GOLGA6L7

Summary

GOLGA6L7 (golgin A6 family like 7, HGNC:37442) is a protein-coding gene on chromosome 15q13.1, encoding Golgin subfamily A member 6-like protein 7 (A0A1B0GV03).

Predicted to be located in cis-Golgi network.

Source: NCBI Gene 728310 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 3 total
• MANE Select transcript: NM_001365371

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37442
Approved symbol	GOLGA6L7
Name	golgin A6 family like 7
Location	15q13.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000261649
Ensembl biotype	protein_coding
Entrez	728310

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 1 protein_coding, 1 retained_intron

ENST00000567390, ENST00000569815

RefSeq mRNA: 1 — MANE Select: NM_001365371 NM_001365371

CCDS: CCDS91969

Canonical transcript exons

ENST00000567390 — 9 exons

Exon	Start	End
ENSE00002577913	28843734	28843875
ENSE00002617327	28841832	28843440
ENSE00002619414	28848499	28848644
ENSE00002620568	28845529	28845635
ENSE00002625497	28844205	28844263
ENSE00003793457	28846220	28846249
ENSE00003793674	28847064	28847192
ENSE00003797819	28845900	28845950
ENSE00003800771	28845718	28845811

Expression profiles

Bgee: expression breadth ubiquitous, 120 present calls, max score 91.69.

Top tissues by expression

128 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	91.69	gold quality
right testis	UBERON:0004534	91.33	gold quality
testis	UBERON:0000473	89.86	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.73	silver quality
right hemisphere of cerebellum	UBERON:0014890	67.13	gold quality
cerebellum	UBERON:0002037	67.05	gold quality
cerebellar cortex	UBERON:0002129	66.92	gold quality
cerebellar hemisphere	UBERON:0002245	66.78	gold quality
endocervix	UBERON:0000458	65.49	gold quality
primary visual cortex	UBERON:0002436	64.54	gold quality
right adrenal gland	UBERON:0001233	64.00	gold quality
superior frontal gyrus	UBERON:0002661	63.87	gold quality
right adrenal gland cortex	UBERON:0035827	63.79	gold quality
left adrenal gland	UBERON:0001234	63.67	gold quality
left adrenal gland cortex	UBERON:0035825	63.23	gold quality
ectocervix	UBERON:0012249	62.03	gold quality
adrenal gland	UBERON:0002369	61.35	gold quality
uterine cervix	UBERON:0000002	60.77	gold quality
vagina	UBERON:0000996	60.76	gold quality
right atrium auricular region	UBERON:0006631	59.06	gold quality
apex of heart	UBERON:0002098	58.75	gold quality
heart left ventricle	UBERON:0002084	57.99	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	57.71	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	56.52	gold quality
descending thoracic aorta	UBERON:0002345	56.46	gold quality
lower esophagus	UBERON:0013473	56.08	gold quality
lower esophagus muscularis layer	UBERON:0035833	56.05	gold quality
heart	UBERON:0000948	55.38	gold quality
hypothalamus	UBERON:0001898	55.21	gold quality
mucosa of stomach	UBERON:0001199	54.91	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.44

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (10): GOLGA6L2 (ENSG00000174450), GOLGA6L4 (ENSG00000184206), GOLGA6L9 (ENSG00000197978), GOLGA6L25 (ENSG00000227717), GOLGA6L24 (ENSG00000237850), GOLGA6L26 (ENSG00000273756), GOLGA6L1 (ENSG00000273976), GOLGA6L6 (ENSG00000277322), GOLGA6L22 (ENSG00000277865), GOLGA6L10 (ENSG00000278662)

Protein

Protein identifiers

Golgin subfamily A member 6-like protein 7 — A0A1B0GV03 (reviewed: A0A1B0GV03)

All UniProt accessions (1): A0A1B0GV03

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the GOLGA6 family.

RefSeq proteins (1): NP_001352300* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR026737	GOLGA6L	Family
IPR043937	GOLGA_C	Conserved_site

Pfam: PF19046

UniProt features (14 total): compositionally biased region 9, region of interest 3, chain 1, coiled-coil region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A0A1B0GV03-F1	73.47	0.20

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 6 (showing top): chr15q13, GOCC_CIS_GOLGI_NETWORK, PBXIP1_TARGET_GENES, ANDERSON_BLOOD_CN54GP140_ADJUVANTED_WITH_GLA_AF_AGE_18_45YO_1DY_UP, ANDERSON_BLOOD_CN54GP140_ADJUVANTED_WITH_GLA_AF_AGE_18_45YO_7DY_UP, GOCC_GOLGI_APPARATUS

