GNG11

Summary

GNG11 (G protein subunit gamma 11, HGNC:4403) is a protein-coding gene on chromosome 7q21.3, encoding Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 (P61952). Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems.

This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a lipid-anchored, cell membrane protein. As a member of the heterotrimeric G protein complex, this protein plays a role in this transmembrane signaling system. This protein is also subject to carboxyl-terminal processing. Decreased expression of this gene is associated with splenic marginal zone lymphomas.

Source: NCBI Gene 2791 — RefSeq curated summary.

At a glance

• GWAS associations: 14
• Clinical variants (ClinVar): 4 total — 1 pathogenic
• MANE Select transcript: NM_004126

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:4403
Approved symbol	GNG11
Name	G protein subunit gamma 11
Location	7q21.3
Locus type	gene with protein product
Status	Approved
Aliases	GNGT11
Ensembl gene	ENSG00000127920
Ensembl biotype	protein_coding
OMIM	604390
Entrez	2791

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000248564

RefSeq mRNA: 1 — MANE Select: NM_004126 NM_004126

CCDS: CCDS5634

Canonical transcript exons

ENST00000248564 — 2 exons

Exon	Start	End
ENSE00000877334	93926091	93928610
ENSE00001031672	93921735	93922233

Expression profiles

Bgee: expression breadth ubiquitous, 282 present calls, max score 98.48.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 110.2123 / max 1543.2620, expressed in 1401 samples.

FANTOM5 promoters (9 alternative TSS)

Promoter ID	TPM avg	Samples expressed
79583	35.7040	1293
79577	27.1441	1217
79576	15.3357	1137
79578	11.8112	1090
79584	10.0766	1089
79582	6.8492	1037
79579	1.1999	523
79580	1.1543	551
79581	0.9373	453

Top tissues by expression

294 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pigmented layer of retina	UBERON:0001782	98.48	gold quality
tendon of biceps brachii	UBERON:0008188	98.27	gold quality
periodontal ligament	UBERON:0008266	98.03	gold quality
monocyte	CL:0000576	97.42	gold quality
stromal cell of endometrium	CL:0002255	97.37	gold quality
mammary duct	UBERON:0001765	97.34	gold quality
mononuclear cell	CL:0000842	97.13	gold quality
germinal epithelium of ovary	UBERON:0001304	96.96	gold quality
seminal vesicle	UBERON:0000998	96.81	gold quality
parietal pleura	UBERON:0002400	96.50	gold quality
placenta	UBERON:0001987	96.32	gold quality
adipose tissue	UBERON:0001013	96.07	gold quality
leukocyte	CL:0000738	96.05	gold quality
diaphragm	UBERON:0001103	96.00	gold quality
adult organism	UBERON:0007023	95.99	gold quality
metanephric glomerulus	UBERON:0004736	95.93	gold quality
connective tissue	UBERON:0002384	95.82	gold quality
adipose tissue of abdominal region	UBERON:0007808	95.76	gold quality
heart right ventricle	UBERON:0002080	95.69	gold quality
renal glomerulus	UBERON:0000074	95.60	gold quality
omental fat pad	UBERON:0010414	95.55	gold quality
peritoneum	UBERON:0002358	95.53	gold quality
pleura	UBERON:0000977	95.48	gold quality
synovial joint	UBERON:0002217	95.12	gold quality
skin of hip	UBERON:0001554	95.07	gold quality
subcutaneous adipose tissue	UBERON:0002190	94.86	gold quality
vena cava	UBERON:0004087	94.80	gold quality
decidua	UBERON:0002450	94.63	gold quality
lower lobe of lung	UBERON:0008949	94.39	gold quality
epithelium of mammary gland	UBERON:0003244	94.28	gold quality

Single-cell (SCXA)

Detected in 65 experiment(s), a significant marker in 62.

