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Atlas / Gene / GNA13

GNA13

gene
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Also known as G13MGC46138

Summary

GNA13 (G protein subunit alpha 13, HGNC:4381) is a protein-coding gene on chromosome 17q24.1, encoding Guanine nucleotide-binding protein subunit alpha-13 (Q14344). Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Enables G protein activity. Involved in Rho-activating G protein-coupled receptor signaling pathway. Located in cytosol and nucleus.

Source: NCBI Gene 10672 — RefSeq curated summary.

At a glance

  • GWAS associations: 3
  • Clinical variants (ClinVar): 37 total — 1 pathogenic
  • Cancer driver (intOGen): loss-of-function (tumor-suppressor-like) across 3 cancer types
  • MANE Select transcript: NM_006572

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:4381
Approved symbolGNA13
NameG protein subunit alpha 13
Location17q24.1
Locus typegene with protein product
StatusApproved
AliasesG13, MGC46138
Ensembl geneENSG00000120063
Ensembl biotypeprotein_coding
OMIM604406
Entrez10672

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 protein_coding

ENST00000439174, ENST00000541118, ENST00000866834, ENST00000866835, ENST00000866836, ENST00000929019

RefSeq mRNA: 2 — MANE Select: NM_006572 NM_001282425, NM_006572

CCDS: CCDS11661, CCDS62302

Canonical transcript exons

ENST00000439174 — 4 exons

ExonStartEnd
ENSE000011063096501825365018303
ENSE000012290266505631165056740
ENSE000017982296500928965014829
ENSE000035689256505350265053728

Expression profiles

Bgee: expression breadth ubiquitous, 270 present calls, max score 99.19.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 42.8847 / max 1146.9328, expressed in 1814 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter IDTPM avgSamples expressed
16762327.52031800
1676246.49461557
1676226.23621651
1676251.4595759
1676200.6806175
1676190.2511114
1676210.2423100

Top tissues by expression

293 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
secondary oocyteCL:000065599.19gold quality
oocyteCL:000002399.04gold quality
mucosa of sigmoid colonUBERON:000499398.95gold quality
spermCL:000001998.90gold quality
superficial temporal arteryUBERON:000161498.64gold quality
trabecular bone tissueUBERON:000248398.49gold quality
colonic mucosaUBERON:000031798.48gold quality
jejunal mucosaUBERON:000039998.46gold quality
visceral pleuraUBERON:000240198.42gold quality
epithelium of nasopharynxUBERON:000195198.12gold quality
jejunumUBERON:000211598.10gold quality
lower lobe of lungUBERON:000894998.07gold quality
amniotic fluidUBERON:000017398.05gold quality
parietal pleuraUBERON:000240097.96gold quality
seminal vesicleUBERON:000099897.72gold quality
biceps brachiiUBERON:000150797.70gold quality
skeletal muscle tissue of biceps brachiiUBERON:000450297.68gold quality
tibiaUBERON:000097997.63gold quality
trigeminal ganglionUBERON:000167597.61gold quality
vena cavaUBERON:000408797.56gold quality
mammary ductUBERON:000176597.52gold quality
pericardiumUBERON:000240797.50gold quality
cauda epididymisUBERON:000436097.37gold quality
mucosa of paranasal sinusUBERON:000503097.32gold quality
subthalamic nucleusUBERON:000190697.24gold quality
skin of hipUBERON:000155497.22gold quality
germinal epithelium of ovaryUBERON:000130497.20gold quality
lateral globus pallidusUBERON:000247697.04gold quality
skeletal muscle tissue of rectus abdominisUBERON:000451196.97gold quality
globus pallidusUBERON:000187596.92gold quality

Single-cell (SCXA)

Detected in 6 experiment(s), a significant marker in 5.

ExperimentMarker?Max mean expression
E-GEOD-180759yes1452.36
E-GEOD-81383yes367.95
E-MTAB-8142yes66.68
E-HCAD-4yes37.81
E-MTAB-6075no519.05
E-ANND-3no0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): RUNX2

miRNA regulators (miRDB)

