GNG5

Summary

GNG5 (G protein subunit gamma 5, HGNC:4408) is a protein-coding gene on chromosome 1p22.3, encoding Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 (P63218). Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems.

G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate effector molecules (Gilman, 1987 [PubMed 3113327]; summary by Ahmad et al., 1995) [PubMed 7606925].

Source: NCBI Gene 2787 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 8 total
• MANE Select transcript: NM_005274

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:4408
Approved symbol	GNG5
Name	G protein subunit gamma 5
Location	1p22.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000174021
Ensembl biotype	protein_coding
OMIM	600874
Entrez	2787

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 5 protein_coding, 2 protein_coding_CDS_not_defined

ENST00000370641, ENST00000370645, ENST00000487806, ENST00000686161, ENST00000689285, ENST00000880086, ENST00000923435

RefSeq mRNA: 1 — MANE Select: NM_005274 NM_005274

CCDS: CCDS696

Canonical transcript exons

ENST00000370645 — 4 exons

Exon	Start	End
ENSE00001453220	84506011	84506301
ENSE00001453221	84506436	84506581
ENSE00001921485	84498325	84498548
ENSE00003459775	84501826	84501970

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 98.84.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 208.8821 / max 1186.1659, expressed in 1828 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
12982	180.2863	1828
12984	18.6127	1741
12981	8.9111	1742
12985	0.9396	598
12983	0.1326	38

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of transverse colon	UBERON:0004991	98.84	gold quality
heart left ventricle	UBERON:0002084	98.80	gold quality
apex of heart	UBERON:0002098	98.66	gold quality
right atrium auricular region	UBERON:0006631	98.66	gold quality
heart	UBERON:0000948	98.63	gold quality
hindlimb stylopod muscle	UBERON:0004252	98.62	gold quality
right lung	UBERON:0002167	98.58	gold quality
ventricular zone	UBERON:0003053	98.53	gold quality
lower esophagus mucosa	UBERON:0035834	98.50	gold quality
upper lobe of left lung	UBERON:0008952	98.49	gold quality
metanephros cortex	UBERON:0010533	98.45	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	98.40	gold quality
granulocyte	CL:0000094	98.38	gold quality
gastrocnemius	UBERON:0001388	98.36	gold quality
leukocyte	CL:0000738	98.30	gold quality
monocyte	CL:0000576	98.28	gold quality
transverse colon	UBERON:0001157	98.25	gold quality
body of stomach	UBERON:0001161	98.20	gold quality
body of pancreas	UBERON:0001150	98.19	gold quality
bone marrow	UBERON:0002371	98.19	gold quality
ganglionic eminence	UBERON:0004023	98.19	gold quality
spleen	UBERON:0002106	98.10	gold quality
tonsil	UBERON:0002372	98.10	gold quality
bone marrow cell	CL:0002092	98.08	gold quality
ascending aorta	UBERON:0001496	98.07	gold quality
thoracic aorta	UBERON:0001515	98.07	gold quality
left coronary artery	UBERON:0001626	98.05	gold quality
cortex of kidney	UBERON:0001225	98.04	gold quality
blood	UBERON:0000178	98.03	gold quality
muscle of leg	UBERON:0001383	98.03	gold quality

Single-cell (SCXA)

Detected in 12 experiment(s), a significant marker in 9.

Experiment	Marker?	Max mean expression
E-HCAD-56	yes	2166.46
E-GEOD-93593	yes	480.98
E-CURD-122	yes	56.40
E-HCAD-5	yes	41.78
E-GEOD-137537	yes	30.71
E-MTAB-7316	yes	24.29
E-CURD-46	yes	19.22
E-MTAB-10042	yes	9.47
E-MTAB-6819	no	1040.62
E-GEOD-111727	no	717.37
E-MTAB-3929	no	447.65
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

