GNG4

Summary

GNG4 (G protein subunit gamma 4, HGNC:4407) is a protein-coding gene on chromosome 1q42.3, encoding Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 (P50150). Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems.

Predicted to enable G-protein beta-subunit binding activity. Involved in negative regulation of cell growth. Located in extracellular exosome.

Source: NCBI Gene 2786 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 15 total
• MANE Select transcript: NM_001098722

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:4407
Approved symbol	GNG4
Name	G protein subunit gamma 4
Location	1q42.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000168243
Ensembl biotype	protein_coding
OMIM	604388
Entrez	2786

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 11 protein_coding

ENST00000366597, ENST00000366598, ENST00000391854, ENST00000450593, ENST00000484517, ENST00000901785, ENST00000901786, ENST00000937073, ENST00000937074, ENST00000961844, ENST00000961845

RefSeq mRNA: 3 — MANE Select: NM_001098722 NM_001098721, NM_001098722, NM_004485

CCDS: CCDS1607

Canonical transcript exons

ENST00000391854 — 4 exons

Exon	Start	End
ENSE00001509898	235595400	235595511
ENSE00001509899	235649662	235649784
ENSE00003848164	235547685	235552237
ENSE00003892798	235583740	235583848

Expression profiles

Bgee: expression breadth ubiquitous, 125 present calls, max score 97.99.

FANTOM5 (CAGE): breadth broad, TPM avg 7.3705 / max 431.7931, expressed in 748 samples.

FANTOM5 promoters (13 alternative TSS)

Promoter ID	TPM avg	Samples expressed
18147	4.3610	603
18151	0.9818	352
18152	0.6053	296
18154	0.4111	209
18150	0.2491	131
18144	0.2059	103
18149	0.1310	67
18148	0.0983	56
18146	0.0946	47
18153	0.0882	52

Top tissues by expression

131 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ganglionic eminence	UBERON:0004023	97.99	gold quality
islet of Langerhans	UBERON:0000006	96.12	gold quality
cortical plate	UBERON:0005343	93.90	gold quality
lower esophagus mucosa	UBERON:0035834	91.93	gold quality
ventricular zone	UBERON:0003053	91.83	gold quality
hypothalamus	UBERON:0001898	90.42	gold quality
temporal lobe	UBERON:0001871	88.54	gold quality
amygdala	UBERON:0001876	88.54	gold quality
left ovary	UBERON:0002119	88.28	gold quality
ovary	UBERON:0000992	87.93	gold quality
pituitary gland	UBERON:0000007	87.15	gold quality
caudate nucleus	UBERON:0001873	86.86	gold quality
nucleus accumbens	UBERON:0001882	86.80	gold quality
prefrontal cortex	UBERON:0000451	86.64	gold quality
anterior cingulate cortex	UBERON:0009835	86.42	gold quality
superior frontal gyrus	UBERON:0002661	85.90	gold quality
adenohypophysis	UBERON:0002196	85.46	gold quality
frontal cortex	UBERON:0001870	84.78	gold quality
brain	UBERON:0000955	84.77	gold quality
cerebral cortex	UBERON:0000956	84.20	gold quality
right ovary	UBERON:0002118	84.08	gold quality
putamen	UBERON:0001874	83.90	gold quality
Ammon’s horn	UBERON:0001954	83.44	gold quality
right frontal lobe	UBERON:0002810	82.21	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	82.21	gold quality
right hemisphere of cerebellum	UBERON:0014890	81.65	gold quality
cerebellum	UBERON:0002037	81.59	gold quality
cerebellar cortex	UBERON:0002129	81.54	gold quality
cerebellar hemisphere	UBERON:0002245	81.46	gold quality
prostate gland	UBERON:0002367	80.98	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-5061	yes	25.71
E-GEOD-81547	yes	19.43
E-ANND-3	no	1.41

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

142 targeting GNG4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-12121	99.99	66.64	255
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-6793-5P	99.97	65.95	758
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-185-3P	99.95	67.01	1743
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-3529-3P	99.90	73.55	3045
HSA-MIR-6780A-5P	99.88	66.69	2776
HSA-MIR-3941	99.86	70.54	2735

