GLG1

Summary

GLG1 (golgi glycoprotein 1, HGNC:4316) is a protein-coding gene on chromosome 16q23.1, encoding Golgi apparatus protein 1 (Q92896). Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils).

Predicted to enable fibroblast growth factor binding activity. Predicted to act upstream of or within several processes, including negative regulation of protein processing; negative regulation of transforming growth factor beta receptor signaling pathway; and regulation of chondrocyte differentiation. Located in Golgi apparatus.

Source: NCBI Gene 2734 — RefSeq curated summary.

At a glance

• GWAS associations: 13
• Clinical variants (ClinVar): 179 total
• Druggable target: yes
• MANE Select transcript: NM_001145667

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:4316
Approved symbol	GLG1
Name	golgi glycoprotein 1
Location	16q23.1
Locus type	gene with protein product
Status	Approved
Aliases	MG-160, ESL-1, CFR-1
Ensembl gene	ENSG00000090863
Ensembl biotype	protein_coding
OMIM	600753
Entrez	2734

Gene structure

Transcript identifiers

Ensembl transcripts: 20 — 12 protein_coding, 6 retained_intron, 2 nonsense_mediated_decay

ENST00000205061, ENST00000422840, ENST00000447066, ENST00000561481, ENST00000561942, ENST00000562090, ENST00000563432, ENST00000563646, ENST00000565260, ENST00000565474, ENST00000566601, ENST00000567911, ENST00000567951, ENST00000627032, ENST00000881337, ENST00000881338, ENST00000881339, ENST00000881340, ENST00000881341, ENST00000941220

RefSeq mRNA: 3 — MANE Select: NM_001145667 NM_001145666, NM_001145667, NM_012201

CCDS: CCDS32485, CCDS45526, CCDS45527

Canonical transcript exons

ENST00000422840 — 26 exons

Exon	Start	End
ENSE00000694324	74494760	74494831
ENSE00000694327	74492957	74493140
ENSE00000694330	74491001	74491215
ENSE00000694332	74485796	74485917
ENSE00000694334	74483023	74483124
ENSE00000694336	74480241	74480394
ENSE00001289424	74496441	74496644
ENSE00001663920	74447440	74453334
ENSE00002610428	74606657	74607114
ENSE00003499434	74457874	74457994
ENSE00003500723	74472349	74472411
ENSE00003510120	74459682	74459789
ENSE00003520136	74465676	74465813
ENSE00003525368	74474546	74474632
ENSE00003552175	74462094	74462195
ENSE00003570373	74467756	74467848
ENSE00003596720	74532121	74532153
ENSE00003599228	74503531	74503746
ENSE00003599499	74477396	74477533
ENSE00003613712	74463356	74463479
ENSE00003629366	74468946	74469063
ENSE00003635857	74456649	74456755
ENSE00003647428	74469985	74470073
ENSE00003660806	74508839	74508925
ENSE00003676037	74462488	74462630
ENSE00003683487	74471173	74471286

Expression profiles

Bgee: expression breadth ubiquitous, 299 present calls, max score 98.01.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 94.7028 / max 815.9767, expressed in 1827 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
158115	94.7028	1827