62 targeting GNG5, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6758-5P	100.00	66.21	1470
HSA-MIR-6856-5P	100.00	65.47	1298
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-450A-1-3P	100.00	69.33	1837
HSA-MIR-4500	99.99	72.72	2367
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-98-5P	99.98	72.33	1787
HSA-MIR-485-3P	99.98	70.68	1585
HSA-MIR-539-3P	99.98	70.74	1616
HSA-LET-7D-5P	99.96	71.76	1632
HSA-MIR-4458	99.96	71.64	1650
HSA-MIR-493-5P	99.96	72.47	2382
HSA-LET-7C-3P	99.95	73.42	2862
HSA-MIR-5680	99.91	69.83	3421
HSA-MIR-3140-3P	99.88	68.47	2069
HSA-LET-7A-2-3P	99.87	70.53	1921
HSA-MIR-3919	99.87	69.45	2489
HSA-LET-7G-3P	99.85	70.43	1929
HSA-MIR-4420	99.82	70.08	1624
HSA-MIR-3121-3P	99.82	71.96	3630
HSA-MIR-8080	99.82	67.52	1342
HSA-MIR-181B-2-3P	99.81	70.06	1646
HSA-MIR-181B-3P	99.81	70.06	1646
HSA-MIR-7154-5P	99.69	70.52	1900

Literature-anchored findings (GeneRIF, showing 6)

• rs13093 in the promoter region of GNG5 may be associated with an increased risk of essential hypertension in the Polish population. (PMID:26574874)
• GNG5 was differently expressed in melanosis coli tissues.GNG5 expression was related to cell apoptosis. (PMID:30559147)
• MicroRNA-675-3p regulates IL-1beta-stimulated human chondrocyte apoptosis and cartilage degradation by targeting GNG5. (PMID:32336544)
• GNG5 is an unfavourable independent prognostic indicator of gliomas. (PMID:33000557)
• Exosomes derived from M1 macrophages inhibit the proliferation of the A549 and H1299 lung cancer cell lines via the miRNA-let-7b-5p-GNG5 axis. (PMID:36643646)
• Transcription factor YY1-activated GNG5 facilitates glioblastoma cell growth, invasion, stemness and glycolysis through Wnt/beta-catenin pathway. (PMID:39448763)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	gng5	ENSDARG00000039830
mus_musculus	Gng5	ENSMUSG00000068523
rattus_norvegicus	Gng5	ENSRNOG00000084618
drosophila_melanogaster	Ggamma1	FBGN0004921

Paralogs (11): GNG11 (ENSG00000127920), GNGT1 (ENSG00000127928), GNG5B (ENSG00000133136), GNG3 (ENSG00000162188), GNGT2 (ENSG00000167083), GNG8 (ENSG00000167414), GNG4 (ENSG00000168243), GNG12 (ENSG00000172380), GNG7 (ENSG00000176533), GNG2 (ENSG00000186469), GNG10 (ENSG00000242616)

Protein

Protein identifiers

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 — P63218 (reviewed: P63218)

All UniProt accessions (1): P63218

UniProt curated annotations — full annotation on UniProt →

Function. Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Subunit / interactions. G proteins are composed of 3 units, alpha, beta and gamma.

Subcellular location. Cell membrane.

Similarity. Belongs to the G protein gamma family.

RefSeq proteins (1): NP_005265* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001770	G-protein_gamma	Family
IPR015898	G-protein_gamma-like_dom	Domain
IPR036284	GGL_sf	Homologous_superfamily

Pfam: PF00631

UniProt features (7 total): modified residue 3, initiator methionine 1, chain 1, propeptide 1, lipid moiety-binding region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P63218-F1	88.89	0.61

