.33
E-MTAB-5061	yes	11.89
E-MTAB-6678	yes	10.90
E-GEOD-81547	yes	10.06
E-MTAB-10553	yes	7.29
E-MTAB-8060	no	53.27
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

76 targeting GEM, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-507	99.97	70.11	1915
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-557	99.96	70.01	1640
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-8082	99.95	67.27	1170
HSA-MIR-128-3P	99.95	71.17	2484
HSA-MIR-216A-3P	99.95	71.19	2505
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-548AE-3P	99.93	72.66	4867
HSA-MIR-548AH-3P	99.93	72.54	4872
HSA-MIR-548AM-3P	99.93	72.54	4872
HSA-MIR-548AQ-3P	99.93	72.66	4867
HSA-MIR-450B-5P	99.92	71.48	3175
HSA-MIR-589-3P	99.91	69.62	2088

Literature-anchored findings (GeneRIF, showing 13)

• We discuss the structural and functional properties of RGK proteins and highlight recent work addressing the mechanism of Gem regulation by calmodulin and 14-3-3. (PMID:16242932)
• crystallographic structure and biochemical characterization indicate that Gem G-domain markedly prefers GDP over GTP (PMID:17052716)
• Gem is a bona fide GTPase that exhibits striking structural and biochemical features that should impact its regulation and cellular activities (PMID:17107948)
• GEM plays a key role during C. pneumoniae entry into human cells. (PMID:20233927)
• Gem contains two candidate inhibitory sites, each capable of producing full inhibition of P/Q-type Ca(2+) channels. (PMID:22589533)
• Data show a mechanism by which GTPase Gem contributes to the mitotic progression by maintaining correct spindle length through the kinesin Kif9. (PMID:22964304)
• Gem is involved both in T-cell spontaneous cell migration as well as chemotaxis and plays an important role in cell-to-cell HTLV-1 viral transmission. (PMID:24586148)
• Down regulation of Gem expression was involved in the pathogenesis of hepatocellular carcinoma (HCC), and it might be a favorable independent prognostic parameter for HCC. (PMID:25155751)
• These findings demonstrate a new role of Gem/Gmip/RhoA signaling in cortical actin regulation during early mitotic stages. (PMID:25173885)
• GEM and PPP1R13L were predicted as novel genes which may act as potential target or biomarkers of obesity as they occur with other 21 target genes with known obesity relationship. (PMID:31013288)
• Ras-like Gem GTPase induced by Npas4 promotes activity-dependent neuronal tolerance for ischemic stroke. (PMID:34349016)
• Direct inhibition of CaV2.3 by Gem is dynamin dependent and does not require a direct alfa/beta interaction. (PMID:34837834)
• Decreased expression of GEM in osteoarthritis cartilage regulates chondrogenic differentiation via Wnt/beta-catenin signaling. (PMID:37794464)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	gem	ENSDARG00000029112
mus_musculus	Gem	ENSMUSG00000028214
rattus_norvegicus	Gem	ENSRNOG00000015160

Paralogs (35): RALA (ENSG00000006451), REM1 (ENSG00000088320), RASL10A (ENSG00000100276), RASD2 (ENSG00000100302), RASL12 (ENSG00000103710), RHEB (ENSG00000106615), RASD1 (ENSG00000108551), RERGL (ENSG00000111404), RAP1A (ENSG00000116473), RASL11A (ENSG00000122035), RAP2C (ENSG00000123728), RAP2A (ENSG00000125249), RRAS (ENSG00000126458), RAP1B (ENSG00000127314), RASL11B (ENSG00000128045), KRAS (ENSG00000133703), RRAS2 (ENSG00000133818), RERG (ENSG00000134533), REM2 (ENSG00000139890), RIT1 (ENSG00000143622), RALB (ENSG00000144118), RIT2 (ENSG00000152214), MRAS (ENSG00000158186), DIRAS3 (ENSG00000162595), DIRAS2 (ENSG00000165023), RRAD (ENSG00000166592), RHEBL1 (ENSG00000167550), NKIRAS2 (ENSG00000168256), HRAS (ENSG00000174775), DIRAS1 (ENSG00000176490), RAP2B (ENSG00000181467), ERAS (ENSG00000187682), NKIRAS1 (ENSG00000197885), NRAS (ENSG00000213281), RASL10B (ENSG00000270885)

Protein

Protein identifiers

GTP-binding protein GEM — P55040 (reviewed: P55040)

Alternative names: GTP-binding mitogen-induced T-cell protein, RAS-like protein KIR

All UniProt accessions (2): E5RJF9, P55040

UniProt curated annotations — full annotation on UniProt →

Function. Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.

