GOLGA8B

Summary

GOLGA8B (golgin A8 family member B, HGNC:31973) is a protein-coding gene on chromosome 15q14, encoding Golgin subfamily A member 8B (A8MQT2). May be involved in maintaining Golgi structure.

Predicted to be involved in Golgi organization. Located in Golgi apparatus and cytosol.

Source: NCBI Gene 440270 — RefSeq curated summary.

At a glance

• GWAS associations: 10
• Clinical variants (ClinVar): 34 total
• MANE Select transcript: NM_001023567

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31973
Approved symbol	GOLGA8B
Name	golgin A8 family member B
Location	15q14
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000215252
Ensembl biotype	protein_coding
OMIM	609619
Entrez	440270

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 8 protein_coding, 5 protein_coding_CDS_not_defined, 3 retained_intron

ENST00000342314, ENST00000438958, ENST00000484716, ENST00000562282, ENST00000564575, ENST00000566091, ENST00000566258, ENST00000568555, ENST00000569100, ENST00000569811, ENST00000683415, ENST00000913074, ENST00000913075, ENST00000913076, ENST00000913077, ENST00000967095

RefSeq mRNA: 1 — MANE Select: NM_001023567 NM_001023567

CCDS: CCDS45211

Canonical transcript exons

ENST00000683415 — 24 exons

Exon	Start	End
ENSE00001755662	34532846	34532962
ENSE00001782173	34534054	34534173
ENSE00002585397	34583516	34583651
ENSE00003473026	34529662	34529749
ENSE00003479645	34531648	34531695
ENSE00003487405	34531961	34531999
ENSE00003487620	34531475	34531559
ENSE00003488980	34531269	34531378
ENSE00003490347	34529967	34530074
ENSE00003498995	34545378	34545426
ENSE00003533161	34546935	34546982
ENSE00003534679	34528607	34528750
ENSE00003576794	34527922	34528077
ENSE00003581023	34552895	34553091
ENSE00003584820	34530182	34530268
ENSE00003585819	34537344	34537647
ENSE00003587616	34528372	34528472
ENSE00003589016	34544858	34544953
ENSE00003603959	34528189	34528289
ENSE00003614374	34551138	34551276
ENSE00003662264	34529018	34529274
ENSE00003690685	34553745	34553956
ENSE00003919634	34535865	34535989
ENSE00003920861	34525095	34527834

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 99.36.

FANTOM5 (CAGE): breadth broad, TPM avg 2.4310 / max 172.9098, expressed in 894 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
149260	29.7103	1709
149262	2.4310	894
149261	0.7854	466
149259	0.6417	377

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
body of pancreas	UBERON:0001150	99.36	gold quality
left lobe of thyroid gland	UBERON:0001120	99.07	gold quality
right lobe of thyroid gland	UBERON:0001119	99.06	gold quality
thyroid gland	UBERON:0002046	98.99	gold quality
right uterine tube	UBERON:0001302	98.84	gold quality
right hemisphere of cerebellum	UBERON:0014890	98.40	gold quality
cerebellar cortex	UBERON:0002129	98.30	gold quality
cerebellar hemisphere	UBERON:0002245	98.29	gold quality
cerebellum	UBERON:0002037	98.21	gold quality
right ovary	UBERON:0002118	97.88	gold quality
left ovary	UBERON:0002119	97.88	gold quality
pituitary gland	UBERON:0000007	97.79	gold quality
metanephros cortex	UBERON:0010533	97.69	gold quality
adenohypophysis	UBERON:0002196	97.34	gold quality
ovary	UBERON:0000992	97.10	gold quality
sural nerve	UBERON:0015488	97.10	gold quality
right testis	UBERON:0004534	96.66	gold quality
left testis	UBERON:0004533	96.55	gold quality
superior frontal gyrus	UBERON:0002661	96.43	gold quality
body of uterus	UBERON:0009853	96.40	gold quality
cortex of kidney	UBERON:0001225	96.39	gold quality
right lung	UBERON:0002167	96.39	gold quality
fundus of stomach	UBERON:0001160	96.35	gold quality
left uterine tube	UBERON:0001303	96.34	gold quality
endometrium	UBERON:0001295	96.32	gold quality
prostate gland	UBERON:0002367	96.20	gold quality
body of stomach	UBERON:0001161	96.11	gold quality
right frontal lobe	UBERON:0002810	95.99	gold quality
lower esophagus muscularis layer	UBERON:0035833	95.85	gold quality
descending thoracic aorta	UBERON:0002345	95.81	gold quality