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (4): 2, 2, 65, 65

Function

Pathways and Gene Ontology

Reactome pathways

29 pathways

ID	Pathway
R-HSA-1296041	Activation of G protein gated Potassium channels
R-HSA-163359	Glucagon signaling in metabolic regulation
R-HSA-202040	G-protein activation
R-HSA-381676	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-392170	ADP signalling through P2Y purinoceptor 12
R-HSA-392451	G beta:gamma signalling through PI3Kgamma
R-HSA-392851	Prostacyclin signalling through prostacyclin receptor
R-HSA-400042	Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-4086398	Ca2+ pathway
R-HSA-416476	G alpha (q) signalling events
R-HSA-416482	G alpha (12/13) signalling events
R-HSA-418217	G beta:gamma signalling through PLC beta
R-HSA-418555	G alpha (s) signalling events
R-HSA-418592	ADP signalling through P2Y purinoceptor 1
R-HSA-418594	G alpha (i) signalling events
R-HSA-418597	G alpha (z) signalling events
R-HSA-420092	Glucagon-type ligand receptors
R-HSA-428930	Thromboxane signalling through TP receptor
R-HSA-432040	Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-456926	Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-500657	Presynaptic function of Kainate receptors
R-HSA-6814122	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-8964315	G beta:gamma signalling through BTK
R-HSA-8964616	G beta:gamma signalling through CDC42
R-HSA-9009391	Extra-nuclear estrogen signaling
R-HSA-9634597	GPER1 signaling
R-HSA-9660821	ADORA2B mediated anti-inflammatory cytokines production
R-HSA-9856530	High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
R-HSA-997272	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

MSigDB gene sets: 247 (showing top): REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS, REACTOME_ADRENALINE_NORADRENALINE_INHIBITS_INSULIN_SECRETION, REACTOME_POTASSIUM_CHANNELS, REACTOME_INWARDLY_RECTIFYING_K_CHANNELS, REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION, REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, MORF_HDAC1, MORF_HDAC2, REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION, REACTOME_G_PROTEIN_ACTIVATION, MORF_BUB3, MORF_PRKDC, REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA, REACTOME_G_PROTEIN_BETA_GAMMA_SIGNALLING

GO Biological Process (2): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186)

GO Molecular Function (4): GTPase activity (GO:0003924), PDZ domain binding (GO:0030165), G-protein beta-subunit binding (GO:0031681), protein binding (GO:0005515)

GO Cellular Component (4): heterotrimeric G-protein complex (GO:0005834), plasma membrane (GO:0005886), membrane (GO:0016020), extracellular exosome (GO:0070062)

Reactome top-level categories

Rollup of top-12 pathways:

Category	Pathways
GPCR downstream signalling	5
Signal amplification	3
Regulation of insulin secretion	2
G-protein beta:gamma signalling	2
G protein gated Potassium channels	1
Integration of energy metabolism	1
Opioid Signalling	1
Platelet homeostasis	1
Beta-catenin independent WNT signaling	1
Class B/2 (Secretin family receptors)	1
Aquaporin-mediated transport	1
Platelet activation, signaling and aggregation	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
ribonucleoside triphosphate phosphatase activity	1
protein domain specific binding	1
protein binding	1
binding	1
extrinsic component of cytoplasmic side of plasma membrane	1
plasma membrane protein complex	1
GTPase complex	1
membrane	1
cell periphery	1
cellular anatomical structure	1
extracellular vesicle	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

94 interactions, top by confidence:

A	B	Type	Score
GNB1	GNG5	psi-mi:“MI:0915”(physical association)	0.740
GNG5	GNB1	psi-mi:“MI:0914”(association)	0.740
NFKBIA	POLRMT	psi-mi:“MI:0914”(association)	0.670
GNG5	GNB2	psi-mi:“MI:0914”(association)	0.640
GNG5	GNAI1	psi-mi:“MI:0914”(association)	0.640
GNAI3	RGS12	psi-mi:“MI:0914”(association)	0.640
GNG5	GNB5	psi-mi:“MI:0914”(association)	0.620
GNG5	GNB5	psi-mi:“MI:0915”(physical association)	0.620
GNG5	GOLGA2	psi-mi:“MI:0915”(physical association)	0.560
GNG5	TRAF1	psi-mi:“MI:0915”(physical association)	0.560
KRT31	GNG5	psi-mi:“MI:0915”(physical association)	0.560
GNG5	KRT40	psi-mi:“MI:0915”(physical association)	0.560
MDFI	GNG5	psi-mi:“MI:0915”(physical association)	0.560
EPS15L1	GNG5	psi-mi:“MI:0915”(physical association)	0.560
AMOTL2	GNG5	psi-mi:“MI:0915”(physical association)	0.560
GNG5	KRT31	psi-mi:“MI:0915”(physical association)	0.560
GNG5	AMOTL2	psi-mi:“MI:0915”(physical association)	0.560
TRAF1	GNG5	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (131): GOLGA2 (Two-hybrid), KRT31 (Two-hybrid), MDFI (Two-hybrid), TRAF1 (Two-hybrid), AMOTL2 (Two-hybrid), EPS15L1 (Two-hybrid), KRT40 (Two-hybrid), GNG5 (Affinity Capture-MS), GNG5 (Affinity Capture-MS), GNG5 (Affinity Capture-MS), GNG5 (Affinity Capture-MS), GNG5 (Affinity Capture-MS), GNG5 (Affinity Capture-MS), GNG5 (Affinity Capture-MS), GNG5 (Affinity Capture-MS)

