GJD2-DT

Summary

GJD2-DT (GJD2 divergent transcript, HGNC:55560) is a long non-coding RNA gene on chromosome 15q14.

Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting.

Source: NCBI Gene 101928174 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55560
Approved symbol	GJD2-DT
Name	GJD2 divergent transcript
Location	15q14
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000250007
Ensembl biotype	lncRNA
Entrez	101928174
RNAcentral	URS000009E1B8 — lncRNA, 2727 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 14 lncRNA

ENST00000503496, ENST00000558707, ENST00000661009, ENST00000671663, ENST00000693120, ENST00000713607, ENST00000808234, ENST00000808235, ENST00000808236, ENST00000808237, ENST00000808238, ENST00000808239, ENST00000808240, ENST00000808241

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000503496 — 3 exons

Exon	Start	End
ENSE00002019837	34777271	34777431
ENSE00002024668	34810496	34813284
ENSE00002077716	34755084	34755221

Expression profiles

Bgee: expression breadth ubiquitous, 114 present calls, max score 94.99.

Top tissues by expression

114 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right atrium auricular region	UBERON:0006631	94.99	gold quality
apex of heart	UBERON:0002098	90.10	gold quality
heart left ventricle	UBERON:0002084	89.44	gold quality
colonic epithelium	UBERON:0000397	88.59	gold quality
heart	UBERON:0000948	88.34	gold quality
islet of Langerhans	UBERON:0000006	79.99	gold quality
pituitary gland	UBERON:0000007	72.02	gold quality
urinary bladder	UBERON:0001255	70.66	gold quality
adenohypophysis	UBERON:0002196	70.62	gold quality
superior frontal gyrus	UBERON:0002661	69.61	gold quality
hindlimb stylopod muscle	UBERON:0004252	69.25	gold quality
prefrontal cortex	UBERON:0000451	68.57	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.15	gold quality
nucleus accumbens	UBERON:0001882	67.84	gold quality
frontal cortex	UBERON:0001870	67.79	gold quality
anterior cingulate cortex	UBERON:0009835	67.74	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.73	gold quality
primary visual cortex	UBERON:0002436	67.38	gold quality
skeletal muscle tissue	UBERON:0001134	66.76	gold quality
caudate nucleus	UBERON:0001873	66.71	gold quality
right frontal lobe	UBERON:0002810	66.68	gold quality
tibial artery	UBERON:0007610	66.57	gold quality
popliteal artery	UBERON:0002250	66.55	gold quality
cerebral cortex	UBERON:0000956	66.07	gold quality
adrenal tissue	UBERON:0018303	65.22	gold quality
ascending aorta	UBERON:0001496	64.96	gold quality
thoracic aorta	UBERON:0001515	64.80	gold quality
ganglionic eminence	UBERON:0004023	64.44	gold quality
brain	UBERON:0000955	64.39	gold quality
pancreas	UBERON:0001264	63.90	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.45

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.