GMEB1

Summary

GMEB1 (glucocorticoid modulatory element binding protein 1, HGNC:4370) is a protein-coding gene on chromosome 1p35.3, encoding Glucocorticoid modulatory element-binding protein 1 (Q9Y692). Acts as a DNA-binding transcriptional regulator involved in modulating the expression of genes responsive to glucocorticoid signaling.

This gene encodes a member of KDWK gene family which associates with GMEB2 protein. The GMEB1-GMEB2 complex is essential for parvovirus DNA replication. Studies in rat for a similar gene suggest that this gene’s role is to modulate the transactivation of the glucocorticoid receptor when it is bound to glucocorticoid response elements. Three alternative spliced transcript variants encoding different isoforms exist.

Source: NCBI Gene 10691 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 66 total
• MANE Select transcript: NM_001319674

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:4370
Approved symbol	GMEB1
Name	glucocorticoid modulatory element binding protein 1
Location	1p35.3
Locus type	gene with protein product
Status	Approved
Aliases	P96PIF, PIF96
Ensembl gene	ENSG00000162419
Ensembl biotype	protein_coding
OMIM	604409
Entrez	10691

Gene structure

Transcript identifiers

Ensembl transcripts: 26 — 25 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000294409, ENST00000361872, ENST00000373816, ENST00000480454, ENST00000853890, ENST00000853891, ENST00000853892, ENST00000853893, ENST00000853894, ENST00000853895, ENST00000853896, ENST00000853897, ENST00000853898, ENST00000853899, ENST00000940222, ENST00000940223, ENST00000940224, ENST00000940225, ENST00000940226, ENST00000940227, ENST00000940228, ENST00000941581, ENST00000941582, ENST00000941583, ENST00000941584, ENST00000941585

RefSeq mRNA: 3 — MANE Select: NM_001319674 NM_001319674, NM_006582, NM_024482

CCDS: CCDS327, CCDS328

Canonical transcript exons

ENST00000373816 — 10 exons

Exon	Start	End
ENSE00001204758	28668784	28668839
ENSE00001204768	28683583	28683740
ENSE00001436096	28690104	28690186
ENSE00001461655	28714073	28719353
ENSE00003468817	28710520	28710642
ENSE00003580428	28704192	28704329
ENSE00003615771	28692942	28693045
ENSE00003627684	28702438	28702569
ENSE00003664454	28691585	28691709
ENSE00003671890	28696927	28697084

Expression profiles

Bgee: expression breadth ubiquitous, 257 present calls, max score 86.44.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.5088 / max 71.7681, expressed in 1772 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
1827	7.4163	1755
1826	1.0925	731

Top tissues by expression

289 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endothelial cell	CL:0000115	86.44	gold quality
secondary oocyte	CL:0000655	85.72	gold quality
buccal mucosa cell	CL:0002336	84.86	silver quality
cortical plate	UBERON:0005343	84.72	gold quality
tibia	UBERON:0000979	83.84	gold quality
visceral pleura	UBERON:0002401	82.89	gold quality
ganglionic eminence	UBERON:0004023	82.46	gold quality
monocyte	CL:0000576	82.37	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.29	gold quality
leukocyte	CL:0000738	82.25	gold quality
mononuclear cell	CL:0000842	82.21	gold quality
parietal pleura	UBERON:0002400	82.19	gold quality
amniotic fluid	UBERON:0000173	82.11	gold quality
germinal epithelium of ovary	UBERON:0001304	82.09	gold quality
blood	UBERON:0000178	81.56	gold quality
calcaneal tendon	UBERON:0003701	81.55	gold quality
pleura	UBERON:0000977	81.07	gold quality
tendon	UBERON:0000043	80.34	gold quality
esophagus squamous epithelium	UBERON:0006920	80.11	gold quality
oocyte	CL:0000023	79.88	gold quality
palpebral conjunctiva	UBERON:0001812	79.77	gold quality
stromal cell of endometrium	CL:0002255	79.63	gold quality
islet of Langerhans	UBERON:0000006	79.05	gold quality
ventricular zone	UBERON:0003053	78.98	gold quality
gingival epithelium	UBERON:0001949	78.85	gold quality
epithelium of nasopharynx	UBERON:0001951	78.69	gold quality
nasopharynx	UBERON:0001728	78.68	gold quality
eye	UBERON:0000970	78.65	gold quality
bone marrow	UBERON:0002371	77.95	gold quality
triceps brachii	UBERON:0001509	77.42	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-MTAB-6058	no	262.22
E-ANND-3	no	4.76

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

2 targets.

