GOLGA8M

Summary

GOLGA8M (golgin A8 family member M, HGNC:44404) is a protein-coding gene on chromosome 15q13.1, encoding Golgin subfamily A member 8M (H3BSY2). It is a selective cancer dependency (DepMap: 14.5% of cell lines).

Predicted to be involved in Golgi organization. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi cis cisterna; Golgi cisterna membrane; and cis-Golgi network.

Source: NCBI Gene 653720 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 12 total
• Cancer dependency (DepMap): dependent in 14.5% of screened cell lines
• MANE Select transcript: NM_001282468

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44404
Approved symbol	GOLGA8M
Name	golgin A8 family member M
Location	15q13.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000188626
Ensembl biotype	protein_coding
Entrez	653720

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 1 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000563027, ENST00000563213

RefSeq mRNA: 1 — MANE Select: NM_001282468 NM_001282468

CCDS: CCDS61572

Canonical transcript exons

ENST00000563027 — 19 exons

Exon	Start	End
ENSE00001597346	28705483	28705739
ENSE00001759101	28706116	28706203
ENSE00002213610	28706399	28706506
ENSE00002235947	28706613	28706699
ENSE00002311899	28707953	28708037
ENSE00002313715	28707748	28707857
ENSE00002577222	28703842	28703917
ENSE00002577898	28702465	28702562
ENSE00002586034	28698583	28702129
ENSE00002595393	28705159	28705227
ENSE00002598353	28712276	28712421
ENSE00002598481	28708126	28708173
ENSE00002598874	28703319	28703410
ENSE00002606367	28702214	28702369
ENSE00002618297	28702645	28702745
ENSE00002620954	28708375	28708413
ENSE00003513022	28710487	28710606
ENSE00003571383	28709267	28709347
ENSE00003668175	28709529	28709588

Expression profiles

Bgee: expression breadth ubiquitous, 128 present calls, max score 86.93.

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	86.93	gold quality
right lobe of thyroid gland	UBERON:0001119	86.73	gold quality
thyroid gland	UBERON:0002046	85.13	gold quality
left lobe of thyroid gland	UBERON:0001120	84.81	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.39	gold quality
left ovary	UBERON:0002119	74.32	gold quality
right ovary	UBERON:0002118	73.51	gold quality
ovary	UBERON:0000992	73.44	gold quality
bone marrow cell	CL:0002092	72.81	gold quality
subcutaneous adipose tissue	UBERON:0002190	71.64	gold quality
adipose tissue	UBERON:0001013	71.31	gold quality
right lobe of liver	UBERON:0001114	71.19	gold quality
omental fat pad	UBERON:0010414	70.94	gold quality
liver	UBERON:0002107	70.88	gold quality
bone marrow	UBERON:0002371	69.61	gold quality
left testis	UBERON:0004533	68.92	gold quality
testis	UBERON:0000473	68.85	gold quality
right testis	UBERON:0004534	68.77	gold quality
thoracic mammary gland	UBERON:0005200	68.17	gold quality
apex of heart	UBERON:0002098	67.30	gold quality
tibial nerve	UBERON:0001323	65.06	gold quality
endocervix	UBERON:0000458	64.88	gold quality
right coronary artery	UBERON:0001625	64.82	gold quality
pituitary gland	UBERON:0000007	64.70	gold quality
descending thoracic aorta	UBERON:0002345	64.45	gold quality
adenohypophysis	UBERON:0002196	64.29	gold quality
right uterine tube	UBERON:0001302	63.01	gold quality
placenta	UBERON:0001987	62.81	gold quality
right atrium auricular region	UBERON:0006631	62.75	gold quality
body of uterus	UBERON:0009853	62.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.98

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

132 targeting GOLGA8M, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593
HSA-MIR-1185-2-3P	99.98	71.04	2593
HSA-MIR-32-5P	99.98	75.21	1964
HSA-MIR-92A-3P	99.98	75.21	1960
HSA-MIR-92B-3P	99.98	75.25	1955
HSA-MIR-25-3P	99.98	74.60	1817
HSA-MIR-363-3P	99.98	74.72	1821
HSA-MIR-367-3P	99.98	74.83	1819
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-493-5P	99.96	72.47	2382
HSA-MIR-3910	99.95	71.13	2227
HSA-LET-7C-3P	99.95	73.42	2862
HSA-MIR-144-3P	99.94	73.98	2698

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 14.5% of screened cell lines.

