GNL2

Summary

GNL2 (G protein nucleolar 2, HGNC:29925) is a protein-coding gene on chromosome 1p34.3, encoding Nucleolar GTP-binding protein 2 (Q13823). GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. It is a common-essential gene (DepMap: required in 99.3% of cancer cell lines).

Enables RNA binding activity. Predicted to be involved in ribosome biogenesis. Located in nucleolus.

Source: NCBI Gene 29889 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 119 total
• Cancer dependency (DepMap): dependent in 99.3% of screened cell lines (common-essential)
• MANE Select transcript: NM_013285

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29925
Approved symbol	GNL2
Name	G protein nucleolar 2
Location	1p34.3
Locus type	gene with protein product
Status	Approved
Aliases	Ngp-1, HUMAUANTIG, Nog2, Nug2
Ensembl gene	ENSG00000134697
Ensembl biotype	protein_coding
OMIM	609365
Entrez	29889

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 8 protein_coding, 7 protein_coding_CDS_not_defined

ENST00000373062, ENST00000462812, ENST00000463351, ENST00000469191, ENST00000479255, ENST00000488496, ENST00000489146, ENST00000490029, ENST00000538069, ENST00000852774, ENST00000918214, ENST00000965152, ENST00000965153, ENST00000965154, ENST00000965155

RefSeq mRNA: 3 — MANE Select: NM_013285 NM_001323623, NM_001323624, NM_013285

CCDS: CCDS421

Canonical transcript exons

ENST00000373062 — 16 exons

Exon	Start	End
ENSE00001079250	37574665	37574823
ENSE00001079259	37574343	37574456
ENSE00001079260	37568851	37569302
ENSE00001079261	37576428	37576556
ENSE00001156082	37593762	37593846
ENSE00001459441	37595759	37595937
ENSE00003460459	37587311	37587495
ENSE00003479534	37583867	37583933
ENSE00003524106	37582778	37582936
ENSE00003569383	37582223	37582336
ENSE00003600297	37567673	37567764
ENSE00003603852	37592712	37592806
ENSE00003623459	37568275	37568357
ENSE00003645971	37590706	37590845
ENSE00003661261	37566816	37567007
ENSE00003791286	37575595	37575699

Expression profiles

Bgee: expression breadth ubiquitous, 292 present calls, max score 96.62.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 26.5413 / max 223.8749, expressed in 1814 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
11786	26.5413	1814

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tendon of biceps brachii	UBERON:0008188	96.62	gold quality
gingival epithelium	UBERON:0001949	95.21	gold quality
tendon	UBERON:0000043	95.06	gold quality
sural nerve	UBERON:0015488	94.77	gold quality
calcaneal tendon	UBERON:0003701	94.71	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	94.44	gold quality
amniotic fluid	UBERON:0000173	93.87	gold quality
gingiva	UBERON:0001828	93.51	gold quality
cervix squamous epithelium	UBERON:0006922	93.41	gold quality
lower esophagus mucosa	UBERON:0035834	93.40	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	93.36	gold quality
gastrocnemius	UBERON:0001388	93.13	gold quality
epithelium of nasopharynx	UBERON:0001951	93.11	gold quality
adenohypophysis	UBERON:0002196	93.09	gold quality
islet of Langerhans	UBERON:0000006	93.06	gold quality
left testis	UBERON:0004533	93.03	gold quality
cartilage tissue	UBERON:0002418	92.98	gold quality
right testis	UBERON:0004534	92.96	gold quality
skin of abdomen	UBERON:0001416	92.86	gold quality
skin of leg	UBERON:0001511	92.49	gold quality
testis	UBERON:0000473	92.47	gold quality
stromal cell of endometrium	CL:0002255	92.43	gold quality
muscle of leg	UBERON:0001383	92.41	gold quality
esophagus mucosa	UBERON:0002469	92.31	gold quality
minor salivary gland	UBERON:0001830	92.29	gold quality
mucosa of transverse colon	UBERON:0004991	92.26	gold quality
peritoneum	UBERON:0002358	92.23	gold quality
omental fat pad	UBERON:0010414	92.23	gold quality
mouth mucosa	UBERON:0003729	92.14	gold quality
rectum	UBERON:0001052	92.11	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 99.3% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 4)

