GMDS-DT

Summary

GMDS-DT (GMDS divergent transcript, HGNC:48993) is a long non-coding RNA gene on chromosome 6p25.3-p25.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48993
Approved symbol	GMDS-DT
Name	GMDS divergent transcript
Location	6p25.3-p25.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000250903
Ensembl biotype	lncRNA
Entrez	100508120
RNAcentral	URS000075E18B — lncRNA, 1606 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 75 — 75 lncRNA

ENST00000456943, ENST00000505870, ENST00000524770, ENST00000525811, ENST00000529893, ENST00000530346, ENST00000530833, ENST00000531092, ENST00000532124, ENST00000532564, ENST00000533653, ENST00000534160, ENST00000534441, ENST00000534468, ENST00000606542, ENST00000606884, ENST00000607519, ENST00000654526, ENST00000654970, ENST00000655727, ENST00000657072, ENST00000657589, ENST00000659523, ENST00000659643, ENST00000660533, ENST00000660978, ENST00000662000, ENST00000663428, ENST00000664738, ENST00000665610, ENST00000666817, ENST00000670895, ENST00000685772, ENST00000687264, ENST00000691004, ENST00000691547, ENST00000702211, ENST00000702338, ENST00000702343, ENST00000702352, ENST00000774032, ENST00000774033, ENST00000774034, ENST00000774035, ENST00000774036, ENST00000774037, ENST00000774038, ENST00000774039, ENST00000774040, ENST00000774041, ENST00000774042, ENST00000774043, ENST00000774044, ENST00000774045, ENST00000774046, ENST00000774047, ENST00000774048, ENST00000774049, ENST00000774050, ENST00000774051, ENST00000774052, ENST00000774053, ENST00000774054, ENST00000774055, ENST00000774056, ENST00000774057, ENST00000774058, ENST00000774059, ENST00000774060, ENST00000774061, ENST00000774062, ENST00000774063, ENST00000774064, ENST00000774065, ENST00000774066

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000456943 — 6 exons

Exon	Start	End
ENSE00001626427	2271816	2273417
ENSE00001670405	2283499	2283774
ENSE00001700084	2263601	2263684
ENSE00001740685	2269698	2269799
ENSE00001790518	2248837	2248926
ENSE00002143945	2245777	2245930

Expression profiles

Bgee: expression breadth ubiquitous, 205 present calls, max score 90.50.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.8047 / max 178.6412, expressed in 1746 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
65441	4.3490	1543
65442	3.4557	1461

Top tissues by expression

234 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	90.50	gold quality
bone marrow cell	CL:0002092	90.36	gold quality
colonic epithelium	UBERON:0000397	90.23	gold quality
calcaneal tendon	UBERON:0003701	86.51	gold quality
right uterine tube	UBERON:0001302	86.49	gold quality
sural nerve	UBERON:0015488	86.38	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.25	gold quality
oviduct epithelium	UBERON:0004804	83.20	gold quality
adenohypophysis	UBERON:0002196	82.87	gold quality
pituitary gland	UBERON:0000007	82.84	gold quality
tendon	UBERON:0000043	82.72	gold quality
body of pancreas	UBERON:0001150	81.91	gold quality
corpus callosum	UBERON:0002336	81.68	gold quality
right lobe of liver	UBERON:0001114	81.56	gold quality
left lobe of thyroid gland	UBERON:0001120	80.81	gold quality
pancreas	UBERON:0001264	80.77	gold quality
thyroid gland	UBERON:0002046	80.59	gold quality
right lobe of thyroid gland	UBERON:0001119	80.49	gold quality
adrenal tissue	UBERON:0018303	80.29	gold quality
metanephros cortex	UBERON:0010533	80.14	gold quality
mucosa of transverse colon	UBERON:0004991	79.93	gold quality
tonsil	UBERON:0002372	79.90	gold quality
tibial artery	UBERON:0007610	79.70	gold quality
popliteal artery	UBERON:0002250	79.69	gold quality
ascending aorta	UBERON:0001496	79.51	gold quality
right coronary artery	UBERON:0001625	79.49	gold quality
aorta	UBERON:0000947	79.47	gold quality
stomach	UBERON:0000945	79.35	gold quality
thoracic aorta	UBERON:0001515	79.31	gold quality
fallopian tube	UBERON:0003889	79.19	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• LncRNA GMDS-AS1 inhibits lung adenocarcinoma development by regulating miR-96-5p/CYLD signaling. (PMID:31860169)
• lncRNA GMDSAS1 upregulates IL6, TNFalpha and IL1beta, and induces apoptosis in human monocytic THP1 cells via miR965p/caspase 2 signaling. (PMID:34981821)
• Epigenetic inhibition of lncRNA GMDS-AS1 by methyltransferase ESET promoted cell viability and metastasis of hepatocellular carcinoma. (PMID:36737533)
• lncRNA GMDS-AS1 restrains lung adenocarcinoma progression via recruiting TAF15 protein to stabilize SIRT1 mRNA. (PMID:37309595)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.