GEMIN7

Summary

GEMIN7 (gem nuclear organelle associated protein 7, HGNC:20045) is a protein-coding gene on chromosome 19q13.32, encoding Gem-associated protein 7 (Q9H840). The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. It is a selective cancer dependency (DepMap: 84.9% of cell lines).

The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear “gems” (Gemini of Cajal bodies), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene.

Source: NCBI Gene 79760 — RefSeq curated summary.

At a glance

• GWAS associations: 10
• Clinical variants (ClinVar): 37 total
• Druggable target: yes
• Cancer dependency (DepMap): dependent in 84.9% of screened cell lines
• MANE Select transcript: NM_024707

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20045
Approved symbol	GEMIN7
Name	gem nuclear organelle associated protein 7
Location	19q13.32
Locus type	gene with protein product
Status	Approved
Aliases	FLJ13956
Ensembl gene	ENSG00000142252
Ensembl biotype	protein_coding
OMIM	607419
Entrez	79760

Gene structure

Transcript identifiers

Ensembl transcripts: 26 — 25 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000270257, ENST00000391951, ENST00000591607, ENST00000591747, ENST00000592351, ENST00000885624, ENST00000885625, ENST00000885626, ENST00000885627, ENST00000885628, ENST00000885629, ENST00000885630, ENST00000885631, ENST00000885632, ENST00000885633, ENST00000925297, ENST00000925298, ENST00000925299, ENST00000925300, ENST00000925301, ENST00000925302, ENST00000925303, ENST00000925304, ENST00000925305, ENST00000956990, ENST00000956991

RefSeq mRNA: 5 — MANE Select: NM_024707 NM_001007269, NM_001007270, NM_001319054, NM_001319055, NM_024707

CCDS: CCDS12654

Canonical transcript exons

ENST00000270257 — 3 exons

Exon	Start	End
ENSE00000953130	45090107	45091518
ENSE00001048656	45079907	45080029
ENSE00002974646	45079260	45079377

Expression profiles

Bgee: expression breadth ubiquitous, 214 present calls, max score 92.92.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.9815 / max 36.5861, expressed in 1435 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
176381	11.5652	1777
176379	1.5750	721
176382	1.3334	745
176380	0.8565	402
176383	0.2167	101

Top tissues by expression

249 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	92.92	gold quality
mucosa of transverse colon	UBERON:0004991	92.87	gold quality
granulocyte	CL:0000094	92.32	gold quality
ileal mucosa	UBERON:0000331	92.06	gold quality
tibialis anterior	UBERON:0001385	91.50	silver quality
monocyte	CL:0000576	90.56	gold quality
leukocyte	CL:0000738	90.33	gold quality
gastrocnemius	UBERON:0001388	89.84	gold quality
hindlimb stylopod muscle	UBERON:0004252	88.95	gold quality
muscle of leg	UBERON:0001383	88.87	gold quality
spleen	UBERON:0002106	88.74	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.89	gold quality
right lobe of liver	UBERON:0001114	87.81	gold quality
body of stomach	UBERON:0001161	87.50	gold quality
esophagus mucosa	UBERON:0002469	87.49	gold quality
skeletal muscle organ	UBERON:0014892	87.49	gold quality
apex of heart	UBERON:0002098	87.01	gold quality
small intestine Peyer’s patch	UBERON:0003454	86.33	gold quality
transverse colon	UBERON:0001157	86.28	gold quality
adenohypophysis	UBERON:0002196	86.27	gold quality
skin of leg	UBERON:0001511	86.25	gold quality
heart left ventricle	UBERON:0002084	86.18	gold quality
skin of abdomen	UBERON:0001416	86.16	gold quality
lymph node	UBERON:0000029	85.86	gold quality
cardiac ventricle	UBERON:0002082	85.74	gold quality
blood	UBERON:0000178	84.99	gold quality
esophagus	UBERON:0001043	84.88	gold quality
right hemisphere of cerebellum	UBERON:0014890	84.81	gold quality
pituitary gland	UBERON:0000007	84.74	gold quality
vermiform appendix	UBERON:0001154	84.67	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	10.19