198 targeting GNA13, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-3163100.0077.238605
HSA-LET-7A-3P100.0074.033932
HSA-LET-7B-3P100.0074.083913
HSA-LET-7F-1-3P100.0074.023928
HSA-MIR-98-3P100.0074.083907
HSA-MIR-3646100.0073.565283
HSA-MIR-3613-3P100.0076.367965
HSA-MIR-6833-3P100.0070.633197
HSA-MIR-4768-5P100.0069.492861
HSA-MIR-30A-5P100.0076.313233
HSA-MIR-30B-5P100.0076.293248
HSA-MIR-30C-5P100.0076.293248
HSA-MIR-30D-5P100.0076.323233
HSA-MIR-30E-5P100.0076.323242
HSA-MIR-5692A100.0074.406850
HSA-MIR-7110-3P100.0073.182486
HSA-MIR-548AW99.9972.573559
HSA-MIR-371B-5P99.9975.344759
HSA-MIR-366299.9973.825684
HSA-MIR-428299.9975.366408
HSA-MIR-196A-1-3P99.9972.152772
HSA-MIR-616-5P99.9875.584775
HSA-MIR-373-5P99.9875.364753
HSA-MIR-520D-5P99.9873.344883
HSA-MIR-524-5P99.9873.434882
HSA-MIR-1213699.9872.815713
HSA-MIR-806899.9873.852376
HSA-MIR-433-3P99.9869.371203
HSA-MIR-548N99.9871.944170
HSA-MIR-60799.9773.625593

Literature-anchored findings (GeneRIF, showing 40)

  • Galpha12 and Galpha13 negatively regulate the adhesive functions of cadherin (PMID:11976333)
  • Galpha13 is not associated with lipid rafts (PMID:12117999)
  • Galpha13 can induce ppET-1 gene expression through a JNK-mediated pathway. (PMID:12135322)
  • co-stimulation of G(12/13) and G(i) pathways is sufficient to activate GPIIb/IIIa in human platelets in a mechanism that involves intracellular calcium (PMID:12297512)
  • These results suggest that protein kinase A blocks Rho activation by phosphorylation of Galpha(13) Thr(203). (PMID:12399457)
  • Selective activation of Galpha(12) and Galpha(13) by thrombin and LPA, respectively, is determined by the N-terminal short sequences of alpha subunits. (PMID:12594220)
  • Several features of a typical alpha/RGS interaction are preserved in the alpha(13)/p115RhoGEF interaction. (PMID:15735747)
  • Galpha13-induced VASP phosphorylation that involves activation of RhoA and MEKK1, phosphorylation and degradation of IkappaB, release of PKA catalytic subunit from the complex with IkappaB and NF-kappaB, and subsequent phosphorylation of VASP (PMID:16046415)
  • analysis of the molecular mechanism of how the human TXA2 receptor interacts with G alpha 13 to activate intracellular signaling (PMID:16212421)
  • Estrogen receptor alpha interacts with Galpha13 to drive actin remodeling and endothelial cell migration. (PMID:16601072)
  • Results identify the G12 family proteins Galpha12 and 13 as important regulators of prostate cancer invasion and suggest that these proteins may be targeted to limit invasion- and metastasis-induced prostate cancer patient mortality. (PMID:16787920)
  • Galpha13-Rho signaling axis is required for SDF-1-induced migration through CXCR4 (PMID:17056591)
  • Distinct regions of Galpha13 participate in its regulatory interactions with RGS homology domain-containing RhoGEFs. (PMID:17449226)
  • analysis of a novel cross-talk exerted from the LPA/Galpha(13)/p115RhoGEF/RhoA pathway to the beta(2)-adrenergic receptor/Galpha(s)/adenylyl cyclase pathway (PMID:17493936)
  • G alpha(12/13) regulate basal p53 levels via mdm4, which constitutes a cell signaling pathway distinct from p53 phosphorylations elicited by genotoxic stress. (PMID:17510313)
  • role in regulating ASK1 expression levels (PMID:17595347)
  • provides first examination of Galpha12 and Galpha13 in the human heart, demonstrating selective activation of human atrial Galpha12 and Galpha13 by endothelin and angiotensin receptors, respectively (PMID:17878759)
