GOLGA8G

Summary

GOLGA8G (golgin A8 family member G, HGNC:25328) is a protein-coding gene on chromosome 15q13.1, encoding Golgin subfamily A member 8G (P0DX53).

Predicted to be involved in Golgi organization. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi cis cisterna; Golgi cisterna membrane; and cis-Golgi network.

Source: NCBI Gene 283768 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 1 total
• MANE Select transcript: NM_001350919

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25328
Approved symbol	GOLGA8G
Name	golgin A8 family member G
Location	15q13.1
Locus type	gene with protein product
Status	Approved
Aliases	DKFZp434K052
Ensembl gene	ENSG00000183629
Ensembl biotype	protein_coding
Entrez	283768

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 7 retained_intron, 1 protein_coding

ENST00000382949, ENST00000524859, ENST00000525590, ENST00000561497, ENST00000562627, ENST00000568534, ENST00000569308, ENST00000570018

RefSeq mRNA: 3 — MANE Select: NM_001350919 NM_001350919, NM_001368078, NM_001368080

CCDS: CCDS86439

Canonical transcript exons

ENST00000525590 — 19 exons

Exon	Start	End
ENSE00001655749	28528886	28528933
ENSE00001730921	28529207	28529245
ENSE00002603788	28519611	28522757
ENSE00003458494	28526902	28526989
ENSE00003476031	28522843	28522995
ENSE00003508519	28530100	28530180
ENSE00003528127	28523085	28523185
ENSE00003537410	28527185	28527292
ENSE00003545668	28528508	28528617
ENSE00003547131	28526255	28526511
ENSE00003581121	28532826	28532971
ENSE00003587272	28523943	28524034
ENSE00003594757	28523268	28523368
ENSE00003598116	28530364	28530423
ENSE00003636710	28531009	28531128
ENSE00003665792	28525919	28525987
ENSE00003670326	28524472	28524547
ENSE00003680072	28527399	28527488
ENSE00003685356	28528713	28528797

Expression profiles

Bgee: expression breadth broad, 81 present calls, max score 87.60.

Top tissues by expression

108 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right testis	UBERON:0004534	87.60	gold quality
left testis	UBERON:0004533	87.43	gold quality
testis	UBERON:0000473	86.39	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.40	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	74.98	gold quality
stromal cell of endometrium	CL:0002255	58.52	gold quality
putamen	UBERON:0001874	53.97	gold quality
cortical plate	UBERON:0005343	50.35	gold quality
hindlimb stylopod muscle	UBERON:0004252	48.54	gold quality
caudate nucleus	UBERON:0001873	45.72	gold quality
sural nerve	UBERON:0015488	44.97	gold quality
cortex of kidney	UBERON:0001225	44.69	gold quality
prefrontal cortex	UBERON:0000451	44.13	silver quality
liver	UBERON:0002107	43.37	silver quality
right coronary artery	UBERON:0001625	43.27	silver quality
urinary bladder	UBERON:0001255	43.25	gold quality
right lobe of liver	UBERON:0001114	43.11	silver quality
left lobe of thyroid gland	UBERON:0001120	42.34	silver quality
vermiform appendix	UBERON:0001154	42.33	gold quality
right lobe of thyroid gland	UBERON:0001119	42.18	gold quality
ectocervix	UBERON:0012249	41.77	gold quality
thyroid gland	UBERON:0002046	41.66	silver quality
right atrium auricular region	UBERON:0006631	41.57	gold quality
body of pancreas	UBERON:0001150	41.52	silver quality
right adrenal gland cortex	UBERON:0035827	41.36	gold quality
nucleus accumbens	UBERON:0001882	41.05	gold quality
duodenum	UBERON:0002114	40.87	gold quality
frontal cortex	UBERON:0001870	40.37	silver quality
muscle of leg	UBERON:0001383	40.36	gold quality
primary visual cortex	UBERON:0002436	40.36	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	golga2	ENSDARG00000063197
mus_musculus	Golga2	ENSMUSG00000002546
rattus_norvegicus	Golga2l1	ENSRNOG00000050262
drosophila_melanogaster	GM130	FBGN0034697
caenorhabditis_elegans		WBGENE00018017

Paralogs (18): GOLGA6D (ENSG00000140478), GOLGA8F (ENSG00000153684), GOLGA6A (ENSG00000159289), GOLGA2 (ENSG00000167110), GOLGA6C (ENSG00000167195), GOLGA8A (ENSG00000175265), GOLGA8Q (ENSG00000178115), GOLGA8J (ENSG00000179938), GOLGA8R (ENSG00000186399), GOLGA8M (ENSG00000188626), GOLGA8O (ENSG00000206127), GOLGA6B (ENSG00000215186), GOLGA8B (ENSG00000215252), GOLGA8N (ENSG00000232653), GOLGA8K (ENSG00000249931), GOLGA8T (ENSG00000261247), GOLGA8S (ENSG00000261739), GOLGA8H (ENSG00000261794)

Protein

Protein identifiers

Golgin subfamily A member 8G — P0DX53 (reviewed: P0DX53)

All UniProt accessions (2): P0DX53, A0A0G2JP48

UniProt curated annotations — full annotation on UniProt →

Miscellaneous. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Similarity. Belongs to the GOLGA8 family.