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (2): cis-Golgi network (GO:0005801), Golgi apparatus (GO:0005794)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
intracellular membrane-bounded organelle	2
binding	1
Golgi apparatus	1
cytoplasm	1
endomembrane system	1

Protein interactions and networks

STRING

162 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
GOLGA6L7	OR5J2	Q8NH18	669
GOLGA6L7	ZNF658	Q5TYW1	621
GOLGA6L7	C2orf81	A6NN90	571
GOLGA6L7	CCDC154	A6NI56	528
GOLGA6L7	SGCZ	Q96LD1	507
GOLGA6L7	STMP1	E0CX11	507
GOLGA6L7	GALNTL5	Q7Z4T8	507
GOLGA6L7	IQCN	Q9H0B3	480
GOLGA6L7	ARL10	Q8N8L6	478
GOLGA6L7	APBA2	Q99767	475
GOLGA6L7	JAKMIP3	Q5VZ66	417
GOLGA6L7	POTEB3	A0JP26	374
GOLGA6L7	GSG1L	Q6UXU4	370
GOLGA6L7	ELOA2	Q8IYF1	349
GOLGA6L7	MYO3B	Q8WXR4	349

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A0J9YWL9, A0A0J9YY54, A0A1B0GV03, A6NEF3, A6NEM1, A6NI86, A8MZA4, B4DH59, D3YVF0, F6QRE9, H0YKK7, H0YM25, P0C6Y7, P0C7A2, P0DX00, P0DX01, P0DX02, P14590, P21263, P22793, P24587, P24710, P48997, P48998, Q07283, Q0II65, Q0P6D6, Q13342, Q3BBV2, Q4R9C9, Q5W0A0, Q6AXX0, Q6NSX1, Q6P5H2, Q6P902, Q86T75, Q8CHD8, Q8N2N9, Q8N660, Q8N7Z2

Diamond homologs: A0A1B0GV03, A1IH00, A6NC78, A6NCC3, A6NDK9, A6NDN3, A6NEF3, A6NEM1, A6NI86, A6NN73, A7E2F4, A8MQT2, A8MZA4, F8WBI6, H0YKK7, H0YM25, H3BPF8, H3BSY2, H3BV12, I6L899, P0CG33, P0CJ92, P0DX00, P0DX01, P0DX02, P0DX52, P0DX53, Q08379, Q62839, Q8N7Z2, Q8N9W4, Q921M4, Q9NYA3, A6NMD2, D6RF30, H3BQL2, Q0D2H9, Q9HBQ8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

3 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

4238 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
15:28842280:G:C	F608L	0.870
15:28842280:G:T	F608L	0.870
15:28842282:A:G	F608L	0.870
15:28843837:A:G	L187P	0.849
15:28843858:A:G	L180P	0.844
15:28843825:A:G	L191P	0.840
15:28845589:A:C	F134L	0.839
15:28845589:A:T	F134L	0.839
15:28845591:A:G	F134L	0.839
15:28842277:G:C	F609L	0.821
15:28842277:G:T	F609L	0.821
15:28842279:A:G	F609L	0.821
15:28843774:A:G	L208P	0.819
15:28845789:A:G	I95T	0.797
15:28843844:C:G	A185P	0.769
15:28845608:A:G	L128P	0.767
15:28847190:A:C	F18L	0.762
15:28847190:A:T	F18L	0.762
15:28847192:A:G	F18L	0.762
15:28845786:A:G	L96P	0.761
15:28842734:A:G	M457T	0.757
15:28844217:A:G	L170P	0.743
15:28848544:C:A	M2I	0.731
15:28848544:C:G	M2I	0.731
15:28848544:C:T	M2I	0.731
15:28845600:A:G	S131P	0.725
15:28845722:A:C	F117L	0.719
15:28845722:A:T	F117L	0.719
15:28845724:A:G	F117L	0.719
15:28845792:C:G	R94P	0.713

dbSNP variants (sampled 300 via entrez): RS1000063010 (15:28844410 G>GTGTCATTTGTGT), RS1000135940 (15:28844406 C>T), RS1000246103 (15:28844467 G>A,T), RS1000742223 (15:28850064 C>G,T), RS1001360666 (15:28844133 A>C,G), RS1001469140 (15:28849530 C>G,T), RS1001498658 (15:28849930 C>A,T), RS1002391423 (15:28845396 G>A,T), RS1003137863 (15:28848747 A>G), RS1003168896 (15:28848847 G>A), RS1003441867 (15:28842431 T>C), RS1004397599 (15:28844887 G>A), RS1004428750 (15:28845141 C>T), RS1005219906 (15:28848613 C>T), RS1005745919 (15:28848724 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
tebuconazole	decreases expression	1
Magnetite Nanoparticles	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.