Top tissues by expression

301 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stromal cell of endometrium	CL:0002255	98.01	gold quality
renal medulla	UBERON:0000362	97.99	gold quality
nipple	UBERON:0002030	97.82	gold quality
tibia	UBERON:0000979	97.75	gold quality
pylorus	UBERON:0001166	97.73	gold quality
cardia of stomach	UBERON:0001162	97.69	gold quality
lateral globus pallidus	UBERON:0002476	97.39	gold quality
corpus callosum	UBERON:0002336	97.31	gold quality
dorsal root ganglion	UBERON:0000044	97.14	gold quality
ventral tegmental area	UBERON:0002691	97.14	gold quality
olfactory bulb	UBERON:0002264	97.09	gold quality
inferior vagus X ganglion	UBERON:0005363	97.09	gold quality
urethra	UBERON:0000057	97.07	gold quality
colonic epithelium	UBERON:0000397	97.00	gold quality
calcaneal tendon	UBERON:0003701	96.98	gold quality
cartilage tissue	UBERON:0002418	96.91	gold quality
trigeminal ganglion	UBERON:0001675	96.85	gold quality
entorhinal cortex	UBERON:0002728	96.80	gold quality
inferior olivary complex	UBERON:0002127	96.76	gold quality
smooth muscle tissue	UBERON:0001135	96.75	gold quality
substantia nigra pars reticulata	UBERON:0001966	96.73	gold quality
descending thoracic aorta	UBERON:0002345	96.63	gold quality
cranial nerve II	UBERON:0000941	96.52	gold quality
postcentral gyrus	UBERON:0002581	96.48	gold quality
caput epididymis	UBERON:0004358	96.44	gold quality
islet of Langerhans	UBERON:0000006	96.40	gold quality
lateral nuclear group of thalamus	UBERON:0002736	96.37	gold quality
parietal lobe	UBERON:0001872	96.36	gold quality
substantia nigra pars compacta	UBERON:0001965	96.35	gold quality
adrenal tissue	UBERON:0018303	96.25	gold quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-CURD-112	yes	14.84
E-CURD-55	no	342.58
E-CURD-88	no	167.27
E-GEOD-137537	no	3.29
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

127 targeting GLG1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-4481	100.00	66.42	1669
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-4645-5P	99.98	65.81	1284
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-6845-3P	99.94	66.88	1439
HSA-MIR-539-5P	99.93	70.30	2855
HSA-MIR-145-5P	99.92	71.13	1836
HSA-MIR-5195-3P	99.92	70.92	1877
HSA-MIR-374A-5P	99.90	71.34	2923
HSA-MIR-374B-5P	99.90	69.98	2734
HSA-MIR-3671	99.90	73.04	3897
HSA-MIR-4493	99.90	66.48	977
HSA-MIR-6780A-5P	99.88	66.69	2776
HSA-LET-7A-2-3P	99.87	70.53	1921
HSA-MIR-548D-3P	99.87	70.67	4362
HSA-MIR-221-5P	99.86	65.45	1052

Literature-anchored findings (GeneRIF, showing 9)

• evaluated in human brain tumors exhibiting varying degrees of malignancy (PMID:12684670)
• a novel variant of the GLG1 gene product called GLG2 is reported; genetic analysis suggests GLG1 & GLG2 are the products of a single gene, the mRNA of which can be processed by alternative splicing to generate different transcripts encoding GLG1 or GLG2 (PMID:15797922)
• under hypoxia, ESL-1 is shed from activated hepatic stellate cells (PMID:19148508)
• C2GnT1 gene expression and the resulting C2-O-sLe(X) carbohydrates produced mediate the adhesive and invasive behaviors of human carcinomas which may influence their metastatic potential. (PMID:21283832)
• expression of Cfr in the Golgi apparatus and on the plasma membrane is finely tuned through two distinct mechanisms for exhibiting different functions. (PMID:21777203)
• Studies indicate that PSGL-1, CD44, and ESL-1 on mature leukocytes are physiologic glycoprotein ligands for endothelial P-selectin and E-selectin. (PMID:22021370)
• circulating prostate cancer cells’ rolling capacity contributes to metastasis, and that is in part controlled by ESL-1. (PMID:25301730)
• Our results highlight the fact that interaction between APN and ESL-1 could provide a fundamental mechanism underlying the anti-atherogenic properties of APN. (PMID:26792720)
• Study identifies NRP2 and ESL-1 as targets for polysialylation in murine microglia and human THP-1 macrophages and reveals a striking convergence in the regulation of the two polysialylated acceptors in the course of inflammatory activation. A pool of polysialylated NRP2 and ESL-1 is assembled after injury or in culture and its shedding is an early response to lipopolysaccharide-induced activation of microglia. (PMID:27159043)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	glg1a	ENSDARG00000061282
danio_rerio	glg1b	ENSDARG00000101210
mus_musculus	Glg1	ENSMUSG00000003316
rattus_norvegicus	Glg1	ENSRNOG00000018668
drosophila_melanogaster	Glg1	FBGN0264561
caenorhabditis_elegans		WBGENE00008800

Protein

Protein identifiers

Golgi apparatus protein 1 — Q92896 (reviewed: Q92896)

Alternative names: CFR-1, Cysteine-rich fibroblast growth factor receptor, E-selectin ligand 1, Golgi sialoglycoprotein MG-160

All UniProt accessions (5): Q92896, H3BM42, H3BQT1, H3BQU9, H3BRD8

UniProt curated annotations — full annotation on UniProt →

Function. Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils).

