GNAS-AS1

Summary

GNAS-AS1 (GNAS antisense RNA 1, HGNC:24872) is a long non-coding RNA gene on chromosome 20q13.32.

This gene produces a paternally-imprinted antisense RNA transcript that helps regulate the GNAS complex locus, which encodes the alpha subunit of the stimulatory G protein. Defects in this gene are a cause of pseudohypoparathyroidism type Ib.

Source: NCBI Gene 149775 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24872
Approved symbol	GNAS-AS1
Name	GNAS antisense RNA 1
Location	20q13.32
Locus type	RNA, long non-coding
Status	Approved
Aliases	SANG, NESP-AS, NESPAS, GNAS1AS, NCRNA00075
Ensembl gene	ENSG00000235590
Ensembl biotype	lncRNA
OMIM	610540
Entrez	149775
RNAcentral	URS00026A217D — lncRNA, 1156 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 17 — 17 lncRNA

ENST00000424094, ENST00000443966, ENST00000598163, ENST00000601795, ENST00000631314, ENST00000685926, ENST00000691748, ENST00000701893, ENST00000716940, ENST00000716945, ENST00000716946, ENST00000716947, ENST00000716948, ENST00000716949, ENST00000716950, ENST00000716951, ENST00000718285

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000424094 — 5 exons

Exon	Start	End
ENSE00001760223	58848879	58848917
ENSE00004031202	58841937	58842229
ENSE00004031204	58842433	58842545
ENSE00004031207	58818919	58819255
ENSE00004031214	58850530	58850903

Expression profiles

Bgee: expression breadth ubiquitous, 148 present calls, max score 67.38.

FANTOM5 (CAGE): breadth broad, TPM avg 1.2865 / max 27.9844, expressed in 529 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
188176	1.2865	529

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
islet of Langerhans	UBERON:0000006	67.38	gold quality
cortical plate	UBERON:0005343	66.08	gold quality
tibia	UBERON:0000979	66.04	silver quality
ventricular zone	UBERON:0003053	65.07	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	63.95	gold quality
ganglionic eminence	UBERON:0004023	63.27	gold quality
hindlimb stylopod muscle	UBERON:0004252	63.16	gold quality
stromal cell of endometrium	CL:0002255	61.40	gold quality
sperm	CL:0000019	59.54	gold quality
adenohypophysis	UBERON:0002196	57.90	gold quality
pancreas	UBERON:0001264	56.95	gold quality
pituitary gland	UBERON:0000007	56.72	gold quality
calcaneal tendon	UBERON:0003701	56.43	gold quality
right testis	UBERON:0004534	55.64	gold quality
testis	UBERON:0000473	55.39	gold quality
adrenal tissue	UBERON:0018303	55.38	gold quality
left testis	UBERON:0004533	55.13	gold quality
left lobe of thyroid gland	UBERON:0001120	55.12	gold quality
thyroid gland	UBERON:0002046	54.73	gold quality
right lobe of thyroid gland	UBERON:0001119	54.60	gold quality
muscle of leg	UBERON:0001383	54.46	gold quality
cardiac muscle of right atrium	UBERON:0003379	54.34	gold quality
left ventricle myocardium	UBERON:0006566	54.23	gold quality
kidney epithelium	UBERON:0004819	53.93	gold quality
epithelial cell of pancreas	CL:0000083	53.72	gold quality
upper arm skin	UBERON:0004263	53.52	gold quality
gastrocnemius	UBERON:0001388	53.18	gold quality
tonsil	UBERON:0002372	52.99	gold quality
tibialis anterior	UBERON:0001385	52.95	silver quality
prefrontal cortex	UBERON:0000451	52.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.41

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• GNASAS gene encodes an antisense GNAS transcript that is expressed only from the paternal allele. (PMID:10749992)
• Data show that of IL10, LEP, ABCA1, GNASAS and MEG3 was higher among individuals who were periconceptionally exposed to the famine compared with their unexposed same-sex siblings. (PMID:19656776)
• We suggest that elevated Nespas level in osteoarthritis are associated with osteoarthritis pathogenesis by suppressing miRs targeting ACSL6 and subsequent ACSL6 upregulation. (PMID:28805067)
• GNAS-AS1/miR-4319/NECAB3 axis promotes tumor progression of non-small cell lung cancer by altering macrophage polarization. (PMID:31267263)
• LncRNA GNAS-AS1 facilitates ER+ breast cancer cells progression by promoting M2 macrophage polarization via regulating miR-433-3p/GATA3 axis. (PMID:32538432)
• STAT3-induced lncRNA GNAS-AS1 accelerates keloid formation by mediating the miR-196a-5p/CXCL12/STAT3 axis in a feedback loop. (PMID:38840411)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.