  • A pronounced and rapid translocation of p115-RhoGEF from the cytosol to the plasma membrane was observed upon activation of several G(12/13)-coupled receptors in a cell type-independent fashion. (PMID:18320579)
  • AC7 is a specific downstream effector of the G(12/13) pathway (PMID:18541530)
  • RGS22 may also play a role in GNA13 translocation from the cytoplasm to the nucleus during spermiogenesis (PMID:18703424)
  • Protein kinase C-related kinase and ROCK are required for thrombin-induced endothelial cell permeability downstream from Galpha12/13 and Galpha11/q (PMID:18713748)
  • G(alpha)(13)-dependent downstream effects on RhoA activation and invasion tightly depend on cell type-specific GAP activities and that G(alpha)(13)-p190RhoGAP signaling might represent a potential target for intervention in melanoma metastasis. (PMID:18922893)
  • LARG activation is regulated by an induced-fit mechanism through the GAP interface of Galpha(13). (PMID:19074425)
  • MEF2 proteins are an important component in Galpha13-mediated angiogenesis. (PMID:19093215)
  • This review gives an overview of Galpha12/13 signaling of G protein-coupled receptors with a focus on RhoGTPase nucleotide exchange factor (RhoGEF) proteins as the immediate mediators of G12/13 activation. (PMID:19226283)
  • The studies highlighted in this review provide compelling evidence that Galpha12 and Galpha13 play pivotal roles in many aspects of cancer invasion and metastasis. (PMID:19422395)
  • Galpha(13) is haploinsufficient for adult angiogenesis in both the female reproductive system and tumor angiogenesis. (PMID:19654325)
  • TXA(2) receptor mediates water influx through aquaporins in astrocytoma cells via TXA(2) receptor-mediated activation of G alpha(12/13), Rho A, Rho kinase and Na(+)/H(+)-exchanger. (PMID:19772916)
  • Galpha12/13 upregulate matrix metalloproteinase-2 via p53 promoting human breast cell invasion. (PMID:20044778)
  • study demonstrates not only a function of integrin alphaIIbbeta3 as a noncanonical Galpha13-coupled receptor but also a new concept of Galpha13-dependent dynamic regulation of RhoA (PMID:20075254)
  • G(alpha)(12) and G(alpha)13) exert a complex pattern of nonredundant effects in small cell lung cancer cells (PMID:20160064)
  • Galpha(12) binds to p120(ctn) and modulates its phosphorylation status through a Rho-independent mechanism. Galpha(12) emerges as an important regulator of p120(ctn) function (PMID:20974127)
  • A new role is described for Galpha13 as a mediator of chemokine receptor CXCR4 endosomal trafficking in human T cells. (PMID:21148034)
  • Galpha(12/13) regulate AP-1-dependent CYR61 induction in vascular smooth muscle, promoting migration, and they are upregulated with CYR61 in arteriosclerotic lesions. (PMID:21212405)
  • Negative regulation of Gq-mediated pathways in platelets by G(12/13) pathways through Fyn kinase (PMID:21592972)
  • alpha subunit of the G protein G13 regulates activity of one or more Gli transcription factors independently of smoothened (PMID:21757753)
  • signaling-selective inhibition of the CXCR4-Galpha(13)-Rho axis prevents the metastatic spread of basal-like breast cancer cells. (PMID:21934106)
  • Activation of p115-RhoGEF requires direct association of Galpha13 and the Dbl homology domain. (PMID:22661716)
  • GNA13 is an important mediator of prostate cancer cell invasion, and miR-182 and miR-200 family members regulate its expression post-transcriptionally (PMID:23329838)
  • Itk enhances Galpha13 mediated activation of serum response factor (SRF) transcriptional activity dependent on its ability to interact with Galpha13, but its kinase activity is not required to enhance SRF activity. (PMID:23454662)