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

28 targeting GEMIN7, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6783-3P	99.89	67.92	2059
HSA-MIR-4779	99.86	66.50	1583
HSA-MIR-4306	99.72	70.50	3630
HSA-MIR-3609	99.52	69.89	2587
HSA-MIR-548AH-5P	99.52	69.73	2626
HSA-MIR-3923	99.52	69.21	446
HSA-MIR-4677-3P	99.49	67.91	1246
HSA-MIR-185-5P	99.35	68.60	2497
HSA-MIR-4644	99.35	69.12	2514
HSA-MIR-3160-5P	99.28	69.07	1938
HSA-MIR-4695-5P	99.06	64.87	1151
HSA-MIR-1294	98.91	69.26	1030
HSA-MIR-9986	98.91	69.28	1024
HSA-MIR-6868-3P	98.63	69.64	2259
HSA-MIR-374B-3P	98.63	68.24	1360
HSA-MIR-3188	98.58	65.60	878
HSA-MIR-4266	98.53	67.29	1035
HSA-MIR-6730-5P	98.03	68.12	1299
HSA-MIR-5681A	97.99	67.17	1658
HSA-MIR-3652	97.71	65.43	1890
HSA-MIR-665	97.60	65.64	1781
HSA-MIR-450B-3P	97.56	66.12	512
HSA-MIR-4430	97.47	65.61	1813
HSA-MIR-148B-5P	97.29	66.30	992
HSA-MIR-6874-3P	97.29	66.34	975
HSA-MIR-769-3P	97.06	64.83	464
HSA-MIR-4793-5P	96.88	65.90	872
HSA-MIR-7706	95.96	63.68	172

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 84.9% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 3)

• Identification and characterization a novel protein component of the survival of motor neurons complex termed Gemin7 using native purified SMN complexes and peptide sequencing by mass spectrometry (PMID:12065586)
• Unrip is recruited to the active SMN complex via a stable interaction with Gemin7 (PMID:16159890)
• Gemin8 has an essential role in the proper structural organization of the SMN complex and the involvement of the heteromeric subunit containing Gemin6, Gemin7, Gemin8, and Unrip in the recruitment of Sm proteins to the snRNP assembly pathway (PMID:17023415)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	gemin7	ENSDARG00000041011
mus_musculus	Gemin7	ENSMUSG00000044709
rattus_norvegicus	Gemin7l1	ENSRNOG00000034168
rattus_norvegicus	Gemin7	ENSRNOG00000049772
caenorhabditis_elegans		WBGENE00007702

Protein

Protein identifiers

Gem-associated protein 7 — Q9H840 (reviewed: Q9H840)

Alternative names: SIP3

All UniProt accessions (1): Q9H840

UniProt curated annotations — full annotation on UniProt →

Function. The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP.

Subunit / interactions. Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG. Interacts with GEMIN6; the interaction is direct. Interacts with STRAP/UNRIP; the interaction is direct. Interacts with GEMIN8; the interaction is direct. Interacts with SNRPB, SNRPD2, SNRPD3 and SNRPE; the interaction is direct.

Subcellular location. Nucleus. Nucleoplasm. Gem. Cytoplasm.

Similarity. Belongs to the gemin-7 family.

RefSeq proteins (5): NP_001007270, NP_001007271, NP_001305983, NP_001305984, NP_078983* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR020338	SMN_gemin7	Family
IPR024642	SUZ-C	Domain
IPR047575	Sm	Domain

Pfam: PF11095

UniProt features (15 total): strand 6, helix 3, domain 2, modified residue 2, chain 1, turn 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
7BBL	X-RAY DIFFRACTION	1.52
1Y96	X-RAY DIFFRACTION	2

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H840-F1	80.43	0.57

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 1, 3

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-191859	snRNP Assembly
R-HSA-9754678	SARS-CoV-2 modulates host translation machinery

MSigDB gene sets: 114 (showing top): GSE45365_NK_CELL_VS_CD8A_DC_DN, MODULE_255, RORA1_01, ROVERSI_GLIOMA_COPY_NUMBER_UP, MODULE_317, TGACCTY_ERR1_Q2, GGGTGGRR_PAX4_03, MUELLER_PLURINET, KOYAMA_SEMA3B_TARGETS_UP, MODULE_480, GOBP_PROTEIN_RNA_COMPLEX_ORGANIZATION, GOBP_RNA_SPLICING, OCT1_06, GOBP_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS, GOBP_SPLICEOSOMAL_SNRNP_ASSEMBLY