Target	Regulation
PER2
TAT

miRNA regulators (miRDB)

43 targeting GMEB1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4481	100.00	66.42	1669
HSA-MIR-4510	100.00	66.60	2050
HSA-MIR-6127	100.00	66.76	2188
HSA-MIR-6129	100.00	66.46	2080
HSA-MIR-6130	100.00	66.69	2012
HSA-MIR-6133	100.00	66.48	2064
HSA-MIR-4745-5P	99.98	65.95	1028
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-3912-5P	99.95	66.11	925
HSA-MIR-7-1-3P	99.91	71.53	4384
HSA-MIR-7-2-3P	99.91	71.40	4394
HSA-MIR-4648	99.91	67.00	710
HSA-MIR-10523-5P	99.91	69.22	2038
HSA-MIR-3529-3P	99.90	73.55	3045
HSA-MIR-30A-3P	99.87	69.74	2928
HSA-MIR-30D-3P	99.87	69.92	2917
HSA-MIR-30E-3P	99.87	69.68	2942
HSA-MIR-204-5P	99.79	71.62	2439
HSA-MIR-211-5P	99.79	71.65	2440
HSA-MIR-1299	99.77	71.24	2389
HSA-MIR-5093	99.67	69.26	2291
HSA-MIR-6832-3P	99.52	70.44	1726
HSA-MIR-6833-5P	99.50	68.93	1161
HSA-MIR-520A-5P	99.35	66.72	1632
HSA-MIR-525-5P	99.35	66.85	1615
HSA-MIR-504-3P	99.30	67.18	1745
HSA-MIR-6878-3P	99.24	64.23	920
HSA-MIR-4426	99.17	66.74	1949
HSA-MIR-6734-3P	99.15	66.27	1627
HSA-MIR-935	98.82	69.36	1072

Literature-anchored findings (GeneRIF, showing 6)

• consensus DNA recognition motif for two KDWK transcription factors identifies flexible-length, CpG-methylation sensitive cognate binding sites in the majority of human promoters (PMID:11743720)
• 1.55 A resolution crystal structure of a central portion of GMEB1, encompassing its SAND domain (PMID:12702733)
• GMEB1 is capable of binding to the prodomain of caspase-2; findings indicated that GMEB1 might be an endogenous inhibitory protein that selectively interacts with prodomain of caspase-2 to disrupt the autoactivation (PMID:15555560)
• GMEB1 is an endogenous regulator that selectively binds to initiator procaspases and inhibits caspase-induced apoptosis (PMID:16497673)
• GMEB1 effectively attenuated caspase activation and apoptosis caused by these stresses in human neuroblastoma SK-N-MC cells, indicating that it functions as a potent inhibitor of caspase activation and apoptosis in response to oxidative stress. (PMID:18455874)
• Our findings show the de-ubiquitinase USP40 regulates the ubiquitination and degradation of CFLARL; and GMEB1 acts as a bridge protein for USP40 and CFLARL. Mechanistically, we found GMEB1 inhibits the activation of CASP8 by modulating ubiquitination and degradation of CFLARL (PMID:31046799)

Cross-species orthologs

7 orthologs

Organism	Symbol	Gene ID
danio_rerio	gmeb1	ENSDARG00000062060
mus_musculus	Gmeb1	ENSMUSG00000028901
rattus_norvegicus	Gmeb1	ENSRNOG00000010910
caenorhabditis_elegans		WBGENE00007732
caenorhabditis_elegans		WBGENE00008092
caenorhabditis_elegans		WBGENE00010010
caenorhabditis_elegans		WBGENE00015285

Paralogs (1): GMEB2 (ENSG00000101216)

Protein

Protein identifiers

Glucocorticoid modulatory element-binding protein 1 — Q9Y692 (reviewed: Q9Y692)

