GGT7

Summary

GGT7 (gamma-glutamyltransferase 7, HGNC:4259) is a protein-coding gene on chromosome 20q11.22, encoding Glutathione hydrolase 7 (Q9UJ14). Hydrolyzes and transfers gamma-glutamyl moieties from glutathione and other gamma-glutamyl compounds to acceptors.

This gene is a member of a gene family that encodes enzymes involved in both the metabolism of glutathione and in the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene consists of a heavy and a light chain, and it can interact with CT120, a plasma membrane-associated protein that is possibly involved in lung carcinogenesis.

Source: NCBI Gene 2686 — RefSeq curated summary.

At a glance

• GWAS associations: 9
• Clinical variants (ClinVar): 103 total
• Druggable target: yes
• MANE Select transcript: NM_178026

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:4259
Approved symbol	GGT7
Name	gamma-glutamyltransferase 7
Location	20q11.22
Locus type	gene with protein product
Status	Approved
Aliases	D20S101, dJ18C9.2
Ensembl gene	ENSG00000131067
Ensembl biotype	protein_coding
OMIM	612342
Entrez	2686

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 13 protein_coding, 1 nonsense_mediated_decay

ENST00000336431, ENST00000427420, ENST00000469018, ENST00000470952, ENST00000885988, ENST00000885989, ENST00000885990, ENST00000885991, ENST00000885992, ENST00000885993, ENST00000885994, ENST00000916019, ENST00000916020, ENST00000916021

RefSeq mRNA: 2 — MANE Select: NM_178026 NM_001351702, NM_178026

CCDS: CCDS13242

Canonical transcript exons

ENST00000336431 — 15 exons

Exon	Start	End
ENSE00001630039	34859969	34860042
ENSE00001652470	34863313	34863548
ENSE00001663829	34860254	34860321
ENSE00001712832	34844720	34845491
ENSE00001715119	34854531	34854619
ENSE00001722304	34852389	34852538
ENSE00001737341	34859443	34859639
ENSE00001764330	34856806	34856893
ENSE00001791460	34861445	34861562
ENSE00001806527	34854796	34854923
ENSE00001919755	34872647	34872856
ENSE00003560714	34849961	34850060
ENSE00003626044	34852155	34852272
ENSE00003688917	34851231	34851368
ENSE00003785877	34862814	34862965

Expression profiles

Bgee: expression breadth ubiquitous, 228 present calls, max score 97.44.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 9.0935 / max 109.0096, expressed in 1650 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
187007	8.4271	1638
187008	0.5802	316
187005	0.0624	11
187006	0.0238	8

Top tissues by expression

251 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	97.44	gold quality
cerebellar hemisphere	UBERON:0002245	97.34	gold quality
cerebellar cortex	UBERON:0002129	97.20	gold quality
cerebellum	UBERON:0002037	96.25	gold quality
adenohypophysis	UBERON:0002196	96.19	gold quality
apex of heart	UBERON:0002098	95.71	gold quality
right frontal lobe	UBERON:0002810	95.61	gold quality
pituitary gland	UBERON:0000007	95.15	gold quality
right lobe of thyroid gland	UBERON:0001119	94.71	gold quality
Brodmann (1909) area 9	UBERON:0013540	94.69	gold quality
left lobe of thyroid gland	UBERON:0001120	94.15	gold quality
gastrocnemius	UBERON:0001388	93.84	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	93.33	gold quality
mucosa of stomach	UBERON:0001199	93.25	gold quality
cardiac muscle of right atrium	UBERON:0003379	93.11	gold quality
body of pancreas	UBERON:0001150	93.04	gold quality
anterior cingulate cortex	UBERON:0009835	92.91	gold quality
thyroid gland	UBERON:0002046	92.89	gold quality
metanephros cortex	UBERON:0010533	92.81	gold quality
muscle of leg	UBERON:0001383	92.80	gold quality
hypothalamus	UBERON:0001898	92.68	gold quality
body of stomach	UBERON:0001161	92.58	gold quality
right uterine tube	UBERON:0001302	92.51	gold quality
nasal cavity epithelium	UBERON:0005384	92.43	silver quality
right coronary artery	UBERON:0001625	92.32	gold quality
prefrontal cortex	UBERON:0000451	92.22	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	92.16	gold quality
right ovary	UBERON:0002118	92.10	gold quality
ascending aorta	UBERON:0001496	92.06	gold quality
thoracic aorta	UBERON:0001515	92.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.55

