GOLGA7B

Summary

GOLGA7B (golgin A7 family member B, HGNC:31668) is a protein-coding gene on chromosome 10q24.2, encoding Golgin subfamily A member 7B (Q2TAP0). Play a role in cell adhesion by regulating the plasma membrane localization of the palmitoyltransferase ZDHHC5.

Enables enzyme binding activity. Predicted to be involved in protein targeting to membrane. Predicted to be located in Golgi membrane and plasma membrane. Predicted to be part of palmitoyltransferase complex.

Source: NCBI Gene 401647 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 25 total
• MANE Select transcript: NM_001010917

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31668
Approved symbol	GOLGA7B
Name	golgin A7 family member B
Location	10q24.2
Locus type	gene with protein product
Status	Approved
Aliases	bA459F3.4, bA451M19.3
Ensembl gene	ENSG00000155265
Ensembl biotype	protein_coding
OMIM	614189
Entrez	401647

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 6 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000370602, ENST00000423054, ENST00000856898, ENST00000856899, ENST00000962863, ENST00000962864, ENST00000962865

RefSeq mRNA: 1 — MANE Select: NM_001010917 NM_001010917

CCDS: CCDS31265

Canonical transcript exons

ENST00000370602 — 5 exons

Exon	Start	End
ENSE00001020002	97863930	97864082
ENSE00001097773	97859458	97859583
ENSE00001097774	97864168	97864269
ENSE00001453124	97865590	97871578
ENSE00001453125	97849843	97850315

Expression profiles

Bgee: expression breadth ubiquitous, 186 present calls, max score 95.54.

FANTOM5 (CAGE): breadth broad, TPM avg 3.9871 / max 190.4514, expressed in 574 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
106474	2.5210	501
106475	1.2051	279
106473	0.1478	61
106476	0.1003	43
106472	0.0128	3

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	95.54	gold quality
cerebellar hemisphere	UBERON:0002245	95.34	gold quality
cerebellar cortex	UBERON:0002129	95.26	gold quality
cerebellum	UBERON:0002037	94.54	gold quality
cerebellar vermis	UBERON:0004720	92.10	gold quality
right frontal lobe	UBERON:0002810	90.80	gold quality
anterior cingulate cortex	UBERON:0009835	89.83	gold quality
cortical plate	UBERON:0005343	89.68	gold quality
Brodmann (1909) area 9	UBERON:0013540	89.07	gold quality
upper arm skin	UBERON:0004263	88.40	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	88.18	gold quality
frontal cortex	UBERON:0001870	88.06	gold quality
neocortex	UBERON:0001950	87.91	gold quality
prefrontal cortex	UBERON:0000451	87.85	gold quality
kidney epithelium	UBERON:0004819	87.59	gold quality
cerebral cortex	UBERON:0000956	87.15	gold quality
Ammon’s horn	UBERON:0001954	86.61	gold quality
parietal lobe	UBERON:0001872	86.50	gold quality
postcentral gyrus	UBERON:0002581	86.46	gold quality
amygdala	UBERON:0001876	86.27	gold quality
hypothalamus	UBERON:0001898	85.84	gold quality
cardiac muscle of right atrium	UBERON:0003379	85.80	gold quality
brain	UBERON:0000955	85.53	gold quality
superior frontal gyrus	UBERON:0002661	85.17	gold quality
temporal lobe	UBERON:0001871	85.00	gold quality
nucleus accumbens	UBERON:0001882	84.71	gold quality
left ventricle myocardium	UBERON:0006566	84.67	gold quality
forebrain	UBERON:0001890	84.63	gold quality
primary visual cortex	UBERON:0002436	83.80	gold quality
occipital lobe	UBERON:0002021	83.69	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.49

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

157 targeting GOLGA7B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-6740-5P	100.00	65.64	932
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-485-3P	99.98	70.68	1585
HSA-MIR-539-3P	99.98	70.74	1616
HSA-MIR-4715-3P	99.98	66.03	670
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-MIR-4267	99.96	66.53	2368
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-23A-3P	99.95	74.24	3163
HSA-MIR-23B-3P	99.95	74.24	3163
HSA-MIR-23C	99.95	73.92	3192
HSA-MIR-1236-3P	99.94	68.04	1695
HSA-MIR-329-3P	99.91	66.56	1234
HSA-MIR-362-3P	99.91	66.38	1267
HSA-MIR-6783-3P	99.89	67.92	2059
HSA-MIR-1343-3P	99.89	66.78	1815