Single-cell (SCXA)

Detected in 6 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-MTAB-8410	yes	22.50
E-ANND-3	yes	14.87
E-HCAD-1	yes	10.95
E-GEOD-137537	yes	6.55
E-MTAB-11268	no	557.41
E-CURD-112	no	3.41

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

93 targeting GOLGA8B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-485-3P	99.98	70.68	1585
HSA-MIR-539-3P	99.98	70.74	1616
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-32-5P	99.98	75.21	1964
HSA-MIR-92A-3P	99.98	75.21	1960
HSA-MIR-92B-3P	99.98	75.25	1955
HSA-MIR-25-3P	99.98	74.60	1817
HSA-MIR-363-3P	99.98	74.72	1821
HSA-MIR-367-3P	99.98	74.83	1819
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-144-3P	99.94	73.98	2698
HSA-MIR-3143	99.93	71.96	3104
HSA-MIR-4760-3P	99.93	70.50	2385

Literature-anchored findings (GeneRIF, showing 1)

• Silencing GOLGA8B inhibits cell invasion and metastasis by suppressing STAT3 signaling pathway in lung squamous cell carcinoma. (PMID:35593117)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	golga2	ENSDARG00000063197
mus_musculus	Golga2	ENSMUSG00000002546
rattus_norvegicus	Golga2l1	ENSRNOG00000050262
drosophila_melanogaster	GM130	FBGN0034697
caenorhabditis_elegans		WBGENE00018017

Paralogs (18): GOLGA6D (ENSG00000140478), GOLGA8F (ENSG00000153684), GOLGA6A (ENSG00000159289), GOLGA2 (ENSG00000167110), GOLGA6C (ENSG00000167195), GOLGA8A (ENSG00000175265), GOLGA8Q (ENSG00000178115), GOLGA8J (ENSG00000179938), GOLGA8G (ENSG00000183629), GOLGA8R (ENSG00000186399), GOLGA8M (ENSG00000188626), GOLGA8O (ENSG00000206127), GOLGA6B (ENSG00000215186), GOLGA8N (ENSG00000232653), GOLGA8K (ENSG00000249931), GOLGA8T (ENSG00000261247), GOLGA8S (ENSG00000261739), GOLGA8H (ENSG00000261794)

Protein

Protein identifiers

Golgin subfamily A member 8B — A8MQT2 (reviewed: A8MQT2)

Alternative names: Golgin-67

All UniProt accessions (2): A8MQT2, C9J1B5

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in maintaining Golgi structure.

Subcellular location. Golgi apparatus. Golgi stack membrane.

Tissue specificity. Highly expressed in brain, heart and kidney. Detected at lower levels in liver, thymus, spleen, lung and peripheral blood leukocytes.

Domain organisation. Extended rod-like protein with coiled-coil domains.

Miscellaneous. Antibodies against GM88 are present in serum from a patient with Sjoegren syndrome. Sera from patients with Sjoegren syndrome often contain antibodies that react with normal components of the Golgi complex.

Similarity. Belongs to the GOLGA8 family.