Experiment	Marker?	Max mean expression
E-MTAB-10432	yes	11594.28
E-GEOD-139324	yes	9796.07
E-MTAB-8207	yes	8458.84
E-MTAB-6701	yes	8287.31
E-MTAB-9221	yes	6652.80
E-GEOD-149689	yes	6410.44
E-HCAD-4	yes	5715.29
E-MTAB-6308	yes	4131.89
E-HCAD-24	yes	4005.98
E-GEOD-124263	yes	3846.62
E-GEOD-130148	yes	3806.10
E-MTAB-10662	yes	3658.42
E-MTAB-7407	yes	3504.24
E-HCAD-1	yes	3491.73
E-HCAD-11	yes	2742.06

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

26 targeting GNG11, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3667-3P	99.99	67.17	1636
HSA-MIR-493-5P	99.96	72.47	2382
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-652-5P	99.91	67.49	505
HSA-MIR-5582-3P	99.86	72.48	4221
HSA-MIR-1323	99.83	69.89	2471
HSA-MIR-6875-3P	99.82	70.26	2983
HSA-MIR-4668-5P	99.79	70.58	3782
HSA-MIR-4766-5P	99.75	69.23	2662
HSA-MIR-548O-3P	99.74	69.30	2228
HSA-MIR-4422	99.72	72.07	2908
HSA-MIR-4677-5P	99.70	70.09	1940
HSA-MIR-587	99.64	70.86	2611
HSA-MIR-2116-5P	99.32	69.34	1273
HSA-MIR-10524-5P	99.05	66.08	963
HSA-MIR-6728-3P	98.63	67.63	1534
HSA-MIR-4720-3P	98.50	68.88	988
HSA-MIR-204-3P	97.80	66.84	1656
HSA-MIR-4646-5P	97.70	66.84	1692
HSA-MIR-22-5P	97.67	68.92	1355
HSA-MIR-4314	97.50	67.30	1369
HSA-MIR-4436B-5P	96.71	68.37	1346
HSA-MIR-454-5P	96.51	68.35	263
HSA-MIR-3174	94.63	63.64	577
HSA-MIR-1298-3P	94.05	64.84	620

Literature-anchored findings (GeneRIF, showing 2)

• Collectively, these results suggest a novel senescence pathway mediated by GNG11 in response to environmental cues. (PMID:17092487)
• expression of GNG11 induced the generation of reactive oxygen species (ROS) and abnormal nuclear morphology in SUSM-1 cells but not in HeLa cells (PMID:28380310)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	gngt1	ENSDARG00000035798
mus_musculus	Gng11	ENSMUSG00000032766
rattus_norvegicus	Gng11	ENSRNOG00000050469
drosophila_melanogaster	Ggamma1	FBGN0004921

Paralogs (11): GNGT1 (ENSG00000127928), GNG5B (ENSG00000133136), GNG3 (ENSG00000162188), GNGT2 (ENSG00000167083), GNG8 (ENSG00000167414), GNG4 (ENSG00000168243), GNG12 (ENSG00000172380), GNG5 (ENSG00000174021), GNG7 (ENSG00000176533), GNG2 (ENSG00000186469), GNG10 (ENSG00000242616)

Protein

Protein identifiers

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 — P61952 (reviewed: P61952)

All UniProt accessions (2): P61952, Q53Y01

UniProt curated annotations — full annotation on UniProt →

Function. Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Subunit / interactions. G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-3, but not with beta-2.

Subcellular location. Cell membrane.

Tissue specificity. Abundantly expressed in all tissues tested except for brain.

Similarity. Belongs to the G protein gamma family.

RefSeq proteins (1): NP_004117* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001770	G-protein_gamma	Family
IPR015898	G-protein_gamma-like_dom	Domain
IPR036284	GGL_sf	Homologous_superfamily

Pfam: PF00631

UniProt features (5 total): chain 1, propeptide 1, region of interest 1, modified residue 1, lipid moiety-binding region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P61952-F1	88.61	0.59

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 70, 70

Function

Pathways and Gene Ontology

Reactome pathways

29 pathways

ID	Pathway
R-HSA-1296041	Activation of G protein gated Potassium channels
R-HSA-163359	Glucagon signaling in metabolic regulation
R-HSA-202040	G-protein activation
R-HSA-381676	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-392170	ADP signalling through P2Y purinoceptor 12
R-HSA-392451	G beta:gamma signalling through PI3Kgamma
R-HSA-392851	Prostacyclin signalling through prostacyclin receptor
R-HSA-400042	Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-4086398	Ca2+ pathway
R-HSA-416476	G alpha (q) signalling events
R-HSA-416482	G alpha (12/13) signalling events
R-HSA-418217	G beta:gamma signalling through PLC beta
R-HSA-418555	G alpha (s) signalling events
R-HSA-418592	ADP signalling through P2Y purinoceptor 1
R-HSA-418594	G alpha (i) signalling events
R-HSA-418597	G alpha (z) signalling events
R-HSA-420092	Glucagon-type ligand receptors
R-HSA-428930	Thromboxane signalling through TP receptor
R-HSA-432040	Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-456926	Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-500657	Presynaptic function of Kainate receptors
R-HSA-6814122	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-8964315	G beta:gamma signalling through BTK
R-HSA-8964616	G beta:gamma signalling through CDC42
R-HSA-9009391	Extra-nuclear estrogen signaling
R-HSA-9634597	GPER1 signaling
R-HSA-9660821	ADORA2B mediated anti-inflammatory cytokines production
R-HSA-9856530	High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
R-HSA-997272	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