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	golga2	ENSDARG00000063197
mus_musculus	Golga2	ENSMUSG00000002546
rattus_norvegicus	Golga2l1	ENSRNOG00000050262
drosophila_melanogaster	GM130	FBGN0034697
caenorhabditis_elegans		WBGENE00018017

Paralogs (18): GOLGA6D (ENSG00000140478), GOLGA8F (ENSG00000153684), GOLGA6A (ENSG00000159289), GOLGA2 (ENSG00000167110), GOLGA6C (ENSG00000167195), GOLGA8A (ENSG00000175265), GOLGA8Q (ENSG00000178115), GOLGA8J (ENSG00000179938), GOLGA8G (ENSG00000183629), GOLGA8R (ENSG00000186399), GOLGA8O (ENSG00000206127), GOLGA6B (ENSG00000215186), GOLGA8B (ENSG00000215252), GOLGA8N (ENSG00000232653), GOLGA8K (ENSG00000249931), GOLGA8T (ENSG00000261247), GOLGA8S (ENSG00000261739), GOLGA8H (ENSG00000261794)

Protein

Protein identifiers

Golgin subfamily A member 8M — H3BSY2 (reviewed: H3BSY2)

All UniProt accessions (1): H3BSY2

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the GOLGA8 family.

Isoforms (3)

UniProt ID	Names	Canonical?
H3BSY2-1	1	yes
H3BSY2-2	2
H3BSY2-3	3

RefSeq proteins (1): NP_001269397* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR024858	GOLGA	Family
IPR043937	GOLGA_C	Conserved_site
IPR043976	GOLGA_cons_dom	Domain

Pfam: PF15070, PF19046

UniProt features (15 total): splice variant 5, region of interest 4, compositionally biased region 3, coiled-coil region 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-H3BSY2-F1	67.68	0.26

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 36 (showing top): chr15q13, GOBP_ENDOMEMBRANE_SYSTEM_ORGANIZATION, GOBP_GOLGI_ORGANIZATION, GOCC_GOLGI_STACK, GOCC_GOLGI_CISTERNA, GOCC_CIS_GOLGI_NETWORK, GOCC_GOLGI_CISTERNA_MEMBRANE, GOCC_ORGANELLE_SUBCOMPARTMENT, GOCC_GOLGI_CIS_CISTERNA, MIR3662, MIR520D_5P, MIR524_5P, MIR4262, MIR181A_5P_MIR181B_5P, MIR181D_5P

GO Biological Process (1): Golgi organization (GO:0007030)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (4): Golgi cis cisterna (GO:0000137), cis-Golgi network (GO:0005801), Golgi cisterna membrane (GO:0032580), Golgi apparatus (GO:0005794)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
Golgi cisterna	2
intracellular membrane-bounded organelle	2
organelle organization	1
endomembrane system organization	1
binding	1
Golgi apparatus	1
organelle membrane	1
cytoplasm	1
endomembrane system	1

Protein interactions and networks

STRING

176 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
GOLGA8M	SMIM31	A0A1B0GVY4	665
GOLGA8M	LRRC9	Q6ZRR7	621
GOLGA8M	UROC1	Q96N76	506
GOLGA8M	POTEB3	A0JP26	476
GOLGA8M	ARPC1A	Q92747	397
GOLGA8M	OR4M2	Q8NGB6	367
GOLGA8M	HHLA1	C9JL84	357
GOLGA8M	APBA2	Q99767	333
GOLGA8M	SLC39A8	Q9C0K1	290
GOLGA8M	UGT2B10	P36537	288
GOLGA8M	OC90	Q02509	269
GOLGA8M	ITSN2	Q9NZM3	238
GOLGA8M	CDC45	O75419	232
GOLGA8M	HERC2	O95714	224
GOLGA8M	CHRFAM7A	Q494W8	220

IntAct

0 interactions, top by confidence:

BioGRID (3): GOLGA8M (Proximity Label-MS), TBRG4 (Cross-Linking-MS (XL-MS)), UBXN1 (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: A2AHC3, A2AMT1, A6NCC3, A6NN73, D3Z8E6, D6RF30, E7F5E1, H3BPF8, H3BQL2, H3BSY2, O15061, O35668, P0DX52, P0DX53, P53814, P54256, P54257, P62025, P97434, Q02435, Q06002, Q06637, Q0D2H9, Q0VF96, Q12934, Q3UHU5, Q3V0F0, Q5DU05, Q5T5Y3, Q5TF21, Q60664, Q62627, Q63312, Q6AW69, Q6NZL0, Q6PHN1, Q6WCQ1, Q70IV5, Q80VC9, Q80Y56

