GMEB2

Summary

GMEB2 (glucocorticoid modulatory element binding protein 2, HGNC:4371) is a protein-coding gene on chromosome 20q13.33, encoding Glucocorticoid modulatory element-binding protein 2 (Q9UKD1). Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids.

This gene is a member of KDWK gene family. The product of this gene associates with GMEB1 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the glucocorticoid receptor bound to glucocorticoid response elements. This gene appears to use multiple polyadenylation sites.

Source: NCBI Gene 26205 — RefSeq curated summary.

At a glance

• GWAS associations: 9
• Clinical variants (ClinVar): 77 total — 1 likely-pathogenic
• MANE Select transcript: NM_012384

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:4371
Approved symbol	GMEB2
Name	glucocorticoid modulatory element binding protein 2
Location	20q13.33
Locus type	gene with protein product
Status	Approved
Aliases	P79PIF, KIAA1269, PIF79
Ensembl gene	ENSG00000101216
Ensembl biotype	protein_coding
OMIM	607451
Entrez	26205

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 8 protein_coding, 1 retained_intron

ENST00000266068, ENST00000370069, ENST00000370077, ENST00000889842, ENST00000889843, ENST00000889844, ENST00000936808, ENST00000936809, ENST00000951328

RefSeq mRNA: 1 — MANE Select: NM_012384 NM_012384

CCDS: CCDS13528

Canonical transcript exons

ENST00000370077 — 10 exons

Exon	Start	End
ENSE00000663497	63604743	63604840
ENSE00001417477	63626956	63627101
ENSE00001451682	63619267	63619454
ENSE00003843772	63587605	63590729
ENSE00004283370	63597757	63597860
ENSE00004283371	63592022	63592144
ENSE00004283372	63602965	63603092
ENSE00004283373	63592533	63592670
ENSE00004283374	63593011	63593082
ENSE00004283376	63595610	63595767

Expression profiles

Bgee: expression breadth ubiquitous, 269 present calls, max score 93.87.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 12.5436 / max 193.3725, expressed in 1795 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
188392	11.4260	1787
188391	1.1176	426

Top tissues by expression

283 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
parotid gland	UBERON:0001831	93.87	gold quality
buccal mucosa cell	CL:0002336	88.22	gold quality
thymus	UBERON:0002370	86.94	gold quality
mucosa of urinary bladder	UBERON:0001259	86.71	silver quality
ileal mucosa	UBERON:0000331	86.23	gold quality
pancreatic ductal cell	CL:0002079	86.17	silver quality
granulocyte	CL:0000094	84.33	gold quality
right lobe of thyroid gland	UBERON:0001119	83.96	gold quality
tibialis anterior	UBERON:0001385	83.78	gold quality
blood	UBERON:0000178	83.59	gold quality
cartilage tissue	UBERON:0002418	83.50	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.43	gold quality
left lobe of thyroid gland	UBERON:0001120	83.13	gold quality
tendon of biceps brachii	UBERON:0008188	83.06	gold quality
thyroid gland	UBERON:0002046	82.89	gold quality
oocyte	CL:0000023	82.85	gold quality
dorsal motor nucleus of vagus nerve	UBERON:0002870	82.65	gold quality
endothelial cell	CL:0000115	81.90	gold quality
saphenous vein	UBERON:0007318	81.76	gold quality
pylorus	UBERON:0001166	81.42	gold quality
upper leg skin	UBERON:0004262	81.35	gold quality
trachea	UBERON:0003126	81.34	gold quality
inferior olivary complex	UBERON:0002127	81.19	gold quality
tongue squamous epithelium	UBERON:0006919	81.11	silver quality
olfactory bulb	UBERON:0002264	81.02	gold quality
amniotic fluid	UBERON:0000173	80.94	gold quality
lower esophagus mucosa	UBERON:0035834	80.92	gold quality
cerebellar vermis	UBERON:0004720	80.77	silver quality
apex of heart	UBERON:0002098	80.67	gold quality
skin of hip	UBERON:0001554	80.60	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.28