Isoforms (2)

UniProt ID	Names	Canonical?
A8MQT2-1	1	yes
A8MQT2-2	2

RefSeq proteins (1): NP_001018861* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR024858	GOLGA	Family
IPR043937	GOLGA_C	Conserved_site
IPR043976	GOLGA_cons_dom	Domain

Pfam: PF15070, PF19046

UniProt features (25 total): sequence conflict 12, region of interest 5, compositionally biased region 4, coiled-coil region 2, chain 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A8MQT2-F1	70.37	0.28

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 85 (showing top): chr15q14, GOBP_ENDOMEMBRANE_SYSTEM_ORGANIZATION, AACTGGA_MIR145, GOBP_GOLGI_ORGANIZATION, GOCC_GOLGI_STACK, GOCC_GOLGI_CISTERNA, GOCC_CIS_GOLGI_NETWORK, GOCC_GOLGI_CISTERNA_MEMBRANE, GOCC_ORGANELLE_SUBCOMPARTMENT, CAGTATT_MIR200B_MIR200C_MIR429, WHITFIELD_CELL_CYCLE_S, LU_EZH2_TARGETS_DN, GOCC_GOLGI_CIS_CISTERNA, JAK2_DN.V1_DN, BANP_TARGET_GENES

GO Biological Process (1): Golgi organization (GO:0007030)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (6): Golgi cis cisterna (GO:0000137), Golgi apparatus (GO:0005794), cis-Golgi network (GO:0005801), cytosol (GO:0005829), Golgi cisterna membrane (GO:0032580), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
Golgi cisterna	2
cytoplasm	2
intracellular membrane-bounded organelle	2
cellular anatomical structure	2
organelle organization	1
endomembrane system organization	1
binding	1
endomembrane system	1
Golgi apparatus	1
organelle membrane	1

Protein interactions and networks

STRING

392 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
GOLGA8B	GOLGA3	Q08378	666
GOLGA8B	KRTAP4-5	Q9BYR2	603
GOLGA8B	GOLGA1	Q92805	595
GOLGA8B	GOLGB1	Q14789	572
GOLGA8B	GOLGA4	Q13439	557
GOLGA8B	RIMBP3	Q9UFD9	448
GOLGA8B	GOLGA5	Q8TBA6	423
GOLGA8B	TMPRSS13	Q9BYE2	420
GOLGA8B	GJD2	Q9UKL4	400
GOLGA8B	FAM156A	Q8NDB6	358
GOLGA8B	GOLGA2	Q08379	353
GOLGA8B	USO1	O60763	341
GOLGA8B	LDLRAD2	Q5SZI1	322
GOLGA8B	TMEM273	Q5T292	314
GOLGA8B	I3L0A0	I3L0A0	311

IntAct

2 interactions, top by confidence:

A	B	Type	Score
FMR1	GOLGA8B	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (5): GOLGA8B (Proximity Label-MS), GOLGA8B (Affinity Capture-MS), GOLGA8B (Affinity Capture-MS), HIST1H1E (Cross-Linking-MS (XL-MS)), GOLGA8B (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: A2AM05, A6NC78, A6NCC3, A6NDK9, A6NDN3, A6NJZ7, A6NMD2, A6NN73, A6NNM3, A7E2F4, A8MQT2, D6RF30, F8WBI6, H3BPF8, H3BQL2, H3BSY2, H3BV12, I6L899, P0CG33, P0CJ92, P0DO97, P0DX52, P0DX53, P54257, Q0D2H9, Q0KK56, Q2M243, Q3T1I3, Q3TCJ8, Q3V0F0, Q5BK57, Q5XHZ2, Q6AW69, Q6AXN6, Q6PHN1, Q7TME2, Q8BG89, Q8BGY3, Q8C0G2, Q8K389

Diamond homologs: A0A1B0GV03, A1IH00, A6NC78, A6NCC3, A6NDK9, A6NDN3, A6NEF3, A6NEM1, A6NI86, A6NN73, A7E2F4, A8MQT2, A8MZA4, F8WBI6, H0YKK7, H0YM25, H3BPF8, H3BSY2, H3BV12, I6L899, P0CG33, P0CJ92, P0DX00, P0DX01, P0DX02, P0DX52, P0DX53, Q08379, Q62839, Q8N7Z2, Q8N9W4, Q921M4, Q9NYA3, A6NMD2, D6RF30, H3BQL2, Q0D2H9, Q9HBQ8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