• GNL2 and SEC13 are required for nonsense-mediated mRNA decay pathway in human cells. (PMID:25452588)
• NGP-1 promotes cell cycle progression through the activation of the p53/p21(Cip-1/Waf1) pathway. (PMID:26203195)
• Study of the G Protein Nucleolar 2 Value in Liver Hepatocellular Carcinoma Treatment and Prognosis. (PMID:34337013)
• Functional analysis of the 1p34.3 risk locus implicates GNL2 in high-grade serous ovarian cancer. (PMID:34965383)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	gnl2	ENSDARG00000098080
mus_musculus	Gnl2	ENSMUSG00000028869
rattus_norvegicus	Gnl2	ENSRNOG00000009430
drosophila_melanogaster	Ns2	FBGN0034243
caenorhabditis_elegans	ngp-1	WBGENE00003596

Paralogs (6): LSG1 (ENSG00000041802), NOA1 (ENSG00000084092), GNL3L (ENSG00000130119), MTG1 (ENSG00000148824), GNL3 (ENSG00000163938), GNL1 (ENSG00000204590)

Protein

Protein identifiers

Nucleolar GTP-binding protein 2 — Q13823 (reviewed: Q13823)

Alternative names: Autoantigen NGP-1

All UniProt accessions (3): Q13823, H0YG10, Q5T0F3

UniProt curated annotations — full annotation on UniProt →

Function. GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels.

Subunit / interactions. Interacts with LYAR and RPL23A. Interacts with the nuclear importin-beta receptor and, at a lower extent, with importin-alpha.

Subcellular location. Nucleus. Nucleolus.

Tissue specificity. Widely expressed, with the highest expression level in testis.

Similarity. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.

RefSeq proteins (3): NP_001310552, NP_001310553, NP_037417* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR006073	GTP-bd	Domain
IPR012971	NOG2_N_dom	Domain
IPR023179	GTP-bd_ortho_bundle_sf	Homologous_superfamily
IPR024929	GNL2_CP_dom	Domain
IPR027417	P-loop_NTPase	Homologous_superfamily
IPR030378	G_CP_dom	Domain
IPR050755	TRAFAC_YlqF/YawG_RiboMat	Family

Pfam: PF01926, PF08153

UniProt features (34 total): mutagenesis site 16, compositionally biased region 6, region of interest 4, binding site 2, modified residue 2, chain 1, domain 1, sequence variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

23 structures.

PDB	Method	Resolution (Å)
8FL3	ELECTRON MICROSCOPY	2.53
8FL7	ELECTRON MICROSCOPY	2.55
8FL6	ELECTRON MICROSCOPY	2.62
8FL2	ELECTRON MICROSCOPY	2.67
8FL9	ELECTRON MICROSCOPY	2.75
8IDT	ELECTRON MICROSCOPY	2.8
8RL2	ELECTRON MICROSCOPY	2.84
8FL4	ELECTRON MICROSCOPY	2.89
8FL0	ELECTRON MICROSCOPY	2.91
8IDY	ELECTRON MICROSCOPY	3
8INF	ELECTRON MICROSCOPY	3
8FKZ	ELECTRON MICROSCOPY	3.04
9QIW	ELECTRON MICROSCOPY	3.04
6LU8	ELECTRON MICROSCOPY	3.13
8INE	ELECTRON MICROSCOPY	3.2
8INK	ELECTRON MICROSCOPY	3.2
8IPD	ELECTRON MICROSCOPY	3.2
8IPY	ELECTRON MICROSCOPY	3.2
6LSS	ELECTRON MICROSCOPY	3.23
8IE3	ELECTRON MICROSCOPY	3.3
8IR1	ELECTRON MICROSCOPY	3.3
8IR3	ELECTRON MICROSCOPY	3.5
8IPX	ELECTRON MICROSCOPY	4.3

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q13823-F1	73.37	0.40

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (2): 317–324; 361–365

Post-translational modifications (2): 1, 504

Mutagenesis-validated functional residues (16):