GO Biological Process (4): spliceosomal snRNP assembly (GO:0000387), mRNA splicing, via spliceosome (GO:0000398), mRNA processing (GO:0006397), RNA splicing (GO:0008380)

GO Molecular Function (2): RNA binding (GO:0003723), protein binding (GO:0005515)

GO Cellular Component (9): nucleoplasm (GO:0005654), cytoplasm (GO:0005737), cytosol (GO:0005829), nuclear body (GO:0016604), SMN complex (GO:0032797), SMN-Sm protein complex (GO:0034719), Gemini of Cajal bodies (GO:0097504), Sm-like protein family complex (GO:0120114), nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Metabolism of non-coding RNA	1
SARS-CoV-2-host interactions	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
RNA processing	2
cytoplasm	2
Sm-like protein family complex	2
mRNA splicing, via spliceosome	1
protein-RNA complex assembly	1
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	1
mRNA processing	1
mRNA metabolic process	1
nucleic acid binding	1
binding	1
nuclear lumen	1
intracellular anatomical structure	1
nucleoplasm	1
intracellular membraneless organelle	1
SMN-Sm protein complex	1
SMN complex	1
nuclear body	1
protein-containing complex	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

698 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
GEMIN7	GEMIN2	O14893	993
GEMIN7	GEMIN6	Q8WXD5	993
GEMIN7	STRAP	Q9Y3F4	974
GEMIN7	GEMIN8	Q9NWZ8	968
GEMIN7	DDX20	Q9UHI6	943
GEMIN7	GEMIN5	Q8TEQ6	937
GEMIN7	GEMIN4	P57678	881
GEMIN7	CSDE1	O75534	782
GEMIN7	SNRPE	P08578	682
GEMIN7	SMN1	Q16637	675
GEMIN7	SNRPB	P14678	584
GEMIN7	HNRNPR	O43390	561
GEMIN7	PHAX	Q9H814	548
GEMIN7	SNRPD3	P43331	534
GEMIN7	COIL	P38432	533

IntAct

81 interactions, top by confidence:

A	B	Type	Score
GEMIN6	GEMIN7	psi-mi:“MI:0915”(physical association)	0.960
GEMIN7	GEMIN6	psi-mi:“MI:0915”(physical association)	0.960
GEMIN6	GEMIN7	psi-mi:“MI:0407”(direct interaction)	0.960
SMN1	GEMIN2	psi-mi:“MI:0914”(association)	0.960
SNRPF	GEMIN2	psi-mi:“MI:0914”(association)	0.910
STK24	STRN	psi-mi:“MI:0914”(association)	0.870
SNRPE	GEMIN2	psi-mi:“MI:0914”(association)	0.770
GEMIN7	STRAP	psi-mi:“MI:0407”(direct interaction)	0.760
STRAP	GEMIN7	psi-mi:“MI:0407”(direct interaction)	0.760
GEMIN7	SNRNP70	psi-mi:“MI:0914”(association)	0.730
GEMIN4	SNRNP70	psi-mi:“MI:0914”(association)	0.730
NCKIPSD	GEMIN2	psi-mi:“MI:0914”(association)	0.640
SNRNP70	GEMIN2	psi-mi:“MI:0914”(association)	0.640
STRAP	CDK2AP1	psi-mi:“MI:0914”(association)	0.530
DDX20	GAPDHS	psi-mi:“MI:0914”(association)	0.530
SNRNP70	GTPBP1	psi-mi:“MI:0914”(association)	0.530
SNRPE	PRMT5	psi-mi:“MI:0914”(association)	0.530
GEMIN7	GEMIN2	psi-mi:“MI:0914”(association)	0.530

