GOLGA6L25

Summary

GOLGA6L25 (golgin A6 family like 25, HGNC:55711) is a protein-coding gene on chromosome 15q13.1, encoding Golgin subfamily A member 6-like protein 25 (P0DX01).

At a glance

• Clinical variants (ClinVar): 1 total
• MANE Select transcript: NM_001365373

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55711
Approved symbol	GOLGA6L25
Name	golgin A6 family like 25
Location	15q13.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000227717
Ensembl biotype	protein_coding
Entrez	100132202

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000620691

RefSeq mRNA: 1 — MANE Select: NM_001365373 NM_001365373

CCDS: CCDS91968

Canonical transcript exons

ENST00000619605 — 0 exons

Expression profiles

Bgee: expression breadth broad, 13 present calls, max score 82.15.

Top tissues by expression

121 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	82.15	gold quality
right testis	UBERON:0004534	81.11	gold quality
testis	UBERON:0000473	81.05	gold quality
sural nerve	UBERON:0015488	66.92	gold quality
superior frontal gyrus	UBERON:0002661	38.68	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
hindlimb stylopod muscle	UBERON:0004252	35.29	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
anterior cingulate cortex	UBERON:0009835	30.70	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
liver	UBERON:0002107	29.06	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	28.83	silver quality
tonsil	UBERON:0002372	28.56	gold quality
cerebral cortex	UBERON:0000956	28.47	silver quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
primary visual cortex	UBERON:0002436	27.39	gold quality
cortex of kidney	UBERON:0001225	27.11	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
leukocyte	CL:0000738	26.50	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
monocyte	CL:0000576	26.39	gold quality
muscle of leg	UBERON:0001383	26.37	gold quality
gall bladder	UBERON:0002110	25.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.66

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (10): GOLGA6L2 (ENSG00000174450), GOLGA6L4 (ENSG00000184206), GOLGA6L9 (ENSG00000197978), GOLGA6L24 (ENSG00000237850), GOLGA6L7 (ENSG00000261649), GOLGA6L26 (ENSG00000273756), GOLGA6L1 (ENSG00000273976), GOLGA6L6 (ENSG00000277322), GOLGA6L22 (ENSG00000277865), GOLGA6L10 (ENSG00000278662)

Protein

Protein identifiers

Golgin subfamily A member 6-like protein 25 — P0DX01 (reviewed: P0DX01)

All UniProt accessions (2): P0DX01, A0A087X1J6

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the GOLGA6 family.

RefSeq proteins (1): NP_001352302* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR026737	GOLGA6L	Family

UniProt features (14 total): region of interest 6, compositionally biased region 6, chain 1, coiled-coil region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0DX01-F1	71.04	0.14

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 1 (showing top): chr15q13

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A0J9YWL9, A0A0J9YY54, A0A1B0GV03, A6NEF3, A6NEM1, A6NI86, A8MZA4, B4DH59, D3YVF0, F6QRE9, H0YKK7, H0YM25, P0C6Y7, P0C7A2, P0DX00, P0DX01, P0DX02, P14590, P21263, P22793, P24587, P24710, P48997, P48998, Q07283, Q0II65, Q0P6D6, Q13342, Q3BBV2, Q4R9C9, Q5W0A0, Q6AXX0, Q6NSX1, Q6P5H2, Q6P902, Q86T75, Q8CHD8, Q8N2N9, Q8N660, Q8N7Z2

Diamond homologs: A0A1B0GV03, A1IH00, A6NC78, A6NCC3, A6NDK9, A6NDN3, A6NEF3, A6NEM1, A6NI86, A6NN73, A7E2F4, A8MQT2, A8MZA4, F8WBI6, H0YKK7, H0YM25, H3BPF8, H3BSY2, H3BV12, I6L899, P0CG33, P0CJ92, P0DX00, P0DX01, P0DX02, P0DX52, P0DX53, Q08379, Q62839, Q8N7Z2, Q8N9W4, Q921M4, Q9NYA3, A6NMD2, D6RF30, H3BQL2, Q0D2H9, Q9HBQ8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

1 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1009456209 (15:28560891 C>G,T), RS1010947363 (15:28559075 T>C), RS1011062141 (15:28556261 C>T), RS1012691793 (15:28553016 G>C,T), RS1019586394 (15:28556410 G>C), RS1024969858 (15:28553021 G>C), RS1025313811 (15:28562889 A>G), RS1029457497 (15:28560474 G>A), RS1031013758 (15:28554021 A>G), RS1031066121 (15:28556239 C>A,T), RS1046707109 (15:28556182 T>C), RS1048246052 (15:28556103 G>C), RS1048360056 (15:28551799 A>C), RS1052263782 (15:28564213 T>C), RS1052376759 (15:28558556 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.