Regulation

Is transcription factor: yes

JASPAR motifs

Motif	Name	Family
MA0862.1	GMEB2	GMEB

JASPAR matrix evidence (PMIDs): PMID:11743720

miRNA regulators (miRDB)

73 targeting GMEB2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-5193	100.00	67.26	1744
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-3605-5P	99.96	67.12	932
HSA-MIR-10527-5P	99.91	72.28	3754
HSA-MIR-4648	99.91	67.00	710
HSA-MIR-659-3P	99.85	70.69	1620
HSA-MIR-765	99.84	68.24	2442
HSA-MIR-6764-5P	99.75	67.89	2304
HSA-MIR-11181-3P	99.75	66.38	2205
HSA-MIR-6752-3P	99.72	66.71	1587
HSA-MIR-379-3P	99.69	69.60	1524
HSA-MIR-411-3P	99.69	69.63	1524
HSA-MIR-5093	99.67	69.26	2291
HSA-MIR-6715B-5P	99.64	69.63	1420
HSA-MIR-1915-3P	99.58	66.79	1988

Literature-anchored findings (GeneRIF, showing 1)

• consensus DNA recognition motif for two KDWK transcription factors identifies flexible-length, CpG-methylation sensitive cognate binding sites in the majority of human promoters (PMID:11743720)

Cross-species orthologs

7 orthologs

Organism	Symbol	Gene ID
danio_rerio	gmeb2	ENSDARG00000093240
mus_musculus	Gmeb2	ENSMUSG00000038705
rattus_norvegicus	Gmeb2	ENSRNOG00000013339
caenorhabditis_elegans		WBGENE00007732
caenorhabditis_elegans		WBGENE00008092
caenorhabditis_elegans		WBGENE00010010
caenorhabditis_elegans		WBGENE00015285

Paralogs (1): GMEB1 (ENSG00000162419)

Protein

Protein identifiers

Glucocorticoid modulatory element-binding protein 2 — Q9UKD1 (reviewed: Q9UKD1)

Alternative names: DNA-binding protein p79PIF, Parvovirus initiation factor p79

All UniProt accessions (1): Q9UKD1

UniProt curated annotations — full annotation on UniProt →

Function. Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Also binds to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.

Subunit / interactions. Homodimer, and heterodimer of GMEB1 and GMEB2. GMEB1 and GMEB2 form the parvovirus initiator complex (PIF). Interacts with the glucocorticoid receptor (NR3C1). May interact with CREB-binding protein (CBP).

Subcellular location. Nucleus. Cytoplasm.

Tissue specificity. Expressed in peripheral blood lymphocytes and fetal liver. Expressed preferentially in reproductive and/or developmentally important cells, such as testis, placenta, bone marrow and fetal tissues.

RefSeq proteins (1): NP_036516* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000770	SAND_dom	Domain
IPR010919	SAND-like_dom_sf	Homologous_superfamily
IPR059099	GMEB1/2/Spe-44_dom	Domain

Pfam: PF01342, PF25892

UniProt features (17 total): binding site 8, sequence conflict 3, cross-link 2, chain 1, domain 1, modified residue 1, coiled-coil region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9UKD1-F1	61.98	0.30

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (8): 175; 110; 136; 140; 143; 154; 167; 171

Post-translational modifications (3): 373, 155, 155

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 92 (showing top): BLALOCK_ALZHEIMERS_DISEASE_UP, TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P, GCM_NF2, CTTTGTA_MIR524, YOSHIMURA_MAPK8_TARGETS_UP, NIKOLSKY_BREAST_CANCER_20Q12_Q13_AMPLICON, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, HOLLEMAN_DAUNORUBICIN_B_ALL_DN, HOLLEMAN_DAUNORUBICIN_ALL_DN, GSE13522_CTRL_VS_T_CRUZI_BRAZIL_STRAIN_INF_SKIN_UP, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, HMG20B_TARGET_GENES, NR1I2_TARGET_GENES, RBM34_TARGET_GENES, SFMBT1_TARGET_GENES

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), transcription by RNA polymerase II (GO:0006366)