34 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	26
Likely benign	3
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

2227 predictions. Top by Δscore:

Variant	Effect	Δscore
15:34527830:AAGAT:A	acceptor_gain	1.0000
15:34527831:AGAT:A	acceptor_gain	1.0000
15:34527832:GAT:G	acceptor_gain	1.0000
15:34527835:C:CA	acceptor_loss	1.0000
15:34527835:C:CC	acceptor_gain	1.0000
15:34527836:T:C	acceptor_gain	1.0000
15:34527837:T:C	acceptor_gain	1.0000
15:34527837:T:TC	acceptor_gain	1.0000
15:34527918:TCA:T	donor_loss	1.0000
15:34527920:A:AC	donor_gain	1.0000
15:34527920:AC:A	donor_gain	1.0000
15:34527920:ACCAC:A	donor_gain	1.0000
15:34527921:C:CC	donor_gain	1.0000
15:34527921:CC:C	donor_gain	1.0000
15:34527921:CCA:C	donor_gain	1.0000
15:34527921:CCACC:C	donor_gain	1.0000
15:34528073:TTCAC:T	acceptor_gain	1.0000
15:34528074:TCAC:T	acceptor_gain	1.0000
15:34528075:CAC:C	acceptor_gain	1.0000
15:34528075:CACC:C	acceptor_gain	1.0000
15:34528076:AC:A	acceptor_gain	1.0000
15:34528077:CC:C	acceptor_gain	1.0000
15:34528078:C:CC	acceptor_gain	1.0000
15:34528078:C:T	acceptor_gain	1.0000
15:34528184:CCTAC:C	donor_loss	1.0000
15:34528187:A:AC	donor_gain	1.0000
15:34528187:A:T	donor_loss	1.0000
15:34528187:ACCTT:A	donor_gain	1.0000
15:34528188:C:CA	donor_loss	1.0000
15:34528188:C:CC	donor_gain	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000021874 (15:34557116 C>T), RS1000048982 (15:34580126 C>A,G,T), RS1000079509 (15:34527281 C>T), RS1000368100 (15:34583551 G>A), RS1000369302 (15:34570094 A>T), RS1000554823 (15:34583697 C>G,T), RS1000601849 (15:34527549 A>G), RS1000648037 (15:34579070 A>ATGTG), RS1000778443 (15:34574280 A>G), RS1001018621 (15:34579186 G>C), RS1001021431 (15:34552403 T>C), RS1001023917 (15:34553222 C>A), RS1001364444 (15:34568224 G>A), RS1001487691 (15:34525837 T>C,G), RS1001538235 (15:34554402 A>G)

Disease associations

OMIM: gene MIM:609619 | disease phenotypes:

GenCC curated gene-disease

Mondo (1): primary ovarian failure (MONDO:0005387)

Orphanet (1): NON RARE IN EUROPE: Primary ovarian failure (Orphanet:619)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

10 associations (top):

Study	Trait	p-value
GCST000795_1	Refractive error	2.000000e-14
GCST003830_19	Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1)	2.000000e-08
GCST003830_3	Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1)	8.000000e-08
GCST003997_51	Myopia	4.000000e-62
GCST006291_128	Spherical equivalent or myopia (age of diagnosis)	2.000000e-65
GCST009517_3	Cerebrospinal fluid neurofilament light levels	3.000000e-07
GCST009962_4	High myopia	1.000000e-24
GCST010002_165	Refractive error	2.000000e-245
GCST012400_130	Low myopia vs hyperopia	1.000000e-29
GCST012403_14	High myopia	5.000000e-26

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0005921	FEV change measurement
EFO:0004847	age at onset