Diamond homologs: A0A1B0GV03, A1IH00, A6NC78, A6NCC3, A6NDK9, A6NDN3, A6NEF3, A6NEM1, A6NI86, A6NN73, A7E2F4, A8MQT2, A8MZA4, F8WBI6, H0YKK7, H0YM25, H3BPF8, H3BSY2, H3BV12, I6L899, P0CG33, P0CJ92, P0DX00, P0DX01, P0DX02, P0DX52, P0DX53, Q08379, Q62839, Q8N7Z2, Q8N9W4, Q921M4, Q9NYA3, A6NMD2, D6RF30, H3BQL2, Q0D2H9, Q9HBQ8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

12 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	12
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2787 predictions. Top by Δscore:

Variant	Effect	Δscore
15:28702210:TCACC:T	donor_loss	1.0000
15:28702211:CACCA:C	donor_loss	1.0000
15:28702212:A:AC	donor_gain	1.0000
15:28702212:ACC:A	donor_loss	1.0000
15:28702213:C:CC	donor_gain	1.0000
15:28702213:CCA:C	donor_gain	1.0000
15:28702365:TTCAC:T	acceptor_gain	1.0000
15:28702366:TCAC:T	acceptor_gain	1.0000
15:28702367:CAC:C	acceptor_gain	1.0000
15:28702367:CACC:C	acceptor_gain	1.0000
15:28702368:AC:A	acceptor_gain	1.0000
15:28702369:CC:C	acceptor_gain	1.0000
15:28702370:C:CC	acceptor_gain	1.0000
15:28702463:A:T	donor_loss	1.0000
15:28702464:CC:C	donor_loss	1.0000
15:28702476:C:CA	donor_gain	1.0000
15:28702643:A:AC	donor_gain	1.0000
15:28702644:C:CC	donor_gain	1.0000
15:28703314:CTCA:C	donor_loss	1.0000
15:28703315:TCA:T	donor_loss	1.0000
15:28703316:CACCA:C	donor_loss	1.0000
15:28703317:A:AC	donor_gain	1.0000
15:28703317:ACCA:A	donor_loss	1.0000
15:28703318:C:CC	donor_gain	1.0000
15:28703327:C:A	donor_gain	1.0000
15:28703412:T:C	acceptor_loss	1.0000
15:28703869:G:C	donor_gain	1.0000
15:28704055:T:TA	donor_gain	1.0000
15:28704068:G:C	donor_gain	1.0000
15:28704080:G:C	donor_gain	1.0000

AlphaMissense

4179 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
15:28705649:A:G	L322P	0.864
15:28709289:A:G	L96P	0.823
15:28702299:G:C	F546L	0.815
15:28702299:G:T	F546L	0.815
15:28702301:A:G	F546L	0.815
15:28705670:A:G	L315P	0.809
15:28706429:C:A	W252C	0.807
15:28706429:C:G	W252C	0.807
15:28707830:A:G	L170P	0.804
15:28702674:G:C	F480L	0.802
15:28702674:G:T	F480L	0.802
15:28702676:A:G	F480L	0.802
15:28712287:C:G	A13P	0.794
15:28706431:A:G	W252R	0.778
15:28706431:A:T	W252R	0.778
15:28708030:A:G	L135P	0.777
15:28712282:C:A	K14N	0.774
15:28712282:C:G	K14N	0.774
15:28705682:A:G	L311P	0.770
15:28710601:T:A	K18N	0.767
15:28710601:T:G	K18N	0.767
15:28710605:A:G	L17S	0.759
15:28708382:A:G	L114P	0.748
15:28701987:A:C	F622L	0.735
15:28701987:A:T	F622L	0.735
15:28701989:A:G	F622L	0.735
15:28709268:A:G	L103S	0.732
15:28706417:C:A	M256I	0.722
15:28706417:C:G	M256I	0.722
15:28706417:C:T	M256I	0.722

dbSNP variants (sampled 300 via entrez): RS1000124177 (15:28701707 G>A), RS1000496296 (15:28704604 G>A,C), RS1000569765 (15:28704357 T>G), RS1000626697 (15:28698738 C>G,T), RS1000713115 (15:28710132 C>A,T), RS1000808933 (15:28699039 G>T), RS1000840244 (15:28715190 A>G), RS1001078427 (15:28710813 T>G), RS1001797580 (15:28698261 T>A), RS1001887628 (15:28709734 C>G,T), RS1001897859 (15:28703947 T>C,G), RS1001976716 (15:28698660 T>C), RS1002054150 (15:28714784 C>A,G), RS1002148917 (15:28715083 G>C,T), RS1002529927 (15:28709503 C>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases expression	1
Okadaic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.