Literature-anchored findings (GeneRIF, showing 5)

• Common genetic variation in GNG4 and KCNQ2 was associated with cognitive decline. In human brain tissue data sets, both GNG4 and KCNQ2 show higher expression in hippocampus relative to other brain regions. (PMID:29338302)
• G-protein subunit gamma-4 expression has potential for detection, prediction and therapeutic targeting in liver metastasis of gastric cancer. (PMID:33854208)
• Identifying GNG4 might play an important role in colorectal cancer TMB. (PMID:34275892)
• G-Protein Subunit Gamma 4 as a Potential Biomarker for Predicting the Response of Chemotherapy and Immunotherapy in Bladder Cancer. (PMID:35456499)
• GNG4, as a potential predictor of prognosis, is correlated with immune infiltrates in colon adenocarcinoma. (PMID:37448185)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	GNG4	ENSDARG00000111259
mus_musculus	Gng4	ENSMUSG00000021303
rattus_norvegicus	Gng4	ENSRNOG00000068923

Paralogs (11): GNG11 (ENSG00000127920), GNGT1 (ENSG00000127928), GNG5B (ENSG00000133136), GNG3 (ENSG00000162188), GNGT2 (ENSG00000167083), GNG8 (ENSG00000167414), GNG12 (ENSG00000172380), GNG5 (ENSG00000174021), GNG7 (ENSG00000176533), GNG2 (ENSG00000186469), GNG10 (ENSG00000242616)

Protein

Protein identifiers

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 — P50150 (reviewed: P50150)

All UniProt accessions (2): B1APZ0, P50150

UniProt curated annotations — full annotation on UniProt →

Function. Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Subunit / interactions. G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-2, but not with beta-3. Interacts with KCNK1. Interacts (via C-terminus) with KCNK2/TREK-1 (via N-terminus); this interaction confers ion selectivity to Cl(-) and L-glutamate.

Subcellular location. Cell membrane.

Tissue specificity. Brain, kidney, pancreas, skeletal muscle and faintly in cardiac muscle.

Similarity. Belongs to the G protein gamma family.

RefSeq proteins (3): NP_001092191, NP_001092192, NP_004476 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001770	G-protein_gamma	Family
IPR015898	G-protein_gamma-like_dom	Domain
IPR036284	GGL_sf	Homologous_superfamily

Pfam: PF00631

UniProt features (4 total): chain 1, propeptide 1, modified residue 1, lipid moiety-binding region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P50150-F1	87.79	0.65

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 72, 72

Function

Pathways and Gene Ontology

Reactome pathways

29 pathways

ID	Pathway
R-HSA-1296041	Activation of G protein gated Potassium channels
R-HSA-163359	Glucagon signaling in metabolic regulation
R-HSA-202040	G-protein activation
R-HSA-381676	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-392170	ADP signalling through P2Y purinoceptor 12
R-HSA-392451	G beta:gamma signalling through PI3Kgamma
R-HSA-392851	Prostacyclin signalling through prostacyclin receptor
R-HSA-400042	Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-4086398	Ca2+ pathway
R-HSA-416476	G alpha (q) signalling events
R-HSA-416482	G alpha (12/13) signalling events
R-HSA-418217	G beta:gamma signalling through PLC beta
R-HSA-418555	G alpha (s) signalling events
R-HSA-418592	ADP signalling through P2Y purinoceptor 1
R-HSA-418594	G alpha (i) signalling events
R-HSA-418597	G alpha (z) signalling events
R-HSA-420092	Glucagon-type ligand receptors
R-HSA-428930	Thromboxane signalling through TP receptor
R-HSA-432040	Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-456926	Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-500657	Presynaptic function of Kainate receptors
R-HSA-6814122	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-8964315	G beta:gamma signalling through BTK
R-HSA-8964616	G beta:gamma signalling through CDC42
R-HSA-9009391	Extra-nuclear estrogen signaling
R-HSA-9634597	GPER1 signaling
R-HSA-9660821	ADORA2B mediated anti-inflammatory cytokines production
R-HSA-9856530	High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
R-HSA-997272	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