Subcellular location. Golgi apparatus membrane. Golgi outpost. Cytoplasm. Cytoskeleton. Microtubule organizing center.

Tissue specificity. Widely expressed. Highest levels in pancreas, skeletal muscle, placenta, heart, testis and ovary. Also found in the kidney, liver, lung and brain.

Post-translational modifications. Fucosylation is essential for binding to E-selectin. N-glycosylated. Contains sialic acid residues.

Isoforms (3)

UniProt ID	Names	Canonical?
Q92896-1	1	yes
Q92896-2	2
Q92896-3	3

RefSeq proteins (3): NP_001139138, NP_001139139, NP_036333 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001893	Cys-rich_GLG1_repeat	Repeat
IPR017873	Cys-rich_GLG1_repeat_euk	Repeat
IPR039728	GLG1	Family

Pfam: PF00839

UniProt features (42 total): repeat 16, sequence conflict 8, glycosylation site 5, modified residue 3, topological domain 2, compositionally biased region 2, splice variant 2, signal peptide 1, chain 1, region of interest 1, transmembrane region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q92896-F1	78.35	0.27

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 961, 1201, 1190

Glycosylation sites (5): 165, 210, 581, 677, 786

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-202733	Cell surface interactions at the vascular wall

MSigDB gene sets: 245 (showing top): GOBP_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS, GOBP_NEGATIVE_REGULATION_OF_PROTEOLYSIS, GOBP_CARTILAGE_DEVELOPMENT, GOBP_SKELETAL_SYSTEM_DEVELOPMENT, GOBP_REGULATION_OF_CARTILAGE_DEVELOPMENT, STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, MORF_PSMC2, GOCC_MICROTUBULE_ORGANIZING_CENTER, GOBP_ANIMAL_ORGAN_MORPHOGENESIS, GOBP_BONE_DEVELOPMENT, GOBP_PROTEIN_MATURATION, GATA3_01, GOBP_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY, YY1_02

GO Biological Process (6): transforming growth factor beta receptor signaling pathway (GO:0007179), negative regulation of protein processing (GO:0010955), protein processing (GO:0016485), negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512), regulation of chondrocyte differentiation (GO:0032330), bone morphogenesis (GO:0060349)

GO Molecular Function (2): signaling receptor binding (GO:0005102), fibroblast growth factor binding (GO:0017134)

GO Cellular Component (12): Golgi membrane (GO:0000139), Golgi apparatus (GO:0005794), microtubule organizing center (GO:0005815), plasma membrane (GO:0005886), membrane (GO:0016020), extracellular matrix (GO:0031012), extracellular exosome (GO:0070062), sperm midpiece (GO:0097225), sperm principal piece (GO:0097228), sperm end piece (GO:0097229), cytoplasm (GO:0005737), cytoskeleton (GO:0005856)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Hemostasis	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	6
sperm flagellum	3
cellular response to transforming growth factor beta stimulus	1
transforming growth factor beta receptor superfamily signaling pathway	1
protein processing	1
negative regulation of proteolysis	1
regulation of protein processing	1
negative regulation of protein maturation	1
proteolysis	1
protein maturation	1
transforming growth factor beta receptor signaling pathway	1
regulation of transforming growth factor beta receptor signaling pathway	1
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	1
chondrocyte differentiation	1
regulation of cell differentiation	1
regulation of cartilage development	1
animal organ morphogenesis	1
skeletal system morphogenesis	1
bone development	1
protein binding	1
growth factor binding	1
Golgi apparatus	1
bounding membrane of organelle	1
cytoplasm	1
endomembrane system	1
intracellular membrane-bounded organelle	1
microtubule cytoskeleton	1
membrane	1
cell periphery	1
external encapsulating structure	1
extracellular vesicle	1
intracellular anatomical structure	1
intracellular membraneless organelle	1

