GIHCG

Summary

GIHCG (GIHCG inhibitor of miR-200b/200a/429 expression, HGNC:52649) is a long non-coding RNA gene on chromosome 12q14.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52649
Approved symbol	GIHCG
Name	GIHCG inhibitor of miR-200b/200a/429 expression
Location	12q14.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	lncRNA-GIHCG
Ensembl gene	ENSG00000257698
Ensembl biotype	lncRNA
Entrez	100506844
RNAcentral	URS000075D52A — lncRNA, 711 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 24 — 22 lncRNA, 2 retained_intron

ENST00000546580, ENST00000547492, ENST00000551421, ENST00000553102, ENST00000653595, ENST00000655210, ENST00000655884, ENST00000656617, ENST00000659090, ENST00000660297, ENST00000664635, ENST00000667438, ENST00000668073, ENST00000688407, ENST00000819980, ENST00000819981, ENST00000819982, ENST00000819983, ENST00000819984, ENST00000819985, ENST00000819986, ENST00000819987, ENST00000819988, ENST00000819989

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000546580 — 3 exons

Exon	Start	End
ENSE00003854668	57935298	57935553
ENSE00004225497	57931527	57931737
ENSE00004225502	57935839	57936175

Expression profiles

Bgee: expression breadth ubiquitous, 163 present calls, max score 99.13.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 15.3832 / max 650.9542, expressed in 1666 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
131780	9.3520	1614
131778	4.4404	556
131779	1.5908	762

Top tissues by expression

245 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	99.13	gold quality
right testis	UBERON:0004534	99.12	gold quality
right uterine tube	UBERON:0001302	96.47	gold quality
testis	UBERON:0000473	94.71	gold quality
adenohypophysis	UBERON:0002196	94.35	gold quality
calcaneal tendon	UBERON:0003701	93.57	gold quality
ventricular zone	UBERON:0003053	93.46	gold quality
anterior cingulate cortex	UBERON:0009835	93.05	gold quality
buccal mucosa cell	CL:0002336	92.41	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	92.37	gold quality
Brodmann (1909) area 9	UBERON:0013540	92.16	gold quality
bone marrow cell	CL:0002092	91.88	gold quality
right frontal lobe	UBERON:0002810	91.84	gold quality
prefrontal cortex	UBERON:0000451	91.05	gold quality
hypothalamus	UBERON:0001898	90.78	gold quality
pituitary gland	UBERON:0000007	90.42	gold quality
nucleus accumbens	UBERON:0001882	90.35	gold quality
amygdala	UBERON:0001876	90.28	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	90.23	gold quality
caudate nucleus	UBERON:0001873	90.02	gold quality
putamen	UBERON:0001874	89.76	gold quality
apex of heart	UBERON:0002098	89.42	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.89	gold quality
ganglionic eminence	UBERON:0004023	88.33	gold quality
right atrium auricular region	UBERON:0006631	88.30	gold quality
islet of Langerhans	UBERON:0000006	88.28	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.54	gold quality
left ovary	UBERON:0002119	87.19	gold quality
cortical plate	UBERON:0005343	87.16	gold quality
cardiac atrium	UBERON:0002081	87.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	13.05

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Knockdown of GIHCG significantly represses proliferation and migration of renal cell carcinoma cells. Serum GIHCG level is positively correlated with GIHCG expression in RCC tissues. (PMID:29364470)
• GIHCG is highly expressed in ovarian cancer, which promotes tumor development by stimulating cell cycle progression and cell proliferation by regulating microRNA-429. (PMID:30556850)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.