GNG12-AS1

Summary

GNG12-AS1 (GNG12, DIRAS3 and WLS antisense RNA 1, HGNC:43938) is a long non-coding RNA gene on chromosome 1p31.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43938
Approved symbol	GNG12-AS1
Name	GNG12, DIRAS3 and WLS antisense RNA 1
Location	1p31.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000232284
Ensembl biotype	lncRNA
OMIM	615406
Entrez	100289178
RNAcentral	URS0000759D5C — lncRNA, 2247 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 11 lncRNA

ENST00000413628, ENST00000414904, ENST00000420587, ENST00000434072, ENST00000688125, ENST00000786419, ENST00000786420, ENST00000786421, ENST00000826363, ENST00000826364, ENST00000826365

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000413628 — 9 exons

Exon	Start	End
ENSE00001593768	68121125	68121241
ENSE00001597976	68102655	68102727
ENSE00001611620	68099729	68099792
ENSE00001637585	68117451	68117732
ENSE00001692199	68201969	68202987
ENSE00001694407	67832309	67832436
ENSE00001741121	68071800	68071873
ENSE00001744977	67956156	67956262
ENSE00001796594	68098643	68098836

Expression profiles

Bgee: expression breadth ubiquitous, 127 present calls, max score 82.88.

FANTOM5 (CAGE): breadth broad, TPM avg 0.9706 / max 85.8475, expressed in 560 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
3430	0.7444	396
3429	0.2262	81

Top tissues by expression

127 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.88	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	75.17	gold quality
gall bladder	UBERON:0002110	74.87	gold quality
calcaneal tendon	UBERON:0003701	74.23	gold quality
lower esophagus muscularis layer	UBERON:0035833	74.18	gold quality
lower esophagus	UBERON:0013473	74.15	gold quality
corpus callosum	UBERON:0002336	73.53	gold quality
mucosa of stomach	UBERON:0001199	73.49	gold quality
body of pancreas	UBERON:0001150	73.31	gold quality
skin of abdomen	UBERON:0001416	73.30	gold quality
endometrium	UBERON:0001295	72.86	gold quality
zone of skin	UBERON:0000014	72.48	gold quality
left ovary	UBERON:0002119	72.24	gold quality
skin of leg	UBERON:0001511	71.77	gold quality
ovary	UBERON:0000992	71.76	gold quality
smooth muscle tissue	UBERON:0001135	71.58	gold quality
stromal cell of endometrium	CL:0002255	71.54	gold quality
muscle layer of sigmoid colon	UBERON:0035805	71.26	gold quality
rectum	UBERON:0001052	71.08	gold quality
right ovary	UBERON:0002118	70.97	gold quality
esophagus	UBERON:0001043	70.87	gold quality
pancreas	UBERON:0001264	70.83	gold quality
endocervix	UBERON:0000458	70.75	gold quality
uterine cervix	UBERON:0000002	70.50	gold quality
fundus of stomach	UBERON:0001160	70.37	gold quality
stomach	UBERON:0000945	70.09	gold quality
tibial nerve	UBERON:0001323	69.92	gold quality
ectocervix	UBERON:0012249	69.71	gold quality
right uterine tube	UBERON:0001302	69.70	gold quality
adrenal tissue	UBERON:0018303	69.70	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.30

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• This study showed that while most siRNAs silence GNG12-AS1 post-transcriptionally, siRNA complementary to exon 1 of GNG12-AS1 suppresses its transcription by recruiting Argonaute 2 and inhibiting RNA polymerase II binding. (PMID:26832224)
• Lnc GNG12-AS1 knockdown suppresses glioma progression through the AKT/GSK-3beta/beta-catenin pathway. (PMID:32735016)
• Long non-coding RNAs PTENP1, GNG12-AS1, MAGI2-AS3 and MEG3 as tumor suppressors in breast cancer and their associations with clinicopathological parameters. (PMID:38277283)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.