Protein interactions and networks

STRING

1022 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
GLG1	SELE	P16111	998
GLG1	SELP	P16109	983
GLG1	SELPLG	Q14242	886
GLG1	F11R	Q9Y624	796
GLG1	FGF2	P09038	718
GLG1	VCAM1	P19320	700
GLG1	SELL	P14151	690
GLG1	CD44	P16070	673
GLG1	SPN	P16150	618
GLG1	FGF7	P21781	566
GLG1	ITGB2	P05107	559
GLG1	FGF18	O76093	551
GLG1	FGF16	O43320	547
GLG1	FGF20	Q9NP95	546
GLG1	FGF22	Q9HCT0	544

IntAct

112 interactions, top by confidence:

A	B	Type	Score
PKMYT1	CCNB2	psi-mi:“MI:0914”(association)	0.730
STX3	SNAP23	psi-mi:“MI:0914”(association)	0.660
MAPK7	PFDN6	psi-mi:“MI:0914”(association)	0.640
CAMKV	AP3B1	psi-mi:“MI:0914”(association)	0.640
ETFRF1	NDUFAB1	psi-mi:“MI:0914”(association)	0.640
OSBPL8	CSNK2A2	psi-mi:“MI:0914”(association)	0.640
SDC2	PDPK1	psi-mi:“MI:0914”(association)	0.640
PRKCZ	IPO5	psi-mi:“MI:0914”(association)	0.530
PDPK1	AGRN	psi-mi:“MI:0914”(association)	0.530
FBXO2	TMEM131L	psi-mi:“MI:0914”(association)	0.530
UST	GOLIM4	psi-mi:“MI:0914”(association)	0.530
HADHA	AGRN	psi-mi:“MI:0914”(association)	0.530
LGALS1	LAMA5	psi-mi:“MI:0914”(association)	0.530
UST	CANX	psi-mi:“MI:0914”(association)	0.530
CD44	PDPK1	psi-mi:“MI:0914”(association)	0.530
STX3	NBAS	psi-mi:“MI:0914”(association)	0.530
env	PGRMC1	psi-mi:“MI:0914”(association)	0.460
GLG1	SELE	psi-mi:“MI:0407”(direct interaction)	0.440
	DENR	psi-mi:“MI:0915”(physical association)	0.400
MLKL	CASP8	psi-mi:“MI:0914”(association)	0.350
RFWD3	MBNL1	psi-mi:“MI:0914”(association)	0.350
		psi-mi:“MI:0914”(association)	0.350
	ESYT2	psi-mi:“MI:0914”(association)	0.350
RIPK4	VWA8	psi-mi:“MI:0914”(association)	0.350
HSCB	RBP5	psi-mi:“MI:0914”(association)	0.350
K8.1	EXOC5	psi-mi:“MI:0914”(association)	0.350

BioGRID (186): GLG1 (Affinity Capture-MS), GLG1 (Affinity Capture-MS), GLG1 (Affinity Capture-MS), GLG1 (Affinity Capture-MS), GLG1 (Affinity Capture-MS), GLG1 (Affinity Capture-MS), GLG1 (Affinity Capture-MS), GLG1 (Affinity Capture-MS), GLG1 (Affinity Capture-MS), GLG1 (Affinity Capture-MS), GLG1 (Affinity Capture-MS), GLG1 (Affinity Capture-MS), GLG1 (Affinity Capture-MS), GLG1 (Affinity Capture-MS), GLG1 (Affinity Capture-MS)

ESM2 similar proteins: F1R520, O13035, O18823, O35298, O70367, O75829, O77770, O94985, P02771, P02774, P04276, P05067, P07602, P08592, P0C5H9, P0C5I0, P10960, P12023, P17129, P17404, P20097, P21614, P26779, P28039, P28050, P49066, P53601, P53789, P55145, P79307, P80513, P81405, Q02391, Q28789, Q3SZ57, Q49AH0, Q5IS80, Q60495, Q61207, Q61543