Alternative names: DNA-binding protein p96PIF, Parvovirus initiation factor p96

All UniProt accessions (2): B1AT47, Q9Y692

UniProt curated annotations — full annotation on UniProt →

Function. Acts as a DNA-binding transcriptional regulator involved in modulating the expression of genes responsive to glucocorticoid signaling. Specifically binds AT-rich DNA motifs known as glucocorticoid modulatory elements (GMEs), repressing or enhancing transcription depending on cellular context. Forms heterodimeric complexes with GMEB2, which enhances its DNA-binding specificity and transcriptional activity. This complex plays a critical role in the repression of glucocorticoid receptor (GR/NR3C1) transcriptional activity, acting as a negative modulator of glucocorticoid signaling. Regulates dopamine-enriched midbrain genes, including tyrosine hydroxylase/TH and the dopamine transporter SLC6A3, essential for dopamine signaling. Also binds the transferrin receptor promoter. In the cytoplasm, inhibits caspase activation and neuronal apoptosis by stabilizing CFLARL and blocking pro-caspase 8 activation.

Subunit / interactions. Homodimer, and heterodimer with GMEB2. GMEB1 and GMEB2 form the parvovirus initiator complex (PIF). Interacts with the glucocorticoid receptor (NR3C1) and NCOA2/TIF2. May interact with HSP27 and CREB-binding protein (CBP). Interacts with USP40 and CFLAR; these interactions allow USP40-mediated CFLAR deubiquitination. Interacts with TRAF3; this interaction enhances the anti-apoptotic activity of GMEB1.

Subcellular location. Nucleus. Cytoplasm.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9Y692-1	1	yes
Q9Y692-2	2

RefSeq proteins (3): NP_001306603, NP_006573, NP_077808 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000770	SAND_dom	Domain
IPR010919	SAND-like_dom_sf	Homologous_superfamily
IPR059099	GMEB1/2/Spe-44_dom	Domain

Pfam: PF01342, PF25892

UniProt features (30 total): binding site 8, strand 5, helix 5, sequence conflict 3, initiator methionine 1, chain 1, modified residue 1, splice variant 1, sequence variant 1, domain 1, turn 1, region of interest 1, coiled-coil region 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
1OQJ	X-RAY DIFFRACTION	1.55

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y692-F1	57.89	0.26

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (8): 170; 174; 178; 113; 139; 143; 146; 157

Post-translational modifications (1): 2

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 126 (showing top): GSE45365_NK_CELL_VS_CD8A_DC_MCMV_INFECTION_DN, chr1p35, GOMF_HEAT_SHOCK_PROTEIN_BINDING, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_DN, GOBP_POSITIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II, GOMF_DNA_BINDING_TRANSCRIPTION_ACTIVATOR_ACTIVITY, ATF2_S_UP.V1_DN, IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_UP, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, ATF5_TARGET_GENES, CBX7_TARGET_GENES, E2F2_TARGET_GENES, GLI3_TARGET_GENES, NFE2L1_TARGET_GENES

GO Biological Process (3): regulation of transcription by RNA polymerase II (GO:0006357), negative regulation of apoptotic process (GO:0043066), positive regulation of transcription by RNA polymerase II (GO:0045944)

GO Molecular Function (12): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228), protein-macromolecule adaptor activity (GO:0030674), identical protein binding (GO:0042802), metal ion binding (GO:0046872), Hsp27 protein binding (GO:0051008), sequence-specific double-stranded DNA binding (GO:1990837), DNA binding (GO:0003677), DNA-binding transcription factor activity (GO:0003700), protein binding (GO:0005515), sequence-specific DNA binding (GO:0043565)

GO Cellular Component (4): chromatin (GO:0000785), nucleus (GO:0005634), nucleoplasm (GO:0005654), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	3
cellular anatomical structure	3
regulation of DNA-templated transcription	2
transcription by RNA polymerase II	2
regulation of transcription by RNA polymerase II	2
protein binding	2
apoptotic process	1
regulation of apoptotic process	1
negative regulation of programmed cell death	1
positive regulation of DNA-templated transcription	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
DNA-binding transcription factor activity, RNA polymerase II-specific	1
DNA-binding transcription activator activity	1
positive regulation of transcription by RNA polymerase II	1
molecular adaptor activity	1
cation binding	1
heat shock protein binding	1
double-stranded DNA binding	1
sequence-specific DNA binding	1
nucleic acid binding	1
transcription cis-regulatory region binding	1
transcription regulator activity	1
binding	1
DNA binding	1
chromosome	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