Literature-anchored findings (GeneRIF, showing 2)

• This work uncovers a novel mechanism of DHHC5 regulation by Golga7b and demonstrates a role for the DHHC5/Golga7b complex in the regulation of cell adhesion. (PMID:31402609)
• Golgin A7 family member B (GOLGA7B) is a plausible novel gene associating high glycaemic index diet with acne vulgaris. (PMID:35416335)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	golga7ba	ENSDARG00000036295
danio_rerio	golga7bb	ENSDARG00000105099
mus_musculus	Golga7b	ENSMUSG00000042532
rattus_norvegicus	Golga7b	ENSRNOG00000015051
drosophila_melanogaster	CG5447	FBGN0039427
caenorhabditis_elegans		WBGENE00013323

Paralogs (1): GOLGA7 (ENSG00000147533)

Protein

Protein identifiers

Golgin subfamily A member 7B — Q2TAP0 (reviewed: Q2TAP0)

All UniProt accessions (1): Q2TAP0

UniProt curated annotations — full annotation on UniProt →

Function. Play a role in cell adhesion by regulating the plasma membrane localization of the palmitoyltransferase ZDHHC5. May be involved in protein transport from Golgi to cell surface.

Subcellular location. Cell membrane. Golgi apparatus membrane.

Tissue specificity. Expressed in brain, but not in lung, nor chondrocytes.

Post-translational modifications. Palmitoylated by ZDHHC5. Palmitoylation is required for the maintenance of ZDHHC5 at the plasma membrane.

Miscellaneous. Shares an exon with the neighboring tail-to-tail oriented gene CRTAC1.

Similarity. Belongs to the ERF4 family.

RefSeq proteins (1): NP_001010917* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR019383	Golgin_A_7/ERF4	Domain
IPR051371	Ras_palmitoyltransferase	Family

Pfam: PF10256

UniProt features (7 total): compositionally biased region 2, lipid moiety-binding region 2, chain 1, region of interest 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q2TAP0-F1	81.71	0.45

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 78, 81

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 66 (showing top): GOBP_PROTEIN_TARGETING, GOBP_PROTEIN_TARGETING_TO_MEMBRANE, RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_DN, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE, LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN, GOBP_LOCALIZATION_WITHIN_MEMBRANE, GOCC_TRANSFERASE_COMPLEX, MEISSNER_NPC_HCP_WITH_H3K4ME2, MIKKELSEN_IPS_HCP_WITH_H3_UNMETHYLATED, MIKKELSEN_ES_HCP_WITH_H3_UNMETHYLATED, MIKKELSEN_MEF_HCP_WITH_H3K27ME3, GOCC_PALMITOYLTRANSFERASE_COMPLEX, ANDERSEN_CHOLANGIOCARCINOMA_CLASS1, MIR8485, MIR4531

GO Biological Process (1): protein targeting to membrane (GO:0006612)

GO Molecular Function (2): enzyme binding (GO:0019899), protein binding (GO:0005515)

GO Cellular Component (5): Golgi membrane (GO:0000139), palmitoyltransferase complex (GO:0002178), plasma membrane (GO:0005886), Golgi apparatus (GO:0005794), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
protein targeting	1
establishment of protein localization to membrane	1
protein binding	1
binding	1
Golgi apparatus	1
bounding membrane of organelle	1
transferase complex	1
membrane	1
cell periphery	1
cytoplasm	1
endomembrane system	1
intracellular membrane-bounded organelle	1
cellular anatomical structure	1