Isoforms (3)

UniProt ID	Names	Canonical?
P0DX53-1	1	yes
P0DX53-4	4
P0DX53-5	5

RefSeq proteins (3): NP_001337848, NP_001355007, NP_001355009 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR024858	GOLGA	Family
IPR043937	GOLGA_C	Conserved_site
IPR043976	GOLGA_cons_dom	Domain

Pfam: PF15070, PF19046

UniProt features (20 total): region of interest 6, compositionally biased region 5, splice variant 4, coiled-coil region 3, chain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0DX53-F1	69.25	0.39

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 16 (showing top): chr15q13, NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN, AACTGGA_MIR145, GOCC_CIS_GOLGI_NETWORK, KIM_WT1_TARGETS_DN, WILCOX_RESPONSE_TO_PROGESTERONE_UP, CAGTATT_MIR200B_MIR200C_MIR429, CTACTGT_MIR199A, MEBARKI_HCC_PROGENITOR_WNT_UP, MEBARKI_HCC_PROGENITOR_WNT_UP_CTNNB1_DEPENDENT, MEBARKI_HCC_PROGENITOR_WNT_UP_BLOCKED_BY_FZD8CRD, MEBARKI_HCC_PROGENITOR_WNT_UP_CTNNB1_DEPENDENT_BLOCKED_BY_FZD8CRD, TTGCCAA_MIR182, GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367, TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (2): cis-Golgi network (GO:0005801), Golgi apparatus (GO:0005794)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
intracellular membrane-bounded organelle	2
binding	1
Golgi apparatus	1
cytoplasm	1
endomembrane system	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

2 interactions, top by confidence:

A	B	Type	Score
GOLGA8G	GOLGA8J	psi-mi:“MI:0914”(association)	0.350

ESM2 similar proteins: A2AHC3, A2AMT1, A6NCC3, A6NN73, D3Z8E6, D6RF30, E7F5E1, H3BPF8, H3BQL2, H3BSY2, O15061, O35668, P0DX52, P0DX53, P53814, P54256, P54257, P62025, P97434, Q02435, Q06002, Q06637, Q0D2H9, Q0VF96, Q12934, Q3UHU5, Q3V0F0, Q5DU05, Q5T5Y3, Q5TF21, Q60664, Q62627, Q63312, Q6AW69, Q6NZL0, Q6PHN1, Q6WCQ1, Q70IV5, Q80VC9, Q80Y56

Diamond homologs: A0A1B0GV03, A1IH00, A6NC78, A6NCC3, A6NDK9, A6NDN3, A6NEF3, A6NEM1, A6NI86, A6NN73, A7E2F4, A8MQT2, A8MZA4, F8WBI6, H0YKK7, H0YM25, H3BPF8, H3BSY2, H3BV12, I6L899, P0CG33, P0CJ92, P0DX00, P0DX01, P0DX02, P0DX52, P0DX53, Q08379, Q62839, Q8N7Z2, Q8N9W4, Q921M4, Q9NYA3, A6NMD2, D6RF30, H3BQL2, Q0D2H9, Q9HBQ8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

1 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2593 predictions. Top by Δscore:

Variant	Effect	Δscore
15:28522840:CACCA:C	donor_loss	1.0000
15:28522841:A:AC	donor_gain	1.0000
15:28522841:A:T	donor_loss	1.0000
15:28522841:ACCAC:A	donor_gain	1.0000
15:28522842:C:CC	donor_gain	1.0000
15:28522842:CCA:C	donor_gain	1.0000
15:28522842:CCACC:C	donor_gain	1.0000
15:28522991:TTCAC:T	acceptor_gain	1.0000
15:28522992:TCAC:T	acceptor_gain	1.0000
15:28522993:CAC:C	acceptor_gain	1.0000
15:28522993:CACC:C	acceptor_gain	1.0000
15:28522994:AC:A	acceptor_gain	1.0000
15:28522995:CC:C	acceptor_gain	1.0000
15:28522995:CCTG:C	acceptor_loss	1.0000
15:28522996:C:CA	acceptor_loss	1.0000
15:28522996:C:CC	acceptor_gain	1.0000
15:28523080:TCTA:T	donor_loss	1.0000
15:28523081:CTAC:C	donor_loss	1.0000
15:28523082:TACCT:T	donor_loss	1.0000
15:28523083:ACCT:A	donor_loss	1.0000
15:28523096:C:CA	donor_gain	1.0000
15:28523181:CTTTC:C	acceptor_gain	1.0000
15:28523263:CTCA:C	donor_gain	1.0000
15:28523266:A:AC	donor_gain	1.0000
15:28523267:C:CA	donor_gain	1.0000
15:28523267:CTG:C	donor_gain	1.0000
15:28523267:CTGA:C	donor_gain	1.0000
15:28523267:CTGAT:C	donor_gain	1.0000
15:28523290:A:AC	donor_gain	1.0000
15:28523291:C:CC	donor_gain	1.0000

AlphaMissense

4259 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000122938 (15:28533729 C>T), RS1000237674 (15:28532845 A>G), RS1001337827 (15:28531952 A>G), RS1001450788 (15:28531321 A>G), RS1003122738 (15:28519153 G>A), RS1003417812 (15:28520091 G>A), RS1006029503 (15:28526156 C>G,T), RS1007147800 (15:28523622 C>T), RS1007263787 (15:28520374 A>G), RS1009259774 (15:28520230 T>C), RS1010150317 (15:28533438 G>A), RS1010210943 (15:28531519 T>A), RS1010679738 (15:28532073 G>C), RS1012237377 (15:28522241 C>T), RS1016091987 (15:28531302 GA>G,GAA)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST009391_1967	Metabolite levels	1.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0010541	trimethylamine-N-oxide measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Progesterone	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.