BioGRID (118): GEMIN6 (Two-hybrid), GEMIN6 (Two-hybrid), GEMIN6 (Two-hybrid), CSNK1D (Affinity Capture-MS), EZH2 (Affinity Capture-MS), ITGB4 (Affinity Capture-MS), SMN1 (Affinity Capture-MS), SNRNP70 (Affinity Capture-MS), SNRPD1 (Affinity Capture-MS), GEMIN2 (Affinity Capture-MS), FARP1 (Affinity Capture-MS), RCL1 (Affinity Capture-MS), YME1L1 (Affinity Capture-MS), STRAP (Affinity Capture-MS), DDX20 (Affinity Capture-MS)

ESM2 similar proteins: A2BIG9, A4IGZ4, B0R0W9, B4H303, B7PXE3, D3ZEY4, G2TRR1, H9JD76, O15116, O74499, O75912, P0C550, P23059, P32019, P33279, P47017, P53905, P87173, Q03606, Q0JKV1, Q17QA0, Q17QV9, Q4R8E0, Q52T38, Q58DC8, Q5E9Z8, Q5ZK92, Q6AZT2, Q6GQ67, Q6NU60, Q6NW58, Q6P5D3, Q8IPZ7, Q8K337, Q8LFL8, Q8VC85, Q945P8, Q96P47, Q96S15, Q9BRA0

Diamond homologs: Q17QA0, Q9CWY4, Q9H840, G2TRR1

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
GEMIN7	“form complex”	“SMN complex”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 69 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Metabolism of non-coding RNA	5	64.7×	1e-06
snRNP Assembly	12	51.8×	1e-15
SARS-CoV-2 modulates host translation machinery	10	45.7×	2e-12
Metabolism of RNA	7	6.0×	7e-03

GO biological processes:

GO term	Partners	Fold	FDR
spliceosomal snRNP assembly	13	121.8×	2e-22
spliceosomal complex assembly	5	48.5×	1e-05
mRNA splicing, via spliceosome	6	8.9×	7e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

37 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	29
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

517 predictions. Top by Δscore:

Variant	Effect	Δscore
19:45075711:A:AC	donor_gain	1.0000
19:45075711:AC:A	donor_gain	1.0000
19:45075711:ACC:A	donor_loss	1.0000
19:45075712:C:CC	donor_gain	1.0000
19:45075712:CC:C	donor_gain	1.0000
19:45075712:CCT:C	donor_gain	1.0000
19:45075712:CCTG:C	donor_gain	1.0000
19:45075859:CGGT:C	acceptor_gain	1.0000
19:45075860:GGT:G	acceptor_gain	1.0000
19:45075861:GT:G	acceptor_gain	1.0000
19:45075862:TCT:T	acceptor_loss	1.0000
19:45075863:C:CC	acceptor_gain	1.0000
19:45075863:CTGCA:C	acceptor_loss	1.0000
19:45090098:A:AG	acceptor_gain	1.0000
19:45090099:C:G	acceptor_gain	1.0000
19:45090102:A:AG	acceptor_gain	1.0000
19:45090105:A:AG	acceptor_gain	1.0000
19:45090105:A:AT	acceptor_loss	1.0000
19:45090106:G:GG	acceptor_gain	1.0000
19:45090106:GC:G	acceptor_gain	1.0000
19:45090106:GCC:G	acceptor_gain	1.0000
19:45090106:GCCA:G	acceptor_gain	1.0000
19:45090106:GCCAA:G	acceptor_gain	1.0000
19:45075708:CTCA:C	donor_gain	0.9900
19:45075712:CCTGA:C	donor_gain	0.9900
19:45075858:GCGGT:G	acceptor_gain	0.9900
19:45075859:CGGTC:C	acceptor_gain	0.9900
19:45075861:GTCT:G	acceptor_gain	0.9900
19:45075862:TCTGC:T	acceptor_gain	0.9900
19:45075866:C:CT	acceptor_gain	0.9900