ESM2 similar proteins: A0A804HLA8, O14610, O60262, O97564, P02698, P30671, P38040, P43425, P50150, P50151, P50153, P50154, P54406, P59768, P61952, P61953, P61954, P63077, P63078, P63210, P63211, P63212, P63213, P63214, P63215, P63216, P63217, P63218, P63219, Q28024, Q4VT26, Q5E9F0, Q5R639, Q5R7U4, Q5RBQ0, Q5REH7, Q61012, Q61016, Q61017, Q6CPB4

Diamond homologs: A0A804HLA8, O60262, P30671, P38040, P43425, P50150, P50151, P50153, P59768, P63077, P63078, P63212, P63213, P63214, P63215, P63216, P63217, P63218, P63219, Q28024, Q4VT26, Q5R639, Q5R7U4, Q5RBQ0, Q5REH7, Q61016, Q80SZ7, Q9CXP8, Q9DAS9, Q9UBI6, Q9UK08, O14610, O97564, P02698, P50154, P54406, P61952, P61953, P61954, P63210

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 82 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
ADP signalling through P2Y purinoceptor 12	10	75.2×	3e-15
Prostacyclin signalling through prostacyclin receptor	7	63.8×	4e-10
G beta:gamma signalling through BTK	6	57.7×	2e-08
Adenylate cyclase inhibitory pathway	5	57.7×	3e-07
G beta:gamma signalling through PLC beta	6	51.9×	3e-08
G beta:gamma signalling through CDC42	6	51.9×	3e-08
Presynaptic function of Kainate receptors	6	49.4×	4e-08
Adrenaline,noradrenaline inhibits insulin secretion	8	47.7×	2e-10

GO biological processes:

GO term	Partners	Fold	FDR
G protein-coupled receptor signaling pathway	11	5.2×	2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

8 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	5
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

294 predictions. Top by Δscore:

Variant	Effect	Δscore
1:84498549:CT:C	acceptor_loss	1.0000
1:84498549:C:CC	acceptor_gain	0.9900
1:84501865:T:A	donor_gain	0.9900
1:84501971:CTAT:C	acceptor_loss	0.9900
1:84501972:T:G	acceptor_loss	0.9900
1:84506009:A:AC	donor_gain	0.9900
1:84506010:C:CC	donor_gain	0.9900
1:84498554:A:AC	acceptor_gain	0.9800
1:84501819:AACTT:A	donor_loss	0.9800
1:84501820:ACTTA:A	donor_loss	0.9800
1:84501821:CTTA:C	donor_loss	0.9800
1:84501822:TTACC:T	donor_loss	0.9800
1:84501823:TA:T	donor_loss	0.9800
1:84506010:CTT:C	donor_gain	0.9800
1:84506011:TTT:T	donor_gain	0.9800
1:84506012:TTT:T	donor_gain	0.9800
1:84498544:GAAAC:G	acceptor_gain	0.9700
1:84498554:A:C	acceptor_gain	0.9700
1:84501689:T:A	donor_gain	0.9700
1:84501971:C:CC	acceptor_gain	0.9700
1:84506008:CACTT:C	donor_gain	0.9700
1:84498546:AAC:A	acceptor_gain	0.9600
1:84501845:C:CT	donor_gain	0.9600
1:84501846:T:TT	donor_gain	0.9600
1:84506007:TCA:T	donor_loss	0.9600
1:84506008:CACT:C	donor_loss	0.9600
1:84506009:A:C	donor_loss	0.9600
1:84498547:AC:A	acceptor_gain	0.9500
1:84498548:CC:C	acceptor_gain	0.9500
1:84501970:CCTAT:C	acceptor_gain	0.9500