Cross-species orthologs

22 orthologs

OrganismSymbolGene ID
danio_reriogna13bENSDARG00000037924
danio_reriogna13aENSDARG00000073765
mus_musculusGna13ENSMUSG00000020611
rattus_norvegicusGna13ENSRNOG00000063135
drosophila_melanogasterctaFBGN0000384
drosophila_melanogasterGalphaiFBGN0001104
drosophila_melanogasterGalphafFBGN0010223
drosophila_melanogasterCG17760FBGN0033756
drosophila_melanogasterCG30054FBGN0050054
caenorhabditis_elegansWBGENE00001664
caenorhabditis_elegansWBGENE00001665
caenorhabditis_elegansWBGENE00001666
caenorhabditis_elegansWBGENE00001667
caenorhabditis_elegansWBGENE00001668
caenorhabditis_elegansWBGENE00001670
caenorhabditis_elegansWBGENE00001671
caenorhabditis_elegansWBGENE00001673
caenorhabditis_elegansWBGENE00001674
caenorhabditis_elegansWBGENE00001675
caenorhabditis_elegansgpa-14WBGENE00001676
caenorhabditis_elegansgpa-16WBGENE00001678
caenorhabditis_elegansgsa-1WBGENE00001745

Paralogs (15): GNA15 (ENSG00000060558), GNAI3 (ENSG00000065135), GNAO1 (ENSG00000087258), GNAS (ENSG00000087460), GNA11 (ENSG00000088256), GNAT1 (ENSG00000114349), GNAI2 (ENSG00000114353), GNAI1 (ENSG00000127955), GNAZ (ENSG00000128266), GNAT2 (ENSG00000134183), GNAL (ENSG00000141404), GNA12 (ENSG00000146535), GNA14 (ENSG00000156049), GNAQ (ENSG00000156052), GNAT3 (ENSG00000214415)

Protein

Protein identifiers

Guanine nucleotide-binding protein subunit alpha-13 — Q14344 (reviewed: Q14344)

All UniProt accessions (1): Q14344

UniProt curated annotations — full annotation on UniProt →

Function. Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway. Inhibits CDH1-mediated cell adhesion in a process independent from Rho activation. In lymphoid follicles, transmits P2RY8- and S1PR2-dependent signals that lead to inhibition of germinal center (GC) B cell growth and migration outside the GC niche.

Subunit / interactions. G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with UBXD5. Interacts with HAX1. Interacts (in GTP-bound form) with PPP5C (via TPR repeats); activates PPP5C phosphatase activity and translocates PPP5C to the cell membrane. Interacts with RGS22. Interacts (in GTP-bound form) with ARHGEF1. Interacts (in GTP-bound form) with ARHGEF11 (via RGS domain). Interacts (in GTP-bound form) with ARHGEF12 (via RGS domain). Interacts with CTNND1. Interacts with GASL2L2. Interacts with GPR35. Interacts with GPR174.

Subcellular location. Cell membrane. Melanosome. Cytoplasm. Nucleus.

Tissue specificity. Expressed in testis, including in Leydig cells and in the seminiferous epithelium, in differentiating cells from the spermatogonia to mature spermatozoa stages and round spermatids (at protein level). Expressed in 99.2% of spermatozoa from healthy individuals, but only in 28.6% of macrocephalic spermatozoa from infertile patients (at protein level).

Post-translational modifications. Palmitoylation is critical for proper membrane localization and signaling. Phosphorylation on Thr-203 by PKA destabilizes the heterotrimer of alpha, beta and gamma, and inhibits Rho activation.

Similarity. Belongs to the G-alpha family. G(12) subfamily.

Isoforms (2)

UniProt IDNamesCanonical?
Q14344-11yes
Q14344-22

RefSeq proteins (2): NP_001269354, NP_006563* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR000469Gprotein_alpha_12/13Family
IPR001019Gprotein_alpha_suFamily
IPR011025GproteinA_insertHomologous_superfamily
IPR027417P-loop_NTPaseHomologous_superfamily

Pfam: PF00503

UniProt features (52 total): helix 11, strand 11, binding site 7, turn 7, region of interest 5, mutagenesis site 3, lipid moiety-binding region 2, chain 1, domain 1, modified residue 1, splice variant 1, sequence variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

17 structures.

PDBMethodResolution (Å)
8IKLELECTRON MICROSCOPY2.33
9GE2ELECTRON MICROSCOPY2.51
7SF8ELECTRON MICROSCOPY2.7
8ZX4ELECTRON MICROSCOPY2.85
9GE3ELECTRON MICROSCOPY2.87
7SF7ELECTRON MICROSCOPY2.9
9E51ELECTRON MICROSCOPY2.9
9ECJELECTRON MICROSCOPY2.9
9IY8ELECTRON MICROSCOPY3.01
8ZX5ELECTRON MICROSCOPY3.03
9IZHELECTRON MICROSCOPY3.04
8KGGELECTRON MICROSCOPY3.06
7YDHELECTRON MICROSCOPY3.1
7T6BELECTRON MICROSCOPY3.19
8H8JELECTRON MICROSCOPY3.2
9JHPELECTRON MICROSCOPY3.35
9V0UELECTRON MICROSCOPY3.51

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q14344-F191.650.82

Antibody-complex structures (SAbDab): 7 — 7T6B, 7YDH, 8H8J, 8KGG, 9IY8, 9IZH, 9JHP

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (7): 197–200; 203; 291–294; 349; 58–63; 62; 173

Post-translational modifications (3): 203, 14, 18

Mutagenesis-validated functional residues (3):

PositionPhenotype
14fails to localize to plasma membranes and failed to activate rho-dependent serum response factor-mediated transcription
18fails to localize to plasma membranes and failed to activate rho-dependent serum response factor-mediated transcription
203abolishes phosphorylation by pka; disrupts heterotrimer stability.