Position	Phenotype
33–35	diffused nuclear localization, loss of nucleolar localization.
39–40	diffused nuclear localization, loss of nucleolar localization.
39–40	no effect on nucleolar localization.
49–50	diffused nuclear localization, loss of nucleolar localization.
227–229	loss of gtp-binding. efficient localization to the nucleus, but excluded from nucleoli.
258	loss of gtp-binding. punctate pattern throughout the nucleus, including nucleoli.
323	no effect on gtp-binding, nor on nucleolar localization.
324	no effect on gtp-binding, nor on nucleolar localization.
325	no effect on gtp-binding, nor on nucleolar localization.
343–345	no effect on gtp-binding, nor on nucleolar localization.
363–364	no effect on gtp-binding, nor on nucleolar localization.
463	no effect on nucleolar localization; when associated with a-475.
475	no effect on nucleolar localization; when associated with a-463.
682–684	no effect on nucleolar localization. predominantly cytoplasmic, with some nucleolar staining; when associated with 711-a
711–713	no effect on nucleolar localization predominantly cytoplasmic, with some nucleolar staining; when associated with 682-aa
724–726	no effect on nucleolar localization. strong nucleolar localization, with some cytoplasmic staining; when associated with

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 161 (showing top): GOBP_RIBOSOME_BIOGENESIS, RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, BROWNE_HCMV_INFECTION_16HR_UP, MORF_HDAC2, PUJANA_CHEK2_PCC_NETWORK, WEI_MYCN_TARGETS_WITH_E_BOX, MILI_PSEUDOPODIA_HAPTOTAXIS_UP, chr1p34, MORF_PRKDC, GARY_CD5_TARGETS_DN, MODULE_86, RYTTCCTG_ETS2_B, SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP

GO Biological Process (1): ribosome biogenesis (GO:0042254)

GO Molecular Function (4): RNA binding (GO:0003723), GTPase activity (GO:0003924), GTP binding (GO:0005525), nucleotide binding (GO:0000166)

GO Cellular Component (3): nucleus (GO:0005634), nucleolus (GO:0005730), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
ribonucleoprotein complex biogenesis	1
nucleic acid binding	1
ribonucleoside triphosphate phosphatase activity	1
guanyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
intracellular membraneless organelle	1
cellular anatomical structure	1

Protein interactions and networks

STRING

3651 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
GNL2	GTPBP4	Q9BZE4	910
GNL2	NSA2	O95478	904
GNL2	RPF2	Q9H7B2	899
GNL2	RPL37A	P12751	852
GNL2	SENP5	Q96HI0	850
GNL2	RSL24D1	Q9UHA3	843
GNL2	NMD3	Q96D46	842
GNL2	MDN1	Q9NU22	809
GNL2	SENP3	Q9H4L4	799
GNL2	WDR12	Q9GZL7	773
GNL2	NPM1	P06748	771
GNL2	WDR74	Q6RFH5	766
GNL2	MRTO4	Q9UKD2	760
GNL2	RCC1	P18754	736
GNL2	NOP2	P46087	736

IntAct

301 interactions, top by confidence:

A	B	Type	Score
CDK8	MED19	psi-mi:“MI:2364”(proximity)	0.850
TUBG1	TUBG1	psi-mi:“MI:2364”(proximity)	0.760
N	HNRNPR	psi-mi:“MI:0914”(association)	0.730
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
RANBP6	SLC27A2	psi-mi:“MI:0914”(association)	0.640
RPL14	RRP8	psi-mi:“MI:0914”(association)	0.640
H1-1	RRP8	psi-mi:“MI:0914”(association)	0.640
NOP53	RRP8	psi-mi:“MI:0914”(association)	0.640
NOL12	RRP8	psi-mi:“MI:0914”(association)	0.640
NSA2	TYW5	psi-mi:“MI:0914”(association)	0.530
FGF3	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MECP2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
H1-6	ZNF724	psi-mi:“MI:0914”(association)	0.530
ZNF512	ZNF724	psi-mi:“MI:0914”(association)	0.530
RBM34	NVL	psi-mi:“MI:0914”(association)	0.530
RRP8	NVL	psi-mi:“MI:0914”(association)	0.530
H1-4	IGF2BP3	psi-mi:“MI:0914”(association)	0.530
RPL37A	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
ZNF2	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
RPL18	NOP56	psi-mi:“MI:0914”(association)	0.530
PRR11	NVL	psi-mi:“MI:0914”(association)	0.530
KNOP1	DHX15	psi-mi:“MI:0914”(association)	0.530
RPL30	RRP8	psi-mi:“MI:0914”(association)	0.530
RPL8	RRP8	psi-mi:“MI:0914”(association)	0.530
RPL18A	RRP8	psi-mi:“MI:0914”(association)	0.530
ZBTB48	ZBTB24	psi-mi:“MI:0914”(association)	0.530
PDGFB	DKC1	psi-mi:“MI:0914”(association)	0.530