Subunit / interactions. Interacts with calmodulin in a Ca(2+)-dependent manner. Binds ROCK1.

Subcellular location. Cell membrane.

Tissue specificity. Most abundant in thymus, spleen, kidney, lung, and testis. Less abundant in heart, brain, liver and skeletal muscle.

Post-translational modifications. Phosphorylated on tyrosine residues.

Induction. By mitogens.

Similarity. Belongs to the small GTPase superfamily. RGK family.

RefSeq proteins (2): NP_005252, NP_859053 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001806	Small_GTPase	Family
IPR005225	Small_GTP-bd	Domain
IPR017358	RGK	Family
IPR027417	P-loop_NTPase	Homologous_superfamily
IPR051641	RGK_GTP-binding_reg	Family

Pfam: PF00071

UniProt features (28 total): helix 9, strand 6, region of interest 3, turn 3, binding site 2, sequence conflict 2, chain 1, compositionally biased region 1, sequence variant 1

Structure

Experimental structures (PDB)

3 structures.

PDB	Method	Resolution (Å)
2CJW	X-RAY DIFFRACTION	2.1
2G3Y	X-RAY DIFFRACTION	2.4
2HT6	X-RAY DIFFRACTION	2.4

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P55040-F1	72.50	0.42

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (2): 82–89; 191–194

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9768919	NPAS4 regulates expression of target genes

MSigDB gene sets: 461 (showing top): GSE45365_NK_CELL_VS_BCELL_UP, ATF_B, GOBP_CHROMOSOME_ORGANIZATION, MODULE_255, YAO_HOXA10_TARGETS_VIA_PROGESTERONE_UP, ENK_UV_RESPONSE_KERATINOCYTE_UP, GOBP_CHROMOSOME_LOCALIZATION, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, MODULE_317, CREBP1_Q2, SARRIO_EPITHELIAL_MESENCHYMAL_TRANSITION_DN, NAGASHIMA_NRG1_SIGNALING_UP, CAGCTG_AP4_Q5, GRANDVAUX_IRF3_TARGETS_DN

GO Biological Process (7): mitotic cell cycle (GO:0000278), immune response (GO:0006955), signal transduction (GO:0007165), cell surface receptor signaling pathway (GO:0007166), chromosome organization (GO:0051276), metaphase chromosome alignment (GO:0051310), negative regulation of high voltage-gated calcium channel activity (GO:1901842)

GO Molecular Function (8): magnesium ion binding (GO:0000287), GTPase activity (GO:0003924), calcium channel regulator activity (GO:0005246), calmodulin binding (GO:0005516), GTP binding (GO:0005525), GDP binding (GO:0019003), nucleotide binding (GO:0000166), protein binding (GO:0005515)

GO Cellular Component (7): nucleus (GO:0005634), plasma membrane (GO:0005886), cytoplasmic side of plasma membrane (GO:0009898), midbody (GO:0030496), spindle midzone (GO:0051233), mitotic spindle (GO:0072686), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Transcriptional Regulation by NPAS4	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
guanyl ribonucleotide binding	2
spindle	2
cell cycle	1
mitotic nuclear division	1
immune system process	1
response to stimulus	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
signal transduction	1
organelle organization	1
chromosome localization	1
nuclear chromosome segregation	1
high voltage-gated calcium channel activity	1
negative regulation of voltage-gated calcium channel activity	1
metal ion binding	1
ribonucleoside triphosphate phosphatase activity	1
calcium channel activity	1
ion channel regulator activity	1
protein binding	1
purine ribonucleoside triphosphate binding	1
anion binding	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
binding	1
intracellular membrane-bounded organelle	1
membrane	1
cell periphery	1
plasma membrane	1
cytoplasmic side of membrane	1

Protein interactions and networks

STRING

1905 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
GEM	KIF9	Q9HAQ2	911
GEM	KIR2DL1	P43626	562
GEM	GPATCH11	Q8N954	510
GEM	CALM1	P02593	477
GEM	CALML4	Q96GE6	472
GEM	CALML6	Q8TD86	460
GEM	CALML3	P27482	459
GEM	CALML5	Q9NZT1	459
GEM	HERC1	Q15751	426
GEM	KCNMA1	Q12791	403
GEM	SNX5	Q9Y5X3	349
GEM	MDN1	Q9NU22	339
GEM	MPP7	Q5T2T1	298
GEM	FHL1	Q13642	296
GEM	FRMPD2	Q68DX3	291