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
D016649	Primary Ovarian Insufficiency	C12.050.351.500.056.630.750; C12.100.250.056.630.750; C19.391.630.750

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

32 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases expression, decreases expression, affects cotreatment, increases abundance	4
methacrylaldehyde	affects cotreatment, increases expression, increases abundance	2
Acrolein	affects cotreatment, increases expression, increases abundance	2
Air Pollutants	affects cotreatment, increases abundance, increases expression	2
Arsenic	increases expression, decreases expression, affects cotreatment, increases abundance	2
Ozone	affects cotreatment, increases expression, increases abundance	2
Tobacco Smoke Pollution	affects expression, decreases expression	2
alpha-pinene	increases expression, increases abundance, affects cotreatment	1
trichostatin A	increases expression	1
tris(2-butoxyethyl) phosphate	affects expression	1
nickel sulfate	decreases expression	1
K 7174	increases expression	1
jinfukang	decreases expression	1
NSC 689534	affects binding, increases expression	1
mono-isobutyl phthalate	affects expression	1
Resveratrol	affects cotreatment, increases expression	1
Temozolomide	affects response to substance	1
Benzo(a)pyrene	affects methylation	1
Carmustine	affects response to substance	1
Cisplatin	affects response to substance	1
Copper	affects binding, increases expression	1
DDT	increases expression	1
Doxorubicin	increases expression	1
Hydrogen Peroxide	affects expression	1
Plant Extracts	affects cotreatment, increases expression	1
Valproic Acid	increases expression	1
Vincristine	decreases expression	1
Cyclosporine	increases methylation	1
Aflatoxin B1	increases methylation	1
Acrylamide	decreases expression	1

Clinical trials (associated diseases)