MSigDB gene sets: 312 (showing top): GSE45365_CD8A_DC_VS_CD11B_DC_IFNAR_KO_UP, GSE18804_BRAIN_VS_COLON_TUMORAL_MACROPHAGE_UP, BEGUM_TARGETS_OF_PAX3_FOXO1_FUSION_UP, MODULE_52, WALLACE_PROSTATE_CANCER_RACE_UP, REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS, REACTOME_ADRENALINE_NORADRENALINE_INHIBITS_INSULIN_SECRETION, REACTOME_POTASSIUM_CHANNELS, REACTOME_INWARDLY_RECTIFYING_K_CHANNELS, REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION, REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS, MODULE_45, MODULE_64, REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION, LI_WILMS_TUMOR_VS_FETAL_KIDNEY_2_DN

GO Biological Process (2): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186)

GO Molecular Function (3): GTPase activity (GO:0003924), G-protein beta-subunit binding (GO:0031681), protein binding (GO:0005515)

GO Cellular Component (3): heterotrimeric G-protein complex (GO:0005834), plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-12 pathways:

Category	Pathways
GPCR downstream signalling	5
Signal amplification	3
Regulation of insulin secretion	2
G-protein beta:gamma signalling	2
G protein gated Potassium channels	1
Integration of energy metabolism	1
Opioid Signalling	1
Platelet homeostasis	1
Beta-catenin independent WNT signaling	1
Class B/2 (Secretin family receptors)	1
Aquaporin-mediated transport	1
Platelet activation, signaling and aggregation	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
ribonucleoside triphosphate phosphatase activity	1
protein binding	1
binding	1
extrinsic component of cytoplasmic side of plasma membrane	1
plasma membrane protein complex	1
GTPase complex	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

34 interactions, top by confidence:

A	B	Type	Score
GNAI3	RGS12	psi-mi:“MI:0914”(association)	0.640
GNG11	CEP44	psi-mi:“MI:0915”(physical association)	0.560
GNG11	REP15	psi-mi:“MI:0915”(physical association)	0.560
GNG11	GNB1	psi-mi:“MI:0914”(association)	0.500
GNG11	GNB2	psi-mi:“MI:0914”(association)	0.500
GNG11	GNB3	psi-mi:“MI:0914”(association)	0.500
GNB4	GNG11	psi-mi:“MI:0915”(physical association)	0.500
GNB3	GNG11	psi-mi:“MI:0915”(physical association)	0.500
GNB2	GNG11	psi-mi:“MI:0915”(physical association)	0.500
GNB1	GNG11	psi-mi:“MI:0915”(physical association)	0.500
GNG11	PDCL	psi-mi:“MI:0915”(physical association)	0.400
GNG11	AMOTL2	psi-mi:“MI:0915”(physical association)	0.370
GNG11	GNAI1	psi-mi:“MI:0914”(association)	0.350
GNG11	GNAS	psi-mi:“MI:0914”(association)	0.350
GNG11	Ntsr1	psi-mi:“MI:0914”(association)	0.350
GNAS	GNG11	psi-mi:“MI:0914”(association)	0.350
SMURF1	GNG11	psi-mi:“MI:2364”(proximity)	0.270
GNG11	CEP44	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (19): GNG11 (Two-hybrid), MEOX2 (Two-hybrid), CEP44 (Two-hybrid), GNG11 (Affinity Capture-MS), AMOTL2 (Two-hybrid), GNG11 (Co-localization), GNG11 (Affinity Capture-MS), PDCL (Affinity Capture-MS), ZHX1 (Two-hybrid), CEP44 (Two-hybrid), REP15 (Two-hybrid), GNG11 (Reconstituted Complex), GNG11 (Reconstituted Complex), GNG11 (Affinity Capture-MS), GNG11 (Affinity Capture-MS)