IntAct

435 interactions, top by confidence:

A	B	Type	Score
TRIM23	GEM	psi-mi:“MI:0915”(physical association)	0.820
TFIP11	GEM	psi-mi:“MI:0915”(physical association)	0.780
GEM	TFIP11	psi-mi:“MI:0915”(physical association)	0.780
PDLIM7	GEM	psi-mi:“MI:0915”(physical association)	0.740
GEM	AHCYL1	psi-mi:“MI:0915”(physical association)	0.720
GEM	TRIM27	psi-mi:“MI:0915”(physical association)	0.720
GEM	KRTAP10-7	psi-mi:“MI:0915”(physical association)	0.720
GOLGA2	GEM	psi-mi:“MI:0915”(physical association)	0.720
TRAF1	GEM	psi-mi:“MI:0915”(physical association)	0.720
KRT31	GEM	psi-mi:“MI:0915”(physical association)	0.720
KCTD9	GEM	psi-mi:“MI:0915”(physical association)	0.720
GEM	INO80E	psi-mi:“MI:0915”(physical association)	0.720
LZTS2	GEM	psi-mi:“MI:0915”(physical association)	0.720
GEM	BLZF1	psi-mi:“MI:0915”(physical association)	0.720
IKZF3	GEM	psi-mi:“MI:0915”(physical association)	0.720
AHCYL1	GEM	psi-mi:“MI:0915”(physical association)	0.720
GEM	GOLGA2	psi-mi:“MI:0915”(physical association)	0.720
GEM	TRAF1	psi-mi:“MI:0915”(physical association)	0.720
GEM	KCTD9	psi-mi:“MI:0915”(physical association)	0.720
INO80E	GEM	psi-mi:“MI:0915”(physical association)	0.720

BioGRID (164): GOLGA2 (Two-hybrid), KRT31 (Two-hybrid), TRIM27 (Two-hybrid), TCF4 (Two-hybrid), TRAF1 (Two-hybrid), BLZF1 (Two-hybrid), PNMA1 (Two-hybrid), AHCYL1 (Two-hybrid), RUNDC3A (Two-hybrid), IKZF3 (Two-hybrid), TFIP11 (Two-hybrid), KCTD9 (Two-hybrid), TRIM54 (Two-hybrid), CCDC102B (Two-hybrid), COG8 (Two-hybrid)

ESM2 similar proteins: A1DZY4, A6QP66, O35626, O35929, O88910, O88954, P0C0E4, P35295, P51157, P51158, P53667, P53668, P53669, P55040, P55041, P55043, P63032, P63033, Q06AU5, Q12829, Q13368, Q13637, Q3SWY9, Q5E9J3, Q5FVY2, Q5R541, Q5RFI2, Q6DGN0, Q6IMA3, Q6IMA7, Q6IMB1, Q6P0U3, Q6T310, Q8AVS6, Q8IYK8, Q8QFP8, Q8VEL9, Q8VHP8, Q8VHQ4, Q8WXH6

Diamond homologs: A1L1L6, F4J0W4, O59781, P0CO78, P0CO79, P31021, P34148, P34150, P39722, P55040, P55041, Q298L5, Q2HJF8, Q2UM43, Q32LU1, Q4I2W2, Q4PB75, Q4WN24, Q55G45, Q5ABR2, Q5B5L3, Q5E9M9, Q5R541, Q5ZM73, Q5ZM83, Q623S8, Q6C2J1, Q6CY37, Q6DIS1, Q6FIR8, Q6NVC5, Q758X6, Q7RZA2, Q7TSA0, Q864R5, Q8BG51, Q8IMX7, Q8IXI1, Q8IXI2, Q8JZN7

SIGNOR signaling

18 interactions.