790 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
GMEB1	TFRC	P02786	647
GMEB1	HSPB2	Q16082	605
GMEB1	HSPB1	P04792	557
GMEB1	HSPB3	Q12988	553
GMEB1	AIRE	O43918	462
GMEB1	NRIP1	P48552	460
GMEB1	YIPF1	Q9Y548	450
GMEB1	TAT	P17735	415
GMEB1	TRIM54	Q9BYV2	394
GMEB1	HIBADH	P31937	379
GMEB1	ITGB5	P18084	375
GMEB1	NR3C1	P04150	358
GMEB1	SF3A2	Q15428	347
GMEB1	UBE2I	P50550	347
GMEB1	ZBTB11	O95625	343

IntAct

48 interactions, top by confidence:

A	B	Type	Score
SDC2	PDPK1	psi-mi:“MI:0914”(association)	0.640
SSRP1	H3C1	psi-mi:“MI:0914”(association)	0.610
CD44	PDPK1	psi-mi:“MI:0914”(association)	0.530
TRAF3	GMEB1	psi-mi:“MI:0915”(physical association)	0.510
GMEB1	GMEB2	psi-mi:“MI:0915”(physical association)	0.500
GPC1	SNAP23	psi-mi:“MI:0915”(physical association)	0.400
GPC1	GANAB	psi-mi:“MI:0915”(physical association)	0.400
GMEB1	NS	psi-mi:“MI:0915”(physical association)	0.370
NS1	GMEB1	psi-mi:“MI:0915”(physical association)	0.370
NS2	GMEB1	psi-mi:“MI:0915”(physical association)	0.370
NS	GMEB1	psi-mi:“MI:0915”(physical association)	0.370
	GMEB1	psi-mi:“MI:0915”(physical association)	0.370
GMEB1	UBE2I	psi-mi:“MI:0915”(physical association)	0.370
IFNA14	GMEB1	psi-mi:“MI:0915”(physical association)	0.370
GMEB1	SMAD3	psi-mi:“MI:0915”(physical association)	0.370
ATF7IP	GMEB1	psi-mi:“MI:0915”(physical association)	0.370
SMAD1	GMEB1	psi-mi:“MI:0915”(physical association)	0.370
GMEB1	SNIP1	psi-mi:“MI:0915”(physical association)	0.370

BioGRID (61): GMEB1 (Two-hybrid), GMEB1 (Two-hybrid), GMEB1 (Two-hybrid), GMEB1 (Reconstituted Complex), GMEB1 (Affinity Capture-Western), GMEB2 (Affinity Capture-MS), GMEB1 (Affinity Capture-MS), GMEB1 (Affinity Capture-MS), MATN4 (Affinity Capture-MS), DHRS2 (Affinity Capture-MS), WDR54 (Affinity Capture-MS), GMEB1 (Affinity Capture-MS), GMEB1 (Affinity Capture-MS), GMEB1 (Two-hybrid), GMEB1 (Affinity Capture-Western)

ESM2 similar proteins: A0JMF8, B1WAV2, F2Z3T4, O02818, O77627, O88873, O93602, P05411, P05412, P05627, P12981, P15336, P16951, P17325, P18870, P22415, P31367, P48381, P54864, P56432, P58929, P79703, Q00969, Q04073, Q07956, Q07957, Q0V989, Q0V9K5, Q16656, Q24312, Q2HJ87, Q2TAL8, Q32NR3, Q4R3I8, Q4V872, Q502P7, Q58A65, Q5EAP5, Q5FWL0, Q61069

Diamond homologs: O75398, O77562, O88450, O88873, P58929, Q18171, Q24180, Q2HJ87, Q3KRF1, Q8BVK9, Q921C6, Q9JL60, Q9QUZ8, Q9UKD1, Q9Y692, Q9Z1T5, P23497, Q13342, A9CPT4, Q09415, Q9BXT4, Q9H930, Q9N1Q5, Q9VU41, Q9HB58, Q99388, A2A8L1, D3ZD32, F4KBP5, O15164, O16102, O43918, O96028, O97159, Q09698, Q12830, Q14839, Q5SPL2, Q64127, Q6E2N3

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 48 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Diseases associated with glycosaminoglycan metabolism	5	119.0×	5e-08
Attachment and Entry	5	93.9×	1e-07
Defective B4GALT7 causes EDS, progeroid type	5	89.2×	1e-07
Defective B3GAT3 causes JDSSDHD	5	89.2×	1e-07
Defective B3GALT6 causes EDSP2 and SEMDJL1	5	89.2×	1e-07
HS-GAG degradation	5	77.6×	2e-07
Respiratory syncytial virus (RSV) attachment and entry	5	77.6×	2e-07
Initiation of coagulation cascade	5	74.3×	2e-07