Function

Pathways and Gene Ontology

Reactome pathways

6 pathways

IDPathway
R-HSA-193648NRAGE signals death through JNK
R-HSA-416482G alpha (12/13) signalling events
R-HSA-428930Thromboxane signalling through TP receptor
R-HSA-456926Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-9013148CDC42 GTPase cycle
R-HSA-9013149RAC1 GTPase cycle

MSigDB gene sets: 411 (showing top): GOBP_MORPHOGENESIS_OF_AN_EPITHELIUM, RNGTGGGC_UNKNOWN, TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_DUCTAL_NORMAL_UP, ELVIDGE_HYPOXIA_DN, GOBP_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING, GOBP_EPITHELIUM_DEVELOPMENT, GOBP_REGULATION_OF_BLOOD_PRESSURE, GOBP_REGULATION_OF_CELL_MORPHOGENESIS, GOBP_CIRCULATORY_SYSTEM_PROCESS, GOBP_SYNAPSE_ASSEMBLY, BROWNE_HCMV_INFECTION_8HR_UP, NKX25_02, REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION, GOBP_PLATELET_ACTIVATION, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP

GO Biological Process (17): branching involved in blood vessel morphogenesis (GO:0001569), in utero embryonic development (GO:0001701), signal transduction (GO:0007165), adenylate cyclase-modulating G protein-coupled receptor signaling pathway (GO:0007188), adenylate cyclase-activating G protein-coupled receptor signaling pathway (GO:0007189), Rho protein signal transduction (GO:0007266), regulation of blood pressure (GO:0008217), regulation of cell shape (GO:0008360), regulation of fibroblast migration (GO:0010762), cell differentiation (GO:0030154), platelet activation (GO:0030168), regulation of small GTPase mediated signal transduction (GO:0051056), regulation of postsynapse assembly (GO:0150052), Rho-activating G protein-coupled receptor signaling pathway (GO:0160221), angiogenesis (GO:0001525), G protein-coupled receptor signaling pathway (GO:0007186), intracellular signal transduction (GO:0035556)

GO Molecular Function (11): GTPase activity (GO:0003924), G protein activity (GO:0003925), guanyl-nucleotide exchange factor activity (GO:0005085), GTP binding (GO:0005525), G-protein beta/gamma-subunit complex binding (GO:0031683), D5 dopamine receptor binding (GO:0031752), metal ion binding (GO:0046872), nucleotide binding (GO:0000166), G protein-coupled receptor binding (GO:0001664), protein binding (GO:0005515), guanyl nucleotide binding (GO:0019001)

GO Cellular Component (11): nucleus (GO:0005634), cytoplasm (GO:0005737), cytosol (GO:0005829), heterotrimeric G-protein complex (GO:0005834), plasma membrane (GO:0005886), focal adhesion (GO:0005925), membrane (GO:0016020), brush border membrane (GO:0031526), melanosome (GO:0042470), extracellular exosome (GO:0070062), postsynapse (GO:0098794)

Reactome top-level categories

Rollup of top-5 pathways:

CategoryPathways
RHO GTPase cycle2
Cell death signalling via NRAGE, NRIF and NADE1
GPCR downstream signalling1
Signal amplification1
Platelet activation, signaling and aggregation1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
cellular anatomical structure4
blood vessel morphogenesis2
G protein-coupled receptor signaling pathway2
small GTPase-mediated signal transduction2
regulation of biological quality2
signal transduction2
intracellular anatomical structure2
angiogenesis1
branching morphogenesis of an epithelial tube1
chordate embryonic development1
cell communication1
cellular process1
signaling1
regulation of cellular process1
cellular response to stimulus1
adenylate cyclase activity1
adenylate cyclase-modulating G protein-coupled receptor signaling pathway1
adenylate cyclase activator activity1
blood circulation1
regulation of cell morphogenesis1
fibroblast migration1
regulation of cell migration1
cellular developmental process1
cell activation1
blood coagulation1
regulation of intracellular signal transduction1
regulation of synapse assembly1
postsynapse assembly1
regulation of postsynapse organization1
anatomical structure formation involved in morphogenesis1
G protein-coupled receptor activity1
ribonucleoside triphosphate phosphatase activity1
GTPase activity1
molecular function regulator activity1
GTP binding1
GDP binding1
GTPase regulator activity1
guanyl ribonucleotide binding1
purine ribonucleoside triphosphate binding1
protein-containing complex binding1