75 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT00417066	PHASE4	COMPLETED	Flexible GnRH Antagonist vs Flare up GnRH Agonist Protocol in Poor Responders
NCT00732693	PHASE4	COMPLETED	Evaluation of Physiologic and Standard Sex Steroid Replacement Regimens in Women With Premature Ovarian Failure
NCT00837616	PHASE4	COMPLETED	Estrogen Dosing in Turner Syndrome: Pharmacology and Metabolism
NCT01853501	PHASE4	UNKNOWN	Effects of ADSC Therapy in Women With POF
NCT02783937	PHASE4	COMPLETED	Filgrastim for Premature Ovarian Insufficiency
NCT03535480	PHASE4	UNKNOWN	Autologous Bone Marrow Stem Cell Ovarian Transplantation to Restore Ovarian Function in Premature Ovarian Failure
NCT00140998	PHASE3	COMPLETED	Estrogen Treatment (Oral vs. Patches) in Turner Syndrome
NCT00001951	PHASE2	COMPLETED	Hormone Replacement in Young Women With Premature Ovarian Failure
NCT00370019	PHASE2	WITHDRAWN	Effects of an Estrogen Replacement Therapy Skin Patch on Ovulation in Women With Premature Ovarian Failure
NCT00429494	PHASE2	COMPLETED	GnRH Analogue for Ovarian Function Preservation in Hematopoietic Stem Cell Transplantation Patients
NCT03816852	PHASE2	SUSPENDED	The Safety and Efficiency Study of Mesenchymal Stem Cell (19#iSCLife®-POI) in Premature Ovarian Insufficiency
NCT04536467	PHASE2	UNKNOWN	Prevention of Chemotherapy-Induced Ovarian Failure With Goserelin in Premenopausal Lymphoma Patients
NCT06117982	PHASE2	COMPLETED	The Impact of Granulocyte Colony Stimulating Factor on Premature Ovarian Insufficiency
NCT02912104	PHASE1	COMPLETED	A Therapeutic Trial of Human Amniotic Epithelial Cells Transplantation for Primary Ovarian Failure
NCT03178695	PHASE1	COMPLETED	Inovium Ovarian Rejuvenation Trials
NCT04815213	PHASE1	ACTIVE_NOT_RECRUITING	The Use of Expandeded Mesenchymal Stromal Cells (MSC) in Premature Ovarian Failure (POF) in Adult Humans
NCT05138367	PHASE1	COMPLETED	Effects of UCA-PSCs in Women With POF
NCT06132542	PHASE1	UNKNOWN	Autologous ADMSC Transplantation in Patients With POI
NCT00948857	PHASE2/PHASE3	TERMINATED	Dehydroepiandrosterone (DHEA) Treatment and Premature Ovarian Failure (POF)
NCT04031456	PHASE2/PHASE3	RECRUITING	Autologous PRP Infusion May Restore Ovarian Function and May Promote Folliculogenesis in POI Patients
NCT02043743	PHASE1/PHASE2	UNKNOWN	Autologous Stem Cells Transplantation in Patients With Idiopathic and Drug Induced Premature Ovarian Failure
NCT02062931	PHASE1/PHASE2	UNKNOWN	Autologous Mesenchymal Stem Cells Transplantation In Women With Premature Ovarian Failure
NCT02151890	PHASE1/PHASE2	COMPLETED	Pregnancy After Stem Cell Transplantation in Premature Ovarian Failure
NCT02372474	PHASE1/PHASE2	COMPLETED	It is a Real The First Baby Of Autologous Stem Cell Therapy in Premature Ovarian Failure
NCT02603744	PHASE1/PHASE2	UNKNOWN	Autologous Adipose Derived Mesenchymal Stromal Cells Transplantation in Women With Premature Ovarian Failure (POF)
NCT02644447	PHASE1/PHASE2	COMPLETED	Transplantation of HUC-MSCs With Injectable Collagen Scaffold for POF
NCT03069209	PHASE1/PHASE2	UNKNOWN	Autologous Bone Marrow-Derived Stem Cell Transplantation in Patients With Premature Ovarian Failure (POF)
NCT03985462	PHASE1/PHASE2	WITHDRAWN	Very Small Embryonic-like Stem Cells for Ovary
NCT04009473	PHASE1/PHASE2	UNKNOWN	Stem Cell Therapy and Growth Factor Ovarian in Vitro Activation
NCT04071574	PHASE1/PHASE2	COMPLETED	Comparative Study on the Efficacy of Ovarian Stimulation Protocols on the Success Rate of ICSI in Female Infertility
NCT04922398	PHASE1/PHASE2	UNKNOWN	Ovarian Injection of PRP (Platelet -Rich Plasma) Vs Normal Saline in Premature Ovarian Insufficiency
NCT05462379	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING	Autologous Heterotopic Fresh Ovarian Graft in Woman With LACC Eligible for Pelvic Radiotherapy Treatment.
NCT06202547	PHASE1/PHASE2	UNKNOWN	Intra-ovarian Injection of MSC-EVs in Idiopathic Premature Ovarian Failure
NCT01129947	EARLY_PHASE1	WITHDRAWN	The Use of DHEA in Women With Premature Ovarian Failure
NCT05522634	EARLY_PHASE1	UNKNOWN	A Clinical Study of Chinese Herbal Compound TJAOA101 in the Treatment of Premature Ovarian Insufficiency
NCT07308327	EARLY_PHASE1	ACTIVE_NOT_RECRUITING	The Influence of Gut Microbiota on Ovarian Function: A Single-center, Randomized,Double Blind, Parallel-controlled, Exploratory Clinical Trial
NCT00001275	Not specified	COMPLETED	Ovarian Follicle Function in Patients With Primary Ovarian Failure
NCT00001306	Not specified	COMPLETED	Steroid Therapy in Autoimmune Premature Ovarian Failure
NCT00006156	Not specified	COMPLETED	Feasibility Study for Development of an Early Test for Ovarian Failure
NCT00119925	Not specified	UNKNOWN	‘SPRING’-Study: Subfertility Guidelines: Patient Related Implementation in the Netherlands Among Gynaecologists