GO biological processes:

GO term	Partners	Fold	FDR
cell migration	6	9.0×	7e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

66 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	55
Likely benign	1
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

1422 predictions. Top by Δscore:

Variant	Effect	Δscore
1:28668836:GACG:G	donor_gain	1.0000
1:28668838:CGG:C	donor_loss	1.0000
1:28668840:G:GG	donor_gain	1.0000
1:28683582:GCA:G	acceptor_gain	1.0000
1:28690072:A:AG	acceptor_gain	1.0000
1:28690073:G:GG	acceptor_gain	1.0000
1:28690073:GTTT:G	acceptor_gain	1.0000
1:28691576:T:A	acceptor_gain	1.0000
1:28691583:A:AG	acceptor_gain	1.0000
1:28691584:G:GC	acceptor_gain	1.0000
1:28691584:GA:G	acceptor_gain	1.0000
1:28691584:GAT:G	acceptor_gain	1.0000
1:28691584:GATA:G	acceptor_gain	1.0000
1:28691584:GATAC:G	acceptor_gain	1.0000
1:28691709:GGTAA:G	donor_loss	1.0000
1:28691710:GTA:G	donor_loss	1.0000
1:28691711:T:A	donor_loss	1.0000
1:28692934:A:AG	acceptor_gain	1.0000
1:28692935:C:G	acceptor_gain	1.0000
1:28692938:TTA:T	acceptor_loss	1.0000
1:28692939:TA:T	acceptor_loss	1.0000
1:28692940:A:AG	acceptor_gain	1.0000
1:28692941:G:GG	acceptor_gain	1.0000
1:28692941:GT:G	acceptor_gain	1.0000
1:28692941:GTT:G	acceptor_gain	1.0000
1:28692941:GTTC:G	acceptor_gain	1.0000
1:28692941:GTTCA:G	acceptor_gain	1.0000
1:28693042:TCAGG:T	donor_loss	1.0000
1:28693043:CAGG:C	donor_loss	1.0000
1:28693046:G:GA	donor_loss	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000005795 (1:28668261 A>T), RS1000015565 (1:28705882 C>T), RS1000079220 (1:28706217 G>A,C,T), RS1000137848 (1:28715138 C>G), RS1000154731 (1:28673366 C>T), RS1000241276 (1:28686476 A>C,G), RS1000243431 (1:28673121 C>G,T), RS1000260096 (1:28690953 C>A,G,T), RS1000283385 (1:28693135 T>C), RS1000297301 (1:28699629 C>G), RS1000417269 (1:28668901 C>A,G,T), RS1000469180 (1:28667920 G>T), RS1000511847 (1:28715416 G>A), RS1000519712 (1:28704007 C>G,T), RS1000604722 (1:28668085 T>C)

Disease associations

OMIM: gene MIM:604409 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST90002379_3	Basophil count	4.000000e-09

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0005090	basophil count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

34 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression	3
sodium arsenite	affects cotreatment, decreases expression, increases abundance, increases stability	2
Tretinoin	increases expression	2
aristolochic acid I	decreases expression	1
TAK-243	increases sumoylation	1
triphenyl phosphate	affects expression	1
beta-lapachone	increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
cobaltous chloride	decreases expression	1
manganese chloride	increases abundance, affects cotreatment, decreases expression	1
benzo(e)pyrene	decreases methylation	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	increases expression	1
monomethylarsonous acid	decreases expression	1
abrine	increases expression	1
(+)-JQ1 compound	decreases expression	1
Leflunomide	increases expression	1
Acetaminophen	decreases expression	1
Arsenic	affects cotreatment, decreases expression, increases abundance	1
Doxorubicin	decreases expression	1
Manganese	affects cotreatment, decreases expression, increases abundance	1
Methapyrilene	decreases methylation	1
Rotenone	decreases expression	1
Smoke	decreases expression	1
Thiram	increases expression	1
Tobacco Smoke Pollution	increases expression	1
Tunicamycin	decreases expression	1
Urethane	increases expression	1
Cyclosporine	increases expression	1
Cadmium Chloride	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.