Protein interactions and networks

STRING

2719 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
GNA13ARHGEF1Q92888985
GNA13ESR1P03372985
GNA13ARHGEF12Q9NZN5970
GNA13ITGB3P05106948
GNA13S1PR2O95136930
GNA13ARHGEF11O15085897
GNA13RHOAP06749893
GNA13S1PR3Q99500890
GNA13HCLS1P14317874
GNA13GNA12Q03113860
GNA13CTTNQ14247859
GNA13GPR55Q9Y2T6854
GNA13RGS13O14921829
GNA13AKT1P31749799
GNA13RIC8AQ9NPQ8797

IntAct

130 interactions, top by confidence:

ABTypeScore
RAMACRNMTpsi-mi:“MI:0914”(association)0.810
CFTRESYT2psi-mi:“MI:2364”(proximity)0.710
GNG8GNB5psi-mi:“MI:0914”(association)0.640
GNG5GNB5psi-mi:“MI:0914”(association)0.620
SMAD4LATS1psi-mi:“MI:0914”(association)0.600
GNA13SMAD4psi-mi:“MI:0915”(physical association)0.600
SMAD4GNA13psi-mi:“MI:2364”(proximity)0.600
SMAD4GNA13psi-mi:“MI:0915”(physical association)0.600
GNA13ARHGEF1psi-mi:“MI:0915”(physical association)0.560
ARHGEF1GNA13psi-mi:“MI:0914”(association)0.560
CD81C2orf72psi-mi:“MI:0914”(association)0.530
SLC25A41NUDT19psi-mi:“MI:0914”(association)0.530
TMEM185ATSPAN6psi-mi:“MI:0914”(association)0.530
GNG10GNASpsi-mi:“MI:0914”(association)0.530
GNG2GNB5psi-mi:“MI:0914”(association)0.530
DUSP3ERLIN1psi-mi:“MI:0914”(association)0.530
GNG5GNASpsi-mi:“MI:0914”(association)0.530
CD53FAM171A2psi-mi:“MI:0914”(association)0.530
PLEKHG4BARHGEF11psi-mi:“MI:0914”(association)0.500
GNA13AKT1psi-mi:“MI:2364”(proximity)0.470
GNA13AKT1psi-mi:“MI:0915”(physical association)0.470
GIMAP4GNA13psi-mi:“MI:0915”(physical association)0.400

BioGRID (187): AIP (Two-hybrid), GNA13 (Affinity Capture-Western), GNA13 (Affinity Capture-Western), CXCR5 (Affinity Capture-Western), CXCR4 (Affinity Capture-Western), F2R (Affinity Capture-Western), GNA13 (Affinity Capture-MS), GNA13 (Affinity Capture-MS), GNA13 (Phenotypic Enhancement), GNA13 (Affinity Capture-MS), GNA13 (Affinity Capture-MS), GNA13 (Affinity Capture-MS), GNA13 (Affinity Capture-MS), GNA13 (Affinity Capture-MS), GNA13 (Affinity Capture-MS)

ESM2 similar proteins: A0A1D5PPP7, F1NV61, O01382, O02002, O08738, O35397, O89094, O89110, P29452, P29594, P31944, P42574, P42575, P43527, P55211, P55212, P55213, P55215, P55865, P55866, P55867, P70343, P70677, P89116, Q08DY9, Q0IIM3, Q14344, Q14790, Q153Z0, Q2PFV2, Q3T0P5, Q504J1, Q5IS54, Q5IS99, Q60431, Q60446, Q61699, Q66HA8, Q8BLR2, Q8C3Q9

Diamond homologs: A8MTJ3, B0XRA0, B2RSH2, O13055, O13315, O15975, O15976, O42784, O70443, O73819, O74227, O74259, O88302, O95837, P04695, P04696, P04897, P04899, P08239, P08752, P08753, P08754, P09471, P0C7Q4, P10824, P10825, P11488, P16378, P16894, P18872, P19086, P19087, P19627, P20353, P20612, P21278, P21279, P23625, P27044, P27045

SIGNOR signaling

59 interactions.