AlphaMissense

433 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:84501938:G:C	F38L	0.999
1:84501938:G:T	F38L	0.999
1:84501940:A:G	F38L	0.999
1:84501875:G:C	F59L	0.998
1:84501875:G:T	F59L	0.998
1:84501877:A:G	F59L	0.998
1:84501877:A:T	F59I	0.997
1:84501948:A:G	L35S	0.997
1:84501957:G:T	A32D	0.997
1:84501881:A:C	N57K	0.996
1:84501881:A:T	N57K	0.996
1:84501958:C:G	A32P	0.996
1:84501877:A:C	F59V	0.995
1:84501939:A:G	F38S	0.995
1:84501961:C:G	A31P	0.995
1:84506042:A:G	L17P	0.995
1:84501876:A:G	F59S	0.994
1:84501937:A:G	C39R	0.994
1:84501876:A:C	F59C	0.993
1:84501909:A:G	L48P	0.993
1:84501909:A:T	L48Q	0.993
1:84501915:T:A	D46V	0.993
1:84501915:T:C	D46G	0.993
1:84501935:A:C	C39W	0.992
1:84506042:A:T	L17H	0.992
1:84501906:A:G	L49P	0.991
1:84501915:T:G	D46A	0.991
1:84501936:C:T	C39Y	0.991
1:84506019:G:T	R25S	0.991
1:84506031:C:G	A21P	0.991

dbSNP variants (sampled 300 via entrez): RS1000162749 (1:84502854 G>C), RS1000484855 (1:84499206 T>C), RS1000619714 (1:84503204 G>T), RS1000656357 (1:84503946 T>C), RS1001336357 (1:84499475 T>C), RS1001489782 (1:84499148 G>A), RS1001987266 (1:84506353 C>T), RS1002185600 (1:84505836 C>T), RS1002607059 (1:84508509 CT>C), RS1002625224 (1:84506455 A>C), RS1002706419 (1:84505621 G>A), RS1003009928 (1:84500944 C>T), RS1003168553 (1:84500554 T>G), RS1003338371 (1:84502461 C>T), RS1003612888 (1:84507230 G>A)

Disease associations

OMIM: gene MIM:600874 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

32 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects expression, increases methylation	2
sodium arsenite	decreases expression, increases expression	2
aristolochic acid I	decreases expression, increases expression	1
FR900359	decreases phosphorylation	1
daidzein	affects cotreatment, affects expression	1
triphenyl phosphate	affects expression	1
lead acetate	increases expression	1
daidzin	affects expression, affects cotreatment	1
genistin	affects cotreatment, affects expression	1
glycitein	affects cotreatment, affects expression	1
glycitin	affects cotreatment, affects expression	1
ICG 001	increases expression	1
bisphenol S	affects cotreatment, increases expression	1
jinfukang	affects cotreatment, decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Atrazine	increases expression	1
Caffeine	increases phosphorylation	1
Chelating Agents	affects binding, increases expression	1
Cisplatin	affects cotreatment, decreases expression	1
Copper	affects binding, increases expression	1
Dexamethasone	affects cotreatment, increases expression	1
Indomethacin	affects cotreatment, increases expression	1
Ivermectin	decreases expression	1
Potassium Dichromate	increases expression	1
Thiram	increases expression	1
Tobacco Smoke Pollution	affects expression	1
Tretinoin	increases expression	1
Urethane	decreases expression	1
1-Methyl-3-isobutylxanthine	increases expression, affects cotreatment	1
Cyclosporine	increases expression	1

Cellosaurus cell lines

3 cell lines: 2 cancer cell line, 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B2XW	Abcam HEK293T GNG5 KO	Transformed cell line	Female
CVCL_SQ18	HAP1 GNG5 (-) 1	Cancer cell line	Male
CVCL_XP24	HAP1 GNG5 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.