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

53 targeting GGT7, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-8082	99.95	67.27	1170
HSA-MIR-450B-5P	99.92	71.48	3175
HSA-MIR-145-5P	99.92	71.13	1836
HSA-MIR-5195-3P	99.92	70.92	1877
HSA-MIR-3180-5P	99.82	69.12	2422
HSA-MIR-4639-5P	99.81	67.37	1028
HSA-MIR-204-5P	99.79	71.62	2439
HSA-MIR-211-5P	99.79	71.65	2440
HSA-MIR-4319	99.76	69.83	2586
HSA-MIR-4446-5P	99.72	69.19	2544
HSA-MIR-1296-3P	99.72	64.04	636
HSA-MIR-4755-5P	99.71	70.34	2716
HSA-MIR-5006-3P	99.71	70.26	2728
HSA-MIR-518A-5P	99.70	69.01	2209
HSA-MIR-527	99.70	69.01	2209
HSA-MIR-7-5P	99.67	70.53	1809
HSA-MIR-6716-5P	99.56	68.62	1244
HSA-MIR-671-5P	99.52	67.11	1277
HSA-MIR-4708-3P	99.51	67.99	870
HSA-MIR-125A-5P	99.36	70.59	1640
HSA-MIR-125B-5P	99.36	70.36	1662
HSA-MIR-4505	99.27	67.81	2678
HSA-MIR-5787	99.22	67.86	2628
HSA-MIR-6852-5P	99.17	66.69	2073
HSA-MIR-6506-5P	99.04	65.66	1386
HSA-MIR-622	98.99	66.48	1050
HSA-MIR-6770-5P	98.97	66.76	1853
HSA-MIR-6871-5P	98.90	66.67	671

Literature-anchored findings (GeneRIF, showing 5)

• GGTL3 protein interacts with CT120, a plasma membrane-associated protein possibly involved in lung carcinogenesis. (PMID:12270127)
• Our study demonstrates that GGT7 is a novel player in GBM growth and that GGT7 can play a critical role in tumorigenesis by regulating anti-oxidative damage. (PMID:25884624)
• A genome-wide association study identifies novel association between genetic variants in GGT7 and LINC00944 and hypertension. (PMID:34047475)
• [The role of polymorphic variants rs11546155 and rs6119534 of the GGT7 gene and risk factors in the development of acute pancreatitis]. (PMID:35596634)
• Gamma-glutamyltransferase 7 suppresses gastric cancer by cooperating with RAB7 to induce mitophagy. (PMID:35662282)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	GGT7	ENSDARG00000115805
mus_musculus	Ggt7	ENSMUSG00000027603
rattus_norvegicus	Ggt7	ENSRNOG00000018441
drosophila_melanogaster	CG17636	FBGN0025837
drosophila_melanogaster	Ggt-1	FBGN0030932

Paralogs (6): GGT5 (ENSG00000099998), GGT1 (ENSG00000100031), GGTLC2 (ENSG00000100121), GGTLC1 (ENSG00000149435), GGT6 (ENSG00000167741), GGTLC3 (ENSG00000274252)

Protein

Protein identifiers

Glutathione hydrolase 7 — Q9UJ14 (reviewed: Q9UJ14)

Alternative names: Gamma-glutamyltransferase 7, Gamma-glutamyltransferase-like 3, Gamma-glutamyltransferase-like 5, Gamma-glutamyltranspeptidase 7

All UniProt accessions (4): Q9UJ14, A0A0D9SF08, A0A0D9SFH0, A2A2G5

UniProt curated annotations — full annotation on UniProt →

Function. Hydrolyzes and transfers gamma-glutamyl moieties from glutathione and other gamma-glutamyl compounds to acceptors.

Subunit / interactions. Interacts with TLCD3A. Heterodimer composed of the light and heavy chains. The active site is located in the light chain.

Subcellular location. Membrane.

Tissue specificity. Widely expressed, but at low level, except in the airway epithelial cells. Detected in brain, heart, kidney, liver, lung, spleen, testis and trachea.

Post-translational modifications. Cleaved by autocatalysis into a large and a small subunit and the autocatalytic cleavage is essential to the functional activation of the enzyme.

Pathway. Sulfur metabolism; glutathione metabolism.

Similarity. Belongs to the gamma-glutamyltransferase family.