BioGRID (468): GNL2 (Affinity Capture-MS), GNL2 (Affinity Capture-MS), GNL2 (Affinity Capture-MS), GNL2 (Affinity Capture-MS), GNL2 (Affinity Capture-MS), GNL2 (Affinity Capture-MS), GNL2 (Affinity Capture-MS), GNL2 (Affinity Capture-MS), GNL2 (Affinity Capture-MS), GNL2 (Affinity Capture-MS), GNL2 (Affinity Capture-MS), GNL2 (Affinity Capture-MS), GNL2 (Affinity Capture-MS), GNL2 (Co-fractionation), GNL2 (Co-fractionation)

ESM2 similar proteins: A2XGQ1, G0S8F1, J9VQ03, O14236, O44411, O94659, P0CS94, P36776, P53145, P53742, Q02892, Q10190, Q10LF7, Q13823, Q21086, Q2YDM7, Q3UM18, Q4R8L2, Q54N72, Q59HJ6, Q5BJT6, Q5E9R3, Q5ZJD3, Q6C036, Q6CM00, Q6CSP9, Q6FRV0, Q6FWS1, Q6NY89, Q74ZK6, Q75DA4, Q7SHR8, Q8MT06, Q99LH1, Q99ME9, Q99P77, Q9BZE4, Q9C3Z4, Q9C6I8, Q9C923

Diamond homologs: A2XGQ1, A4SDB8, A5GR60, A5IMB8, A5N2K5, A5VWQ6, A6LT31, A8EXG4, A8GM60, A8GQS1, A8GUK6, A9KFU3, A9NDV6, B0JFL6, B0KG04, B1JFJ3, B1LBK5, B1X0B0, B2TPB6, B2UX10, B3EGV8, B3PN57, B3QQY9, B3WE42, B4S596, B6J7Q3, B7K1S0, B8GAY7, B8I8N7, B9K8C0, C3PMD9, C4K1B9, J9VQ03, O14236, O67679, O74791, P0CS94, P36915, P36916, P40010

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 220 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Peptide chain elongation	24	21.9×	4e-24
Viral mRNA Translation	24	21.9×	4e-24
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	24	21.7×	5e-24
SRP-dependent cotranslational protein targeting to membrane	29	20.9×	3e-28
Selenocysteine synthesis	24	20.8×	1e-23
Eukaryotic Translation Termination	24	20.8×	1e-23
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	24	20.3×	1e-23
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	24	20.3×	1e-23

GO biological processes:

GO term	Partners	Fold	FDR
negative regulation of DNA recombination	5	28.8×	6e-05
chromosome condensation	6	25.9×	1e-05
cytoplasmic translation	27	25.6×	4e-28
negative regulation of mRNA splicing, via spliceosome	5	19.6×	3e-04
ribosome biogenesis	5	16.0×	7e-04
ribosomal large subunit biogenesis	7	15.9×	3e-05
translation	28	14.8×	3e-22
rRNA processing	19	13.8×	4e-14

Disease & clinical

Clinical variants and AI predictions

ClinVar

119 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	99
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2326 predictions. Top by Δscore:

Variant	Effect	Δscore
1:37567003:CTCCG:C	acceptor_gain	1.0000
1:37568268:A:C	donor_gain	1.0000
1:37568270:TTCAC:T	donor_loss	1.0000
1:37568271:T:TA	donor_gain	1.0000
1:37568271:TCACC:T	donor_loss	1.0000
1:37568272:CACCT:C	donor_loss	1.0000
1:37568274:C:CG	donor_loss	1.0000
1:37568274:CCT:C	donor_gain	1.0000
1:37568353:ATATT:A	acceptor_gain	1.0000
1:37568354:TATT:T	acceptor_gain	1.0000
1:37568355:ATT:A	acceptor_gain	1.0000
1:37568356:TT:T	acceptor_gain	1.0000
1:37568357:TCT:T	acceptor_loss	1.0000
1:37568358:C:CA	acceptor_loss	1.0000
1:37568358:C:CC	acceptor_gain	1.0000
1:37568359:T:G	acceptor_loss	1.0000
1:37568845:TATTA:T	donor_loss	1.0000
1:37568847:TTACC:T	donor_loss	1.0000
1:37568848:TACC:T	donor_loss	1.0000
1:37568849:A:T	donor_loss	1.0000
1:37568850:C:CA	donor_loss	1.0000
1:37568850:CCTGA:C	donor_gain	1.0000
1:37569303:C:CC	acceptor_gain	1.0000
1:37569306:T:TC	acceptor_gain	1.0000
1:37574337:TCTTA:T	donor_loss	1.0000
1:37574338:CTTAC:C	donor_loss	1.0000
1:37574339:TTACC:T	donor_loss	1.0000
1:37574340:TACCT:T	donor_loss	1.0000
1:37574341:A:C	donor_loss	1.0000
1:37574452:CCACC:C	acceptor_gain	1.0000