MSigDB gene sets: 279 (showing top): CREL_01, REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS, MORF_MSH3, REACTOME_ADRENALINE_NORADRENALINE_INHIBITS_INSULIN_SECRETION, REACTOME_POTASSIUM_CHANNELS, REACTOME_INWARDLY_RECTIFYING_K_CHANNELS, REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION, REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS, GOBP_NEGATIVE_REGULATION_OF_CELL_GROWTH, MORF_BRCA1, GOBP_GROWTH, CREBP1_Q2, REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION, MORF_RAD51L3, MODULE_66

GO Biological Process (4): G protein-coupled receptor signaling pathway (GO:0007186), regulation of G protein-coupled receptor signaling pathway (GO:0008277), negative regulation of cell growth (GO:0030308), signal transduction (GO:0007165)

GO Molecular Function (2): G-protein beta-subunit binding (GO:0031681), protein binding (GO:0005515)

GO Cellular Component (5): heterotrimeric G-protein complex (GO:0005834), plasma membrane (GO:0005886), synapse (GO:0045202), extracellular exosome (GO:0070062), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-12 pathways:

Category	Pathways
GPCR downstream signalling	5
Signal amplification	3
Regulation of insulin secretion	2
G-protein beta:gamma signalling	2
G protein gated Potassium channels	1
Integration of energy metabolism	1
Opioid Signalling	1
Platelet homeostasis	1
Beta-catenin independent WNT signaling	1
Class B/2 (Secretin family receptors)	1
Aquaporin-mediated transport	1
Platelet activation, signaling and aggregation	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
G protein-coupled receptor activity	1
signal transduction	1
G protein-coupled receptor signaling pathway	1
regulation of signal transduction	1
regulation of cell growth	1
cell growth	1
negative regulation of growth	1
negative regulation of cellular process	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
protein binding	1
binding	1
extrinsic component of cytoplasmic side of plasma membrane	1
plasma membrane protein complex	1
GTPase complex	1
membrane	1
cell periphery	1
cell junction	1
extracellular vesicle	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1482 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
GNG4	GNG11	P50152	971
GNG4	GNGT2	O14610	876
GNG4	GNGT1	P63211	846
GNG4	GNB4	Q9HAV0	834
GNG4	PLCB2	Q00722	750
GNG4	GNB3	P16520	720
GNG4	GNG13	Q9P2W3	716
GNG4	GNB1	P04697	693
GNG4	GNB5	O14775	628
GNG4	GNAO1	P09471	581
GNG4	INSL5	Q9Y5Q6	550
GNG4	PENK	P01210	524
GNG4	CCL19	Q99731	511
GNG4	GRIK2	Q13002	492
GNG4	PLCB3	Q01970	488

IntAct

150 interactions, top by confidence:

A	B	Type	Score
GNG4	GNAI1	psi-mi:“MI:0914”(association)	0.640
Kcnk2	GNG4	psi-mi:“MI:0915”(physical association)	0.580
GNG4	Kcnk2	psi-mi:“MI:0915”(physical association)	0.580
GNG4	FHL2	psi-mi:“MI:0915”(physical association)	0.560
GNG4	GNB1	psi-mi:“MI:0914”(association)	0.530
GNG4	GNB5	psi-mi:“MI:0914”(association)	0.500
GNG4	GNB5	psi-mi:“MI:0915”(physical association)	0.500
ARHGEF12	GNG4	psi-mi:“MI:0407”(direct interaction)	0.440
GNG4	MAST2	psi-mi:“MI:0407”(direct interaction)	0.440
GNG4	HTRA1	psi-mi:“MI:0407”(direct interaction)	0.440
GNG4	PDZD7	psi-mi:“MI:0407”(direct interaction)	0.440
GNG4	PDZK1	psi-mi:“MI:0407”(direct interaction)	0.440
GNG4	ARHGEF11	psi-mi:“MI:0407”(direct interaction)	0.440
GNG4	SCRIB	psi-mi:“MI:0407”(direct interaction)	0.440
GNG4	TAX1BP3	psi-mi:“MI:0407”(direct interaction)	0.440
GNG4	RADIL	psi-mi:“MI:0407”(direct interaction)	0.440
GNG4	SHANK1	psi-mi:“MI:0407”(direct interaction)	0.440
GNG4	MAST1	psi-mi:“MI:0407”(direct interaction)	0.440
GNG4	GOPC	psi-mi:“MI:0407”(direct interaction)	0.440
GNG4	SNX27	psi-mi:“MI:0407”(direct interaction)	0.440
GNG4	TAMALIN	psi-mi:“MI:0407”(direct interaction)	0.440
GNG4	LNX1	psi-mi:“MI:0407”(direct interaction)	0.440
GRID2IP	GNG4	psi-mi:“MI:0407”(direct interaction)	0.440
GNG4	GORASP1	psi-mi:“MI:0407”(direct interaction)	0.440
GORASP2	GNG4	psi-mi:“MI:0407”(direct interaction)	0.440
GNG4	PARD3B	psi-mi:“MI:0407”(direct interaction)	0.440