A	Effect	B	Mechanism
GEM	“down-regulates activity”	CACNB2	binding
GEM	“down-regulates activity”	ROCK2	binding
CALM1	“up-regulates activity”	GEM	binding
CALM2	“up-regulates activity”	GEM	binding
CALM3	“up-regulates activity”	GEM	binding
YWHAG	“up-regulates quantity by stabilization”	GEM	binding
YWHAQ	“up-regulates quantity by stabilization”	GEM	binding
YWHAZ	“up-regulates quantity by stabilization”	GEM	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 88 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
intermediate filament organization	5	15.8×	9e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

49 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	34
Likely benign	2
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

1959 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
8:94250539:G:A	S221F	1.000
8:94250585:C:A	G206W	1.000
8:94250585:C:G	G206R	1.000
8:94250585:C:T	G206R	1.000
8:94252051:T:C	D194G	1.000
8:94252056:T:A	K192N	1.000
8:94252056:T:G	K192N	1.000
8:94252057:T:A	K192I	1.000
8:94252063:C:T	G190D	1.000
8:94252066:A:T	V189D	1.000
8:94252140:G:C	S164R	1.000
8:94252140:G:T	S164R	1.000
8:94252142:T:G	S164R	1.000
8:94252160:A:G	S158P	1.000
8:94260259:C:T	G82E	1.000
8:94260260:C:A	G82W	1.000
8:94250479:A:G	L241P	0.999
8:94250482:C:G	R240P	0.999
8:94250491:C:G	R237P	0.999
8:94250501:C:G	G234R	0.999
8:94250539:G:T	S221Y	0.999
8:94250540:A:G	S221P	0.999
8:94250550:G:C	F217L	0.999
8:94250550:G:T	F217L	0.999
8:94250552:A:G	F217L	0.999
8:94250556:G:C	C215W	0.999
8:94250557:C:T	C215Y	0.999
8:94250558:A:G	C215R	0.999
8:94250572:G:T	A210E	0.999
8:94250573:C:G	A210P	0.999

dbSNP variants (sampled 300 via entrez): RS1000203951 (8:94250109 C>A), RS1000230939 (8:94249230 G>A), RS1000328112 (8:94256293 TC>T), RS1000328441 (8:94262964 G>T), RS1000382830 (8:94262363 C>A,T), RS1000699755 (8:94256503 G>A), RS1000917685 (8:94261410 G>A,C,T), RS1001045851 (8:94255549 C>T), RS1001642594 (8:94258012 T>C), RS1001717806 (8:94258301 C>T), RS1001745189 (8:94261694 A>G,T), RS1001873012 (8:94252086 C>A,G,T), RS1002006318 (8:94261977 C>A), RS1002030620 (8:94264297 T>A,C), RS1002284407 (8:94251641 C>T)

Disease associations

OMIM: gene MIM:600164 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST004162_31	Carotid plaque burden	4.000000e-06
GCST005196_161	Coronary artery disease	1.000000e-06
GCST007269_224	Pulse pressure	5.000000e-11
GCST010866_131	Coronary artery disease	1.000000e-09

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0006501	carotid plaque build
EFO:0005763	pulse pressure measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

108 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Estradiol	affects cotreatment, increases expression, decreases expression, decreases reaction	6
bisphenol A	increases expression, affects cotreatment	4
Silicon Dioxide	increases expression	4
sodium arsenite	decreases expression, increases expression	3
Acetaminophen	increases expression, affects response to substance	3
Methotrexate	affects cotreatment, increases expression, decreases expression	3
Valproic Acid	affects expression, increases expression	3
Cyclosporine	increases expression	3
Aflatoxin B1	affects expression, increases expression	3
Asbestos, Crocidolite	affects expression, increases expression	3
trichostatin A	affects expression, decreases reaction, decreases expression, increases expression	2
torcetrapib	increases expression	2
(+)-JQ1 compound	affects cotreatment, affects expression, decreases expression	2
Benzo(a)pyrene	increases expression, increases methylation	2
Calcitriol	increases expression	2
Copper	decreases expression, increases expression, affects binding	2
Dexamethasone	decreases expression, affects cotreatment, increases expression	2
Doxorubicin	affects expression, decreases expression	2
Phenylmercuric Acetate	decreases expression, affects cotreatment	2
Tobacco Smoke Pollution	affects expression, increases expression	2
Cadmium Chloride	increases expression	2
Thapsigargin	increases expression	2
aristolochic acid I	increases expression	1
bisphenol F	affects cotreatment, increases expression	1
methylmercuric chloride	increases expression	1
methyleugenol	increases expression	1
senecionine	increases expression	1
senkirkine	increases expression	1
heliotrine	increases expression	1
2-methyl-4-isothiazolin-3-one	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.