GOLGA8H

Summary

GOLGA8H (golgin A8 family member H, HGNC:37443) is a protein-coding gene on chromosome 15q13.2, encoding Golgin subfamily A member 8H (P0CJ92).

Predicted to be involved in Golgi organization. Predicted to be located in Golgi apparatus and membrane. Predicted to be active in Golgi cis cisterna; Golgi cisterna membrane; and cis-Golgi network.

Source: NCBI Gene 728498 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001282490

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37443
Approved symbol	GOLGA8H
Name	golgin A8 family member H
Location	15q13.2
Locus type	gene with protein product
Status	Approved
Aliases	GOLGA6L11
Ensembl gene	ENSG00000261794
Ensembl biotype	protein_coding
Entrez	728498

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000566740

RefSeq mRNA: 1 — MANE Select: NM_001282490 NM_001282490

CCDS: CCDS61576

Canonical transcript exons

ENST00000566740 — 19 exons

Exon	Start	End
ENSE00002584367	30613953	30614050
ENSE00002585401	30611278	30611346
ENSE00002587177	30613770	30613870
ENSE00002591224	30604028	30604173
ENSE00002592731	30609999	30610106
ENSE00002594190	30610302	30610389
ENSE00002597092	30612597	30612672
ENSE00002597761	30608467	30608551
ENSE00002603226	30610766	30611022
ENSE00002603308	30614386	30617752
ENSE00002604245	30609806	30609892
ENSE00002605932	30614146	30614301
ENSE00002606355	30608647	30608756
ENSE00002612480	30608331	30608378
ENSE00002615106	30606855	30606914
ENSE00002617841	30608030	30608068
ENSE00002619092	30607096	30607176
ENSE00002625603	30613104	30613195
ENSE00002628047	30605843	30605962

Expression profiles

Bgee: expression breadth ubiquitous, 123 present calls, max score 74.63.

Top tissues by expression

128 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	74.63	gold quality
calcaneal tendon	UBERON:0003701	71.12	gold quality
right testis	UBERON:0004534	69.33	gold quality
descending thoracic aorta	UBERON:0002345	68.83	gold quality
testis	UBERON:0000473	68.28	gold quality
left testis	UBERON:0004533	68.14	gold quality
thoracic aorta	UBERON:0001515	66.62	gold quality
ascending aorta	UBERON:0001496	66.34	gold quality
right lobe of thyroid gland	UBERON:0001119	65.44	gold quality
monocyte	CL:0000576	64.77	gold quality
thyroid gland	UBERON:0002046	64.30	gold quality
left lobe of thyroid gland	UBERON:0001120	63.96	gold quality
leukocyte	CL:0000738	63.25	gold quality
apex of heart	UBERON:0002098	62.83	gold quality
smooth muscle tissue	UBERON:0001135	62.23	gold quality
tibial nerve	UBERON:0001323	60.21	gold quality
ventricular zone	UBERON:0003053	60.06	gold quality
left coronary artery	UBERON:0001626	59.69	gold quality
omental fat pad	UBERON:0010414	59.67	gold quality
body of pancreas	UBERON:0001150	59.45	gold quality
endocervix	UBERON:0000458	59.17	gold quality
bone marrow	UBERON:0002371	58.95	gold quality
right coronary artery	UBERON:0001625	58.64	gold quality
heart left ventricle	UBERON:0002084	58.34	gold quality
adipose tissue	UBERON:0001013	58.18	gold quality
popliteal artery	UBERON:0002250	58.04	gold quality
tibial artery	UBERON:0007610	58.02	gold quality
right lung	UBERON:0002167	57.98	gold quality
muscle of leg	UBERON:0001383	57.77	gold quality
gastrocnemius	UBERON:0001388	57.74	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.39

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

124 targeting GOLGA8H, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-493-5P	99.96	72.47	2382
HSA-LET-7C-3P	99.95	73.42	2862
HSA-MIR-3910	99.95	71.13	2227
HSA-MIR-3912-5P	99.95	66.11	925
HSA-MIR-144-3P	99.94	73.98	2698
HSA-MIR-3143	99.93	71.96	3104
HSA-MIR-4760-3P	99.93	70.50	2385
HSA-MIR-205-3P	99.92	69.92	3165
HSA-MIR-589-3P	99.91	69.62	2088
HSA-MIR-7-1-3P	99.91	71.53	4384
HSA-MIR-7-2-3P	99.91	71.40	4394
HSA-MIR-1305	99.91	71.43	3443
HSA-MIR-374A-5P	99.90	71.34	2923

