GIRGL

Summary

GIRGL (glutamine insufficiency regulator of glutaminase lncRNA, HGNC:55702) is a long non-coding RNA gene on chromosome 7p21.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55702
Approved symbol	GIRGL
Name	glutamine insufficiency regulator of glutaminase lncRNA
Location	7p21.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000233834
Ensembl biotype	lncRNA
OMIM	621353
Entrez	100506098
RNAcentral	URS0000A7764C — lncRNA, 861 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 87 — 86 lncRNA, 1 retained_intron

ENST00000430859, ENST00000439058, ENST00000439446, ENST00000685385, ENST00000685445, ENST00000685994, ENST00000688687, ENST00000689592, ENST00000689666, ENST00000691210, ENST00000738502, ENST00000738503, ENST00000738504, ENST00000738505, ENST00000738506, ENST00000738507, ENST00000738508, ENST00000738509, ENST00000738510, ENST00000738511, ENST00000738512, ENST00000738513, ENST00000738514, ENST00000738515, ENST00000738516, ENST00000738517, ENST00000738518, ENST00000738519, ENST00000738520, ENST00000738521, ENST00000738522, ENST00000738523, ENST00000738524, ENST00000738525, ENST00000738526, ENST00000738527, ENST00000738528, ENST00000738529, ENST00000738530, ENST00000738531, ENST00000738532, ENST00000738533, ENST00000738534, ENST00000738535, ENST00000738536, ENST00000738537, ENST00000738538, ENST00000738539, ENST00000738540, ENST00000738541, ENST00000738542, ENST00000738543, ENST00000738544, ENST00000738545, ENST00000738546, ENST00000738547, ENST00000738548, ENST00000738549, ENST00000738550, ENST00000738551, ENST00000738552, ENST00000738553, ENST00000738554, ENST00000738555, ENST00000738556, ENST00000738557, ENST00000738558, ENST00000738559, ENST00000738560, ENST00000738561, ENST00000738562, ENST00000738563, ENST00000738564, ENST00000738565, ENST00000738566, ENST00000738567, ENST00000738568, ENST00000738569, ENST00000738570, ENST00000738571, ENST00000738572, ENST00000738573, ENST00000738574, ENST00000738575, ENST00000738576, ENST00000738577, ENST00000738578

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000430859 — 7 exons

Exon	Start	End
ENSE00001706881	20218256	20218363
ENSE00001713206	20219583	20219756
ENSE00001727892	20221343	20221700
ENSE00001735647	20217788	20217858
ENSE00004073773	20191720	20191852
ENSE00004073789	20188113	20188189
ENSE00004073798	20217409	20217622

Expression profiles

Bgee: expression breadth ubiquitous, 173 present calls, max score 96.68.

Top tissues by expression

245 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
amniotic fluid	UBERON:0000173	96.68	gold quality
kidney epithelium	UBERON:0004819	92.97	silver quality
ileal mucosa	UBERON:0000331	92.26	gold quality
pancreatic ductal cell	CL:0002079	91.64	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.70	gold quality
epithelial cell of pancreas	CL:0000083	88.72	gold quality
gingival epithelium	UBERON:0001949	88.04	silver quality
oral cavity	UBERON:0000167	85.41	gold quality
jejunal mucosa	UBERON:0000399	84.60	gold quality
body of pancreas	UBERON:0001150	83.92	gold quality
gingiva	UBERON:0001828	83.81	gold quality
duodenum	UBERON:0002114	82.67	gold quality
pancreas	UBERON:0001264	82.34	gold quality
adult mammalian kidney	UBERON:0000082	82.09	gold quality
bronchial epithelial cell	CL:0002328	81.81	gold quality
epithelium of nasopharynx	UBERON:0001951	81.41	silver quality
metanephros cortex	UBERON:0010533	80.86	gold quality
palpebral conjunctiva	UBERON:0001812	80.57	gold quality
islet of Langerhans	UBERON:0000006	80.54	gold quality
bronchus	UBERON:0002185	80.54	gold quality
kidney	UBERON:0002113	78.88	gold quality
esophagus squamous epithelium	UBERON:0006920	77.73	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	76.43	gold quality
buccal mucosa cell	CL:0002336	76.06	gold quality
mucosa of paranasal sinus	UBERON:0005030	75.93	gold quality
cortex of kidney	UBERON:0001225	75.64	gold quality
mouth mucosa	UBERON:0003729	75.23	gold quality
minor salivary gland	UBERON:0001830	74.65	gold quality
tonsil	UBERON:0002372	74.28	gold quality
saliva-secreting gland	UBERON:0001044	74.24	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.71

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.