GO Molecular Function (8): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), identical protein binding (GO:0042802), metal ion binding (GO:0046872), sequence-specific double-stranded DNA binding (GO:1990837), DNA binding (GO:0003677), protein binding (GO:0005515), sequence-specific DNA binding (GO:0043565)

GO Cellular Component (5): chromatin (GO:0000785), nucleus (GO:0005634), nucleoplasm (GO:0005654), cytosol (GO:0005829), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
protein binding	1
cation binding	1
double-stranded DNA binding	1
sequence-specific DNA binding	1
nucleic acid binding	1
binding	1
DNA binding	1
chromosome	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cytoplasm	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

1050 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
GMEB2	TFRC	P02786	648
GMEB2	ARFRP1	Q13795	597
GMEB2	FNDC11	Q9BVV2	550
GMEB2	HSPB2	Q16082	548
GMEB2	ZGPAT	Q8N5A5	529
GMEB2	HSPB1	P04792	525
GMEB2	STMN3	Q9NZ72	515
GMEB2	NR3C1	P04150	501
GMEB2	HSPB3	Q12988	496
GMEB2	TYSND1	Q2T9J0	490
GMEB2	BTBD3	Q9Y2F9	462
GMEB2	TAT	P17735	454
GMEB2	PXMP4	Q9Y6I8	446
GMEB2	NELFB	Q8WX92	437
GMEB2	ZNF341	Q9BYN7	408

IntAct

83 interactions, top by confidence:

A	B	Type	Score
ATXN1	GMEB2	psi-mi:“MI:0915”(physical association)	0.670
SDC2	PDPK1	psi-mi:“MI:0914”(association)	0.640
GMEB2	MXRA8	psi-mi:“MI:0915”(physical association)	0.560
ZMYND19	GMEB2	psi-mi:“MI:0915”(physical association)	0.560
GMEB2	GMEB2	psi-mi:“MI:0915”(physical association)	0.560
CEP19	GMEB2	psi-mi:“MI:0915”(physical association)	0.560
MAP1LC3C	GMEB2	psi-mi:“MI:0915”(physical association)	0.560
TRAF3	GMEB2	psi-mi:“MI:0915”(physical association)	0.560
FHL2	GMEB2	psi-mi:“MI:0915”(physical association)	0.560
PIN1	GMEB2	psi-mi:“MI:0915”(physical association)	0.560
POGZ	GMEB2	psi-mi:“MI:0915”(physical association)	0.560
LMO3	GMEB2	psi-mi:“MI:0915”(physical association)	0.560
POU6F2	GMEB2	psi-mi:“MI:0915”(physical association)	0.560
CDC7	GMEB2	psi-mi:“MI:0915”(physical association)	0.560
LMO2	GMEB2	psi-mi:“MI:0915”(physical association)	0.560
MXRA8	GMEB2	psi-mi:“MI:0915”(physical association)	0.560
GMEB2	TTF2	psi-mi:“MI:0915”(physical association)	0.560
MOB1A	GMEB2	psi-mi:“MI:0915”(physical association)	0.560
CD44	PDPK1	psi-mi:“MI:0914”(association)	0.530
GMEB1	GMEB2	psi-mi:“MI:0915”(physical association)	0.500
CBFA2T3	GMEB2	psi-mi:“MI:0915”(physical association)	0.370
CD44	TCAF2	psi-mi:“MI:0914”(association)	0.350
SDC2	METTL8	psi-mi:“MI:0914”(association)	0.350
SDC1	ARVCF	psi-mi:“MI:0914”(association)	0.350
GMEB1	MATN4	psi-mi:“MI:0914”(association)	0.350
IL7R	FAM171A2	psi-mi:“MI:0914”(association)	0.350

BioGRID (67): GMEB2 (Affinity Capture-RNA), GMEB2 (Affinity Capture-RNA), GMEB2 (Affinity Capture-RNA), GMEB2 (Proximity Label-MS), GMEB2 (Affinity Capture-MS), GMEB2 (Affinity Capture-MS), GMEB2 (Affinity Capture-MS), GMEB2 (Affinity Capture-MS), GMEB2 (Affinity Capture-MS), GMEB2 (Two-hybrid), GMEB2 (Two-hybrid), GMEB2 (Two-hybrid), POU6F2 (Two-hybrid), MOB1A (Two-hybrid), FHL2 (Two-hybrid)