Diamond homologs: Q02391, Q19459, Q61543, Q62638, Q92896, Q9Z1E9

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 148 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
HS-GAG degradation	5	23.2×	8e-04
Respiratory syncytial virus (RSV) attachment and entry	5	23.2×	8e-04
Glycosaminoglycan metabolism	6	12.3×	1e-03
Retinoid metabolism and transport	5	11.6×	3e-03
Programmed Cell Death	6	8.2×	4e-03
Metabolism of carbohydrates and carbohydrate derivatives	7	7.9×	2e-03
Apoptosis	5	7.8×	9e-03
Death Receptor Signaling	6	7.8×	5e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

179 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	136
Likely benign	3
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

5007 predictions. Top by Δscore:

Variant	Effect	Δscore
16:74453333:ACCTA:A	acceptor_loss	1.0000
16:74453334:CCTAG:C	acceptor_loss	1.0000
16:74456643:CATTA:C	donor_loss	1.0000
16:74456644:ATTAC:A	donor_loss	1.0000
16:74456645:TTAC:T	donor_loss	1.0000
16:74456646:TACC:T	donor_loss	1.0000
16:74456648:C:CT	donor_loss	1.0000
16:74456751:CATTT:C	acceptor_gain	1.0000
16:74456752:ATTT:A	acceptor_gain	1.0000
16:74456753:TTT:T	acceptor_gain	1.0000
16:74456754:TT:T	acceptor_gain	1.0000
16:74456756:C:A	acceptor_loss	1.0000
16:74456756:C:CC	acceptor_gain	1.0000
16:74456757:T:A	acceptor_loss	1.0000
16:74457872:A:AC	donor_gain	1.0000
16:74457873:C:CC	donor_gain	1.0000
16:74457873:CGA:C	donor_gain	1.0000
16:74457873:CGACG:C	donor_gain	1.0000
16:74459678:TTA:T	donor_loss	1.0000
16:74459679:TAC:T	donor_loss	1.0000
16:74459680:A:C	donor_loss	1.0000
16:74459681:CCTTT:C	donor_gain	1.0000
16:74462191:AGGCG:A	acceptor_gain	1.0000
16:74462192:GGCG:G	acceptor_gain	1.0000
16:74462193:GCG:G	acceptor_gain	1.0000
16:74462194:CG:C	acceptor_gain	1.0000
16:74462194:CGC:C	acceptor_gain	1.0000
16:74462194:CGCTG:C	acceptor_loss	1.0000
16:74462195:GC:G	acceptor_loss	1.0000
16:74462196:C:CC	acceptor_gain	1.0000

AlphaMissense

7814 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:74456664:C:A	W1119C	1.000
16:74456664:C:G	W1119C	1.000
16:74456677:C:G	R1115P	1.000
16:74456686:A:G	L1112P	1.000
16:74456697:G:C	C1108W	1.000
16:74456698:C:G	C1108S	1.000
16:74456698:C:T	C1108Y	1.000
16:74456699:A:G	C1108R	1.000
16:74456699:A:T	C1108S	1.000
16:74456743:A:G	L1093P	1.000
16:74457902:G:C	C1079W	1.000
16:74457903:C:G	C1079S	1.000
16:74457903:C:T	C1079Y	1.000
16:74457904:A:G	C1079R	1.000
16:74457904:A:T	C1079S	1.000
16:74457926:A:C	C1071W	1.000
16:74457927:C:A	C1071F	1.000
16:74457927:C:G	C1071S	1.000
16:74457927:C:T	C1071Y	1.000
16:74457928:A:G	C1071R	1.000
16:74457928:A:T	C1071S	1.000
16:74457939:A:G	L1067P	1.000
16:74457939:A:T	L1067H	1.000
16:74459725:A:G	L1034P	1.000
16:74462103:G:C	C1009W	1.000
16:74462104:C:T	C1009Y	1.000
16:74462105:A:G	C1009R	1.000
16:74462128:A:G	L1001P	1.000
16:74462178:A:C	C984W	1.000
16:74462179:C:G	C984S	1.000

dbSNP variants (sampled 300 via entrez): RS1000005265 (16:74463153 G>A), RS1000008857 (16:74582795 G>C), RS1000017853 (16:74560538 T>C), RS1000038585 (16:74483518 A>G), RS1000041766 (16:74529457 T>C), RS1000060979 (16:74582632 A>C), RS1000064064 (16:74563404 G>A), RS1000068892 (16:74518397 A>G), RS1000074675 (16:74529162 T>G), RS1000110870 (16:74550744 A>G,T), RS1000111950 (16:74483123 T>C,G), RS1000135624 (16:74519504 C>T), RS1000159758 (16:74542633 T>C,G), RS1000171137 (16:74596094 G>C), RS1000188381 (16:74463936 C>A)