AEffectBMechanism
NMBRup-regulatesGNA13binding
FZD3up-regulatesGNA13binding
LPAR2up-regulatesGNA13binding
LPAR3up-regulatesGNA13binding
AGTR1up-regulatesGNA13binding
F2Rup-regulatesGNA13
GNA13up-regulatesRHOAbinding
F2Rup-regulatesGNA13binding
F2RL3up-regulatesGNA13binding
S1PR2up-regulatesGNA13binding
LPAR1up-regulatesGNA13binding
GNA13“up-regulates activity”ARHGEF11binding
GNA13“up-regulates activity”ARHGEF1binding
GPR55“up-regulates activity”GNA13binding
GPR174“up-regulates activity”GNA13binding
TBXA2R“up-regulates activity”GNA13binding
P2RY2“up-regulates activity”GNA13binding
ADRA1A“up-regulates activity”GNA13binding
PRLHR“up-regulates activity”GNA13binding
GPR35“up-regulates activity”GNA13binding
LPAR5“up-regulates activity”GNA13binding
P2RY4“up-regulates activity”GNA13binding
P2RY13“up-regulates activity”GNA13binding
CNR1“up-regulates activity”GNA13binding
LPAR6“up-regulates activity”GNA13binding
P2RY10“up-regulates activity”GNA13binding
HCRTR2“up-regulates activity”GNA13binding
GALR2“up-regulates activity”GNA13binding
FFAR2“up-regulates activity”GNA13binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 139 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

PathwayPartnersFoldFDR
Prostacyclin signalling through prostacyclin receptor1060.7×3e-14
G beta:gamma signalling through BTK957.7×5e-13
ADP signalling through P2Y purinoceptor 121155.2×9e-15
G beta:gamma signalling through PLC beta951.9×1e-12
G beta:gamma signalling through CDC42951.9×1e-12
Presynaptic function of Kainate receptors949.4×2e-12
G-protein activation1048.1×2e-13
Thromboxane signalling through TP receptor1048.1×2e-13

GO biological processes:

GO termPartnersFoldFDR
G protein-coupled receptor signaling pathway195.6×1e-06

Disease & clinical

Cancer significance

From intOGen — cancer-driver classification: loss-of-function (tumor-suppressor-like) across 3 cancer types — BLCA, DLBCLNOS, MLYM.

Clinical variants and AI predictions

ClinVar

37 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic1
Likely pathogenic0
Uncertain significance27
Likely benign0
Benign2

Top pathogenic / likely-pathogenic (1)

Variant IDHGVSClassification
625758GRCh37/hg19 17q24.1(chr17:62787370-63402628)Pathogenic

SpliceAI

987 predictions. Top by Δscore:

VariantEffectΔscore
17:65018246:CACT:Cdonor_loss1.0000
17:65018247:ACTTA:Adonor_loss1.0000
17:65018248:CT:Cdonor_loss1.0000
17:65018249:TTAC:Tdonor_loss1.0000
17:65018250:TA:Tdonor_loss1.0000
17:65018251:A:ACdonor_gain1.0000
17:65018251:A:Tdonor_loss1.0000
17:65018252:C:CAdonor_gain1.0000
17:65018252:CT:Cdonor_gain1.0000
17:65018252:CTG:Cdonor_gain1.0000
17:65018252:CTGG:Cdonor_gain1.0000
17:65018252:CTGGT:Cdonor_gain1.0000
17:65018300:CACC:Cacceptor_gain1.0000
17:65018301:ACCC:Aacceptor_loss1.0000
17:65018302:CC:Cacceptor_gain1.0000
17:65018303:CC:Cacceptor_gain1.0000
17:65018303:CCTAA:Cacceptor_loss1.0000
17:65018304:C:CCacceptor_gain1.0000
17:65018305:T:Aacceptor_loss1.0000
17:65022399:A:Cacceptor_gain1.0000
17:65022400:T:TCacceptor_gain1.0000
17:65053500:A:ACdonor_gain1.0000
17:65053500:AC:Adonor_gain1.0000
17:65053501:C:CTdonor_gain1.0000
17:65053501:CC:Cdonor_gain1.0000
17:65053501:CCA:Cdonor_gain1.0000
17:65053501:CCAG:Cdonor_gain1.0000
17:65053501:CCAGT:Cdonor_gain1.0000
17:65053724:CATAC:Cacceptor_gain1.0000
17:65053726:TAC:Tacceptor_gain1.0000