BioGRID (50): TFIP11 (Two-hybrid), USHBP1 (Two-hybrid), GNG4 (Affinity Capture-MS), GNG4 (Affinity Capture-MS), GNG4 (Affinity Capture-MS), GNG4 (Affinity Capture-MS), GNAI3 (Affinity Capture-MS), GNAI1 (Affinity Capture-MS), GNAS (Affinity Capture-MS), GNAI2 (Affinity Capture-MS), GNB4 (Affinity Capture-MS), MOSPD2 (Affinity Capture-MS), GNAQ (Affinity Capture-MS), PDCL (Affinity Capture-MS), GNB1 (Affinity Capture-MS)

ESM2 similar proteins: A0A804HLA8, O14610, O60262, O97564, P02698, P30671, P38040, P43425, P50150, P50151, P50153, P50154, P54406, P59768, P61952, P61953, P61954, P63077, P63078, P63210, P63211, P63212, P63213, P63214, P63215, P63216, P63217, P63218, P63219, Q28024, Q4VT26, Q5E9F0, Q5R639, Q5R7U4, Q5RBQ0, Q5REH7, Q61012, Q61016, Q61017, Q6CPB4

Diamond homologs: A0A1W2PPG7, O60262, P30671, P43425, P50150, P50153, P59768, P63212, P63213, P63214, P63215, P63216, Q28024, Q5R639, Q5R7U4, Q5RBQ0, Q61016, Q9DAS9, Q9UBI6, A0A804HLA8, P38040, P50151, P63077, P63078, P63217, P63218, P63219, Q4VT26, Q5REH7, Q80SZ7, Q9CXP8, Q9UK08, O14610, O97564, P02698, P50154, P54406, P61952, P61953, P61954

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 93 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Prostacyclin signalling through prostacyclin receptor	5	48.5×	1e-06
ADP signalling through P2Y purinoceptor 12	6	48.0×	1e-07
Ras activation upon Ca2+ influx through NMDA receptor	5	46.0×	2e-06
Unblocking of NMDA receptors, glutamate binding and activation	5	43.9×	2e-06
Negative regulation of NMDA receptor-mediated neuronal transmission	5	43.9×	2e-06
Long-term potentiation	5	38.4×	3e-06
Adrenaline,noradrenaline inhibits insulin secretion	6	38.1×	3e-07
Assembly and cell surface presentation of NMDA receptors	9	36.8×	2e-10

GO biological processes:

GO term	Partners	Fold	FDR
establishment or maintenance of epithelial cell apical/basal polarity	10	66.0×	9e-14
protein localization to synapse	6	52.2×	2e-07
receptor clustering	7	49.6×	2e-08
regulation of postsynaptic membrane neurotransmitter receptor levels	6	33.8×	2e-06
cell-cell adhesion	10	11.5×	2e-06
protein-containing complex assembly	8	10.3×	7e-05
regulation of small GTPase mediated signal transduction	5	8.2×	8e-03
chemical synaptic transmission	7	6.2×	4e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

15 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	9
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1578 predictions. Top by Δscore:

Variant	Effect	Δscore
1:235552132:T:TA	donor_gain	1.0000
1:235549547:G:C	acceptor_gain	0.9900
1:235552135:T:TA	donor_gain	0.9900
1:235583734:GCTTA:G	donor_loss	0.9900
1:235583735:CTTA:C	donor_loss	0.9900
1:235583736:TTA:T	donor_loss	0.9900
1:235583737:TA:T	donor_loss	0.9900
1:235583738:A:AG	donor_loss	0.9900
1:235583739:C:CA	donor_loss	0.9900
1:235595394:CCTTA:C	donor_loss	0.9900
1:235595395:CTTAC:C	donor_loss	0.9900
1:235595396:TTAC:T	donor_loss	0.9900
1:235595397:TAC:T	donor_loss	0.9900
1:235595398:ACCT:A	donor_loss	0.9900
1:235595399:CCTG:C	donor_gain	0.9900
1:235595509:CAC:C	acceptor_gain	0.9900
1:235649657:CTTA:C	donor_loss	0.9900
1:235649658:TTA:T	donor_loss	0.9900
1:235649659:TA:T	donor_loss	0.9900
1:235649660:AC:A	donor_gain	0.9900
1:235649661:C:A	donor_loss	0.9900
1:235649661:CC:C	donor_gain	0.9900
1:235583846:CCC:C	acceptor_gain	0.9800
1:235583847:CC:C	acceptor_gain	0.9800
1:235583847:CCC:C	acceptor_gain	0.9800
1:235583848:CC:C	acceptor_gain	0.9800
1:235583849:C:CC	acceptor_gain	0.9800
1:235583850:T:C	acceptor_loss	0.9800
1:235595510:ACCTG:A	acceptor_loss	0.9800
1:235595512:C:G	acceptor_loss	0.9800

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000017347 (1:235593872 G>A), RS1000033319 (1:235563622 T>C,G), RS1000055573 (1:235598993 C>T), RS1000069639 (1:235637316 A>G), RS1000085373 (1:235563404 A>C), RS1000105103 (1:235551556 CAACAAA>C), RS1000115497 (1:235589316 CAGAGAG>C,CAG), RS1000142433 (1:235625361 G>A), RS1000224684 (1:235583986 C>T), RS1000231857 (1:235642884 C>T), RS1000233129 (1:235631287 G>A), RS1000242078 (1:235593949 C>G,T), RS1000269434 (1:235619496 G>A), RS1000314115 (1:235584358 C>G), RS1000316030 (1:235649104 G>A)

Disease associations

OMIM: gene MIM:604388 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST000096_5	Aging traits	6.000000e-06
GCST003074_5	Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging)	5.000000e-08
GCST009379_10	Type 2 diabetes	5.000000e-10

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004704	age at menopause
EFO:0007707	cerebral amyloid deposition measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

51 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression	6
methylmercuric chloride	increases expression, affects cotreatment	4
Benzo(a)pyrene	affects methylation, decreases expression, increases methylation	4
bisphenol A	decreases expression, decreases methylation, increases methylation	3
Tretinoin	decreases expression	3
sodium arsenite	increases expression, decreases expression	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
Particulate Matter	increases abundance, increases expression	2
aristolochic acid I	decreases expression	1
titanium dioxide	decreases methylation	1
arsenite	increases methylation	1
butyraldehyde	decreases expression	1
benzo(e)pyrene	increases methylation	1
S-(1,2-dichlorovinyl)cysteine	decreases reaction, increases expression	1
tamibarotene	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	increases expression, decreases expression, affects cotreatment	1
abrine	increases expression	1
dorsomorphin	affects cotreatment, increases expression, decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Air Pollutants	increases abundance, increases expression	1
Ethanol	affects cotreatment, decreases expression	1
Atrazine	increases expression	1
Carbamazepine	affects expression	1
Diclofenac	affects expression	1
Estradiol	affects cotreatment, decreases expression	1
Ethyl Methanesulfonate	increases expression	1
Folic Acid	affects cotreatment, decreases expression	1
Formaldehyde	increases expression	1
Lead	affects expression	1
Lipopolysaccharides	increases expression, decreases reaction	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B2XV	Abcam HEK293T GNG4 KO	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.