ESM2 similar proteins: A2RSY1, F1R7R1, O54972, O75069, O75151, O88873, P0CH95, P49140, P58929, Q02225, Q06455, Q13233, Q1LY51, Q24767, Q2VPU4, Q2YDD2, Q3KR73, Q499B3, Q4VGL6, Q5F3B1, Q5PQS6, Q5TC82, Q60416, Q60698, Q61909, Q62415, Q62739, Q66IV1, Q6F6B3, Q6NUC6, Q6NYU6, Q7Z3K3, Q80TJ7, Q80W04, Q8BZH4, Q8CHY6, Q8CID0, Q8K2L8, Q8NEM7, Q8TEK3

Diamond homologs: O43439, O54972, O70374, O75081, O75398, O77562, O88450, O88873, P23497, P58929, Q06455, Q13342, Q3KRF1, Q5F3B1, Q61909, Q8BVK9, Q921C6, Q9H930, Q9HB58, Q9IAB2, Q9UKD1, Q9Z1T5, Q24180, Q18171, Q2HJ87, Q9JL60, Q9QUZ8, Q9Y692, Q99388, Q9N1Q5

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 51 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Extracellular matrix organization	5	10.9×	1e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

77 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	1
Uncertain significance	62
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
1326329	GRCh37/hg19 20q13.33(chr20:61826780-62660844)	Likely pathogenic

SpliceAI

2175 predictions. Top by Δscore:

Variant	Effect	Δscore
20:63590725:CAGGG:C	acceptor_gain	1.0000
20:63590726:AGGG:A	acceptor_gain	1.0000
20:63590727:GGG:G	acceptor_gain	1.0000
20:63590728:GG:G	acceptor_gain	1.0000
20:63590728:GGC:G	acceptor_loss	1.0000
20:63590730:C:CC	acceptor_gain	1.0000
20:63590730:CTG:C	acceptor_loss	1.0000
20:63590731:T:A	acceptor_loss	1.0000
20:63592126:T:C	acceptor_gain	1.0000
20:63592142:CAT:C	acceptor_gain	1.0000
20:63592142:CATCT:C	acceptor_gain	1.0000
20:63592145:C:CC	acceptor_gain	1.0000
20:63592146:T:C	acceptor_gain	1.0000
20:63592146:T:TC	acceptor_gain	1.0000
20:63592527:TCTCA:T	donor_loss	1.0000
20:63592528:CTCA:C	donor_loss	1.0000
20:63592529:TCACC:T	donor_loss	1.0000
20:63592530:CA:C	donor_loss	1.0000
20:63592531:A:AT	donor_loss	1.0000
20:63592649:C:CT	acceptor_gain	1.0000
20:63592649:C:T	acceptor_gain	1.0000
20:63592652:C:CT	acceptor_gain	1.0000
20:63592666:GTCAT:G	acceptor_gain	1.0000
20:63592667:TCAT:T	acceptor_gain	1.0000
20:63592668:CAT:C	acceptor_gain	1.0000
20:63592668:CATC:C	acceptor_gain	1.0000
20:63592669:AT:A	acceptor_gain	1.0000
20:63592671:C:CC	acceptor_gain	1.0000
20:63592672:T:G	acceptor_loss	1.0000
20:63592673:G:C	acceptor_gain	1.0000