AlphaMissense

830 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:45090353:T:C	F80S	0.994
19:45090470:T:A	L119H	0.991
19:45090319:A:C	S69R	0.989
19:45090321:C:A	S69R	0.989
19:45090321:C:G	S69R	0.989
19:45090434:T:C	L107P	0.989
19:45090419:T:C	F102S	0.988
19:45090187:T:C	F25L	0.986
19:45090189:T:A	F25L	0.986
19:45090189:T:G	F25L	0.986
19:45090310:T:G	Y66D	0.986
19:45090425:T:A	V104E	0.985
19:45090463:G:C	A117P	0.985
19:45090482:A:T	D123V	0.985
19:45090314:T:C	L67P	0.983
19:45090493:T:G	Y127D	0.982
19:45090434:T:A	L107Q	0.981
19:45090389:T:C	F92S	0.980
19:45090449:G:A	G112D	0.976
19:45090470:T:C	L119P	0.975
19:45090482:A:C	D123A	0.975
19:45090481:G:C	D123H	0.974
19:45090483:C:A	D123E	0.974
19:45090483:C:G	D123E	0.974
19:45090383:C:A	A90D	0.973
19:45090464:C:A	A117E	0.973
19:45090482:A:G	D123G	0.973
19:45090470:T:G	L119R	0.972
19:45090473:G:C	R120P	0.972
19:45090311:A:C	Y66S	0.971

dbSNP variants (sampled 300 via entrez): RS1000032922 (19:45073654 G>A), RS1000132736 (19:45079173 A>G), RS1000141476 (19:45077508 G>T), RS1000363910 (19:45083598 T>C), RS1000545230 (19:45083060 T>C,G), RS1000612333 (19:45089514 G>C), RS1000646217 (19:45083762 G>A), RS1000657357 (19:45078132 A>C,G), RS1000740619 (19:45084118 C>G,T), RS1001351208 (19:45078797 G>A), RS1001430582 (19:45074869 G>A,C), RS1001540621 (19:45078370 G>A,C), RS1001589249 (19:45086482 A>G), RS1001634573 (19:45089009 T>G), RS1001832017 (19:45083318 G>A)

Disease associations

OMIM: gene MIM:607419 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

10 associations (top):

Study	Trait	p-value
GCST004069_16	Cerebrospinal fluid AB1-42 levels	6.000000e-10
GCST005950_15	Body mass index x sex x age interaction (4df test)	2.000000e-10
GCST005951_56	Body mass index	1.000000e-06
GCST005952_8	Body mass index (age>50)	9.000000e-12
GCST005954_4	Body mass index x age interaction	2.000000e-07
GCST007320_89	Alzheimer’s disease or family history of Alzheimer’s disease	1.000000e-08
GCST007827_13	Alzheimer’s disease or HDL levels (pleiotropy)	7.000000e-22
GCST007827_3	Alzheimer’s disease or HDL levels (pleiotropy)	1.000000e-97
GCST007827_5	Alzheimer’s disease or HDL levels (pleiotropy)	7.000000e-74
GCST007827_8	Alzheimer’s disease or HDL levels (pleiotropy)	3.000000e-36

EFO canonical traits (6, from GWAS)

EFO ID	Trait name
EFO:0004670	beta-amyloid 1-42 measurement
EFO:0004340	body mass index
EFO:0008007	age at assessment
EFO:0008343	sex interaction measurement
EFO:0009268	family history of Alzheimer’s disease
EFO:0004612	high density lipoprotein cholesterol measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4105841 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

21 total (human), top 21 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
GSK-J4	decreases expression	1
FR900359	increases phosphorylation	1
sodium arsenite	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
Grape Seed Proanthocyanidins	affects cotreatment, decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Leflunomide	decreases expression	1
Benzo(a)pyrene	decreases methylation	1
Catechin	affects cotreatment, decreases expression	1
Ethyl Methanesulfonate	decreases expression	1
Gallic Acid	decreases expression	1
Ivermectin	decreases expression	1
Methyl Methanesulfonate	decreases expression	1
Plant Extracts	affects cotreatment, increases expression	1
Smoke	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Valproic Acid	increases expression	1
Cadmium Chloride	decreases expression	1
Copper Sulfate	decreases expression	1
Lactic Acid	decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4012567	Binding	Binding affinity to GEMIN7 in human INA-6 cells after 3 hrs by nanoLC-MS/MS method	Ugi Reaction-Derived α-Acyl Aminocarboxamides Bind to Phosphatidylinositol 3-Kinase-Related Kinases, Inhibit HSF1-Dependent Heat Shock Response, and Induce Apoptosis in Multiple Myeloma Cells. — J Med Chem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.