Disease associations

OMIM: gene MIM:600753 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

13 associations (top):

Study	Trait	p-value
GCST000187_1	Breast cancer	4.000000e-07
GCST002023_2	Testicular germ cell tumor	5.000000e-12
GCST004608_205	Granulocyte percentage of myeloid white cells	2.000000e-15
GCST004609_222	Monocyte percentage of white cells	6.000000e-14
GCST004633_38	Neutrophil percentage of white cells	5.000000e-10
GCST007325_45	General risk tolerance (MTAG)	5.000000e-08
GCST008368_7	Plasma anti-thyroid peroxidase levels	2.000000e-06
GCST90002379_176	Basophil count	3.000000e-09
GCST90002393_273	Monocyte count	2.000000e-11
GCST90002394_538	Monocyte percentage of white cells	2.000000e-32
GCST90002398_300	Neutrophil count	4.000000e-16
GCST90002399_267	Neutrophil percentage of white cells	3.000000e-16
GCST90002407_559	White blood cell count	5.000000e-09

EFO canonical traits (7, from GWAS)

EFO ID	Trait name
EFO:0007997	granulocyte percentage of myeloid white cells
EFO:0007989	monocyte percentage of leukocytes
EFO:0007990	neutrophil percentage of leukocytes
EFO:0008579	risk-taking behaviour
EFO:0005090	basophil count
EFO:0005091	monocyte count
EFO:0004833	neutrophil count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067320 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

4 potent at pChembl≥5 of 4 total, top 4 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
6.79	Kd	161.6	nM	CHEMBL5653589
6.79	ED50	161.6	nM	CHEMBL5653589
5.18	Kd	6563	nM	CHEMBL3752910
5.18	ED50	6563	nM	CHEMBL3752910

PubChem BioAssay actives

2 with measured affinity, of 4 total; 2 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2148432: Binding affinity to human GLG1 incubated for 45 mins by Kinobead based pull down assay	kd	0.1616	uM
4-methyl-3-[(1-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2148432: Binding affinity to human GLG1 incubated for 45 mins by Kinobead based pull down assay	kd	6.5633	uM

CTD chemical–gene interactions

56 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	increases expression	3
Air Pollutants	affects cotreatment, decreases expression, increases abundance, affects expression	2
Ozone	affects expression, affects cotreatment, decreases expression, increases abundance	2
Cadmium Chloride	decreases expression, increases expression	2
aristolochic acid I	decreases expression	1
bisphenol F	increases expression	1
testosterone enanthate	affects expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	increases abundance, affects cotreatment, decreases expression	1
deoxynivalenol	decreases expression	1
sodium arsenate	decreases expression	1
pyrogallol 1,3-dimethyl ether	affects cotreatment, increases expression	1
butyraldehyde	decreases expression	1
perfluorooctanoic acid	decreases expression	1
aflatoxin B2	decreases methylation	1
methacrylaldehyde	affects cotreatment, decreases expression, increases abundance	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
chloropicrin	increases expression	1
K 7174	increases expression	1
ICG 001	increases expression	1
bisphenol B	increases expression	1
abrine	decreases expression	1
bisphenol S	increases expression	1
jinfukang	increases expression	1
bisphenol AF	increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Zoledronic Acid	decreases expression	1
Vorinostat	decreases expression	1
Acrolein	affects cotreatment, decreases expression, increases abundance	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651474	Binding	Binding affinity to human GLG1 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Cellosaurus cell lines

3 cell lines: 3 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D1MU	Abcam K-562 GLG1 KO	Cancer cell line	Female
CVCL_D2JE	Abcam Raji GLG1 KO	Cancer cell line	Male
CVCL_UQ61	Abcam Jurkat GLG1 KO	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.