AlphaMissense

3429 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
20:63595698:G:C	S177R	1.000
20:63595698:G:T	S177R	1.000
20:63595700:T:G	S177R	1.000
20:63595704:G:C	C175W	1.000
20:63595705:C:A	C175F	1.000
20:63595705:C:G	C175S	1.000
20:63595705:C:T	C175Y	1.000
20:63595706:A:G	C175R	1.000
20:63595706:A:T	C175S	1.000
20:63595716:G:C	C171W	1.000
20:63595717:C:G	C171S	1.000
20:63595717:C:T	C171Y	1.000
20:63595718:A:G	C171R	1.000
20:63595718:A:T	C171S	1.000
20:63595737:G:C	F164L	1.000
20:63595737:G:T	F164L	1.000
20:63595738:A:G	F164S	1.000
20:63595739:A:G	F164L	1.000
20:63595757:C:G	D158H	1.000
20:63595767:C:A	R154S	1.000
20:63595767:C:G	R154S	1.000
20:63597757:C:A	R154M	1.000
20:63597757:C:G	R154T	1.000
20:63597760:A:G	L153P	1.000
20:63597760:A:T	L153H	1.000
20:63597762:C:A	M152I	1.000
20:63597762:C:G	M152I	1.000
20:63597762:C:T	M152I	1.000
20:63597778:C:G	R147P	1.000
20:63597779:G:T	R147S	1.000

dbSNP variants (sampled 300 via entrez): RS1000041142 (20:63612965 T>A), RS1000060214 (20:63623892 A>C), RS1000080615 (20:63600549 C>G), RS1000099795 (20:63617707 C>T), RS1000136866 (20:63600858 G>A,C), RS1000152286 (20:63606873 A>T), RS1000228666 (20:63623019 C>T), RS1000255626 (20:63595329 G>A), RS1000262887 (20:63606553 T>A), RS1000441719 (20:63614363 G>A,C), RS1000450322 (20:63628912 G>A), RS1000453276 (20:63594372 G>A), RS1000485696 (20:63605959 GA>G,GAA), RS1000613544 (20:63599570 C>T), RS1000673083 (20:63628107 G>C)

Disease associations

OMIM: gene MIM:607451 | disease phenotypes: MIM:121200, MIM:613720

GenCC curated gene-disease

Mondo (2): seizures, benign familial neonatal, 1 (MONDO:0007365), developmental and epileptic encephalopathy, 7 (MONDO:0013387)

Orphanet (2): Self-limited neonatal epilepsy (Orphanet:1949), KCNQ2-related developmental and epileptic encephalopathy (Orphanet:439218)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

9 associations (top):

Study	Trait	p-value
GCST001942_22	Prostate cancer	4.000000e-16
GCST010002_71	Refractive error	1.000000e-14
GCST010796_2607	Electrocardiogram morphology (amplitude at temporal datapoints)	2.000000e-09
GCST010796_2608	Electrocardiogram morphology (amplitude at temporal datapoints)	3.000000e-08
GCST010796_2609	Electrocardiogram morphology (amplitude at temporal datapoints)	4.000000e-09
GCST010796_2610	Electrocardiogram morphology (amplitude at temporal datapoints)	2.000000e-09
GCST010796_2611	Electrocardiogram morphology (amplitude at temporal datapoints)	2.000000e-09
GCST010796_2612	Electrocardiogram morphology (amplitude at temporal datapoints)	6.000000e-09
GCST90002405_409	Reticulocyte count	3.000000e-09

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004327	electrocardiography
EFO:0007986	reticulocyte count

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
C567743	Epilepsy, Benign Neonatal, 1, And-Or Myokymia (supp.)

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

27 total (human), top 27 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	decreases expression, affects expression	5
Arsenic	affects methylation, increases abundance, increases expression	2
GSK-J4	increases expression	1
TAK-243	increases sumoylation	1
triphenyl phosphate	affects expression	1
sodium arsenate	decreases expression	1
trichostatin A	decreases expression	1
sodium arsenite	increases abundance, increases expression	1
coumarin	affects phosphorylation	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
abrine	increases expression	1
jinfukang	affects cotreatment, decreases expression	1
Vorinostat	decreases expression	1
Benzene	increases expression	1
Benzo(a)pyrene	affects methylation	1
Carbamazepine	affects expression	1
Cisplatin	affects cotreatment, decreases expression	1
Dichlorodiphenyl Dichloroethylene	decreases expression	1
Doxorubicin	decreases expression	1
Methyl Methanesulfonate	increases expression	1
Smoke	decreases expression	1
Thiram	increases expression	1
Tobacco Smoke Pollution	increases expression	1
Cyclosporine	increases expression	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.