GOLGA6L26

Summary

GOLGA6L26 (golgin A6 family like 26, HGNC:56306) is a protein-coding gene on chromosome 15q11.2, encoding Golgin subfamily A member 6-like protein 26 (P0DX02).

At a glance

• MANE Select transcript: NM_001382446

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:56306
Approved symbol	GOLGA6L26
Name	golgin A6 family like 26
Location	15q11.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000273756
Ensembl biotype	protein_coding
Entrez	102723623

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000618455

RefSeq mRNA: 1 — MANE Select: NM_001382446 NM_001382446

CCDS: CCDS91963

Canonical transcript exons

ENST00000618455 — 9 exons

Exon	Start	End
ENSE00001772841	23334016	23334196
ENSE00003719096	23326935	23328158
ENSE00003719320	23329284	23329342
ENSE00003732271	23331105	23331155
ENSE00003736586	23330923	23331016
ENSE00003739287	23330721	23330827
ENSE00003752863	23328812	23328953
ENSE00003754842	23332241	23332369
ENSE00003935942	23324535	23326278

Expression profiles

Bgee: expression breadth broad, 18 present calls, max score 82.76.

Top tissues by expression

94 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.76	gold quality
left testis	UBERON:0004533	72.15	gold quality
testis	UBERON:0000473	71.98	gold quality
right testis	UBERON:0004534	69.34	gold quality
sural nerve	UBERON:0015488	44.34	silver quality
ventricular zone	UBERON:0003053	40.11	gold quality
superior frontal gyrus	UBERON:0002661	39.47	gold quality
bone marrow cell	CL:0002092	39.06	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
skeletal muscle tissue	UBERON:0001134	36.37	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
hindlimb stylopod muscle	UBERON:0004252	35.45	gold quality
muscle tissue	UBERON:0002385	33.25	gold quality
bone marrow	UBERON:0002371	33.22	gold quality
monocyte	CL:0000576	31.72	silver quality
leukocyte	CL:0000738	31.35	silver quality
tonsil	UBERON:0002372	30.57	gold quality
vermiform appendix	UBERON:0001154	30.27	silver quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
liver	UBERON:0002107	28.77	gold quality
lymph node	UBERON:0000029	28.76	gold quality
right uterine tube	UBERON:0001302	28.19	gold quality
duodenum	UBERON:0002114	28.14	gold quality
placenta	UBERON:0001987	27.57	gold quality
cortex of kidney	UBERON:0001225	27.37	gold quality
muscle of leg	UBERON:0001383	27.37	silver quality
primary visual cortex	UBERON:0002436	27.25	gold quality
calcaneal tendon	UBERON:0003701	27.00	gold quality
islet of Langerhans	UBERON:0000006	26.90	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.52

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (10): GOLGA6L2 (ENSG00000174450), GOLGA6L4 (ENSG00000184206), GOLGA6L9 (ENSG00000197978), GOLGA6L25 (ENSG00000227717), GOLGA6L24 (ENSG00000237850), GOLGA6L7 (ENSG00000261649), GOLGA6L1 (ENSG00000273976), GOLGA6L6 (ENSG00000277322), GOLGA6L22 (ENSG00000277865), GOLGA6L10 (ENSG00000278662)

Protein

Protein identifiers

Golgin subfamily A member 6-like protein 26 — P0DX02 (reviewed: P0DX02)

All UniProt accessions (2): P0DX02, A0A8I5KQN6

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the GOLGA6 family.

RefSeq proteins (1): NP_001369375* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR026737	GOLGA6L	Family

UniProt features (12 total): region of interest 5, compositionally biased region 5, chain 1, coiled-coil region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0DX02-F1	76.12	0.23

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 1 (showing top): chr15q11

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A0J9YWL9, A0A0J9YY54, A0A1B0GV03, A6NEF3, A6NEM1, A6NI86, A8MZA4, B4DH59, D3YVF0, F6QRE9, H0YKK7, H0YM25, P0C6Y7, P0C7A2, P0DX00, P0DX01, P0DX02, P14590, P21263, P22793, P24587, P24710, P48997, P48998, Q07283, Q0II65, Q0P6D6, Q13342, Q3BBV2, Q4R9C9, Q5W0A0, Q6AXX0, Q6NSX1, Q6P5H2, Q6P902, Q86T75, Q8CHD8, Q8N2N9, Q8N660, Q8N7Z2

Diamond homologs: A0A1B0GV03, A1IH00, A6NC78, A6NCC3, A6NDK9, A6NDN3, A6NEF3, A6NEM1, A6NI86, A6NN73, A7E2F4, A8MQT2, A8MZA4, F8WBI6, H0YKK7, H0YM25, H3BPF8, H3BSY2, H3BV12, I6L899, P0CG33, P0CJ92, P0DX00, P0DX01, P0DX02, P0DX52, P0DX53, Q08379, Q62839, Q8N7Z2, Q8N9W4, Q921M4, Q9NYA3, A6NMD2, D6RF30, H3BQL2, Q0D2H9, Q9HBQ8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

4444 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1003301556 (15:23330150 C>A,T), RS1005077184 (15:23327182 T>G), RS1011656537 (15:23330271 C>A,G), RS1011708873 (15:23332708 A>C,G), RS1014911059 (15:23327413 T>C), RS1022173092 (15:23330364 A>G), RS1030814771 (15:23334065 A>G), RS1031343487 (15:23331471 C>A,T), RS1036457947 (15:23332165 T>C), RS1036573976 (15:23329976 C>T), RS1043165673 (15:23332733 C>T), RS1049247634 (15:23329824 T>G), RS1055776867 (15:23330159 G>C), RS1056229518 (15:23332539 GA>G,GAA), RS111143840 (15:23327655 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.