GHRLOS

Summary

GHRLOS (ghrelin opposite strand/antisense RNA, HGNC:33885) is a long non-coding RNA gene on chromosome 3p25.3.

This gene is an antisense gene of the ghrelin/obestatin prepropeptide gene. Alternatively spliced transcript variants have been identified and they may function as non-coding regulatory RNAs.

Source: NCBI Gene 100126793 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33885
Approved symbol	GHRLOS
Name	ghrelin opposite strand/antisense RNA
Location	3p25.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	NCRNA00068, GHRL-AS1
Ensembl gene	ENSG00000240288
Ensembl biotype	lncRNA
OMIM	618445
Entrez	100126793
RNAcentral	URS000075D280 — lncRNA, 1782 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000439539, ENST00000603771, ENST00000605014, ENST00000605105, ENST00000662597

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000439539 — 4 exons

Exon	Start	End
ENSE00001614716	10285754	10285853
ENSE00001620959	10287414	10287481
ENSE00001778021	10287945	10288102
ENSE00003695075	10292068	10293449

Expression profiles

Bgee: expression breadth ubiquitous, 162 present calls, max score 84.75.

Top tissues by expression

243 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.75	gold quality
bone marrow cell	CL:0002092	78.29	gold quality
tendon of biceps brachii	UBERON:0008188	78.28	silver quality
buccal mucosa cell	CL:0002336	78.07	silver quality
pancreatic ductal cell	CL:0002079	77.41	silver quality
sural nerve	UBERON:0015488	77.05	gold quality
kidney epithelium	UBERON:0004819	76.70	gold quality
cardiac muscle of right atrium	UBERON:0003379	73.89	gold quality
left ventricle myocardium	UBERON:0006566	73.67	gold quality
granulocyte	CL:0000094	72.08	gold quality
body of stomach	UBERON:0001161	71.62	gold quality
stomach	UBERON:0000945	69.83	gold quality
monocyte	CL:0000576	69.68	gold quality
tendon	UBERON:0000043	68.68	gold quality
apex of heart	UBERON:0002098	68.45	gold quality
blood	UBERON:0000178	68.35	gold quality
fundus of stomach	UBERON:0001160	68.27	gold quality
lower esophagus mucosa	UBERON:0035834	68.17	gold quality
mucosa of transverse colon	UBERON:0004991	68.09	gold quality
tonsil	UBERON:0002372	67.58	gold quality
tibia	UBERON:0000979	67.30	silver quality
corpus epididymis	UBERON:0004359	67.14	gold quality
colonic epithelium	UBERON:0000397	67.11	silver quality
stromal cell of endometrium	CL:0002255	66.92	gold quality
right lobe of thyroid gland	UBERON:0001119	66.71	gold quality
left lobe of thyroid gland	UBERON:0001120	66.67	gold quality
quadriceps femoris	UBERON:0001377	66.12	gold quality
thyroid gland	UBERON:0002046	66.05	gold quality
gastrocnemius	UBERON:0001388	65.92	gold quality
muscle of leg	UBERON:0001383	65.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.44

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• GHRLOS RNA transcripts display several features of non-coding (ncRNA) genes, including 5’ capping, polyadenylation, extensive splicing and short open reading frames. The gene is also non-conserved, with differential and tissue-restricted expression. (PMID:18954468)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.