Protein interactions and networks

STRING

496 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
GOLGA7B	ZDHHC5	Q9C0B5	602
GOLGA7B	GOLGA1	Q92805	558
GOLGA7B	CCDC182	A6NF36	496
GOLGA7B	MEAK7	Q6P9B6	491
GOLGA7B	GOLGA6B	A6NDN3	477
GOLGA7B	GOLGA2	Q08379	473
GOLGA7B	ZDHHC20	Q5W0Z9	464
GOLGA7B	ZDHHC16	Q969W1	427
GOLGA7B	DHX32	Q7L7V1	417
GOLGA7B	GOLGA6A	Q9NYA3	415
GOLGA7B	ZDHHC6	Q9H6R6	410
GOLGA7B	ZDHHC9	Q9Y397	408
GOLGA7B	FAM43B	Q6ZT52	406
GOLGA7B	GOLGA3	Q08378	389
GOLGA7B	FAM135B	Q49AJ0	381

IntAct

17 interactions, top by confidence:

A	B	Type	Score
ZDHHC5	GOLGA7B	psi-mi:“MI:0915”(physical association)	0.650
ZDHHC5	GOLGA7B	psi-mi:“MI:0403”(colocalization)	0.650
HGS	GOLGA7B	psi-mi:“MI:0915”(physical association)	0.560
GOLGA7B	ZNF564	psi-mi:“MI:0915”(physical association)	0.560
GOLGA7B	ZDHHC15	psi-mi:“MI:0915”(physical association)	0.560
FADD	CHUK	psi-mi:“MI:0914”(association)	0.350
GOLGA7B	FGFR1	psi-mi:“MI:0914”(association)	0.350
ZDHHC5	IGKV2D-24	psi-mi:“MI:0914”(association)	0.350
CLDND1	TNFRSF10B	psi-mi:“MI:0914”(association)	0.350
HGS	GOLGA7B	psi-mi:“MI:0915”(physical association)	0.000
ZNF564	GOLGA7B	psi-mi:“MI:0915”(physical association)	0.000
GOLGA7B	ZDHHC15	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (17): ZDHHC5 (Affinity Capture-MS), SUN2 (Affinity Capture-MS), FGFR1 (Affinity Capture-MS), ZDHHC5 (Affinity Capture-MS), SUN2 (Affinity Capture-MS), FGFR1 (Affinity Capture-MS), GOLGA7B (Affinity Capture-MS), GOLGA7B (Two-hybrid), HGS (Two-hybrid), ZNF564 (Two-hybrid), ZDHHC5 (Affinity Capture-MS), SUN2 (Affinity Capture-MS), FGFR1 (Affinity Capture-MS), SPRR3 (Affinity Capture-MS), GOLGA7B (Affinity Capture-MS)

ESM2 similar proteins: A1L4L8, A2VDU1, B4FF80, B4FUS3, B6SGC5, B6TYV8, B6TZ45, D9HP19, D9HP20, D9HP23, D9HP25, D9HP26, D9HP27, O74837, P0CS25, P0CW97, P0CW98, Q07549, Q08EJ0, Q2TAP0, Q3EBY6, Q3ZCB2, Q499U8, Q4V786, Q52T38, Q5REK4, Q5TGY1, Q5U2S1, Q6DGP4, Q6GLN5, Q8L7E9, Q8R0W6, Q8S8T8, Q91WU4, Q94051, Q9BN19, Q9BT67, Q9C004, Q9D428, Q9LQU2

Diamond homologs: Q2TAP0, Q5EA55, Q5ZLC9, Q6AYQ1, Q7Z5G4, Q91W53, Q9D428

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

25 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	22
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

864 predictions. Top by Δscore:

Variant	Effect	Δscore
10:97863927:CA:C	acceptor_loss	1.0000
10:97863928:A:AG	acceptor_gain	1.0000
10:97863928:A:AT	acceptor_loss	1.0000
10:97863928:AGATC:A	acceptor_gain	1.0000
10:97863929:G:GG	acceptor_gain	1.0000
10:97863929:GATC:G	acceptor_gain	1.0000
10:97863929:GATCG:G	acceptor_gain	1.0000
10:97864079:G:GT	donor_gain	1.0000
10:97864080:A:T	donor_gain	1.0000
10:97864265:GGGTT:G	donor_gain	1.0000
10:97864266:GGTTG:G	donor_gain	1.0000
10:97864267:G:T	donor_gain	1.0000
10:97850312:CGAGG:C	donor_loss	0.9900
10:97850314:AGGTA:A	donor_loss	0.9900
10:97850315:GGT:G	donor_loss	0.9900
10:97850316:G:T	donor_loss	0.9900
10:97850317:T:G	donor_loss	0.9900
10:97859579:GCCGG:G	donor_gain	0.9900
10:97863929:GA:G	acceptor_gain	0.9900
10:97863929:GAT:G	acceptor_gain	0.9900
10:97864064:G:GT	donor_gain	0.9900
10:97864078:AGAAG:A	donor_loss	0.9900
10:97864079:GAAGG:G	donor_loss	0.9900
10:97864080:AAGG:A	donor_loss	0.9900
10:97864081:AG:A	donor_loss	0.9900
10:97864082:GGTGG:G	donor_loss	0.9900
10:97864083:GT:G	donor_loss	0.9900
10:97864084:T:A	donor_loss	0.9900
10:97864162:TTGCA:T	acceptor_loss	0.9900
10:97864163:TGCA:T	acceptor_loss	0.9900

AlphaMissense

1101 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
10:97859509:T:C	F22L	1.000
10:97859511:T:A	F22L	1.000
10:97859511:T:G	F22L	1.000
10:97859519:G:C	R25T	1.000
10:97859519:G:T	R25I	1.000
10:97859520:A:C	R25S	1.000
10:97859520:A:T	R25S	1.000
10:97859548:T:C	F35L	1.000
10:97859549:T:C	F35S	1.000
10:97859550:C:A	F35L	1.000
10:97859550:C:G	F35L	1.000
10:97864232:T:C	L119P	1.000
10:97864247:C:A	P124H	1.000
10:97864258:G:A	G128R	1.000
10:97864258:G:C	G128R	1.000
10:97864258:G:T	G128W	1.000
10:97864259:G:A	G128E	1.000
10:97859548:T:G	F35V	0.999
10:97859549:T:G	F35C	0.999
10:97859573:T:A	L43Q	0.999
10:97859573:T:C	L43P	0.999
10:97863967:T:A	L59H	0.999
10:97863967:T:C	L59P	0.999
10:97863971:C:A	N60K	0.999
10:97863971:C:G	N60K	0.999
10:97863987:G:C	A66P	0.999
10:97863988:C:A	A66D	0.999
10:97864020:G:C	G77R	0.999
10:97864023:T:C	C78R	0.999
10:97864030:C:A	A80D	0.999

dbSNP variants (sampled 300 via entrez): RS1000140194 (10:97864514 G>A), RS1000178042 (10:97868070 G>A), RS1000214410 (10:97851853 C>A,T), RS1000267667 (10:97859161 C>A,T), RS1000313707 (10:97871227 T>C,G), RS1000671278 (10:97860541 C>T), RS1000787039 (10:97851952 G>A,T), RS1000986988 (10:97866045 AG>A,AGG), RS1001103114 (10:97865809 C>A), RS1001166245 (10:97849438 C>A,T), RS1001218730 (10:97849808 G>A,C), RS1001242352 (10:97850988 T>G), RS1001339142 (10:97856842 A>C), RS1001376502 (10:97858988 T>C), RS1001392314 (10:97864529 G>A)

Disease associations

OMIM: gene MIM:614189 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST002497_25	Blood pressure	3.000000e-07

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0005763	pulse pressure measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

20 total (human), top 20 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
propionaldehyde	increases expression	1
bisphenol A	increases expression	1
sodium arsenite	decreases expression	1
butyraldehyde	increases expression	1
S-(1,2-dichlorovinyl)cysteine	affects cotreatment, decreases expression	1
pentanal	increases expression	1
di-n-butylphosphoric acid	affects expression	1
abrine	increases expression	1
jinfukang	increases expression	1
(+)-JQ1 compound	decreases expression	1
Aldehydes	increases expression	1
Benzo(a)pyrene	decreases methylation	1
Dichlorodiphenyl Dichloroethylene	decreases expression	1
Lead	affects expression	1
Lipopolysaccharides	affects cotreatment, decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Triclosan	increases expression	1
Valproic Acid	decreases methylation	1
Cadmium Chloride	increases expression	1
Okadaic Acid	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.