AlphaMissense

4827 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:37575647:C:T	G364D	1.000
1:37575648:C:G	G364R	1.000
1:37575652:A:C	C362W	1.000
1:37575653:C:T	C362Y	1.000
1:37575654:A:G	C362R	1.000
1:37575662:A:G	L359P	1.000
1:37575696:A:G	W348R	1.000
1:37575696:A:T	W348R	1.000
1:37576438:C:T	G343D	1.000
1:37576501:C:T	G322D	1.000
1:37576502:C:G	G322R	1.000
1:37576525:C:T	G314E	1.000
1:37576526:C:A	G314W	1.000
1:37576528:A:T	V313D	1.000
1:37582263:C:T	G290D	1.000
1:37582797:A:G	L259P	1.000
1:37582806:T:A	K256I	1.000
1:37574416:A:G	L448P	0.999
1:37574822:A:T	V382D	0.999
1:37575605:A:G	L378P	0.999
1:37575648:C:A	G364C	0.999
1:37575650:G:T	P363Q	0.999
1:37575655:G:C	D361E	0.999
1:37575655:G:T	D361E	0.999
1:37575656:T:A	D361V	0.999
1:37575656:T:C	D361G	0.999
1:37575656:T:G	D361A	0.999
1:37575657:C:G	D361H	0.999
1:37575659:A:T	I360N	0.999
1:37575668:A:T	I357K	0.999

dbSNP variants (sampled 300 via entrez): RS1000007899 (1:37591416 G>A), RS1000085217 (1:37592673 T>C), RS1000150854 (1:37595646 T>C), RS1000218777 (1:37596913 C>T), RS1000230444 (1:37589554 C>T), RS1000269390 (1:37573849 G>A,C), RS1000288291 (1:37566749 A>C), RS1000411046 (1:37572166 T>C), RS1000463555 (1:37572373 C>A), RS1000469391 (1:37594159 T>C), RS1000580522 (1:37573466 A>T), RS1000636444 (1:37587894 T>C), RS1000780324 (1:37581208 G>A,T), RS1000791982 (1:37571064 G>A,T), RS1000906963 (1:37570687 T>C)

Disease associations

OMIM: gene MIM:609365 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST002115_4	Axial length	4.000000e-13
GCST003476_2	Eyebrow thickness	7.000000e-06
GCST006464_2	Endometrial cancer	4.000000e-08
GCST006465_9	Endometrial cancer (endometrioid histology)	3.000000e-08

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0005318	axial length measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

40 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Estradiol	increases expression, affects expression, affects cotreatment, decreases expression	3
Cyclosporine	increases expression	2
Aflatoxin B1	increases methylation, affects cotreatment, decreases expression	2
dicrotophos	decreases expression	1
alpha-pinene	decreases expression, increases abundance, affects cotreatment	1
bisphenol A	affects expression	1
deoxynivalenol	increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
sodium arsenite	affects cotreatment, increases abundance, increases expression	1
cobaltous chloride	decreases expression	1
manganese chloride	increases abundance, increases expression, affects cotreatment	1
methacrylaldehyde	affects cotreatment, decreases expression, increases abundance	1
di-n-butylphosphoric acid	affects expression	1
K 7174	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	decreases expression, affects cotreatment	1
abrine	increases expression	1
(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	increases expression	1
LDN 193189	affects cotreatment, decreases expression	1
Acrolein	affects cotreatment, decreases expression, increases abundance	1
Air Pollutants	affects cotreatment, decreases expression, increases abundance	1
Air Pollutants, Occupational	affects expression	1
Arbutin	increases expression	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Benzo(a)pyrene	affects methylation	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Hydrogen Peroxide	affects expression	1
Manganese	increases abundance, increases expression, affects cotreatment	1
Ozone	decreases expression, increases abundance, affects cotreatment	1
Progesterone	decreases expression, affects cotreatment	1
Ribonucleotides	affects binding	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.