Isoforms (4)

UniProt ID	Names	Canonical?
Q9UJ14-1	1, a	yes
Q9UJ14-4	2
Q9UJ14-5	3, GGTL3B, B
Q9UJ14-6	4

RefSeq proteins (2): NP_001338631, NP_821158* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000101	GGT_peptidase	Family
IPR029055	Ntn_hydrolases_N	Homologous_superfamily
IPR043137	GGT_ssub_C	Homologous_superfamily
IPR043138	GGT_lsub	Homologous_superfamily

Pfam: PF01019

Catalyzed reactions (Rhea), 3 shown:

• an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide] (RHEA:23904)
• glutathione + H2O = L-cysteinylglycine + L-glutamate (RHEA:28807)
• an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate (RHEA:59468)

UniProt features (30 total): glycosylation site 10, splice variant 8, modified residue 4, chain 2, topological domain 2, sequence conflict 1, transmembrane region 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9UJ14-F1	85.00	0.72

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (4): 83, 17, 72, 79

Glycosylation sites (10): 198, 267, 283, 330, 353, 394, 452, 519, 523, 586

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-174403	Glutathione synthesis and recycling
R-HSA-5423646	Aflatoxin activation and detoxification
R-HSA-9753281	Paracetamol ADME

MSigDB gene sets: 146 (showing top): GSE45365_CD8A_DC_VS_CD11B_DC_IFNAR_KO_MCMV_INFECTION_UP, REACTOME_BIOLOGICAL_OXIDATIONS, NIKOLSKY_BREAST_CANCER_20Q11_AMPLICON, GOBP_MODIFIED_AMINO_ACID_CATABOLIC_PROCESS, DARWICHE_PAPILLOMA_PROGRESSION_RISK, GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS, GOBP_LEUKOTRIENE_BIOSYNTHETIC_PROCESS, GOBP_ORGANIC_ACID_BIOSYNTHETIC_PROCESS, GOBP_PEPTIDE_METABOLIC_PROCESS, GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS, GOBP_SULFUR_COMPOUND_BIOSYNTHETIC_PROCESS, GOBP_SULFUR_COMPOUND_CATABOLIC_PROCESS, KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM, GOBP_AMIDE_METABOLIC_PROCESS, GOBP_NONRIBOSOMAL_PEPTIDE_BIOSYNTHETIC_PROCESS

GO Biological Process (5): glutathione biosynthetic process (GO:0006750), glutathione catabolic process (GO:0006751), leukotriene D4 biosynthetic process (GO:1901750), negative regulation of response to oxidative stress (GO:1902883), glutathione metabolic process (GO:0006749)

GO Molecular Function (6): glutathione gamma-glutamate hydrolase (GO:0036374), obsolete leukotriene C4 gamma-glutamyl transferase activity (GO:0103068), protein binding (GO:0005515), transferase activity (GO:0016740), acyltransferase activity (GO:0016746), hydrolase activity (GO:0016787)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Glutathione conjugation	1
Biological oxidations	1
Drug ADME	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
glutathione metabolic process	2
sulfur compound biosynthetic process	2
catalytic activity	2
nonribosomal peptide biosynthetic process	1
modified amino acid biosynthetic process	1
modified amino acid catabolic process	1
sulfur compound catabolic process	1
leukotriene biosynthetic process	1
fatty acid derivative biosynthetic process	1
response to oxidative stress	1
negative regulation of response to stimulus	1
regulation of response to oxidative stress	1
modified amino acid metabolic process	1
sulfur compound metabolic process	1
omega peptidase activity	1
threonine-type peptidase activity	1
binding	1
transferase activity	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1046 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
GGT7	TLCD3A	Q8TBR7	927
GGT7	ALPG	P10696	767
GGT7	GOT1L1	Q8NHS2	710
GGT7	SLC3A2	P08195	671
GGT7	ALPI	P09923	657
GGT7	GOT1	P17174	656
GGT7	ALPP	P05187	651
GGT7	LDHAL6B	Q9BYZ2	626
GGT7	NPEPPS	P55786	626
GGT7	LDHAL6A	Q6ZMR3	624
GGT7	LDHC	P07864	607
GGT7	ALPL	P05186	591
GGT7	GPT	P24298	508
GGT7	GOT2	P00505	503
GGT7	SACK1C	Q9BQN1	496

IntAct

145 interactions, top by confidence:

A	B	Type	Score
GGT7	LHFPL5	psi-mi:“MI:0915”(physical association)	0.890
LHFPL5	GGT7	psi-mi:“MI:0915”(physical association)	0.890
TUSC3	RPN2	psi-mi:“MI:0914”(association)	0.730
GGT7	GPR25	psi-mi:“MI:0915”(physical association)	0.720
GGT7	MALL	psi-mi:“MI:0915”(physical association)	0.720
GGT7	TMEM242	psi-mi:“MI:0915”(physical association)	0.720
TMEM242	GGT7	psi-mi:“MI:0915”(physical association)	0.720
MALL	GGT7	psi-mi:“MI:0915”(physical association)	0.720
GPR25	GGT7	psi-mi:“MI:0915”(physical association)	0.720
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
IFT27	IFT56	psi-mi:“MI:0914”(association)	0.690
LNPEP	GGT7	psi-mi:“MI:0915”(physical association)	0.560
CLDN19	GGT7	psi-mi:“MI:0915”(physical association)	0.560
SLC35A4	GGT7	psi-mi:“MI:0915”(physical association)	0.560
TSPO2	GGT7	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (169): GPR25 (Two-hybrid), MALL (Two-hybrid), LHFPL5 (Two-hybrid), TMEM242 (Two-hybrid), GGT7 (Two-hybrid), NAALAD2 (Affinity Capture-MS), GGT7 (Affinity Capture-MS), PIGB (Affinity Capture-MS), GGT7 (Affinity Capture-MS), ALG12 (Affinity Capture-MS), GGT7 (Affinity Capture-MS), DDX11 (Affinity Capture-MS), MANEA (Affinity Capture-MS), POMT1 (Affinity Capture-MS), FAM69A (Affinity Capture-MS)

ESM2 similar proteins: A6NGU5, B5MD39, B6EWW8, D4B387, F8S0Z7, O35409, O77564, P07314, P07686, P0DPU3, P0DPU6, P15693, P17439, P19111, P19440, P20735, P21588, P24822, P24823, P36268, P36269, P49614, P58242, P70627, Q04609, Q05927, Q0V8L2, Q14390, Q29548, Q2KHZ8, Q501L1, Q5RFI5, Q5RFU0, Q5TYS5, Q5XIG6, Q60928, Q680I5, Q68FH4, Q6DH69, Q6GMR7

Diamond homologs: A6NGU5, B5MD39, B8NM71, D4B387, O14194, P07314, P0DPU3, P0DPU6, P18956, P19440, P20735, P36267, P36268, P36269, P54422, P63186, Q05902, Q0V8L2, Q14390, Q60928, Q680I5, Q8VYW6, Q99JP7, Q99MZ4, Q9BX51, Q9CAR5, Q9I406, Q9M0G0, Q9QWE9, Q9UJ14, Q9US04, Q9Z2A9, A7YWM1, Q6IE08, Q6P531, Q6PDE7, P15557, Q05053, Q51693, A6T9C8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

103 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	90
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

3034 predictions. Top by Δscore:

Variant	Effect	Δscore
20:34849959:A:AC	donor_gain	1.0000
20:34849960:C:CT	donor_gain	1.0000
20:34852269:GGAG:G	acceptor_gain	1.0000
20:34852273:C:CC	acceptor_gain	1.0000
20:34852392:A:C	donor_gain	1.0000
20:34852535:CTTG:C	acceptor_gain	1.0000
20:34852536:TTG:T	acceptor_gain	1.0000
20:34852537:TG:T	acceptor_gain	1.0000
20:34852539:C:CC	acceptor_gain	1.0000
20:34854526:CCCA:C	donor_loss	1.0000
20:34854527:CCAC:C	donor_loss	1.0000
20:34854528:CA:C	donor_loss	1.0000
20:34854529:A:AT	donor_loss	1.0000
20:34854530:C:CA	donor_loss	1.0000
20:34854617:GGT:G	acceptor_gain	1.0000
20:34854618:GT:G	acceptor_gain	1.0000
20:34854618:GTCT:G	acceptor_loss	1.0000
20:34854619:TC:T	acceptor_loss	1.0000
20:34854620:C:CC	acceptor_gain	1.0000
20:34854621:T:G	acceptor_loss	1.0000
20:34854626:A:C	acceptor_gain	1.0000
20:34854630:A:T	acceptor_gain	1.0000
20:34854790:CCTTA:C	donor_loss	1.0000
20:34854791:CTTA:C	donor_loss	1.0000
20:34854792:TTACC:T	donor_loss	1.0000
20:34854793:TA:T	donor_loss	1.0000
20:34854795:C:T	donor_loss	1.0000
20:34854795:CCT:C	donor_gain	1.0000
20:34859439:TTAC:T	donor_loss	1.0000
20:34859440:TA:T	donor_loss	1.0000