ESM2 similar proteins: A0A804HLA8, O14610, O60262, O97564, P02698, P30671, P38040, P43425, P50150, P50151, P50153, P50154, P54406, P59768, P61952, P61953, P61954, P63077, P63078, P63210, P63211, P63212, P63213, P63214, P63215, P63216, P63217, P63218, P63219, Q28024, Q4VT26, Q5E9F0, Q5R639, Q5R7U4, Q5RBQ0, Q5REH7, Q61012, Q61016, Q61017, Q6CPB4

Diamond homologs: O14610, O60262, O97564, P02698, P30671, P43425, P50150, P50151, P50153, P50154, P54406, P59768, P61952, P61953, P61954, P63077, P63078, P63210, P63211, P63212, P63213, P63214, P63215, P63216, P63217, P63218, P63219, Q28024, Q5E9F0, Q5R639, Q5R7U4, Q5RBQ0, Q5REH7, Q61012, Q61016, Q61017, Q80SZ7, Q9CXP8, Q9DAS9, Q9NFZ2

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 15 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Prostacyclin signalling through prostacyclin receptor	5	273.2×	4e-11
ADP signalling through P2Y purinoceptor 12	6	270.8×	2e-13
Adrenaline,noradrenaline inhibits insulin secretion	5	179.0×	2e-10
ADORA2B mediated anti-inflammatory cytokines production	7	161.5×	1e-13
GPER1 signaling	7	158.0×	1e-13
Glucagon signaling in metabolic regulation	5	157.3×	4e-10
Glucagon-type ligand receptors	5	157.3×	4e-10
G alpha (z) signalling events	7	148.3×	1e-13

GO biological processes:

GO term	Partners	Fold	FDR
G protein-coupled receptor signaling pathway	7	18.1×	4e-06

Disease & clinical

Clinical variants and AI predictions

ClinVar

4 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	1
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
563412	GRCh37/hg19 7q21.3(chr7:93285237-96280817)x1	Pathogenic

SpliceAI

108 predictions. Top by Δscore:

Variant	Effect	Δscore
7:93922230:ACAA:A	donor_gain	1.0000
7:93922231:CAA:C	donor_gain	1.0000
7:93922233:AG:A	donor_loss	1.0000
7:93922234:G:GG	donor_gain	1.0000
7:93922229:AACAA:A	donor_gain	0.9900
7:93922232:AA:A	donor_gain	0.9900
7:93926083:T:G	acceptor_gain	0.9900
7:93926084:A:AG	acceptor_gain	0.9900
7:93926089:A:AG	acceptor_loss	0.9900
7:93926089:A:G	acceptor_gain	0.9900
7:93926090:G:GC	acceptor_loss	0.9900
7:93926090:GGT:G	acceptor_gain	0.9800
7:93922210:G:GT	donor_gain	0.9700
7:93926088:A:AG	acceptor_gain	0.9700
7:93926088:AAG:A	acceptor_gain	0.9700
7:93922214:TG:T	donor_gain	0.9600
7:93926082:A:AG	acceptor_gain	0.9600
7:93926085:C:G	acceptor_gain	0.9600
7:93922189:G:GT	donor_gain	0.9500
7:93926090:G:GG	acceptor_gain	0.9400
7:93922215:G:GT	donor_gain	0.9300
7:93922237:A:AG	donor_gain	0.9000
7:93922238:G:GG	donor_gain	0.9000
7:93926088:AAGGT:A	acceptor_gain	0.9000
7:93926090:GGTGT:G	acceptor_gain	0.8800
7:93926197:G:GT	donor_gain	0.8500
7:93926198:C:T	donor_gain	0.8500
7:93926090:G:A	acceptor_gain	0.8300
7:93926246:G:GT	donor_gain	0.8100
7:93926089:AG:A	acceptor_gain	0.7800

AlphaMissense

480 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:93922227:A:C	R30S	0.997
7:93922227:A:T	R30S	0.997
7:93922202:T:C	L22P	0.995
7:93922226:G:C	R30T	0.995
7:93926184:T:C	F64L	0.991
7:93926186:T:A	F64L	0.991
7:93926186:T:G	F64L	0.991
7:93926180:C:A	N62K	0.989
7:93926180:C:G	N62K	0.989
7:93922226:G:T	R30I	0.987
7:93926145:G:C	D51H	0.987
7:93926146:A:C	D51A	0.987
7:93926147:T:A	D51E	0.987
7:93926147:T:G	D51E	0.987
7:93926146:A:G	D51G	0.985
7:93926146:A:T	D51V	0.985
7:93926152:T:C	L53P	0.985
7:93926152:T:A	L53Q	0.984
7:93926185:T:C	F64S	0.984
7:93926184:T:A	F64I	0.983
7:93926189:A:C	K65N	0.982
7:93926189:A:T	K65N	0.982
7:93922199:A:C	Q21P	0.979
7:93926178:A:G	N62D	0.979
7:93922225:A:G	R30G	0.978
7:93926113:T:A	I40K	0.978
7:93926113:T:G	I40R	0.976
7:93926125:T:A	I44N	0.976
7:93926152:T:G	L53R	0.976
7:93926181:C:T	P63S	0.976

dbSNP variants (sampled 300 via entrez): RS1000016433 (7:93921801 G>T), RS1000139722 (7:93925826 TGACCAAC>T), RS1000536198 (7:93921333 C>T), RS1000861076 (7:93927307 C>T), RS1000975201 (7:93926984 C>T), RS1001048813 (7:93925023 G>A), RS1001432773 (7:93920552 G>A), RS1002386024 (7:93925056 T>TGGGAGGCTGA), RS1002476447 (7:93919845 T>A,C), RS1002539929 (7:93923370 A>G), RS1002550411 (7:93927932 A>G), RS1002768563 (7:93920109 A>T), RS1003947060 (7:93925468 T>C), RS1003997705 (7:93925225 A>G), RS1004866882 (7:93922167 A>G)

Disease associations

OMIM: gene MIM:604390 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

14 associations (top):

Study	Trait	p-value
GCST001969_2	Heart rate	7.000000e-12
GCST003818_37	Resting heart rate	5.000000e-21
GCST004732_11	Heart rate variability traits (pvRSA/HF)	2.000000e-11
GCST004732_12	Heart rate variability traits (pvRSA/HF)	2.000000e-11
GCST004733_14	Heart rate variability traits (RMSSD)	8.000000e-16
GCST004733_15	Heart rate variability traits (RMSSD)	8.000000e-19
GCST004734_19	Heart rate variability traits (SDNN)	4.000000e-17
GCST004734_9	Heart rate variability traits (SDNN)	5.000000e-19
GCST004863_15	Mosquito bite size	2.000000e-07
GCST005846_6	Heart rate response to recovery post exercise (10 sec)	7.000000e-12
GCST005847_8	Heart rate response to recovery post exercise (20 sec)	9.000000e-11
GCST005848_14	Heart rate response to recovery post exercise (50 sec)	4.000000e-11
GCST005849_13	Heart rate response to recovery post exercise (40 sec)	2.000000e-12
GCST005850_5	Heart rate response to recovery post exercise (30 sec)	2.000000e-11

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0008003	heart rate variability measurement
EFO:0008378	mosquito bite reaction size measurement
EFO:0009185	heart rate response to recovery post exercise

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

60 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	decreases expression, increases methylation, affects cotreatment, increases expression, affects expression	8
Benzo(a)pyrene	increases expression, increases methylation	4
trichostatin A	affects cotreatment, increases expression	3
Air Pollutants	decreases expression, increases abundance	3
Aflatoxin B1	affects expression, increases expression, increases methylation	3
Particulate Matter	decreases expression, increases abundance	3
bisphenol A	decreases expression, affects cotreatment	2
cobaltous chloride	decreases expression	2
Vorinostat	increases expression, affects cotreatment	2
Panobinostat	affects cotreatment, increases expression	2
Acetaminophen	decreases expression, increases expression	2
Estradiol	affects expression, affects cotreatment, increases expression	2
Phenylmercuric Acetate	affects cotreatment, increases expression	2
Smoke	decreases expression, increases expression	2
Tetrachlorodibenzodioxin	increases expression	2
Tretinoin	decreases expression, increases expression	2
Asbestos, Crocidolite	increases expression	2
aristolochic acid I	decreases expression	1
2,4-dichlorophenol	increases methylation	1
methylmercuric chloride	increases expression	1
triphenyl phosphate	affects expression	1
lead acetate	increases expression	1
2,5,2’,5’-tetrachlorobiphenyl	increases expression	1
arsenite	affects binding, increases reaction	1
methylparaben	decreases expression	1
sodium arsenite	increases expression	1
zinc chromate	increases abundance, increases expression	1
bleomycetin	decreases expression	1
cupric chloride	increases expression	1
nickel sulfate	increases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B1T3	Abcam HeLa GNG11 KO	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.