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	golga2	ENSDARG00000063197
mus_musculus	Golga2	ENSMUSG00000002546
rattus_norvegicus	Golga2l1	ENSRNOG00000050262
drosophila_melanogaster	GM130	FBGN0034697
caenorhabditis_elegans		WBGENE00018017

Paralogs (18): GOLGA6D (ENSG00000140478), GOLGA8F (ENSG00000153684), GOLGA6A (ENSG00000159289), GOLGA2 (ENSG00000167110), GOLGA6C (ENSG00000167195), GOLGA8A (ENSG00000175265), GOLGA8Q (ENSG00000178115), GOLGA8J (ENSG00000179938), GOLGA8G (ENSG00000183629), GOLGA8R (ENSG00000186399), GOLGA8M (ENSG00000188626), GOLGA8O (ENSG00000206127), GOLGA6B (ENSG00000215186), GOLGA8B (ENSG00000215252), GOLGA8N (ENSG00000232653), GOLGA8K (ENSG00000249931), GOLGA8T (ENSG00000261247), GOLGA8S (ENSG00000261739)

Protein

Protein identifiers

Golgin subfamily A member 8H — P0CJ92 (reviewed: P0CJ92)

All UniProt accessions (1): P0CJ92

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the GOLGA8 family.

RefSeq proteins (1): NP_001269419* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR024858	GOLGA	Family
IPR043937	GOLGA_C	Conserved_site
IPR043976	GOLGA_cons_dom	Domain

Pfam: PF15070, PF19046

UniProt features (10 total): region of interest 4, compositionally biased region 3, coiled-coil region 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0CJ92-F1	69.64	0.38

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 51 (showing top): chr15q13, GOBP_ENDOMEMBRANE_SYSTEM_ORGANIZATION, GOBP_GOLGI_ORGANIZATION, GOCC_GOLGI_STACK, GOCC_GOLGI_CISTERNA, GOCC_CIS_GOLGI_NETWORK, GOCC_GOLGI_CISTERNA_MEMBRANE, GOCC_ORGANELLE_SUBCOMPARTMENT, GOCC_GOLGI_CIS_CISTERNA, MIR3662, MIR520D_5P, MIR524_5P, MIR4262, MIR181A_5P_MIR181B_5P, MIR181D_5P

GO Biological Process (1): Golgi organization (GO:0007030)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (4): Golgi cis cisterna (GO:0000137), cis-Golgi network (GO:0005801), Golgi cisterna membrane (GO:0032580), Golgi apparatus (GO:0005794)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
Golgi cisterna	2
intracellular membrane-bounded organelle	2
organelle organization	1
endomembrane system organization	1
binding	1
Golgi apparatus	1
organelle membrane	1
cytoplasm	1
endomembrane system	1

Protein interactions and networks

STRING

234 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
GOLGA8H	CEP15	Q9HBI5	447
GOLGA8H	MTMR10	Q9NXD2	431
GOLGA8H	CCDC142	Q17RM4	415
GOLGA8H	C16orf78	Q8WTQ4	395
GOLGA8H	PAGR1	Q9BTK6	395
GOLGA8H	ARHGAP11B	Q3KRB8	371
GOLGA8H	CHRFAM7A	Q494W8	359
GOLGA8H	OTUD7A	Q8TE49	359
GOLGA8H	C2orf81	A6NN90	349
GOLGA8H	BRICD5	Q6PL45	337
GOLGA8H	TNRC6C	Q9HCJ0	328
GOLGA8H	TLK2	Q86UE8	321
GOLGA8H	COQ8A	Q8NI60	305
GOLGA8H	RNF151	Q2KHN1	300
GOLGA8H	TTC31	Q49AM3	299

IntAct

0 interactions, top by confidence:

BioGRID (1): HLF (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: A2AM05, A2RUR9, A5D8S1, A6H5Y1, A6NC78, A6NDN3, A6NMD2, A9JSR5, A9ZSY0, D6RF30, H3BQL2, H3BSY2, P0CJ92, Q19UN5, Q3TCJ8, Q3URK1, Q3V036, Q3V125, Q3ZRW6, Q3ZRW7, Q49A88, Q5CZC0, Q5IR70, Q5R6R3, Q5R8Y4, Q5TB80, Q640L3, Q66HB6, Q6AXN6, Q6ZQ06, Q811D2, Q86TE4, Q86V48, Q8BGY3, Q8CDM4, Q8IYA2, Q8K2J4, Q8K389, Q8R4U7, Q8TC20