AlphaMissense

2500 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
17:65014515:C:AK292N1.000
17:65014515:C:GK292N1.000
17:65014694:A:GW233R1.000
17:65014694:A:TW233R1.000
17:65056409:G:AS62F1.000
17:65056410:A:GS62P1.000
17:65056411:C:AK61N1.000
17:65056411:C:GK61N1.000
17:65056412:T:AK61M1.000
17:65056413:T:GK61Q1.000
17:65056415:C:TG60D1.000
17:65056416:C:GG60R1.000
17:65056431:C:GG55R1.000
17:65014279:A:GL371P0.999
17:65014291:A:GL367P0.999
17:65014294:A:TI366N0.999
17:65014314:G:CF359L0.999
17:65014314:G:TF359L0.999
17:65014316:A:GF359L0.999
17:65014345:G:TA349D0.999
17:65014504:A:GL296P0.999
17:65014516:T:AK292M0.999
17:65014516:T:GK292T0.999
17:65014517:T:CK292E0.999
17:65014518:G:CN291K0.999
17:65014518:G:TN291K0.999
17:65014525:A:GF289S0.999
17:65014528:A:GL288P0.999
17:65014575:A:CF272L0.999
17:65014575:A:TF272L0.999

dbSNP variants (sampled 300 via entrez): RS1000022849 (17:65034434 G>A), RS1000027528 (17:65052395 C>A,T), RS1000046497 (17:65024733 G>A), RS1000051636 (17:65058470 G>T), RS1000094801 (17:65041239 A>C), RS1000094819 (17:65046216 T>C), RS1000199725 (17:65036341 G>A), RS1000231217 (17:65016068 C>T), RS1000241001 (17:65015718 C>A), RS1000272680 (17:65057355 A>G), RS1000431380 (17:65022233 G>A,T), RS1000467595 (17:65038832 T>C), RS1000483111 (17:65036590 C>G), RS1000498584 (17:65038681 C>T), RS1000698895 (17:65044777 T>C)

Disease associations

OMIM: gene MIM:604406 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

StudyTraitp-value
GCST002409_1White matter microstructure (global fractional anisotropy)3.000000e-10
GCST010703_337Brain morphology (MOSTest)3.000000e-10
GCST010726_67Periventricular white matter hyperintensities8.000000e-06

EFO canonical traits (3, from GWAS)

EFO IDTrait name
EFO:0005674white matter microstructure measurement
EFO:0004346neuroimaging measurement
EFO:0005665white matter hyperintensity measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

60 total (human), top 30 by PubMed support.

ChemicalActions (top 5)PubMed papers
bisphenol Aaffects cotreatment, affects expression, decreases expression, increases expression4
Benzo(a)pyreneincreases expression, increases methylation3
Valproic Aciddecreases methylation, increases expression, decreases expression3
Cisplatinaffects cotreatment, increases expression, decreases expression2
Tobacco Smoke Pollutionaffects expression, increases expression2
Cyclosporineincreases expression2
aristolochic acid Idecreases expression1
GSK-J4increases expression1
2,4,6-tribromophenolincreases expression1
methylmercuric chlorideincreases expression1
decabromobiphenyl etherincreases expression1
arseniteincreases methylation1
tris(1,3-dichloro-2-propyl)phosphateincreases expression1
sodium arseniteincreases expression1
cobaltous chlorideaffects cotreatment, increases expression1
tetrabromobisphenol Aincreases expression1
perfluorooctanoic acidincreases expression1
aflatoxin B2decreases methylation1
lead chlorideaffects cotreatment, increases expression1
lysophosphatidic aciddecreases reaction, increases phosphorylation1
cadmium sulfateaffects cotreatment, increases expression1
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridinedecreases expression1
3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanolincreases activity, affects binding, affects reaction1
di-n-butylphosphoric acidaffects expression1
CGP 52608increases reaction, affects binding1
K 7174increases expression1
Grape Seed Proanthocyanidinsaffects cotreatment, increases expression1
pentabrominated diphenyl ether 100increases expression1
hexabrominated diphenyl ether 153increases expression1
jinfukangdecreases expression1

Cellosaurus cell lines

3 cell lines: 2 cancer cell line, 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

CellosaurusNameCategorySex
CVCL_B1DKAbcam HCT 116 GNA13 KOCancer cell lineMale
CVCL_B1T0Abcam HeLa GNA13 KOCancer cell lineFemale
CVCL_D9FKUbigene HEK293 GNA13 KOTransformed cell lineFemale

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 75

This page pulls from 75 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomereactomeparentrefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot