GNG14

Summary

GNG14 (G protein subunit gamma 14, HGNC:53439) is a protein-coding gene on chromosome 19p13.13, encoding Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 (A0A1W2PPG7). Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems.

Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex.

Source: NCBI Gene 105372280 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 1 total
• MANE Select transcript: NM_001316692

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53439
Approved symbol	GNG14
Name	G protein subunit gamma 14
Location	19p13.13
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000283980
Ensembl biotype	protein_coding
Entrez	105372280

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000640117, ENST00000640151

RefSeq mRNA: 1 — MANE Select: NM_001316692 NM_001316692

CCDS: CCDS86708

Canonical transcript exons

ENST00000640151 — 1 exons

Exon	Start	End
ENSE00003810279	12687998	12688422

Expression profiles

Bgee: expression breadth ubiquitous, 117 present calls, max score 92.91.

Top tissues by expression

130 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	92.91	gold quality
right uterine tube	UBERON:0001302	62.22	gold quality
mucosa of stomach	UBERON:0001199	60.37	gold quality
cerebellar hemisphere	UBERON:0002245	53.60	gold quality
cerebellum	UBERON:0002037	53.33	gold quality
cerebellar cortex	UBERON:0002129	53.16	gold quality
right hemisphere of cerebellum	UBERON:0014890	52.86	gold quality
superior frontal gyrus	UBERON:0002661	51.76	gold quality
lower esophagus mucosa	UBERON:0035834	51.72	gold quality
nucleus accumbens	UBERON:0001882	51.66	gold quality
skin of leg	UBERON:0001511	51.41	gold quality
zone of skin	UBERON:0000014	50.90	gold quality
skin of abdomen	UBERON:0001416	50.16	gold quality
right frontal lobe	UBERON:0002810	49.16	gold quality
fallopian tube	UBERON:0003889	48.67	gold quality
Brodmann (1909) area 9	UBERON:0013540	47.35	gold quality
left testis	UBERON:0004533	47.18	gold quality
right testis	UBERON:0004534	47.18	gold quality
testis	UBERON:0000473	46.77	gold quality
descending thoracic aorta	UBERON:0002345	46.37	gold quality
metanephros cortex	UBERON:0010533	46.33	gold quality
caudate nucleus	UBERON:0001873	46.18	gold quality
esophagus mucosa	UBERON:0002469	46.18	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	46.03	gold quality
right lobe of thyroid gland	UBERON:0001119	45.40	gold quality
fundus of stomach	UBERON:0001160	45.40	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	44.93	gold quality
right adrenal gland cortex	UBERON:0035827	44.66	gold quality
body of uterus	UBERON:0009853	44.63	gold quality
brain	UBERON:0000955	44.32	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 — A0A1W2PPG7 (reviewed: A0A1W2PPG7)

All UniProt accessions (2): A0A1W2PPG7, A0A1W2PRI1

UniProt curated annotations — full annotation on UniProt →

Function. Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Subunit / interactions. G proteins are composed of 3 units; alpha, beta and gamma.

Subcellular location. Cell membrane.

Similarity. Belongs to the G protein gamma family.

RefSeq proteins (1): NP_001303621* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001770	G-protein_gamma	Family
IPR015898	G-protein_gamma-like_dom	Domain
IPR036284	GGL_sf	Homologous_superfamily

UniProt features (2 total): chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A0A1W2PPG7-F1	71.75	0.19

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 12 (showing top): GOCC_CYTOPLASMIC_SIDE_OF_MEMBRANE, GOCC_SIDE_OF_MEMBRANE, GOCC_MEMBRANE_PROTEIN_COMPLEX, GOCC_EXTRINSIC_COMPONENT_OF_CYTOPLASMIC_SIDE_OF_PLASMA_MEMBRANE, GOCC_EXTRINSIC_COMPONENT_OF_MEMBRANE, chr19p13, GOCC_EXTRINSIC_COMPONENT_OF_PLASMA_MEMBRANE, GOCC_PLASMA_MEMBRANE_PROTEIN_COMPLEX, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOMF_G_PROTEIN_BETA_SUBUNIT_BINDING, GOCC_GTPASE_COMPLEX, GOCC_CYTOPLASMIC_SIDE_OF_PLASMA_MEMBRANE

GO Biological Process (2): G protein-coupled receptor signaling pathway (GO:0007186), signal transduction (GO:0007165)

GO Molecular Function (1): G-protein beta-subunit binding (GO:0031681)

GO Cellular Component (3): heterotrimeric G-protein complex (GO:0005834), plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
G protein-coupled receptor activity	1
signal transduction	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
protein binding	1
extrinsic component of cytoplasmic side of plasma membrane	1
plasma membrane protein complex	1
GTPase complex	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

248 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
GNG14	GNGT1	P63211	506
GNG14	GNG3	P29798	378
GNG14	GNG11	P50152	374
GNG14	GNG5	P30670	370
GNG14	PDE2A	O00408	340
GNG14	CCL19	Q99731	323
GNG14	GYPC	P04921	247
GNG14	TCIM	Q9NR00	243
GNG14	GNB2	P11016	228
GNG14	CD6	P30203	223
GNG14	MCM6	Q14566	220
GNG14	GNB4	Q9HAV0	217
GNG14	TRPC6	Q9Y210	216
GNG14	NPPC	P23582	212
GNG14	PDC	P20941	205

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A1D8PTI7, A0A1L8H579, A0A1W2PPG7, A1X8D9, G1TZ76, O64650, O74330, P03131, P06459, P09003, P0C567, P0DOC8, P11332, P17387, P24051, P35997, P36826, P36833, P38711, P40569, P42677, P47903, P47904, P55833, P68834, P68835, P68958, P68959, Q02271, Q13670, Q1X709, Q2KHT7, Q39072, Q3T0B7, Q5RBK1, Q5RGZ1, Q67616, Q67708, Q6DRC3, Q6ZWU9

Diamond homologs: A0A1W2PPG7, O60262, P30671, P43425, P50150, P50153, P59768, P63212, P63213, P63214, P63215, P63216, Q28024, Q5R639, Q5R7U4, Q5RBQ0, Q61016, Q9DAS9, Q9UBI6, A0A804HLA8, O14610, O97564, P02698, P38040, P50151, P50154, P54406, P61952, P61953, P61954, P63077, P63078, P63210, P63211, P63217, P63218, P63219, Q4VT26, Q5E9F0, Q5REH7

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

1 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

704 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:12688277:T:C	F39L	0.633
19:12688279:C:A	F39L	0.633
19:12688279:C:G	F39L	0.633
19:12688340:T:C	F60L	0.565
19:12688342:C:A	F60L	0.565
19:12688342:C:G	F60L	0.565

dbSNP variants (sampled 300 via entrez): RS1000454114 (19:12687597 C>A), RS1000740503 (19:12687190 G>A), RS1001326994 (19:12686677 G>A), RS1002010236 (19:12688306 C>A,G), RS1002194606 (19:12687677 G>A), RS1002572463 (19:12688551 C>G,T), RS1003181063 (19:12686313 C>T), RS1004188156 (19:12686801 G>A), RS1004304288 (19:12687138 A>G), RS1005854869 (19:12688055 A>G), RS1006385591 (19:12688260 C>T), RS1006527666 (19:12688706 C>T), RS1007242770 (19:12688200 C>T), RS1008251022 (19:12686226 C>G), RS1009324860 (19:12688812 A>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
aristolochic acid I	increases expression	1
2-methyl-4-isothiazolin-3-one	increases expression	1
Smoke	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.