Diamond homologs: A0A1B0GV03, A1IH00, A6NC78, A6NCC3, A6NDK9, A6NDN3, A6NEF3, A6NEM1, A6NI86, A6NN73, A7E2F4, A8MQT2, A8MZA4, F8WBI6, H0YKK7, H0YM25, H3BPF8, H3BSY2, H3BV12, I6L899, P0CG33, P0CJ92, P0DX00, P0DX01, P0DX02, P0DX52, P0DX53, Q08379, Q62839, Q8N7Z2, Q8N9W4, Q921M4, Q9NYA3, A6NMD2, D6RF30, H3BQL2, Q0D2H9, Q9HBQ8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2486 predictions. Top by Δscore:

Variant	Effect	Δscore
15:30605841:A:AG	acceptor_gain	1.0000
15:30605842:G:GG	acceptor_gain	1.0000
15:30605942:G:GA	donor_gain	1.0000
15:30605958:GGGAT:G	donor_gain	1.0000
15:30605959:GGAT:G	donor_gain	1.0000
15:30605959:GGATG:G	donor_gain	1.0000
15:30605960:G:GT	donor_gain	1.0000
15:30605960:G:T	donor_gain	1.0000
15:30605960:GAT:G	donor_gain	1.0000
15:30605963:G:GG	donor_gain	1.0000
15:30606853:A:AG	acceptor_gain	1.0000
15:30606854:G:GG	acceptor_gain	1.0000
15:30607058:A:AG	acceptor_gain	1.0000
15:30607059:C:G	acceptor_gain	1.0000
15:30607063:T:TA	acceptor_gain	1.0000
15:30607069:A:AG	acceptor_gain	1.0000
15:30607070:C:G	acceptor_gain	1.0000
15:30607082:T:TA	acceptor_gain	1.0000
15:30607085:A:AG	acceptor_gain	1.0000
15:30607086:T:G	acceptor_gain	1.0000
15:30607089:A:AG	acceptor_gain	1.0000
15:30607090:C:G	acceptor_gain	1.0000
15:30607093:CA:C	acceptor_loss	1.0000
15:30607094:A:AG	acceptor_gain	1.0000
15:30607094:AG:A	acceptor_loss	1.0000
15:30607095:G:GT	acceptor_gain	1.0000
15:30607095:GA:G	acceptor_gain	1.0000
15:30607095:GAGC:G	acceptor_gain	1.0000
15:30607095:GAGCC:G	acceptor_gain	1.0000
15:30607174:CTGGT:C	donor_loss	1.0000

AlphaMissense

4175 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
15:30614214:T:C	F546L	0.862
15:30614216:C:A	F546L	0.862
15:30614216:C:G	F546L	0.862
15:30610856:T:C	L322P	0.843
15:30607175:T:C	L103P	0.817
15:30610835:T:C	L315P	0.797
15:30604167:G:C	K14N	0.786
15:30604167:G:T	K14N	0.786
15:30610076:G:C	W252C	0.784
15:30610076:G:T	W252C	0.784
15:30607154:T:C	L96P	0.778
15:30604162:G:C	A13P	0.763
15:30605848:A:C	K18N	0.760
15:30605848:A:T	K18N	0.760
15:30610074:T:A	W252R	0.754
15:30610074:T:C	W252R	0.754
15:30610823:T:C	L311P	0.751
15:30613839:T:C	F480L	0.746
15:30613841:C:A	F480L	0.746
15:30613841:C:G	F480L	0.746
15:30608674:T:C	L170P	0.739
15:30605844:T:C	L17S	0.727
15:30608545:T:C	F159L	0.707
15:30608547:T:A	F159L	0.707
15:30608547:T:G	F159L	0.707
15:30611011:T:C	F374L	0.697
15:30611013:C:A	F374L	0.697
15:30611013:C:G	F374L	0.697
15:30608061:T:C	L114P	0.683
15:30610940:T:C	L350P	0.683

dbSNP variants (sampled 300 via entrez): RS1000298908 (15:30608062 G>A), RS1000339122 (15:30612590 C>G,T), RS1000455211 (15:30613099 C>A,G,T), RS1000559738 (15:30608753 C>G,T), RS1000628152 (15:30607860 C>T), RS1000785340 (15:30614776 C>T), RS1000977273 (15:30603514 A>G), RS1001029588 (15:30603360 A>G), RS1001033276 (15:30608950 G>C,T), RS1001537899 (15:30606832 A>G), RS1001643963 (15:30612521 G>A), RS1001850050 (15:30614068 T>C), RS1001970095 (15:30612273 A>G), RS1002364740 (15:30614312 C>A,T), RS1002424445 (15:30602959 G>A,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

7 total (human), top 7 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
entinostat	increases expression, affects cotreatment	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
Smoke	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Valproic Acid	increases expression	1
p-Chloromercuribenzoic Acid	affects cotreatment, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.