AlphaMissense

4262 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
20:34863365:G:T	A118D	0.999
20:34863378:A:G	C114R	0.999
20:34863356:A:T	V121D	0.998
20:34863359:C:T	G120D	0.998
20:34863360:C:G	G120R	0.998
20:34863380:G:T	A113D	0.998
20:34863347:G:T	A124E	0.997
20:34850016:G:C	S590R	0.996
20:34850016:G:T	S590R	0.996
20:34850018:T:G	S590R	0.996
20:34863344:A:G	L125P	0.996
20:34863366:C:G	A118P	0.996
20:34863374:A:G	L115P	0.996
20:34863386:A:T	V111D	0.996
20:34863381:C:G	A113P	0.995
20:34863389:A:T	I110N	0.995
20:34852215:G:C	N509K	0.994
20:34852215:G:T	N509K	0.994
20:34852216:T:A	N509I	0.993
20:34852420:C:G	G480R	0.993
20:34852420:C:T	G480R	0.993
20:34862852:A:C	C173W	0.993
20:34862854:A:G	C173R	0.993
20:34862924:G:C	C149W	0.993
20:34863341:A:T	V126D	0.993
20:34863367:G:C	F117L	0.993
20:34863367:G:T	F117L	0.993
20:34863369:A:G	F117L	0.993
20:34872747:G:C	S23R	0.993
20:34872747:G:T	S23R	0.993

dbSNP variants (sampled 300 via entrez): RS1000027101 (20:34847434 C>T), RS1000196567 (20:34873296 C>T), RS1000461529 (20:34862726 T>A), RS1000495779 (20:34854359 T>A,C), RS1000717154 (20:34868146 G>A), RS1000843929 (20:34868664 T>A), RS1001025822 (20:34845667 G>A), RS1001133368 (20:34853484 C>G), RS1001170363 (20:34862357 A>G), RS1001348652 (20:34860503 A>G), RS1001389294 (20:34862009 T>C), RS1001390807 (20:34871766 C>T), RS1001587997 (20:34849202 A>G), RS1001630875 (20:34863821 A>G), RS1001699045 (20:34848935 C>G)

Disease associations

OMIM: gene MIM:612342 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

9 associations (top):

Study	Trait	p-value
GCST005194_135	Coronary artery disease	2.000000e-07
GCST005956_31	Waist-to-hip ratio adjusted for BMI	8.000000e-08
GCST005958_16	Waist-to-hip ratio adjusted for BMI (age >50)	6.000000e-06
GCST005962_40	Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test)	3.000000e-08
GCST008103_149	Bipolar disorder	3.000000e-06
GCST008747_91	Estimated glomerular filtration rate	2.000000e-19
GCST010142_10	Fish- and plant-related diet	8.000000e-12
GCST012227_1088	Hip circumference adjusted for BMI	4.000000e-18
GCST90002406_551	Reticulocyte fraction of red cells	2.000000e-14

EFO canonical traits (5, from GWAS)

EFO ID	Trait name
EFO:0007788	BMI-adjusted waist-hip ratio
EFO:0008007	age at assessment
EFO:0008343	sex interaction measurement
EFO:0008111	diet measurement
EFO:0008039	BMI-adjusted hip circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL5465368 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

31 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol S	affects cotreatment, increases methylation, decreases expression	2
Aflatoxin B1	decreases methylation	2
GSK-J4	decreases expression	1
FR900359	decreases phosphorylation	1
bismuth tripotassium dicitrate	decreases expression	1
bisphenol A	affects cotreatment, increases expression	1
potassium perchlorate	decreases expression	1
trichostatin A	affects expression	1
beta-lapachone	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
CGP 52608	affects binding, increases reaction	1
abrine	increases expression	1
(+)-JQ1 compound	decreases expression	1
Sunitinib	decreases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Acetaminophen	increases expression	1
Benzo(a)pyrene	increases methylation	1
Caffeine	increases phosphorylation	1
Cisplatin	decreases expression	1
Dexamethasone	affects cotreatment, increases expression, decreases expression	1
Doxorubicin	decreases expression	1
Indomethacin	affects cotreatment, increases expression, decreases expression	1
Isoniazid	increases expression	1
Polychlorinated Biphenyls	affects expression	1
Smoke	decreases expression	1
Tetrachlorodibenzodioxin	affects expression	1
Tobacco Smoke Pollution	decreases expression	1
Valproic Acid	decreases methylation	1
1-Methyl-3-isobutylxanthine	affects cotreatment, increases expression, decreases expression	1
Gold Compounds	increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5338439	Binding	Binding affinity to Ggt7 (unknown origin) at 200 uM preincubated for 2 hrs followed by pronase addition and measured after 30 mins by coomassie blue staining based SDS-PAGE gel analysis	Structurally Diverse Alkaloids with Anti-Renal-Fibrosis Activity from the Centipede Scolopendra subspinipes mutilans. — J Nat Prod

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_SP97	HAP1 GGT7 (-)	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.